{"id":614,"date":"2020-07-11T05:07:35","date_gmt":"2020-07-11T05:07:35","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/harellab\/?page_id=614"},"modified":"2026-02-10T19:19:46","modified_gmt":"2026-02-10T19:19:46","slug":"the-role-of-pharmacological-agents-in-restoring-neuronal-excitability-after-chronic-sci","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/harellab\/the-role-of-pharmacological-agents-in-restoring-neuronal-excitability-after-chronic-sci\/","title":{"rendered":"The role of pharmacological agents in restoring neuronal excitability after chronic SCI"},"content":{"rendered":"

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The role of pharmacological agents in restoring neuronal excitability after chronic SCI<\/h2>\n

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Background<\/h2>\n

SCI leads to complex imbalances in central nervous system (CNS) circuits, resulting in a mix of
underactive circuits that drive voluntary movement, overactive circuits that drive uncontrolled
movement (spasticity), and impaired feedback responses. These imbalances act as barriers to functional recovery after SCI. Thus, drugs aiming to restore a normal balance of excitability within the damaged CNS are potential key therapies in SCI rehabilitation.\u00a0<\/p>\n

We are testing magnetic brain and electrical spinal cord stimulation, along with muscle strength and
task performance during an activity, to better understand how the single-dose drugs influence nerve circuits for improving hand function. To stimulate the brain, we use transcranial magnetic stimulation (TMS). To stimulate the spinal cord, we use \u201clow frequency stimulation\u201d. All of these methods are non-invasive.<\/p>\n

Note: This is a research study testing for temporary changes in nerve transmission and hand function.
There is no expectation of long-term benefit from this study. Any temporary changes seen in this study will be implemented in future studies attempting to prolong that effect.<\/p>\n

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