
{"id":1492,"date":"2022-11-18T07:09:04","date_gmt":"2022-11-18T12:09:04","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/design\/?page_id=1492"},"modified":"2025-08-20T11:08:33","modified_gmt":"2025-08-20T15:08:33","slug":"biomarker-core","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/heddenlab\/biomarker-core\/","title":{"rendered":"Adrc Biomarker Core"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Fullwidth Header &#8211; Background Title &#8211; no slider &#8211; Section 1&#8243; module_class=&#8221;section1_fullwidth_header_bg_title_no_slider-about_us&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_enable_color=&#8221;off&#8221; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_start=&#8221;#141414&#8243; background_color_gradient_end=&#8221;rgba(20,20,20,0.15)&#8221; background_color_gradient_direction=&#8221;1deg&#8221; background_color_gradient_end_position=&#8221;70%&#8221; background_color_gradient_overlays_image=&#8221;on&#8221; background_image=&#8221;https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2022\/08\/DC-Sox2GFP-SOX2-ITGA6-E15.0_02MR.jpg&#8221; background_position=&#8221;top_center&#8221; custom_padding=&#8221;||||false|false&#8221; bottom_divider_style=&#8221;ramp2&#8243; bottom_divider_color=&#8221;#FFFFFF&#8221; bottom_divider_height=&#8221;11vw&#8221; bottom_divider_arrangement=&#8221;above_content&#8221; locked=&#8221;off&#8221; collapsed=&#8221;off&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(0,0,0,0)&#8221; border_color_all=&#8221;RGBA(0,0,0,0)&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;10%||8vw||false|false&#8221; custom_padding_tablet=&#8221;0vw||0vw||true|false&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|tablet&#8221;][et_pb_text admin_label=&#8221;Text &#8211; Title&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;b3e3ff14-5f5c-4608-8ecf-1885ce3da7aa&#8221; header_font=&#8221;||||||||&#8221; header_text_align=&#8221;center&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_font_size=&#8221;48px&#8221; header_line_height=&#8221;60px&#8221; custom_margin=&#8221;||10px||false|false&#8221; header_font_size_tablet=&#8221;40px&#8221; header_font_size_phone=&#8221;24px&#8221; header_font_size_last_edited=&#8221;on|desktop&#8221;]<\/p>\n<h1><strong>Neuroimaging Biomarker Core of the ADRC at Mount Sinai<\/strong><\/h1>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(0,0,0,0)&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Fullwidth Text Over White Background &#8211; Section&#8221; module_class=&#8221;section_fulllwidth_text_simple&#8221; _builder_version=&#8221;4.9.0&#8243; locked=&#8221;off&#8221; collapsed=&#8221;off&#8221;][et_pb_row admin_label=&#8221;row&#8221; _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; header_text_color=&#8221;#00a6e5&#8243;]<\/p>\n<p>H-LAND personnel and collaborators staff the <strong>Neuroimaging Biomarker Core of the <a href=\"https:\/\/icahn.mssm.edu\/research\/adrc\" rel=\"noopener\" target=\"_blank\">Alzheimer\u2019s Disease Research Center<\/a> (ADRC) at the <a href=\"https:\/\/icahn.mssm.edu\/\" rel=\"noopener\" target=\"_blank\">Icahn School of Medicine at Mount Sinai<\/a><\/strong>.<\/p>\n<p>The <strong>Neuroimaging Biomarker Core<\/strong> is focused on applying research on biomarkers obtained from PET and MRI to accurately diagnose Alzheimer\u2019s disease as early as possible, to characterize disease heterogeneity, and to accelerate progress toward prevention and treatment. We provide collaboration and services for imaging biomarker collection and analysis from participants in the ADRC cohort maintained by the Clinical Core, from participants newly recruited by the Outreach, Recruitment, and Engagement Core, and from the broader patient population served by the Mount Sinai community. We provide expertise and recommendations to researchers and clinicians for the inclusion of neuroimaging in studies and clinical trials. We provide training focused on neuroimaging biomarkers for ADRC trainees and consultation services for investigators new to Alzheimer\u2019s disease research. We promote sharing of data and informatics through interactions with the Data Core and with Alzheimer\u2019s disease researchers across the institution. Collaboration with the Genetics and Genomics Core provides the opportunity to identify genetic factors contributing to biomarker evidence for risk of developing Alzheimer\u2019s disease or potential resilience to the disease. The Neuroimaging Biomarker Core broadly supports the integration of biomarker acquisition and analysis into ADRC activities with the aim of accelerating our ability to diagnose Alzheimer\u2019s disease, to differentiate potential contributing factors, and to more precisely target interventions toward those most likely to benefit.<\/p>\n<p><strong>Biomarker Core Personnel:<\/strong><\/p>\n<ul>\n<em>Core Lead:<\/em> <a href=\"https:\/\/labs.icahn.mssm.edu\/heddenlab\/people\/\">Trey Hedden<\/a><\/p>\n<p><em>Co-Investigators: <\/em><br \/>\n<a href=\"https:\/\/profiles.icahn.mssm.edu\/priti-balchandani\" rel=\"noopener\" target=\"_blank\">Priti Balchandani<\/a>, Professor<br \/>\n<a href=\"https:\/\/profiles.icahn.mssm.edu\/nasrin-ghesani\" rel=\"noopener\" target=\"_blank\">Nasrin Ghesani<\/a>, Associate Professor<br \/>\n<a href=\"https:\/\/profiles.icahn.mssm.edu\/andrew-varga\" rel=\"noopener\" target=\"_blank\">Andrew Varga<\/a>, Associate Professor<\/p>\n<p><a href=\"https:\/\/labs.icahn.mssm.edu\/heddenlab\/people\/\"><em>Staff<\/em><\/a>:<br \/>\nCody Ruais, Clinical Research Coordinator<br \/>\nJasmin Richard, Clinical Research Coordinator<br \/>\nRyan Wales, Data Manager<br \/>\nAnna Marin, Postdoctoral Fellow<\/p>\n<p><em>Affiliated Personnel and Referring Physicians:<\/em><br \/>\n<a href=\"https:\/\/profiles.icahn.mssm.edu\/samuel-e-gandy\" rel=\"noopener\" target=\"_blank\">Sam Gandy<\/a>, Professor<br \/>\n<a href=\"https:\/\/profiles.icahn.mssm.edu\/georges-naasan\" rel=\"noopener\" target=\"_blank\">Georges Naasan<\/a>, Associate Professor<br \/>\n<a href=\"https:\/\/profiles.icahn.mssm.edu\/ana-pereira\" rel=\"noopener\" target=\"_blank\">Ana Pereira<\/a>, Associate Professor<br \/>\n<a href=\"https:\/\/profiles.icahn.mssm.edu\/xiang-xu\" rel=\"noopener\" target=\"_blank\">Xiang Xu<\/a>, Assistant Professor<\/p>\n<\/ul>\n<p><strong>Collaborations and Resources:<\/strong><\/p>\n<p>The Neuroimaging Biomarker Core and the ADRC at Mount Sinai are part of the <a href=\"https:\/\/www.nia.nih.gov\/health\/alzheimers-disease-research-centers\" rel=\"noopener\" target=\"_blank\">NIA-funded network of Alzheimer\u2019s Disease Research Centers<\/a>. Funding is provided by NIH\/NIA grant <a href=\"https:\/\/reporter.nih.gov\/search\/9tEpdiM_kkiwnTqIhND2Sw\/project-details\/10149901\" rel=\"noopener\" target=\"_blank\">P30AG066514<\/a> (PI: <a href=\"https:\/\/profiles.icahn.mssm.edu\/mary-sano\" rel=\"noopener\" target=\"_blank\">Mary Sano<\/a>). When publishing data obtained from, supported by, or analyzed in consultation with the Neuroimaging Biomarker Core, please include grant P30AG066514 in the acknowledgements.<\/p>\n<p>The Biomarker Core conducts all of its research imaging studies at the <a href=\"https:\/\/bmeiisinai.org\/\" rel=\"noopener\" target=\"_blank\">BioMedical Engineering and Imaging Institute<\/a> (BMEII) at Mount Sinai. See the BMEII website for information on BMEII <a href=\"https:\/\/bmeiisinai.org\/core-resources\/\" rel=\"noopener\" target=\"_blank\">Core Resources<\/a> (including a pdf description suitable for inclusion in grants), <a href=\"https:\/\/bmeiisinai.org\/resource-fees\/\" rel=\"noopener\" target=\"_blank\">Fees<\/a>, <a href=\"https:\/\/bmeiisinai.org\/starting-a-study\/\" rel=\"noopener\" target=\"_blank\">Starting a Study<\/a> at BMEII, and accessing the <a href=\"https:\/\/bmeiisinai.org\/imaging-research-warehouse\/\" rel=\"noopener\" target=\"_blank\">Imaging Research Warehouse<\/a>.<\/p>\n<p><strong>Services of the Biomarker Core:<\/strong><\/p>\n<ul>\n<li>Consultation on PET and MRI studies (recommended sequences, available analytic packages, etc.)<\/li>\n<li>Advise on SCAN-compliant data collection and transfer of data<\/li>\n<li>SOPs for PET and MRI collection and data banking<\/li>\n<li>Facilities description for grants, letters of support if needed<\/li>\n<li><a href=\"http:\/\/www.neuraceqreadertraining.com\" rel=\"noopener\" target=\"_blank\">Neuraceq (amyloid PET) reader training<\/a> (currently available only to Mount Sinai personnel; email trey.hedden@mssm.edu from your Mount Sinai email address for access code) <\/li>\n<li>Plasma biomarker analytics (currently in development, in conjunction with the Fluid Biomarker and Genomics Core)<\/li>\n<\/ul>\n<p>The Neuroimaging Biomarker Core and affiliated studies contribute data to the <a href=\"https:\/\/scan.naccdata.org\/\" rel=\"noopener\" target=\"_blank\">Standardized Centralized Alzheimer\u2019s &amp; Related Dementias Neuroimaging (SCAN)<\/a> initiative of the <a href=\"https:\/\/naccdata.org\/\" rel=\"noopener\" target=\"_blank\">National Alzheimer\u2019s Coordinating Center (NACC)<\/a>. Contributed data are conducted with standardized protocols and will be publicly accessible through the SCAN website. For researchers interested in using SCAN-compliant imaging protocols, the Neuroimaging Biomarker Core can provide protocols specific to the BMEII scanners at Mount Sinai, <a href=\"https:\/\/files.alz.washington.edu\/scan\/SCAN_MRI_Manual.pdf\" rel=\"noopener\" target=\"_blank\">MRI<\/a> and <a href=\"https:\/\/files.alz.washington.edu\/scan\/SCAN_PET_Manual.pdf\" rel=\"noopener\" target=\"_blank\">PET<\/a> user manuals, and additional guidance.<\/p>\n<p><strong>Selected publicly accessible datasets containing biomarkers of Alzheimer\u2019s disease:<\/strong><\/p>\n<ul>\n<strong><a href=\"https:\/\/www.ncrad.org\/accessing_data.html\" rel=\"noopener\" target=\"_blank\">NCRAD<\/a><\/strong>: CSF, plasma<br \/>\n<strong><a href=\"http:\/\/adni.loni.usc.edu\/data-samples\/access-data\" rel=\"noopener\" target=\"_blank\">ADNI<\/a><\/strong>: CSF, plasma, amyloid PET, MRI<br \/>\n<strong><a href=\"https:\/\/ida.loni.usc.edu\" rel=\"noopener\" target=\"_blank\">LONI<\/a><\/strong> (A4, AIBL, etc.): amyloid PET, MRI<br \/>\n<strong><a href=\"https:\/\/dian.wustl.edu\/our-research\/for-investigators\/dian-observational-study-investigator-resources\/data-and-biospecimens-available-for-request\/\" rel=\"noopener\" target=\"_blank\">DIAN<\/a><\/strong>: CSF, plasma, amyloid PET, FDG PET, MRI<br \/>\n<strong><a href=\"https:\/\/naccdata.org\/requesting-data\" rel=\"noopener\" target=\"_blank\">NACC<\/a><\/strong>: CSF, amyloid PET, MRI<br \/>\n<strong><a href=\"https:\/\/scan.naccdata.org\/\" rel=\"noopener\" target=\"_blank\">SCAN<\/a><\/strong>: amyloid PET, tau PET, MRI<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; 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use_icon_font_size=&#8221;on&#8221; icon_font_size=&#8221;24px&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(0,0,0,0)&#8221; background_enable_color=&#8221;on&#8221;]twitter[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=&#8221;youtube&#8221; url=&#8221;https:\/\/www.youtube.com\/user\/MountSinaiSchool&#8221; use_icon_font_size=&#8221;on&#8221; icon_font_size=&#8221;24px&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(0,0,0,0)&#8221; background_enable_color=&#8221;on&#8221;]youtube[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=&#8221;instagram&#8221; url=&#8221;https:\/\/www.instagram.com\/icahnmountsinai\/&#8221; use_icon_font_size=&#8221;on&#8221; icon_font_size=&#8221;24px&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(0,0,0,0)&#8221; background_enable_color=&#8221;on&#8221;]instagram[\/et_pb_social_media_follow_network][\/et_pb_social_media_follow][et_pb_text _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_font_size=&#8221;24px&#8221;]<\/p>\n<p style=\"text-align: center\"><strong>Contact Us<\/strong><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.9.0&#8243; background_color=&#8221;RGBA(0,0,0,0)&#8221; background_color_gradient_direction=&#8221;38deg&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;|auto|-2px|auto||&#8221; custom_padding=&#8221;0px|||||&#8221; locked=&#8221;off&#8221; collapsed=&#8221;off&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.9.0&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.9.0&#8243; text_font=&#8221;||||||||&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_line_height=&#8221;1.25em&#8221; header_font=&#8221;||||||||&#8221; header_4_font=&#8221;|700||on|||||&#8221; header_4_font_size=&#8221;16px&#8221; header_4_letter_spacing=&#8221;1px&#8221; header_4_line_height=&#8221;1.5em&#8221; background_layout=&#8221;dark&#8221; locked=&#8221;off&#8221;]<\/p>\n<p><strong>E-mail<br \/><\/strong><br \/>\nTrey Hedden: trey.hedden@mssm.edu<br \/>\nCody Ruais: cody.ruais@mssm.edu<br \/>\nJasmin Richard: jasmin.richard@mssm.edu\n<\/p>\n<hr>\n<p>Potential participants, please contact: ADbiomarkers@mssm.edu<\/p>\n<p><strong>Phone<br \/><\/strong>Tel: 212-585-4906<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.9.0&#8243; text_font=&#8221;||||||||&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_line_height=&#8221;1.25em&#8221; header_font=&#8221;||||||||&#8221; header_4_font=&#8221;|700||on|||||&#8221; header_4_font_size=&#8221;16px&#8221; header_4_letter_spacing=&#8221;1px&#8221; header_4_line_height=&#8221;1.5em&#8221; background_layout=&#8221;dark&#8221; locked=&#8221;off&#8221;]<\/p>\n<p><strong>Hedden Laboratory <\/strong><br \/>Trey Hedden, PhD<br \/>Director, Neuroimaging and Biomarker <br \/>Research in Aging and Alzheimer\u2019s Disease at Mount Sinai<\/p>\n<p><strong>Location<\/strong><\/p>\n<p>1399 Park Avenue, Ichan School of Medicine at Mount Sinai<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Neuroimaging Biomarker Core of the ADRC at Mount SinaiH-LAND personnel and collaborators staff the Neuroimaging Biomarker Core of the Alzheimer\u2019s Disease Research Center (ADRC) at the Icahn School of Medicine at Mount Sinai. The Neuroimaging Biomarker Core is focused on applying research on biomarkers obtained from PET and MRI to accurately diagnose Alzheimer\u2019s disease as [&hellip;]<\/p>\n","protected":false},"author":545,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"class_list":["post-1492","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/heddenlab\/wp-json\/wp\/v2\/pages\/1492","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/heddenlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/heddenlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/heddenlab\/wp-json\/wp\/v2\/users\/545"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/heddenlab\/wp-json\/wp\/v2\/comments?post=1492"}],"version-history":[{"count":12,"href":"https:\/\/labs.icahn.mssm.edu\/heddenlab\/wp-json\/wp\/v2\/pages\/1492\/revisions"}],"predecessor-version":[{"id":4597,"href":"https:\/\/labs.icahn.mssm.edu\/heddenlab\/wp-json\/wp\/v2\/pages\/1492\/revisions\/4597"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/heddenlab\/wp-json\/wp\/v2\/media?parent=1492"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}