Publications

Tamari M, Del Bel KL, Ver Heul AM, Zamidar L, Orimo K, Hoshi M, Trier AM, Yano H, Yang TL, Biggs CM, Motomura K, Shibuya R, Yu CD, Xie Z, Iriki H, Wang Z, Auyeung K, Damle G, Demircioglu D, Gregory JK, Hasson D, Dai J, Chang RB, Morita H, Matsumoto K, Jain S, Van Dyken S, Milner JD, Bogunovic D, Hu H, Artis D, Turvey SE, Kim BS.

Sensory neurons promote immune homeostasis in the lung

Cell 2024 Jan

DOI: 10.1016/j.cell.2023.11.027

Xie Z*, Rose L*, Feng J, Zhao Y, Lu Y, Othman R, Kane H, Hibberd TJ, Hu X, Zang K, Yang X, Richardson Q, Venezia OL, Zhakyp A, Gao F, Abe N, Wang Z, Vigeland K, Wang H, Branch C, Dong X, Kim BS, Spencer NJ, Hu H#, and Jackson R#

Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force

Cell. 2025 May

DOI: 10.1016/j.cell.2025.02.031

He Z^*, Zhao Y^*, Rau M, Fitzpatrick J, Sah R, Hu H^#, Yuan P^#.

Structural and functional analysis of human pannexin 2 channel

Nat Commun. 2023 Mar

DOI: 10.1038/s41467-023-37413-z

Hu X^*, Du L^*, Liu S^*, Lan Z, Zang K, Zhao Y, Yang X, Xie Z, Wang PL, Chen L, Samineni VK, Wang Y, Lavine KJ, Gereau IV RW, Wu GF^#, Hu H^#.

A TRPV4-dependent neuro-immune axis in the spinal cord promotes neuropathic pain

J Clin Invest 2023 Mar

DOI: 10.1172/JCI161507

Xie Z^*, Feng J^*, Hibberd TJ^*, Chen BN, Zhao Y, Zang K, Hu X, Yang X, Brookes SJ, Spencer NJ^#, Hu H^#.

Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity

Neuron 2023 Feb

DOI: 10.1016/j.neuron.2022.11.015

Xie Z^*, Feng J^*, Cai T^*, McCarthy R, Eschbach MD, Wang Y, Yi Z, Zhao Y, Zang K, Yuan Y, Hu X, Li F, Liu Q, Das A, England SK and Hu H.

Estrogen metabolites increase nociceptor hyperactivity in a mouse model of uterine pain

JCI Insight 2022 May

DOI: 10.1172/jci.insight.149107

Feng J^#, Zhao Y, Xie Z, Zang K, Sviben S, Hu X, Fitzpatrick JJ, Wen L, Liu Y, Wang T, Lawson K, Liu Q, Yan Y, Dong X, Han L, Wu GF, Kim BS, Hu H^#.

Miswiring of Merkel cell and pruriceptive C fiber drives the itch-scratch cycle

Sci Transl Med 2022 Jul

DOI: 10.1126/scitranslmed.abn4819

Lan Z^*, Chen L^*, Feng J, Xie Z, Liu Z, Wang F, Liu P, Yue X, Du L, Zhao Y, Yang p, Luo J, Zhu Z, Hu X, Cao L, Lu P, Sah R, Lavine K, Kim BS, Hu H.

The mechanosensitive TRPV4 is required for crystal-induced inflammation

Ann Rheum Dis 2021 Dec

DOI: 10.1136/annrheumdis-2021-220295

Wong NR, Mohan J, Kopecky BJ, Guo S, Du L, Leid J, Feng G, Lokshina I, Dmytrenko O, Luehmann H, Bajpai G, Ewald L, Bell L, Patel N, Bredemeyer A, Weinheimer CJ, Nigro JM, Kovacs A, Morimoto S, Bayguinov PO, Fisher MR, Stump WT, Greenberg M, Fitzpatrick JAJ, Epelman S, Kreisel D, Sah R, Liu Y, Hu H, Lavine KJ.

Resident cardiac macrophages mediate adaptive myocardial remodeling

Immunity 2021 Sep

DOI: 10.1016/j.immuni.2021.07.003

Wang F, Trier AM, Li F, Kim S, Chen Z, Chai JN, Mack MR, Morrison SA, Hamilton JD, Baek J, Yang TLB, Ver Heul AM, Xu AZ, Xie Z, Dong X, Kubo M, Hu H, Hsieh CS, Dong X, Liu Q, Margolis DJ, Ardeleanu M, Miller MJ, Kim BS.

A Basophil-Neuronal Axis Promotes Itch

Cell 2021 Jan

DOI: 10.1016/j.cell.2020.12.033

Arnold WR, Carnevale LN, Xie Z, Baylon JL, Tajkhorshid E, Hu H, Das A.

Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel

Nat Commun 2021 Feb

DOI: 10.1038/s41467-021-20946-6

Spencer NJ, Hu H.

Enteric Nervous System: Sensory transduction, neural circuits and gastrointestinal motility

Nat Rev Gastroenterol Hepatol 2020

DOI: 10.1038/s41575-020-0271-2

Li F, Yang W, Jiang H, Guo C, Andrew J. W. Huang AJW, Hu H & Liu Q.

TRPV1 activity and substance P release are required for corneal cold nociception

Nat Commun 2019 Dec

DOI: 10.1038/s41467-019-13536-0

Luo J, Qian A, Oetjen LK, Yu W, Yang P, Feng J, Xie Z, Liu S, Yin S, Dryn D, Cheng J, Riehl TE, Zholos AV, Stenson WF, Kim BS^#, Hu H^#.

TRPV4 channel signaling in macrophages promotes gastrointestinal motility via direct effects on smooth muscle cells

Immunity 2018 Jul

DOI: 10.1016/j.immuni.2018.04.021

Feng J, Luo J, Yang P, Du J, Kim BS, Hu H.

Piezo2 channel-merkel cell signaling modulates the conversion of touch to itch

Science 2018 May

DOI: 10.1126/science.aar5703

Luo J^*, Feng J^*, Yu g, Yang P, Mack MR, Du J, Yu W, Qian A, Zhang Y, Liu S, Yin S, Xu A, Cheng J, Liu Q, O'Neil RG, Xia Y, Ma L, Carlton SM, Kim BS, Liu Q^#, Hu H^#.

Transient receptor potential vanilloid 4-expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch

J Allergy Clin Immun 2018 Feb

DOI: 10.1016/j.jaci.2017.05.051

Oetjen LK, Mack MR, Feng J, Whelan TM, Niu H, Guo CJ, Chen S, Trier AM, Xu AZ, Tripathi SV, Luo J, Gao X, Yang L, Hamilton SL, Wang PL, Brestoff JR, Council ML, Brasington R, Schaffer A, Brombacher F, Hsieh CS, Gereau RW 4th, Miller MJ, Chen ZF, Hu H, Davidson S, Liu Q, Kim BS.

Sensory neurons co-opt classical immune signaling pathways to mediate chronic itch

Cell 2017 Sep

DOI: 10.1016/j.cell.2017.08.006

Feng J^*, Yang P^*, Dryn D, Luo J, Gong X, Liu S, Oetjen LK, Zholos AV, Mei Z, Yin S, Kim BS, Hu H.

Sensory TRP channels contribute differentially to skin inflammation and persistent itch in a mouse model of contact dermatitis

Nat Commun 2017 Oct

DOI: 10.1038/s41467-017-01056-8

Yin S^*, Luo J^*, Qian A, Du J, Yang Q, Zhou S, Yu W, Du G, Clark RB, Walters ET, Carlton SM, Hu H.

Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity

J Clin Invest 2013

DOI: 10.1172/JCI66413