{"id":3,"date":"2023-01-13T16:08:20","date_gmt":"2023-01-13T16:08:20","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/holguinlab\/?page_id=3"},"modified":"2023-01-23T14:55:56","modified_gmt":"2023-01-23T14:55:56","slug":"home","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/holguinlab\/","title":{"rendered":"Home"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”4.9.0″ _module_preset=”default” border_width_bottom=”0.5px” border_color_bottom=”#0C71C3″][et_pb_fullwidth_slider _builder_version=”4.9.0″ _module_preset=”default” auto=”on”][et_pb_slide heading=”Spine Translational Research” use_bg_overlay=”on” bg_overlay_color=”rgba(0,0,0,0.4)” _builder_version=”4.9.0″ _module_preset=”default” background_image=”https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-content\/uploads\/sites\/468\/2023\/01\/Holguin-Banner.png” background_enable_image=”on” sticky_transition=”on”][\/et_pb_slide][et_pb_slide heading=”Spine Translational Research” _builder_version=”4.9.0″ _module_preset=”default” background_image=”https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-content\/uploads\/sites\/468\/2023\/01\/Holguin-Banner.png” background_enable_image=”on” sticky_transition=”on”][\/et_pb_slide][\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Research Section” module_id=”research” module_class=”research-section” _builder_version=”4.9.0″ _module_preset=”default”][et_pb_row _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans|600|||||||” text_text_color=”#0C71C3″ text_font_size=”22px” text_line_height=”1.8em”]Research[\/et_pb_text][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans||||||||” text_font_size=”18px” text_line_height=”1.9em”]<\/p>\n

Intervertebral disc degeneration and osteoporosis of the spine impose a significant socioeconomic burden and treatment for both is lacking. The Holguin laboratory focuses on the biomechanics and mechanobiology of the spine undergoing adaptation to aging, mechanical forces, genetics and injury with an eye towards therapy. Techniques used in the laboratory include molecular (e.g., PCR, qPCR, RNA-sequencing, Western blots), histologic (e.g., staining, IHC, fluorochrome histomorphometry), imaging (e.g., DEXA, microCT, MRI), and biomechanical (e.g., spinal-unit tension-compression, indentation), and genetic rodent models. Dr. Holguin is the Director of the MicroCT Core at Mount Sinai, which includes additional bone phenotyping equipment.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Publications Section” module_id=”publications” module_class=”publications-section” _builder_version=”4.9.0″ _module_preset=”default” background_color=”#0C71C3″ background_image=”https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-content\/uploads\/sites\/468\/2023\/01\/Holguin-Banner2.jpg” parallax=”on” parallax_method=”off”][et_pb_row _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans|600|||||||” text_text_color=”#FFFFFF” text_font_size=”22px” text_line_height=”1.8em”]<\/p>\n

Publications<\/p>\n

[\/et_pb_text][et_pb_accordion open_toggle_background_color=”#006ac1″ closed_toggle_background_color=”#0C71C3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_accordion_item title=”2022″ open=”on” open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”rgba(0,106,193,0.7)” closed_toggle_background_color=”rgba(0,106,193,0.7)” icon_color=”#FFFFFF” use_icon_font_size=”on” _builder_version=”4.9.0″ _module_preset=”default” body_text_color=”#FFFFFF” text_orientation=”left” border_radii=”on|9px|9px|9px|9px” border_width_all=”0.5px” border_color_all=”#FFFFFF” toggle_text_color=”#FFFFFF” toggle_font=”Open Sans|700|||||||” toggle_font_size=”20px”]<\/p>\n

Kroon, T., Bhadouria, N., Niziolek, P., Edwards, D., Clinkenbeard, E.L., Robling, A., Holguin, N.<\/strong>, (2022). Suppression of sost\/sclerostin and dikkopf-1 promote intervertebral disc structure in mice. J Bone and Miner Res. 37(6): 1156-1169. DOI: 10.1002\/jbmr.4546. (Cover; Contribution: Design, Writing, Expenses)<\/p>\n

Bhadouria, N., Niziolek, P., Berman, A., Wallace, J., Holguin, N.<\/strong>, Raloxifene stimulates estrogen reduces sex- and age-related intervertebral disc degeneration in mice by estrogen signaling. Frontiers Bioengineering and Biotechnology. (Accepted, 2022).<\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item title=”2020 – 2016″ open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”rgba(0,106,193,0.7)” closed_toggle_background_color=”rgba(0,106,193,0.7)” icon_color=”#FFFFFF” use_icon_font_size=”on” _builder_version=”4.9.0″ _module_preset=”default” body_text_color=”#FFFFFF” text_orientation=”left” border_radii=”on|9px|9px|9px|9px” border_width_all=”0.5px” border_color_all=”#FFFFFF” toggle_text_color=”#FFFFFF” toggle_font=”Open Sans|700|||||||” toggle_font_size=”20px” open=”off”]<\/p>\n

2020<\/strong>
Silva, M., Holguin, N.<\/strong> (2020) Aging aggravates intervertebral disc degeneration by regulating transcription factors toward chondrogenesis. Faseb J. Dec 24; 34(3): doi.org\/10.1096\/fj.201902109R. (Contribution: Design, Experiments, Writing, Expenses).<\/p>\n

2018<\/strong>
Holguin, N.<\/strong> and Silva, M.J. (2018). In-Vivo nucleus pulposus-specific regulation of adult murine intervertebral disc degeneration via Wnt\/beta-catenin signaling. Sci Rep. Jul 25; 8(1):11191. doi: 10.1038\/s41598-018-29352-3. (Contribution: Design, Experiments, Writing).<\/p>\n

Sun, D., Brodt, M., Zannit, H, Holguin, N.<\/strong> and Silva, M.J. (2018). Evaluation of loading parameters for murine axial tibial loading: Stimulating cortical bone formation while reducing loading duration. J Orthop Res. 2018 Feb;36(2):682-691. doi: 10.1002\/jor.23727. (Contribution: performed loading and consulted).<\/p>\n

2017<\/strong>
Duan X, Sandell LJ, Chinzei N, Holguin N,<\/strong> Silva MJ, Schiavinato A, Rai MF. (2017) Therapeutic efficacy of intra-articular hyaluronan derivative and platelet-rich plasma in mice following axial tibial loading. PLoS One. 2017 Apr 13;12(4): e0175682. doi: 10.1371\/journal.pone.0175682. (Contribution: performed loading and consulted).<\/p>\n

Rai MF, Duan X, Quirk JD, Holguin N,<\/strong> Schmidt EJ, Chinzei N, Silva MJ, Sandell LJ. (2017) Post-Traumatic Osteoarthritis in Mice Following Mechanical Injury to the Synovial Joint. Sci Rep. Mar 27;7: 45223. doi: 10.1038\/srep45223. (Contribution: performed loading and consulted).<\/p>\n

2016<\/strong>
Xin, D., Holguin N,<\/strong> Rai, M.F., Patra, D., Liao, W., Silva, M., Sandell, L. (2016). Early changes in the knee of healer and non-healer mice following non-invasive mechanical injury. J Orthop Res. Sep 3. doi: 10.1002\/jor.23413. (Contribution: performed loading and consulted).
Yan, H., Xin, D., Pan, H, Holguin N, Rai, M.F., Akk, A., Springer, L., Wickline, S., Sandell, L., Pham, C. (2016) Suppressing NF-kB activity in early cartilage responses to injury: a nanotherapeutic approach. Proc Natl Acad Sci USA Oct 11;113(41), E6199-E6208. (Contribution: performed loading and consulted).<\/p>\n

Holguin N,<\/strong> Brodt, M.D., Silva, M.J. (2016). Aging impairs activation of Wnt signaling by mechanical loading in the bone of old mice. J Bone and Miner Res. DOI: 10.1002\/jbmr.2900.<\/p>\n

Holguin N.<\/strong> (2016). CORR Insights: The NLRP3\/Caspase-1\/Interleukin-1\u03b2 Axis Is Active in Human Lumbar Cartilaginous Endplate Degeneration. Clin Orthop Relat Res. 474(8), 1827-1829.<\/p>\n

Holguin N.<\/strong> (2016). CORR Insights: Does sclerostin stimulate fracture healing in a mouse model? Clin Orthop Relat Res. May;474(5):1303-6.<\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item title=”2015 – 2009″ open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”rgba(0,106,193,0.7)” closed_toggle_background_color=”rgba(0,106,193,0.7)” icon_color=”#FFFFFF” use_icon_font_size=”on” _builder_version=”4.9.0″ _module_preset=”default” body_text_color=”#FFFFFF” text_orientation=”left” border_radii=”on|9px|9px|9px|9px” border_width_all=”0.5px” border_color_all=”#FFFFFF” toggle_text_color=”#FFFFFF” toggle_font=”Open Sans|700|||||||” toggle_font_size=”20px” open=”off”]<\/p>\n

2015<\/strong>
Chen J, Holguin N<\/strong>, Yu, S., Silva M.J., Long F. (2015). mTORC2 signaling promotes skeletal growth and bone formation in mice J Bone and Miner Res Feb; 30(2):369-78.<\/p>\n

2014<\/strong>
Holguin N,<\/strong> Brodt, M.D., Sanchez, M.E., Silva, M.J. (2014). Aging diminishes lamellar and woven bone formation induced by tibial compression in adult C57Bl\/6 Bone August; 65: 83-91.<\/p>\n

Holguin N,<\/strong> Aguilar, N., Harland, R., Silva M.J. (2014). The aging mouse partially models the aging human spine: lumbar and coccygeal disc height, composition, mechanical properties and Wnt signaling in young and old mice. J Appl Physiol June; 116(12): 1551-60.<\/p>\n

Wu, P., Holguin N,<\/strong> Silva, M.J., Liao, W., Sandell, L.J. (2014). Early response of mouse joint tissues to noninvasive knee injury suggests treatment targets. Arthritis and Rheumatism May; 66(5): 1256-65.<\/p>\n

2013<\/strong>
Holguin N,<\/strong> Brodt, M.D., Sanchez, M.E., Lynch, M.A., Kotiya, A.A., Silva, M.J. (2013). Adaptation of tibial strength and structure to axial compression is more dependent on loading history than mouse strain. Calcif Tis Int Sep; 93(3): 211-21.<\/p>\n

Holguin N,<\/strong> Martin, J., Elliott, D.M., Judex, S. (2013). Brief, low-intensity vibration partially maintains intervertebral disc mechanics and spinal muscle area during deconditioning. Spine Journal Apr; 13(4):428-36.<\/p>\n

2011<\/strong>
Holguin N,<\/strong> Uzer, G, Chiang, F., Rubin, C., Judex, S. (2011). Brief daily exposure to low-intensity vibration mitigates the degradation of the intervertebral disc in a frequency-specific manner. J Appl Physiol Dec; 111(6):1846-53.<\/p>\n

2010<\/strong>
Holguin N,<\/strong> Judex, S. (2010). Rat intervertebral disc health during hindlimb unloading: brief ambulation with or without whole-body vibration. Aviat Space Environ Med Dec; 81(12)1078-84.<\/p>\n

2009<\/strong>
Holguin N,<\/strong> Muir, J., Rubin, C., Judex, S. (2009). Short applications of very low-magnitude vibrations attenuate expansion of intervertebral disc during extended bed rest. Spine Journal Jun; 9(6):470-7.<\/p>\n

[\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Featured Section” module_id=”featured” module_class=”featured-section” _builder_version=”4.9.0″ _module_preset=”default” background_image=”https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-content\/uploads\/sites\/468\/2023\/01\/Holguin-Banner3.jpg” parallax=”on” parallax_method=”off”][et_pb_row column_structure=”1_3,2_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-content\/uploads\/sites\/468\/2023\/01\/Picture6.png” title_text=”Picture6″ _builder_version=”4.9.0″ _module_preset=”default” animation_style=”fade” border_radii=”on|9px|9px|9px|9px” box_shadow_style=”preset3″ transform_styles__hover_enabled=”off|desktop” transform_scale__hover_enabled=”off|desktop” transform_translate__hover_enabled=”off|desktop” transform_rotate__hover_enabled=”off|desktop” transform_skew__hover_enabled=”off|desktop” transform_origin__hover_enabled=”off|desktop”][\/et_pb_image][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans|600|||||||” text_text_color=”#0C71C3″ text_font_size=”22px” text_line_height=”1.8em”]<\/p>\n

Kroon, T., Bhadouria, N., Niziolek, P., Edwards, D., Clinkenbeard, E.L., Robling, A., Holguin, N., (2022). Suppression of sost\/sclerostin and dikkopf-1 promote intervertebral disc structure in mice. J Bone and Miner Res.<\/i> 37(6): 1156-1169. DOI: 10.1002\/jbmr.4546<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans|600|||||||” text_text_color=”#0C71C3″ text_font_size=”22px” text_line_height=”1.8em”]<\/p>\n

Master\u2019s student Neharika Bhadouria was selected for the Orthopedic Research Society Spine Section Travel Fellowship Award.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-content\/uploads\/sites\/468\/2023\/01\/Picture5.png” title_text=”Picture5″ _builder_version=”4.9.0″ _module_preset=”default” animation_style=”fade” border_radii=”on|9px|9px|9px|9px” box_shadow_style=”preset3″ transform_styles__hover_enabled=”off|desktop” transform_scale__hover_enabled=”off|desktop” transform_translate__hover_enabled=”off|desktop” transform_rotate__hover_enabled=”off|desktop” transform_skew__hover_enabled=”off|desktop” transform_origin__hover_enabled=”off|desktop”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Team Section” module_id=”team” module_class=”team-section” _builder_version=”4.9.0″ _module_preset=”default” border_width_top=”0.5px” border_color_top=”#0C71C3″][et_pb_row _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans|600|||||||” text_text_color=”#0C71C3″ text_font_size=”22px” text_line_height=”1.8em”]<\/p>\n

Team<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”1_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-content\/uploads\/sites\/468\/2023\/01\/team4.png” title_text=”team4″ _builder_version=”4.9.0″ _module_preset=”default” animation_style=”fade” border_width_all=”4px” border_color_all=”#0C71C3″ transform_styles__hover_enabled=”off|desktop” transform_scale__hover_enabled=”off|desktop” transform_translate__hover_enabled=”off|desktop” transform_rotate__hover_enabled=”off|desktop” transform_skew__hover_enabled=”off|desktop” transform_origin__hover_enabled=”off|desktop” border_radii__hover_enabled=”on|hover” border_width_all__hover_enabled=”on|hover” border_width_all__hover=”1px” border_radii__hover=”on|4px|4px|4px|4px”][\/et_pb_image][et_pb_text admin_label=”Nilsson Holguin, PhD” _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans|600|||||||” text_text_color=”#000000″ text_font_size=”16px”]<\/p>\n

Nilsson Holguin, PhD<\/strong>
Assistant Professor
Nilsson.Holguin@mssm.edu<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-content\/uploads\/sites\/468\/2023\/01\/team1.png” title_text=”team1″ _builder_version=”4.9.0″ _module_preset=”default” animation_style=”fade” border_width_all=”4px” border_color_all=”#0C71C3″ transform_styles__hover_enabled=”off|desktop” transform_scale__hover_enabled=”off|desktop” transform_translate__hover_enabled=”off|desktop” transform_rotate__hover_enabled=”off|desktop” transform_skew__hover_enabled=”off|desktop” transform_origin__hover_enabled=”off|desktop” border_radii__hover_enabled=”on|hover” border_width_all__hover_enabled=”on|hover” border_width_all__hover=”1px” border_radii__hover=”on|4px|4px|4px|4px”][\/et_pb_image][et_pb_text admin_label=”Neharika Bhadouria, MS” _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans|600|||||||” text_text_color=”#000000″ text_font_size=”16px”]<\/p>\n

Neharika Bhadouria, MS<\/strong>
(PhD Candidate)<\/em>
Neharika.Bhaduoria@mssm.edu<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-content\/uploads\/sites\/468\/2023\/01\/team2.png” title_text=”team2″ _builder_version=”4.9.0″ _module_preset=”default” animation_style=”fade” border_width_all=”4px” border_color_all=”#0C71C3″ transform_styles__hover_enabled=”off|desktop” transform_scale__hover_enabled=”off|desktop” transform_translate__hover_enabled=”off|desktop” transform_rotate__hover_enabled=”off|desktop” transform_skew__hover_enabled=”off|desktop” transform_origin__hover_enabled=”off|desktop” border_radii__hover_enabled=”on|hover” border_width_all__hover_enabled=”on|hover” border_width_all__hover=”1px” border_radii__hover=”on|4px|4px|4px|4px”][\/et_pb_image][et_pb_text admin_label=”Tori M. Kroon, MS” _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans|600|||||||” text_text_color=”#000000″ text_font_size=”16px”]<\/p>\n

Tori M. Kroon, MS<\/strong>
(PhD Trainee)<\/em>
Tori.Kroon@icahn.mssm.edu<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-content\/uploads\/sites\/468\/2023\/01\/team3.png” title_text=”team3″ _builder_version=”4.9.0″ _module_preset=”default” animation_style=”fade” border_width_all=”4px” border_color_all=”#0C71C3″ transform_styles__hover_enabled=”off|desktop” transform_scale__hover_enabled=”off|desktop” transform_translate__hover_enabled=”off|desktop” transform_rotate__hover_enabled=”off|desktop” transform_skew__hover_enabled=”off|desktop” transform_origin__hover_enabled=”off|desktop” border_radii__hover_enabled=”on|hover” border_width_all__hover_enabled=”on|hover” border_width_all__hover=”1px” border_radii__hover=”on|4px|4px|4px|4px”][\/et_pb_image][et_pb_text admin_label=”Janai Augustin, BS” _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans|600|||||||” text_text_color=”#000000″ text_font_size=”16px”]<\/p>\n

Janai Augustin, BS<\/strong>
(Research Associate)<\/em><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Lab News Section” module_id=”news” module_class=”news-section” _builder_version=”4.9.0″ _module_preset=”default” background_color=”#0C71C3″ background_image=”https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-content\/uploads\/sites\/468\/2023\/01\/Holguin-Banner2.jpg” parallax=”on” parallax_method=”off”][et_pb_row _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text admin_label=”Text” _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans|600|||||||” text_text_color=”#FFFFFF” text_font_size=”22px” text_line_height=”1.8em” custom_padding=”0px||||false|false”]<\/p>\n

Lab News<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”0px||||false|false”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_slider admin_label=”Lab Slider” _builder_version=”4.9.0″ _module_preset=”default”][et_pb_slide heading=”July 2022- ORL Field Day in Central Park” image=”https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-content\/uploads\/sites\/468\/2023\/01\/Picture8.png” _builder_version=”4.9.0″ _module_preset=”default” header_font=”Open Sans|300|||||||” header_text_color=”#FFFFFF” header_font_size=”30px” background_color=”rgba(0,106,193,0.9)” background_enable_color=”on” background_enable_image=”off” border_radii_image=”on|4px|4px|4px|4px” sticky_transition=”on”][\/et_pb_slide][et_pb_slide heading=”Nov. 2019 – Tori Kroon presents at her first ORS PSRS” image=”https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-content\/uploads\/sites\/468\/2023\/01\/Picture3.jpg” _builder_version=”4.9.0″ _module_preset=”default” header_font=”Open Sans|300|||||||” header_text_color=”#FFFFFF” header_font_size=”30px” background_color=”rgba(0,106,193,0.9)” background_enable_color=”on” background_enable_image=”off” border_radii_image=”on|4px|4px|4px|4px” sticky_transition=”on”][\/et_pb_slide][et_pb_slide heading=”Aug. 2021- The Holguin and Clinkenbeard labs escape \u201cContagion\u201d” image=”https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-content\/uploads\/sites\/468\/2023\/01\/Picture4.jpg” _builder_version=”4.9.0″ _module_preset=”default” header_font=”Open Sans|300|||||||” header_text_color=”#FFFFFF” header_font_size=”30px” background_color=”rgba(0,106,193,0.9)” background_enable_color=”on” background_enable_image=”off” border_radii_image=”on|4px|4px|4px|4px” sticky_transition=”on”][\/et_pb_slide][et_pb_slide heading=”Sept. 2022- MicroCT Core opens at Mount Sinai” image=”https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-content\/uploads\/sites\/468\/2023\/01\/Picture7-300×225.png” _builder_version=”4.9.0″ _module_preset=”default” header_font=”Open Sans|300|||||||” header_text_color=”#FFFFFF” header_font_size=”30px” background_color=”rgba(0,106,193,0.9)” background_enable_color=”on” background_enable_image=”off” border_radii_image=”on|4px|4px|4px|4px” sticky_transition=”on”][\/et_pb_slide][\/et_pb_slider][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ disabled_on=”on|on|on” _builder_version=”4.9.0″ _module_preset=”default” custom_margin=”0px||||false|false” custom_padding=”0px||||false|false” disabled=”on”][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-content\/uploads\/sites\/468\/2023\/01\/Picture3.jpg” title_text=”Picture3″ _builder_version=”4.9.0″ _module_preset=”default” animation_style=”fade” border_radii=”on|7px|7px|7px|7px” box_shadow_style=”preset3″ transform_styles__hover_enabled=”off|desktop” transform_scale__hover_enabled=”off|desktop” transform_translate__hover_enabled=”off|desktop” transform_rotate__hover_enabled=”off|desktop” transform_skew__hover_enabled=”off|desktop” transform_origin__hover_enabled=”off|desktop”][\/et_pb_image][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans|600|||||||” text_text_color=”#FFFFFF” text_font_size=”18px” text_line_height=”1.8em”]<\/p>\n

Nov. 2019- Tori Kroon presents at her first ORS PSRS<\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-content\/uploads\/sites\/468\/2023\/01\/Picture4.jpg” title_text=”Picture4″ _builder_version=”4.9.0″ _module_preset=”default” animation_style=”fade” border_radii=”on|7px|7px|7px|7px” box_shadow_style=”preset3″ transform_styles__hover_enabled=”off|desktop” transform_scale__hover_enabled=”off|desktop” transform_translate__hover_enabled=”off|desktop” transform_rotate__hover_enabled=”off|desktop” transform_skew__hover_enabled=”off|desktop” transform_origin__hover_enabled=”off|desktop”][\/et_pb_image][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans|600|||||||” text_text_color=”#FFFFFF” text_font_size=”18px” text_line_height=”1.8em”]<\/p>\n

Aug. 2021- The Holguin and Clinkenbeard
labs escape \u201cContagion\u201d<\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Funding Section” module_id=”funding” module_class=”funding-section” _builder_version=”4.9.0″ _module_preset=”default”][et_pb_row _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text admin_label=”Title Text” _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans|600|||||||” text_text_color=”#0C71C3″ text_font_size=”22px” text_line_height=”1.8em”]<\/p>\n

Funding<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”1_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-content\/uploads\/sites\/468\/2023\/01\/Picture2.png” title_text=”Picture2″ _builder_version=”4.9.0″ _module_preset=”default” animation_style=”fade” border_radii=”on|7px|7px|7px|7px” transform_styles__hover_enabled=”off|desktop” transform_scale__hover_enabled=”off|desktop” transform_translate__hover_enabled=”off|desktop” transform_rotate__hover_enabled=”off|desktop” transform_skew__hover_enabled=”off|desktop” transform_origin__hover_enabled=”off|desktop”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans|600|||||||” text_font_size=”14px” text_line_height=”1.8em”]<\/p>\n

March 2022-2023<\/strong>
Advance Neuroimaging Research Program (ANRP) pilot grant (Holguin, PI)
Title: Spatio-temporal recruitment of myeloid cells in MRI by Wnt signaling-dependent disc injury<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-content\/uploads\/sites\/468\/2023\/01\/Picture1.png” title_text=”Picture1″ _builder_version=”4.9.0″ _module_preset=”default” animation_style=”fade” border_radii=”on|7px|7px|7px|7px” transform_styles__hover_enabled=”off|desktop” transform_scale__hover_enabled=”off|desktop” transform_translate__hover_enabled=”off|desktop” transform_rotate__hover_enabled=”off|desktop” transform_skew__hover_enabled=”off|desktop” transform_origin__hover_enabled=”off|desktop”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans|600|||||||” text_text_color=”#000000″ text_font_size=”14px” text_line_height=”1.8em”]<\/p>\n

Sept. 2022- August 2027<\/strong>
NIAMS: 1R01AR078764 (Holguin, PI)
Title: Repurpose bone therapeutics for intervertebral disc degeneration in aged mice<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Job Section” module_id=”job” module_class=”job-section” _builder_version=”4.9.0″ _module_preset=”default”][et_pb_row _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_divider color=”#0C71C3″ divider_style=”dotted” divider_weight=”0.6px” _builder_version=”4.9.0″ _module_preset=”default”][\/et_pb_divider][et_pb_text admin_label=”Title Text” _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans|600|||||||” text_text_color=”#0C71C3″ text_font_size=”22px” text_line_height=”1.8em”]<\/p>\n

Job Opportunities<\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans||||||||” text_font_size=”18px” text_line_height=”1.8em”]<\/p>\n

We are looking to expand our group to include 1 PhD trainee (or post Doc) and 1 lab manager. Please email Dr. Nilsson Holguin for further information.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Footer Section” _builder_version=”4.9.0″ _module_preset=”default” background_color=”#000000″][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#FFFFFF” text_font_size=”16px”]<\/p>\n

Holguin Laboratory<\/strong>
Nilsson Holguin, PhD
Assistant Professor
Leni & Peter W. May Department of Orthopaedics<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#FFFFFF” text_font_size=”16px”]<\/p>\n

Location<\/strong>
Lab: Annenberg A20-30
Office: Annenberg A20-80A<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#FFFFFF” text_font_size=”16px”]<\/p>\n

Contact:<\/strong>
Phone: 212-241-1664
Email: Nilsson.Holguin@mssm.edu<\/a>
Twitter: @Holguinlab<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

ResearchIntervertebral disc degeneration and osteoporosis of the spine impose a significant socioeconomic burden and treatment for both is lacking. The Holguin laboratory focuses on the biomechanics and mechanobiology of the spine undergoing adaptation to aging, mechanical forces, genetics and injury with an eye towards therapy. Techniques used in the laboratory include molecular (e.g., PCR, qPCR, […]<\/p>\n","protected":false},"author":545,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-3","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-json\/wp\/v2\/pages\/3","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-json\/wp\/v2\/users\/545"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-json\/wp\/v2\/comments?post=3"}],"version-history":[{"count":42,"href":"https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-json\/wp\/v2\/pages\/3\/revisions"}],"predecessor-version":[{"id":132,"href":"https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-json\/wp\/v2\/pages\/3\/revisions\/132"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/holguinlab\/wp-json\/wp\/v2\/media?parent=3"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}