{"id":15,"date":"2019-06-04T17:51:44","date_gmt":"2019-06-04T17:51:44","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/?page_id=15"},"modified":"2022-08-03T12:48:38","modified_gmt":"2022-08-03T16:48:38","slug":"home","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/","title":{"rendered":"Home"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”3.22″ collapsed=”off”][et_pb_fullwidth_slider _builder_version=”4.9.0″ header_font=”||||||||”][et_pb_slide heading=”Harony-Nicolas Lab” _builder_version=”4.9.0″ header_font=”|300|||||||” background_image=”https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-content\/uploads\/sites\/280\/2019\/06\/NBurlant_FBI_Image-copy-3-1-e1560175232472.jpg” background_enable_image=”on” sticky_transition=”on”]<\/p>\n

<\/h1>\n

[\/et_pb_slide][et_pb_slide image=”https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-content\/uploads\/sites\/280\/2021\/11\/Screen-Shot-2021-11-22-at-3.33.29-PM.png” _builder_version=”4.9.0″ body_font=”||||||||” use_background_color_gradient=”on” background_color_gradient_start=”#35b1ff” background_color_gradient_end=”#ffffff” sticky_transition=”on”]<\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n

[\/et_pb_slide][et_pb_slide image=”https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-content\/uploads\/sites\/280\/2021\/11\/Screen-Shot-2021-11-22-at-3.29.18-PM-1.png” _builder_version=”4.9.0″ use_background_color_gradient=”on” background_color_gradient_end=”#f9f9f9″ sticky_transition=”on”]<\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n

[\/et_pb_slide][\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Research” module_id=”research” _builder_version=”4.9.0″ collapsed=”off”][et_pb_row column_structure=”3_4,1_4″ admin_label=”Row” _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” min_height=”688.7px” custom_margin=”|auto|-94px|auto||” custom_padding=”||12px|||”][et_pb_column type=”3_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text admin_label=”Research Header” _builder_version=”4.9.0″ header_font=”||||||||” min_height=”27px”]<\/p>\n

Research<\/h1>\n

[\/et_pb_text][et_pb_text admin_label=”Research Text” _builder_version=”4.9.0″ text_font=”||||||||” text_font_size=”17px” header_font=”||||||||” background_size=”initial” background_position=”top_left” background_repeat=”repeat” min_height=”612px” custom_padding=”||99px|||”]<\/p>\n

Studies in our lab are focused on understanding the mechanisms by which autism-associated mutations lead to the manifestation of behavioral deficits. We specifically ask how these mutations affect brain networks that subserve social behavior and social reward processing, and how these changes lead to social behavior deficits.\u00a0To address these scientific questions, our lab uses transgenic rat models that harbor mutations in autism-high risk genes, including in the Shank3<\/em>gene, and applies behavioral and molecular neuroscience approaches. These include RNAscope, immunohistochemistry, and retro and anterograde labeling for anatomical analysis of specific brain circuits, fiber photometry approaches to record neural activity and\/or assess neurotransmitter levels during social behavior, and cutting-edge chemo-genetic tools to manipulate specific neural circuits, all with the goal to uncover altered brain circuits that can be manipulated with circuit-specific non-invasive interventions to ameliorate social behavior deficits.<\/p>\n

 <\/p>\n

Our\u00a0l<\/span>ab is part of the\u00a0Seaver Autism Center for Research and Treatment\u00a0<\/a>at the\u00a0Icahn School of Medicine at Mount Sinai<\/a>. The Seaver Autism Center is a fully integrated, translational research center that leads progressive studies and provides personalized care to individuals with autism and related rare disorders. As a team, we are dedicated to discovering the biological causes of autism and developing breakthrough treatments.<\/p>\n

\u00a0<\/span><\/p>\n

Learn more<\/a>\u00a0<\/span>about the Seaver Autism Center\u2019s translational research approach to study Shank3<\/em>-deficeincies, Phelan-McDermid syndrome, and autism spectrum disorder.\u00a0 <\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_sidebar orientation=”right” area=”sidebar-1″ admin_label=”Contact Us” _builder_version=”4.9.0″ header_font=”||||||||” body_font=”||||||||” body_font_size=”16.2px” custom_margin=”0px||-19px” custom_padding=”0px||0px” custom_css_after=”content: %22%92e097%22;||position:relative;||font-family: ‘ETmodules’;”][\/et_pb_sidebar][et_pb_social_media_follow _builder_version=”3.19.10″ text_orientation=”left” custom_margin=”-32px||0px|32px” custom_padding=”0px||0px” custom_css_social_follow=”top: -30px|| || “][et_pb_social_media_follow_network social_network=”twitter” url=”https:\/\/twitter.com\/HaronyLab” _builder_version=”3.19.10″ background_color=”#00aced” custom_margin=”0px||0px” follow_button=”off” url_new_window=”on”]twitter[\/et_pb_social_media_follow_network][\/et_pb_social_media_follow][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Team” module_id=”team” _builder_version=”3.22″ min_height=”1219.8px”][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”||8px|||”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text admin_label=”Meet the Team” _builder_version=”4.9.0″ min_height=”9px”]<\/p>\n

Meet the Team<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ make_equal=”on” _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” min_height=”287.4px” custom_margin=”-30px||40px”][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_team_member name=”Hala Harony-Nicolas, PhD” position=”Principal Investigator” image_url=”https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-content\/uploads\/sites\/280\/2021\/11\/Hala_Harony_Nicolas_photo-copy-scaled.jpg” admin_label=”Hala” _builder_version=”4.9.0″ _module_preset=”default” header_font_size=”16px” body_font=”||||||||” body_font_size=”14px”]<\/p>\n

hala.harony-nicolas@mssm.edu<\/a><\/p>\n

 <\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”0px|||” custom_padding__hover=”|||”][et_pb_team_member name=”Keerthi Thirtamara Rajamani, PhD” position=”Postdoctoral Fellow” image_url=”https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-content\/uploads\/sites\/280\/2019\/06\/Keerthi_new-e1560263007962.jpg” admin_label=”Keerthi” _builder_version=”4.9.0″ header_font=”||||||||” header_font_size=”16px” body_font=”||||||||” body_font_size=”14px” custom_margin=”0px|0px|0px|0px” custom_padding=”0px|0px|0px|0px” animation_style=”fade” animation=”fade_in”]<\/p>\n

keerthi.rajamani@mssm.edu<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_team_member name=”Marie Barbier, PhD” position=”Postdoctoral Fellow” image_url=”https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-content\/uploads\/sites\/280\/2020\/03\/mariebright.jpg” admin_label=”Marie” _builder_version=”4.9.0″ header_font=”||||||||” header_font_size=”16px” body_font=”||||||||” body_font_size=”14px” custom_margin=”0px|0px|0px|0px” custom_padding=”0px|0px|0px|0px” animation_style=”fade” animation=”fade_in” locked=”off”]<\/p>\n

marie.barbier@mssm.edu<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_team_member name=”Aya Osman, PhD” position=”Postdoctoral Fellow” image_url=”data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iNTAwIiBoZWlnaHQ9IjUwMCIgdmlld0JveD0iMCAwIDUwMCA1MDAiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyI+CiAgICA8ZyBmaWxsPSJub25lIiBmaWxsLXJ1bGU9ImV2ZW5vZGQiPgogICAgICAgIDxwYXRoIGZpbGw9IiNFQkVCRUIiIGQ9Ik0wIDBoNTAwdjUwMEgweiIvPgogICAgICAgIDxyZWN0IGZpbGwtb3BhY2l0eT0iLjEiIGZpbGw9IiMwMDAiIHg9IjY4IiB5PSIzMDUiIHdpZHRoPSIzNjQiIGhlaWdodD0iNTY4IiByeD0iMTgyIi8+CiAgICAgICAgPGNpcmNsZSBmaWxsLW9wYWNpdHk9Ii4xIiBmaWxsPSIjMDAwIiBjeD0iMjQ5IiBjeT0iMTcyIiByPSIxMDAiLz4KICAgIDwvZz4KPC9zdmc+Cg==” _builder_version=”4.9.0″ _module_preset=”default” header_font=”||||||||” header_font_size=”16px”]<\/p>\n

aya.osman@mssm.edu<\/a><\/p>\n

 <\/p>\n

[\/et_pb_team_member][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”1_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_team_member name=”Amanda Leithead, MS” position=”Graduate Student” image_url=”https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-content\/uploads\/sites\/280\/2021\/11\/Amanda-Reszied-scaled.jpg” admin_label=”Amanda” _builder_version=”4.9.0″ header_font=”||||||||” header_font_size=”16px” body_font=”||||||||” body_font_size=”14px” module_alignment=”left” custom_padding=”|0px||1px” animation_style=”fade” animation=”fade_in” link_option_url=”https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/amanda-leithead\/” hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n

amanda.leithead@icahn.mssm.edu<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_team_member name=”Michelle Kim” position=”Graduate Student” image_url=”https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-content\/uploads\/sites\/280\/2020\/09\/Michelle-Kim-labsite.jpg” admin_label=”Michelle” _builder_version=”4.9.0″ header_font=”||||||||” header_font_size=”16px” body_font=”||||||||” body_font_size=”14px” module_alignment=”left” custom_padding=”|0px||1px” animation_style=”fade” animation=”fade_in” link_option_url=” https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/michelle-kim\/”]<\/p>\n

michelle.kim@icahn.mssm.edu<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_team_member name=”Kristi Niblo” position=”Associate Researcher” image_url=”https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-content\/uploads\/sites\/280\/2019\/06\/zdY96lmQ-e1560262966102.jpeg” admin_label=”Kristi” _builder_version=”3.19.10″ header_font=”||||||||” header_font_size=”16px” body_font=”||||||||” body_font_size=”14px” module_alignment=”left” animation_style=”fade” animation=”fade_in”]<\/p>\n

kristi.niblo@mssm.edu<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_team_member name=”Nicholas Cordero” position=”Undergraduate Student ” image_url=”https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-content\/uploads\/sites\/280\/2021\/11\/IMG_6071-copy-scaled-e1637613885463.jpg” admin_label=”Nick” _builder_version=”4.9.0″ _module_preset=”default” header_font_size=”16px” body_font=”||||||||” body_font_size=”14px” link_option_url=”https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/nicholas-cordero\/”]<\/p>\n

nicholas.cordero@mssm.edu<\/a><\/p>\n

[\/et_pb_team_member][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.9.0″ custom_margin=”30px||30px” custom_padding=”||” animation_style=”fade”][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_team_member name=”Thompson Uwanomen” position=”SURP Intern” image_url=”https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-content\/uploads\/sites\/280\/2022\/08\/TU_Use-min.png” _builder_version=”4.9.0″ _module_preset=”default” header_font=”||||||||” header_font_size=”16px” hover_enabled=”0″ link_option_url=”https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/thompson-uwanomen\/” sticky_enabled=”0″][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” min_height=”30px” custom_padding=”||0px|||”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text admin_label=”Lab Alumni” _builder_version=”4.9.0″ min_height=”25px”]<\/p>\n

Lab Alumni<\/h3>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”3.25″ min_height=”83.4px” custom_margin=”30px||40px”][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_team_member name=”Roberto Robles” position=”Intern” image_url=”https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-content\/uploads\/sites\/280\/2020\/10\/profile_pic.jpg” admin_label=”Roberto” _builder_version=”3.19.10″ header_font=”||||||||” header_font_size=”16px” body_font=”||||||||” body_font_size=”14px” module_alignment=”left” animation_style=”fade” animation=”fade_in”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_team_member name=”Carla Golden” position=”Graduate Student” image_url=”https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-content\/uploads\/sites\/280\/2019\/06\/Carla-e1560263554223.jpg” admin_label=”Carla” _builder_version=”3.19.10″ header_font=”||||||||” header_font_size=”16px” body_font=”||||||||” body_font_size=”14px” module_alignment=”left” animation_style=”fade” animation=”fade_in”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_team_member name=”Natalie Burlant” position=”Associate Researcher” image_url=”https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-content\/uploads\/sites\/280\/2019\/06\/190517-1085-Mario-Morgado-e1560262896592.jpg” admin_label=”Natalie” _builder_version=”3.19.10″ header_font=”||||||||” header_font_size=”16px” body_font=”||||||||” body_font_size=”14px” module_alignment=”left” custom_margin=”|0px||0px” custom_padding=”0px|0px||0px” animation_style=”fade” animation=”fade_in”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_team_member name=”Lacin Koro” position=”Associate Researcher” image_url=”https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-content\/uploads\/sites\/280\/2019\/06\/Lacin-Koro-e1560263882743.png” admin_label=”Lacin” _builder_version=”3.19.10″ header_font=”||||||||” header_font_size=”16px” body_font=”||||||||” body_font_size=”14px” module_alignment=”left” animation_style=”fade” animation=”fade_in”][\/et_pb_team_member][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”3.25″ min_height=”332.4px” custom_margin=”30px||40px”][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_team_member name=”Camille Goldman” position=”SURP Intern” image_url=”https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-content\/uploads\/sites\/280\/2019\/06\/file4-e1560264011367.jpeg” admin_label=”Camille” _builder_version=”3.19.10″ header_font=”||||||||” header_font_size=”16px” body_font=”||||||||” body_font_size=”14px” module_alignment=”left” animation_style=”fade” animation=”fade_in”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_team_member name=”Michael Peruggia” position=”Associate Researcher” image_url=”https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-content\/uploads\/sites\/280\/2019\/06\/Michael-4.jpg” admin_label=”Michael” _builder_version=”3.19.10″ header_font=”||||||||” header_font_size=”16px” body_font=”||||||||” body_font_size=”14px” custom_margin=”0px|0px|0px|0px” custom_padding=”0px|0px|0px|0px” animation_style=”fade” animation=”fade_in”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Publications” module_id=”publications” _builder_version=”4.9.0″ background_color=”#00a6e5″][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text admin_label=”Publications Header” _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#ffffff” header_font=”||||||||” header_2_font=”||||||||”]<\/p>\n

Publications<\/span><\/h1>\n

[\/et_pb_text][et_pb_toggle title=”2022″ admin_label=”2020″ _builder_version=”4.9.0″ title_font=”||||||||” body_font=”||||||||” body_line_height=”1.4em” border_radii=”on|10px|10px|10px|10px” border_width_bottom=”0px” locked=”off” border_radii__hover_enabled=”on”]<\/p>\n

<\/span>Reconsidering animal models used to study autism spectrum disorder: Current state and optimizing future.<\/a><\/p>\n

Silverman JL, Thurm A, Ethridge SB, Soller MM, Petkova SP, Abel T, Bauman MD, Brodkin ES, Harony-Nicolas H, W\u00f6hr M, Halladay A.\u00a0Genes Brain Behav<\/span>. 2022 Mar 14;<\/span>e12803<\/span>. doi: 10.1111\/gbb.12803<\/span><\/span><\/p>\n

[\/et_pb_toggle][et_pb_toggle title=”2021″ admin_label=”2020″ _builder_version=”4.9.0″ title_font=”||||||||” body_font=”||||||||” body_line_height=”1.4em” border_radii=”on|10px|10px|10px|10px” border_width_bottom=”0px” border_radii__hover_enabled=”on”]<\/p>\n

Efficiency of cell-type specific and generic promoters in transducing oxytocin neurons and monitoring their neural activity during lactation.<\/a><\/p>\n

Thirtamara Rajamani K, Leithead AB, Kim M, Barbier M, Peruggia M, Niblo K, Barteczko L, Lefevre A, Grinevich V, Harony-Nicolas H. Sci Rep. 2021 Nov 18;11(1):22541. doi: 10.1038\/s41598-021-01818-x.<\/span><\/p>\n

\n

<\/span><\/p>\n

The interplay between glutamatergic circuits and oxytocin neurons in the hypothalamus and its relevance to neurodevelopmental disorders.<\/a><\/p>\n

Leithead AB, Tasker JG, Harony-Nicolas H. J Neuroendocrinol. 2021 Nov 4:e13061. doi: 10.1111\/jne.13061.<\/span><\/p>\n

\n

A randomized control trial of intranasal oxytocin in Phelan-McDermid Syndrome.<\/a><\/p>\n

Fastman J, Foss-Feig J, Frank Y, Halpern D, Harony-Nicolas H, Layton C, Sandin S, Siper P, Tang L, Trelles P, Zweifach J, Buxbaum JD, Kolevzon A. Mol Autism. 2021 Sep 30;12(1):62. doi: 10.1186\/s13229-021-00459-1.<\/span><\/p>\n

\n

<\/span><\/p>\n

Reduced brain volume and white matter alterations in Shank3-deficient rats.<\/a><\/p>\n

Golden CEM, Wang VX, Harony-Nicolas H, Hof PR, Buxbaum JD. Autism Res. 2021 Sep; 14(9):1837-1842. doi: 10.1002\/aur.2568.<\/span><\/p>\n

[\/et_pb_toggle][et_pb_toggle title=”2020″ admin_label=”2020″ _builder_version=”4.9.0″ title_font=”||||||||” body_font=”||||||||” body_line_height=”1.4em” border_radii=”on|10px|10px|10px|10px” border_width_bottom=”0px” border_radii__hover_enabled=”on”]<\/p>\n

Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats. <\/a><\/p>\n

Jacot-Descombes S, Keshav NU, Dickstein DL, Wicinski B, Janssen WGM, Hiester LL, Sarfo EK, Warda T, Fam MM, Harony-Nicolas H, Buxbaum JD, Hof PR, Varghese M.\u00a0Mol Autism<\/span>. 2020 Nov 17;<\/span>11<\/span>(1)<\/span>:89<\/span>. doi: 10.1186\/s13229-020-00393-8.
<\/span><\/span><\/p>\n

\n

Reduced axonal caliber and structural changes in a rat model of Fragile X syndrome with a deletion of a K-Homology domain of Fmr1.<\/a><\/p>\n

Golden CEM, Yee Y, Wang VX, Harony-Nicolas H, Hof PR, Lerch JP, Buxbaum JD. Transl. Psychiatry<\/span>\u00a02020 Aug; 10(1):280. doi: 10.1038\/s41398-020-00943-x.<\/p>\n

\n

Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors.<\/a><\/p>\n

Anpilov S, Shemesh Y, Eren N, Harony-Nicolas H, Benjamin A, Dine J, Oliveira VEM, Forkosh O, Karamihalev S, H\u00fcttl R, Feldman N, Berger R, Dagan A, Chen G, Neumann ID, Wagner S, Yizhar O, Chen A. Neuron 2020 Aug; 10(1):280. doi: 10.1038\/s41398-020-00943-x.<\/p>\n

<\/div>\n
<\/div>\n

[\/et_pb_toggle][et_pb_toggle title=”2019″ admin_label=”2019″ _builder_version=”3.19.10″ title_font=”||||||||” body_font=”||||||||” body_line_height=”1.4em” border_radii=”on|10px|10px|10px|10px” border_width_bottom=”0px” border_radii__hover_enabled=”on”]<\/p>\n

Deletion of the KH1 Domain of Fmr1<\/em> Leads to Transcriptional Alterations and Attentional Deficits in Rats.<\/a><\/p>\n

Golden CEM, Breen MS, Koro L, Sonar S, Niblo K, Browne A, Burlant N, Di Marino D, De Rubeis S, Baxter MG, Buxbaum JD, Harony-Nicolas H.\u00a0Cerebral Cortex, Volume 29, Issue 5, 2019 May, Pages 2228\u20132244.\u00a0doi:\u00a010.1093\/cercor\/bhz029.<\/p>\n

[\/et_pb_toggle][et_pb_toggle title=”2018″ admin_label=”2018″ _builder_version=”4.9.0″ title_font=”||||||||” body_font=”||||||||” body_line_height=”1.4em” border_radii=”on|10px|10px|10px|10px” border_width_bottom=”0px” border_radii__hover_enabled=”on”]<\/p>\n

Oxytocin as a Modulator of Synaptic Plasticity: Implications for Neurodevelopmental Disorders.<\/a><\/p>\n

Rajamani KT, Wagner S, Grinevich V, Harony-Nicolas H.\u00a0Frontiers in Synaptic Neurosci.<\/span> 2018 Jun; 19.\u00a0doi: 10.3389\/fnsyn.2018.00017.<\/p>\n

\n

Developmental social communication deficits in the Shank3 rat model of phelan-mcdermid syndrome and autism spectrum disorder.<\/a><\/p>\n

Berg EL, Copping NA, Rivera JK, Pride MC, Careaga M, Bauman MD, Berman RF, Lein PJ, Harony-Nicolas H, Buxbaum JD, Ellegood J, Lerch JP, W\u00f6hr M, Silverman JL.\u00a0Autism Res. 2018 Apr; 11(4):587-601. doi: 10.1002\/aur.1925.<\/p>\n

\n

Shank3-deficient rats exhibit degraded cortical responses to sound.<\/a><\/p>\n

Engineer CT, Rahebi KC, Borland MS, Buell EP, Im KW, Wilson LG, Sharma P, Vanneste S, Harony-Nicolas H, Buxbaum JD, Kilgard MP.\u00a0Autism Res. 2018 Jan;11(1):59-68. doi: 10.1002\/aur.1883.<\/p>\n

\n

Oxytocin and Animal Models for Autism Spectrum Disorder.<\/a><\/p>\n

Wagner S, Harony-Nicolas H. Behavioral Pharmacology of Neuropeptides: Oxytocin.Curr Top Behav Neurosci<\/span>. <\/span>2018;<\/span>35<\/span>:213-237<\/span>. <\/span>doi: 10.1007\/7854_2017_15.<\/span><\/p>\n

[\/et_pb_toggle][et_pb_toggle title=”2017″ admin_label=”2017″ _builder_version=”4.9.0″ title_font=”||||||||” body_font=”||||||||” body_line_height=”1.4em” border_radii=”on|10px|10px|10px|10px” border_width_bottom=”0px” border_radii__hover_enabled=”on”]<\/p>\n

Autism spectrum disorder: neuropathology and animal models. <\/a><\/p>\n

Varghese M, Keshav N, Jacot-Descombes S, Warda T, Wicinski B, Dickstein DL, Harony-Nicolas H, De Rubeis S, Drapeau E, Buxbaum JD, Hof PR. Acta Neuropathol<\/span>. 2017 Oct;<\/span>134<\/span>(4)<\/span>:537-566<\/span>. doi: 10.1007\/s00401-017-1736-4.\u00a0<\/span><\/span><\/p>\n

\n

Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat.<\/a><\/p>\n

Harony-Nicolas H, Kay M, Hoffmann JD, Klein ME, Bozdagi-Gunal O, Riad M, Daskalakis NP, Sonar S, Castillo PE, Hof PR, Shapiro ML, Baxter MG, Wagner S, Buxbaum JD.\u00a0eLife 2017 Jan; 6.\u00a0doi:\u00a010.7554\/eLife.18904.<\/p>\n

[\/et_pb_toggle][et_pb_toggle title=”2016″ admin_label=”2016″ _builder_version=”3.19.10″ title_font=”||||||||” body_font=”||||||||” body_line_height=”1.4em” border_radii=”on|10px|10px|10px|10px” border_width_bottom=”0px” border_radii__hover_enabled=”on”]<\/p>\n

Cyfip1 Regulates Presynaptic Activity during Development. <\/a><\/p>\n

Hsiao K, Harony-Nicolas H, Buxbaum JD, Bozdagi-Gunal O, Benson DL.The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Feb; 3.\u00a0doi: 10.1523\/JNEUROSCI.0511-15.2016.<\/p>\n

[\/et_pb_toggle][et_pb_toggle title=”2015″ admin_label=”2015″ _builder_version=”3.19.10″ title_font=”||||||||” body_font=”||||||||” body_line_height=”1.4em” border_radii=”on|10px|10px|10px|10px” border_width_bottom=”0px” border_radii__hover_enabled=”on”]Phelan McDermid Syndrome: From Genetic Discoveries to Animal Models and Treatment. <\/a><\/p>\n

Harony-Nicolas H, De Rubeis S, Kolevzon A, Buxbaum JD. Journal of child neurology 2015 Dec; 30(14).\u00a0doi: 10.1177\/0883073815600872.<\/p>\n

\n

Ultrastructural analyses in the hippocampus CA1 field in Shank3-deficient mice. <\/a><\/p>\n

Uppal N, Puri R, Yuk F, Janssen WG, Bozdagi-Gunal O, Harony-Nicolas H, Dickstein DL, Buxbaum JD, Hof PR. Molecular autism 2015; 6.\u00a0doi:\u00a010.1186\/s13229-015-0036-x.[\/et_pb_toggle][et_pb_toggle title=”2014 & Earlier” admin_label=”2014 & Earlier” _builder_version=”3.19.10″ title_font=”||||||||” body_font=”||||||||” body_line_height=”1.4em” border_radii=”on|10px|10px|10px|10px” border_width_bottom=”0px” border_radii__hover_enabled=”on”]Brain region-specific methylation in the promoter of the murine oxytocin receptor gene is involved in its expression regulation.<\/a><\/p>\n

Harony-Nicolas H, Mamrut S, Brodsky L, Shahar-Gold H, Barki-Harrington L, Wagner S. Psychoneuroendocrinology 2014 Jan; 39.\u00a0doi: 10.1016\/j.psyneuen.2013.10.004.<\/span><\/p>\n

\n

Identification of small exonic CNV from whole-exome sequence data and application to autism spectrum disorder. <\/a><\/p>\n

Poultney CS, Goldberg AP, Drapeau E, Kou Y, Harony-Nicolas H, Kajiwara Y, De Rubeis S, Durand S, Stevens C, Rehnstr\u00f6m K, Palotie A, Daly MJ, Ma’ayan A, Fromer M, Buxbaum JD. American journal of human genetics 2013 Oct; 93(4).\u00a0doi: 10.1016\/j.ajhg.2013.09.001.<\/span><\/p>\n

\n

DNA methylation of specific CpG sites in the promoter region regulates the transcription of the mouse oxytocin receptor. <\/a><\/p>\n

Mamrut S, Harony H, Sood R, Shahar-Gold H, Gainer H, Shi YJ, Barki-Harrington L, Wagner S. PloS one 2013; 8(2).\u00a0doi: 10.1371\/journal.pone.0056869.<\/span><\/p>\n

\n

The contribution of oxytocin and vasopressin to mammalian social behavior: potential role in autism spectrum disorder. <\/a><\/p>\n

Harony H, Wagner S. Neuro-Signals 2010; 18(2).\u00a0doi: 10.1159\/000321035.<\/span><\/p>\n

\n

What do unicellular organisms teach us about DNA methylation?<\/a><\/p>\n

Harony H, Ankri S. Trends in parasitology 2008 May; 24(5). doi: 10.1016\/j.pt.2008.02.002.<\/span><\/p>\n

\n

Sensing DNA methylation in the protozoan parasite Entamoeba histolytica. <\/a><\/p>\n

Lavi T, Isakov E, Harony H, Fisher O, Siman-Tov R, Ankri S. Molecular microbiology 2006 Dec; 62(5).<\/p>\n

\n

DNA methylation and targeting of LINE retrotransposons in Entamoeba histolytica and Entamoeba invadens. <\/a><\/p>\n

Harony H, Bernes S, Siman-Tov R, Ankri S. Molecular and biochemical parasitology 2006 May; 147(1).[\/et_pb_toggle][et_pb_button button_url=”https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/hala.harony-nicolas.1\/bibliography\/public\/” url_new_window=”on” button_text=”PubMed” admin_label=”PubMed” _builder_version=”4.9.0″ custom_button=”on” button_text_size=”17px” button_text_color=”#636363″ button_bg_color=”#FFFFFF” button_border_color=”#FFFFFF” button_border_radius=”7px” button_font=”||||||||” button_icon_color=”#ffffff” button_icon_color__hover_enabled=”on” button_icon_color__hover=”#ffffff” button_text_color__hover_enabled=”on” button_text_color__hover=”#ffffff”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Funding” module_id=”funding” _builder_version=”3.22″ background_color=”#d61c8b”][et_pb_row _builder_version=”3.25″ min_height=”103px” custom_margin=”51px|auto|-60px|auto||”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text admin_label=”Funding Header” _builder_version=”3.27.4″ text_font=”||||||||” text_text_color=”#ffffff” custom_margin=”||0px”]<\/p>\n

Funding<\/span><\/span><\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”3.25″][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-content\/uploads\/sites\/280\/2019\/07\/NIMH-Logo-600×399-600x419_2.png” url=”https:\/\/www.nimh.nih.gov\/index.shtml” url_new_window=”on” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” admin_label=”NIMH” _builder_version=”3.23″ max_width=”90%”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-content\/uploads\/sites\/280\/2021\/11\/seavercenter-logo.png” title_text=”seavercenter logo” url=”https:\/\/icahn.mssm.edu\/research\/seaver” url_new_window=”on” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” admin_label=”Seaver” _builder_version=”4.9.0″][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-content\/uploads\/sites\/280\/2019\/06\/FBI-New-e1561736665277.jpg” url=”https:\/\/icahn.mssm.edu\/research\/friedman” url_new_window=”on” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” admin_label=”FBI” _builder_version=”3.23″ custom_padding=”|||0px”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-content\/uploads\/sites\/280\/2020\/09\/bsf-high-q.jpg” url=”https:\/\/www.bsf.org.il\/” url_new_window=”on” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” admin_label=”BSF” _builder_version=”3.23″ custom_padding=”|||0px”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Positions” _builder_version=”3.22″ background_color=”#f4f4f4″][et_pb_row _builder_version=”3.25″ custom_padding=”54px|0px|54px|0px|false|false”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text admin_label=”Positions Header” module_id=”positions” _builder_version=”3.27.4″ text_font=”||||||||”]<\/p>\n

Join the Team<\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#595959″ header_font=”||||||||”]<\/p>\n

Our lab is always looking for highly motivated scientists with a considerable background in molecular and behavioral neuroscience.<\/p>\n

If you are interested in joining the lab as a postdoctoral fellow or graduate student, please send a cover letter, curriculum vitae, and the names, phone numbers, and email addresses of three references who could provide letters of recommendation to Dr. Hala Harony-Nicolas at:\u00a0\u00a0hala.harony-nicolas@mssm.edu<\/span><\/a>.<\/p>\n

Volunteers with some background in neuroscience and biology and with passion and motivation for science are always welcome. If interested, please send your resume to Dr. Hala Harony-Nicolas at:\u00a0hala.harony-nicolas@mssm.edu<\/a><\/span>.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Gallery” module_id=”gallery” _builder_version=”3.22″ background_color=”#00a6e5″][et_pb_row _builder_version=”3.25″ custom_margin=”0px||”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text admin_label=”Gallery Header” _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#ffffff” header_font=”||||||||” header_text_color=”#FFFFFF” custom_margin=”0px||30px”]<\/p>\n

Gallery<\/span><\/h1>\n

[\/et_pb_text][et_pb_text _builder_version=”3.27.4″ text_font=”||||||||” text_text_color=”#ffffff” header_font=”||||||||” header_text_color=”#ffffff”]<\/p>\n

Awards & Recognitions<\/span><\/h4>\n

[\/et_pb_text][et_pb_gallery gallery_ids=”786,555,630,566,952″ posts_number=”5″ admin_label=”Gallery” _builder_version=”4.9.0″ title_font=”||||||||” title_text_color=”#ffffff” title_font_size=”15px” pagination_font=”||||||||” pagination_text_color=”#ffffff” text_orientation=”left” caption_text_color_tablet=”” caption_text_color_phone=”” caption_text_color_last_edited=”on|desktop” custom_css_gallery_item=”||”][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Gallery” module_id=”gallery” _builder_version=”3.22″ background_color=”#ffffff”][et_pb_row _builder_version=”3.25″ custom_margin=”0px||”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

ResearchStudies in our lab are focused on understanding the mechanisms by which autism-associated mutations lead to the manifestation of behavioral deficits. We specifically ask how these mutations affect brain networks that subserve social behavior and social reward processing, and how these changes lead to social behavior deficits.\u00a0To address these scientific questions, our lab uses transgenic […]<\/p>\n","protected":false},"author":305,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

\"\"\"\"<\/p>

\u00a0<\/p>

\u00a0<\/p>

\u00a0<\/p>

\u00a0<\/p>

\u00a0<\/p>

Dr. Harony-Nicolas\u2019s research is focused on understanding the mechanisms by which ASD-associated mutations lead to the manifestation of behavioral deficits, with an emphasis on the effect of these mutations on the brain oxytocin system, known as a major modulator of mammalian social behavior, and on brain circuits of social behavior. Her lab applies integrated molecular and behavioral neuroscience approaches and uses transgenic rat models for ASD and neurodevelopmental disorders to identify molecular targets for treatment and to uncover altered brain circuits that can be manipulated with circuit-specific non-invasive interventions.<\/p>","_et_gb_content_width":"","footnotes":""},"class_list":["post-15","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-json\/wp\/v2\/pages\/15","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-json\/wp\/v2\/users\/305"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-json\/wp\/v2\/comments?post=15"}],"version-history":[{"count":355,"href":"https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-json\/wp\/v2\/pages\/15\/revisions"}],"predecessor-version":[{"id":1299,"href":"https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-json\/wp\/v2\/pages\/15\/revisions\/1299"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/harony-nicolaslab\/wp-json\/wp\/v2\/media?parent=15"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}