{"id":830,"date":"2020-07-12T10:21:47","date_gmt":"2020-07-12T10:21:47","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/harellab\/?page_id=830"},"modified":"2026-04-13T14:01:55","modified_gmt":"2026-04-13T14:01:55","slug":"spinal-cord-associative-plasticity-scap","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/harellab\/spinal-cord-associative-plasticity-scap\/","title":{"rendered":"Spinal Cord Associative Plasticity (SCAP)"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; custom_margin=&#8221;40px|40px|50px|40px|false|true&#8221; custom_padding=&#8221;0px||0px||true&#8221; border_radii=&#8221;|||60px|&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;3_5,2_5&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;Roboto|300|||||||&#8221; text_text_color=&#8221;#1f2430&#8243; text_font_size=&#8221;22px&#8221; text_line_height=&#8221;1.5em&#8221; header_font=&#8221;||||||||&#8221; header_text_color=&#8221;#1f2430&#8243; header_2_font=&#8221;Roboto|700|||||||&#8221; header_2_text_color=&#8221;#1f2430&#8243; header_2_font_size=&#8221;62px&#8221; custom_margin=&#8221;|-225px||&#8221; custom_padding=&#8221;10%|0px||&#8221; animation_style=&#8221;fade&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Spinal Cord Associative Plasticity (SCAP)<\/h2>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; prev_background_color=&#8221;#ffffff&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#f5f7fa&#8221; custom_margin=&#8221;|40px|40px|40px||true&#8221; top_divider_style=&#8221;wave&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; text_font=&#8221;Roboto|300|||||||&#8221; text_text_color=&#8221;#51596c&#8221; text_font_size=&#8221;20px&#8221; text_line_height=&#8221;1.6em&#8221; header_font=&#8221;Roboto|700|||||||&#8221; header_text_color=&#8221;#1f2430&#8243; header_font_size=&#8221;48px&#8221; header_2_font=&#8221;Roboto|700|||||||&#8221; header_2_font_size=&#8221;48px&#8221; header_2_line_height=&#8221;1.4em&#8221; header_3_font=&#8221;Roboto|700|||||||&#8221; header_3_text_color=&#8221;#1f2430&#8243; header_3_font_size=&#8221;48px&#8221; header_3_line_height=&#8221;1.5em&#8221; custom_margin=&#8221;30px||30px||true&#8221; 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ul_line_height__hover_enabled=&#8221;1em&#8221; ul_text_shadow_style__hover=&#8221;none&#8221; ul_text_shadow_style__hover_enabled=&#8221;none&#8221; ul_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; ul_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; ol_font_size__hover=&#8221;14px&#8221; ol_font_size__hover_enabled=&#8221;14px&#8221; ol_letter_spacing__hover=&#8221;0px&#8221; ol_letter_spacing__hover_enabled=&#8221;0px&#8221; ol_line_height__hover=&#8221;1em&#8221; ol_line_height__hover_enabled=&#8221;1em&#8221; ol_text_shadow_style__hover=&#8221;none&#8221; ol_text_shadow_style__hover_enabled=&#8221;none&#8221; ol_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; ol_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; quote_font_size__hover=&#8221;14px&#8221; quote_font_size__hover_enabled=&#8221;14px&#8221; quote_letter_spacing__hover=&#8221;0px&#8221; quote_letter_spacing__hover_enabled=&#8221;0px&#8221; quote_line_height__hover=&#8221;1em&#8221; quote_line_height__hover_enabled=&#8221;1em&#8221; quote_text_shadow_style__hover=&#8221;none&#8221; quote_text_shadow_style__hover_enabled=&#8221;none&#8221; quote_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; quote_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; text_orientation__hover=&#8221;left&#8221; text_orientation__hover_enabled=&#8221;left&#8221; background_layout__hover=&#8221;light&#8221; background_layout__hover_enabled=&#8221;light&#8221; max_width__hover=&#8221;100%&#8221; max_width__hover_enabled=&#8221;100%&#8221;]<\/p>\n<h2>Background<\/h2>\n<ul>\n<li>People with cervical SCI have reduced connections in nerve circuits between the brain and the hands. Activating spared nerve circuits could be a way to improve recovery.<\/li>\n<li>We are testing different combinations of magnetic and electrical brain and spinal cord stimulation to see if we can improve hand function by activating spared nerve connections.<\/li>\n<li>Preliminary results demonstrate that precisely pairing noninvasive brain and spinal cord stimulation has the potential to facilitate nerve responses in the upper extremity.<\/li>\n<li><strong>Note: <\/strong>This is a research study. This study is testing for temporary changes (up to several days) in nerve transmission and hand function. If we see temporary changes in this study, then future studies would focus on how to prolong that effect.<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/harellab\/wp-content\/uploads\/sites\/355\/2022\/01\/tms-.jpg&#8221; title_text=&#8221;tms-&#8221; align=&#8221;right&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;&#8221; align_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;4.16&#8243; max_width=&#8221;112%&#8221; module_alignment=&#8221;right&#8221; custom_margin=&#8221;40px|0px||&#8221; custom_padding=&#8221;0px|0px|0px||true&#8221; animation_style=&#8221;fade&#8221; custom_css_before=&#8221;z-index: 99;||&#8221; custom_css_main_element=&#8221;z-index: 99;||&#8221; custom_css_after=&#8221;z-index: 99;||&#8221; border_radii=&#8221;||60px|60px|60px&#8221; box_shadow_style=&#8221;preset1&#8243; box_shadow_color=&#8221;rgba(0,0,0,0.13)&#8221; global_colors_info=&#8221;{}&#8221;]<br \/>\n[\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_accordion open_toggle_text_color=&#8221;#267ff8&#8243; open_toggle_background_color=&#8221;#ffffff&#8221; closed_toggle_text_color=&#8221;#1f2430&#8243; closed_toggle_background_color=&#8221;#ffffff&#8221; icon_color=&#8221;#267ff8&#8243; _builder_version=&#8221;4.27.4&#8243; toggle_font=&#8221;Roboto|500|||||||&#8221; body_font=&#8221;Roboto|300|||||||&#8221; body_text_color=&#8221;#51596c&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][et_pb_accordion_item title=&#8221;Eligibility Criteria (summary)&#8221; open=&#8221;on&#8221; _builder_version=&#8221;4.27.4&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Age 18-85 yo with chronic cervical SCI, occurred greater than 12 months ago<\/li>\n<li>Ability to at least slightly move muscles of left or right hand &amp; fingers<\/li>\n<li>No history of severe traumatic brain injury (TBI); not ventilator-dependent; no implanted stimulators or cardiac pacemaker\/defibrillator, no epilepsy<\/li>\n<li>Other eligibility criteria will be screened in person to make sure it is safe for you to participate<\/li>\n<\/ul>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;Procedures&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221;]<\/p>\n<p>Up to 7 visits, up to 3-4 hours each<br \/>The first visit will be a screening visit to determine eligibility.<\/p>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;What you should know&#8221; _builder_version=&#8221;4.27.4&#8243; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<ul>\n<li>\n<p>Electrical and magnetic stimulation can feel like a \u2018shock\u2019 that is temporarily uncomfortable at higher pulse strength<\/p>\n<p>\u00b7 We have never observed a serious adverse event from study procedures during more than 10 years of stimulation studies.<\/p>\n<p>\u00b7 <strong>If you are uncomfortable at any time for any reason, we can stop the procedures. There is no obligation!!<\/strong><\/p>\n<\/li>\n<\/ul>\n<p>[\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; text_font=&#8221;Roboto|300|||||||&#8221; text_text_color=&#8221;#51596c&#8221; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.6em&#8221; header_font=&#8221;Roboto|700|||||||&#8221; header_text_color=&#8221;#1f2430&#8243; header_font_size=&#8221;48px&#8221; header_2_font=&#8221;Work Sans|700|||||||&#8221; header_2_font_size=&#8221;40px&#8221; header_2_line_height=&#8221;1.4em&#8221; header_3_font=&#8221;Roboto|700|||||||&#8221; header_3_text_color=&#8221;#1f2430&#8243; header_3_font_size=&#8221;48px&#8221; header_3_line_height=&#8221;1.5em&#8221; background_color=&#8221;#dbf0fa&#8221; custom_margin=&#8221;30px||30px||true&#8221; custom_padding=&#8221;20px||20px|30px&#8221; animation_style=&#8221;fade&#8221; text_font_size_tablet=&#8221;16px&#8221; text_font_size_phone=&#8221;14px&#8221; text_font_size_last_edited=&#8221;on|phone&#8221; header_2_font_size_tablet=&#8221;30px&#8221; header_2_font_size_phone=&#8221;22px&#8221; header_2_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221; header_font_size__hover=&#8221;30px&#8221; header_font_size__hover_enabled=&#8221;30px&#8221; header_letter_spacing__hover=&#8221;0px&#8221; header_letter_spacing__hover_enabled=&#8221;0px&#8221; header_text_shadow_style__hover=&#8221;none&#8221; header_text_shadow_style__hover_enabled=&#8221;none&#8221; header_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; header_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; text_font_size__hover=&#8221;14px&#8221; text_font_size__hover_enabled=&#8221;14px&#8221; text_letter_spacing__hover=&#8221;0px&#8221; text_letter_spacing__hover_enabled=&#8221;0px&#8221; text_line_height__hover=&#8221;1.7em&#8221; text_line_height__hover_enabled=&#8221;1.7em&#8221; text_text_shadow_style__hover=&#8221;none&#8221; text_text_shadow_style__hover_enabled=&#8221;none&#8221; text_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; text_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; link_font_size__hover=&#8221;14px&#8221; link_font_size__hover_enabled=&#8221;14px&#8221; link_letter_spacing__hover=&#8221;0px&#8221; link_letter_spacing__hover_enabled=&#8221;0px&#8221; link_line_height__hover=&#8221;1em&#8221; link_line_height__hover_enabled=&#8221;1em&#8221; link_text_shadow_style__hover=&#8221;none&#8221; link_text_shadow_style__hover_enabled=&#8221;none&#8221; link_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; link_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; ul_font_size__hover=&#8221;14px&#8221; ul_font_size__hover_enabled=&#8221;14px&#8221; ul_letter_spacing__hover=&#8221;0px&#8221; ul_letter_spacing__hover_enabled=&#8221;0px&#8221; ul_line_height__hover=&#8221;1em&#8221; ul_line_height__hover_enabled=&#8221;1em&#8221; ul_text_shadow_style__hover=&#8221;none&#8221; ul_text_shadow_style__hover_enabled=&#8221;none&#8221; ul_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; ul_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; ol_font_size__hover=&#8221;14px&#8221; ol_font_size__hover_enabled=&#8221;14px&#8221; ol_letter_spacing__hover=&#8221;0px&#8221; ol_letter_spacing__hover_enabled=&#8221;0px&#8221; ol_line_height__hover=&#8221;1em&#8221; ol_line_height__hover_enabled=&#8221;1em&#8221; ol_text_shadow_style__hover=&#8221;none&#8221; ol_text_shadow_style__hover_enabled=&#8221;none&#8221; ol_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; ol_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; quote_font_size__hover=&#8221;14px&#8221; quote_font_size__hover_enabled=&#8221;14px&#8221; quote_letter_spacing__hover=&#8221;0px&#8221; quote_letter_spacing__hover_enabled=&#8221;0px&#8221; quote_line_height__hover=&#8221;1em&#8221; quote_line_height__hover_enabled=&#8221;1em&#8221; quote_text_shadow_style__hover=&#8221;none&#8221; quote_text_shadow_style__hover_enabled=&#8221;none&#8221; quote_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; quote_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; text_orientation__hover=&#8221;left&#8221; text_orientation__hover_enabled=&#8221;left&#8221; background_layout__hover=&#8221;light&#8221; background_layout__hover_enabled=&#8221;light&#8221; max_width__hover=&#8221;100%&#8221; max_width__hover_enabled=&#8221;100%&#8221;]<\/p>\n<p><strong>Investigator<\/strong><br \/>Noam Y. Harel, MD, PhD<\/p>\n<p><strong>Study ID<br \/><\/strong>SCAP<\/p>\n<p><a href=\"https:\/\/labs.icahn.mssm.edu\/harellab\/contact-us\/\"><strong>Contact<\/strong><\/a><br \/>Sig Sigafose or Francisco Castano<\/p>\n<p><strong>Clinicaltrials.gov Identifier<\/strong><br \/><strong><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05163639\">NCT05163639<\/a><\/strong><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_5,1_5,3_5&#8243; _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;-70px||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_5&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_button button_url=&#8221;https:\/\/labs.icahn.mssm.edu\/harellab\/our-research\/&#8221; button_text=&#8221;Back to Studies&#8221; admin_label=&#8221;Button&#8221; _builder_version=&#8221;4.27.4&#8243; custom_button=&#8221;on&#8221; button_text_size=&#8221;14px&#8221; button_text_color=&#8221;#ffffff&#8221; button_bg_color=&#8221;#267ff8&#8243; button_border_color=&#8221;#267ff8&#8243; button_letter_spacing=&#8221;1px&#8221; button_font=&#8221;Roboto|700||on|||||&#8221; button_use_icon=&#8221;off&#8221; background_layout=&#8221;dark&#8221; custom_margin=&#8221;|-70px||0px&#8221; global_colors_info=&#8221;{}&#8221;]<br \/>\n[\/et_pb_button][\/et_pb_column][et_pb_column type=&#8221;1_5&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_button button_url=&#8221;https:\/\/labs.icahn.mssm.edu\/harellab\/contact-us\/&#8221; url_new_window=&#8221;on&#8221; button_text=&#8221;Contact Us&#8221; _builder_version=&#8221;4.16&#8243; custom_button=&#8221;on&#8221; button_text_size=&#8221;14px&#8221; button_text_color=&#8221;#ffffff&#8221; button_bg_color=&#8221;#267ff8&#8243; button_border_color=&#8221;#267ff8&#8243; button_letter_spacing=&#8221;1px&#8221; button_font=&#8221;Roboto|700||on|||||&#8221; button_use_icon=&#8221;off&#8221; background_layout=&#8221;dark&#8221; global_colors_info=&#8221;{}&#8221;]<br \/>\n[\/et_pb_button][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Spinal Cord Associative Plasticity (SCAP)Background People with cervical SCI have reduced connections in nerve circuits between the brain and the hands. Activating spared nerve circuits could be a way to improve recovery. We are testing different combinations of magnetic and electrical brain and spinal cord stimulation to see if we can improve hand function by [&hellip;]<\/p>\n","protected":false},"author":403,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-830","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/pages\/830","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/users\/403"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/comments?post=830"}],"version-history":[{"count":29,"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/pages\/830\/revisions"}],"predecessor-version":[{"id":2659,"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/pages\/830\/revisions\/2659"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/media?parent=830"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}