{"id":482,"date":"2020-07-09T10:50:56","date_gmt":"2020-07-09T10:50:56","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/harellab\/?page_id=482"},"modified":"2026-02-03T20:28:37","modified_gmt":"2026-02-03T20:28:37","slug":"non-invasive-cervical-stimulation-for-als","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/harellab\/non-invasive-cervical-stimulation-for-als\/","title":{"rendered":"Non-Invasive Cervical Stimulation for ALS"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; custom_margin=&#8221;40px|40px|50px|40px|false|true&#8221; custom_padding=&#8221;0px||0px||true&#8221; border_radii=&#8221;|||60px|&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;3_5,2_5&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;Roboto|300|||||||&#8221; text_text_color=&#8221;#1f2430&#8243; text_font_size=&#8221;22px&#8221; text_line_height=&#8221;1.5em&#8221; header_font=&#8221;||||||||&#8221; header_text_color=&#8221;#1f2430&#8243; header_2_font=&#8221;Roboto|700|||||||&#8221; header_2_text_color=&#8221;#1f2430&#8243; header_2_font_size=&#8221;62px&#8221; custom_padding=&#8221;10%||&#8221; animation_style=&#8221;fade&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Non-Invasive Cervical Stimulation for ALS<\/h2>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; prev_background_color=&#8221;#ffffff&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#f5f7fa&#8221; custom_margin=&#8221;|40px|40px|40px||true&#8221; top_divider_style=&#8221;wave&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;Roboto|300|||||||&#8221; text_text_color=&#8221;#51596c&#8221; text_font_size=&#8221;20px&#8221; text_line_height=&#8221;1.6em&#8221; header_font=&#8221;Roboto|700|||||||&#8221; header_text_color=&#8221;#1f2430&#8243; header_font_size=&#8221;48px&#8221; header_2_font=&#8221;Roboto|700|||||||&#8221; header_2_font_size=&#8221;48px&#8221; header_2_line_height=&#8221;1.4em&#8221; header_3_font=&#8221;Roboto|700|||||||&#8221; header_3_text_color=&#8221;#1f2430&#8243; header_3_font_size=&#8221;48px&#8221; header_3_line_height=&#8221;1.5em&#8221; custom_margin=&#8221;30px||30px||true&#8221; animation_style=&#8221;fade&#8221; text_font_size_tablet=&#8221;16px&#8221; text_font_size_phone=&#8221;14px&#8221; text_font_size_last_edited=&#8221;on|phone&#8221; header_2_font_size_tablet=&#8221;30px&#8221; header_2_font_size_phone=&#8221;22px&#8221; header_2_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221; header_font_size__hover=&#8221;30px&#8221; header_font_size__hover_enabled=&#8221;30px&#8221; header_letter_spacing__hover=&#8221;0px&#8221; header_letter_spacing__hover_enabled=&#8221;0px&#8221; header_text_shadow_style__hover=&#8221;none&#8221; header_text_shadow_style__hover_enabled=&#8221;none&#8221; header_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; header_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; text_font_size__hover=&#8221;14px&#8221; text_font_size__hover_enabled=&#8221;14px&#8221; text_letter_spacing__hover=&#8221;0px&#8221; text_letter_spacing__hover_enabled=&#8221;0px&#8221; 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ul_line_height__hover=&#8221;1em&#8221; ul_line_height__hover_enabled=&#8221;1em&#8221; ul_text_shadow_style__hover=&#8221;none&#8221; ul_text_shadow_style__hover_enabled=&#8221;none&#8221; ul_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; ul_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; ol_font_size__hover=&#8221;14px&#8221; ol_font_size__hover_enabled=&#8221;14px&#8221; ol_letter_spacing__hover=&#8221;0px&#8221; ol_letter_spacing__hover_enabled=&#8221;0px&#8221; ol_line_height__hover=&#8221;1em&#8221; ol_line_height__hover_enabled=&#8221;1em&#8221; ol_text_shadow_style__hover=&#8221;none&#8221; ol_text_shadow_style__hover_enabled=&#8221;none&#8221; ol_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; ol_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; quote_font_size__hover=&#8221;14px&#8221; quote_font_size__hover_enabled=&#8221;14px&#8221; quote_letter_spacing__hover=&#8221;0px&#8221; quote_letter_spacing__hover_enabled=&#8221;0px&#8221; quote_line_height__hover=&#8221;1em&#8221; quote_line_height__hover_enabled=&#8221;1em&#8221; quote_text_shadow_style__hover=&#8221;none&#8221; quote_text_shadow_style__hover_enabled=&#8221;none&#8221; quote_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; quote_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; text_orientation__hover=&#8221;left&#8221; text_orientation__hover_enabled=&#8221;left&#8221; background_layout__hover=&#8221;light&#8221; background_layout__hover_enabled=&#8221;light&#8221; max_width__hover=&#8221;100%&#8221; max_width__hover_enabled=&#8221;100%&#8221;]<\/p>\n<h2>Background<\/h2>\n<p>Individuals with amyotrophic lateral sclerosis (ALS) have reduced connections in the nerve circuits between the brain and the hands. We are testing different combinations of magnetic and electrical brain and spinal cord stimulation to better understand how nerve circuits interact with each other in ALS, and also to see if we can temporarily improve hand function by activating spared nerve connections.<\/p>\n<p><span style=\"font-size: 20px\"><strong>Note:<\/strong> This is a research study testing for temporary changes in nerve transmission and hand function. There is no expectation of long-term benefit from this study. Any temporary changes seen in this study will be implemented in future studies attempting to prolong that effect.<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/harellab\/wp-content\/uploads\/sites\/355\/2020\/07\/nerve-cell-2213009_1920.jpg&#8221; align=&#8221;right&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;&#8221; align_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;4.16&#8243; max_width=&#8221;112%&#8221; module_alignment=&#8221;right&#8221; custom_margin=&#8221;40px|0px||&#8221; custom_padding=&#8221;0px|0px|0px||true&#8221; animation_style=&#8221;fade&#8221; custom_css_before=&#8221;z-index: 99;||&#8221; custom_css_main_element=&#8221;z-index: 99;||&#8221; custom_css_after=&#8221;z-index: 99;||&#8221; border_radii=&#8221;||60px|60px|60px&#8221; box_shadow_style=&#8221;preset1&#8243; box_shadow_color=&#8221;rgba(0,0,0,0.13)&#8221; global_colors_info=&#8221;{}&#8221;]<br \/>\n[\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_accordion open_toggle_text_color=&#8221;#267ff8&#8243; open_toggle_background_color=&#8221;#ffffff&#8221; closed_toggle_text_color=&#8221;#1f2430&#8243; closed_toggle_background_color=&#8221;#ffffff&#8221; icon_color=&#8221;#267ff8&#8243; _builder_version=&#8221;4.16&#8243; toggle_font=&#8221;Roboto|500|||||||&#8221; body_font=&#8221;Roboto|300|||||||&#8221; body_text_color=&#8221;#51596c&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_accordion_item title=&#8221;Eligibility Criteria (summary)&#8221; open=&#8221;on&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>Age 18-75 with diagnosis of probable or definite Amyotrophic Lateral Sclerosis<\/li>\n<li>Must have some ability to use fingers in at least one hand<\/li>\n<li>No history of seizures, cardiac arrhythmia, or implanted electrical devices (pacemaker, spine stimulator, baclofen pump, etc)<\/li>\n<li>Other eligibility criteria will be screened in person to make sure it is safe for you to participate.<\/li>\n<\/ul>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;Procedures&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221;]6 visits lasting approximately 3 hours each.<br \/>\nIf you are an ALS participant, the first visit will be a screening visit to determine your eligibility.[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;What should you know&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221;]<\/p>\n<ul>\n<li>Electrical and magnetic stimulation can feel like a \u2018shock\u2019 that is temporarily uncomfortable.<\/li>\n<li>The main risk of magnetic brain stimulation is seizure. BUT:<\/li>\n<li>Seizures are riskier when pulses are given faster than once per second \u2013 in this study, pulses are never given more than once every 5 or 10 seconds;<\/li>\n<li>The exclusion criteria are designed to prevent anyone at risk of seizure from participating.<\/li>\n<li>When performed according to these recommendations, the risk of seizure is less than 1 in 1,000.<\/li>\n<li><strong>If you are uncomfortable at any time for any reason, we can stop the procedures. There is no obligation!!<\/strong><\/li>\n<p>[\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;Roboto|300|||||||&#8221; text_text_color=&#8221;#51596c&#8221; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.6em&#8221; header_font=&#8221;Roboto|700|||||||&#8221; header_text_color=&#8221;#1f2430&#8243; header_font_size=&#8221;48px&#8221; header_2_font=&#8221;Work Sans|700|||||||&#8221; header_2_font_size=&#8221;40px&#8221; header_2_line_height=&#8221;1.4em&#8221; header_3_font=&#8221;Roboto|700|||||||&#8221; header_3_text_color=&#8221;#1f2430&#8243; header_3_font_size=&#8221;48px&#8221; header_3_line_height=&#8221;1.5em&#8221; background_color=&#8221;#dbf0fa&#8221; custom_margin=&#8221;30px||30px||true&#8221; custom_padding=&#8221;20px||20px|30px&#8221; animation_style=&#8221;fade&#8221; text_font_size_tablet=&#8221;16px&#8221; text_font_size_phone=&#8221;14px&#8221; text_font_size_last_edited=&#8221;on|phone&#8221; header_2_font_size_tablet=&#8221;30px&#8221; header_2_font_size_phone=&#8221;22px&#8221; header_2_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221; header_font_size__hover=&#8221;30px&#8221; header_font_size__hover_enabled=&#8221;30px&#8221; header_letter_spacing__hover=&#8221;0px&#8221; header_letter_spacing__hover_enabled=&#8221;0px&#8221; header_text_shadow_style__hover=&#8221;none&#8221; header_text_shadow_style__hover_enabled=&#8221;none&#8221; header_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; header_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; text_font_size__hover=&#8221;14px&#8221; text_font_size__hover_enabled=&#8221;14px&#8221; text_letter_spacing__hover=&#8221;0px&#8221; text_letter_spacing__hover_enabled=&#8221;0px&#8221; text_line_height__hover=&#8221;1.7em&#8221; text_line_height__hover_enabled=&#8221;1.7em&#8221; text_text_shadow_style__hover=&#8221;none&#8221; text_text_shadow_style__hover_enabled=&#8221;none&#8221; text_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; text_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; link_font_size__hover=&#8221;14px&#8221; link_font_size__hover_enabled=&#8221;14px&#8221; link_letter_spacing__hover=&#8221;0px&#8221; link_letter_spacing__hover_enabled=&#8221;0px&#8221; link_line_height__hover=&#8221;1em&#8221; link_line_height__hover_enabled=&#8221;1em&#8221; link_text_shadow_style__hover=&#8221;none&#8221; link_text_shadow_style__hover_enabled=&#8221;none&#8221; link_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; link_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; ul_font_size__hover=&#8221;14px&#8221; ul_font_size__hover_enabled=&#8221;14px&#8221; ul_letter_spacing__hover=&#8221;0px&#8221; ul_letter_spacing__hover_enabled=&#8221;0px&#8221; ul_line_height__hover=&#8221;1em&#8221; ul_line_height__hover_enabled=&#8221;1em&#8221; ul_text_shadow_style__hover=&#8221;none&#8221; ul_text_shadow_style__hover_enabled=&#8221;none&#8221; ul_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; ul_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; ol_font_size__hover=&#8221;14px&#8221; ol_font_size__hover_enabled=&#8221;14px&#8221; ol_letter_spacing__hover=&#8221;0px&#8221; ol_letter_spacing__hover_enabled=&#8221;0px&#8221; ol_line_height__hover=&#8221;1em&#8221; ol_line_height__hover_enabled=&#8221;1em&#8221; ol_text_shadow_style__hover=&#8221;none&#8221; ol_text_shadow_style__hover_enabled=&#8221;none&#8221; ol_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; ol_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; quote_font_size__hover=&#8221;14px&#8221; quote_font_size__hover_enabled=&#8221;14px&#8221; quote_letter_spacing__hover=&#8221;0px&#8221; quote_letter_spacing__hover_enabled=&#8221;0px&#8221; quote_line_height__hover=&#8221;1em&#8221; quote_line_height__hover_enabled=&#8221;1em&#8221; quote_text_shadow_style__hover=&#8221;none&#8221; quote_text_shadow_style__hover_enabled=&#8221;none&#8221; quote_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; quote_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; text_orientation__hover=&#8221;left&#8221; text_orientation__hover_enabled=&#8221;left&#8221; background_layout__hover=&#8221;light&#8221; background_layout__hover_enabled=&#8221;light&#8221; max_width__hover=&#8221;100%&#8221; max_width__hover_enabled=&#8221;100%&#8221;]<\/p>\n<p><strong>Investigator<\/strong><br \/> Noam Y. Harel, MD, PhD<\/p>\n<p><strong>Study ID<br \/><\/strong>HAR-17-33<\/p>\n<p><strong>Contact<\/strong><br \/>Astrea Villarroel-Sanchez<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_5,1_5,3_5&#8243; _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;-70px||0px&#8221; custom_padding=&#8221;||0px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_5&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_button button_url=&#8221;https:\/\/labs.icahn.mssm.edu\/harellab\/our-research\/&#8221; button_text=&#8221;Back to Studies&#8221; _builder_version=&#8221;4.16&#8243; custom_button=&#8221;on&#8221; button_text_size=&#8221;14px&#8221; button_text_color=&#8221;#ffffff&#8221; button_bg_color=&#8221;#267ff8&#8243; button_border_color=&#8221;#267ff8&#8243; button_letter_spacing=&#8221;1px&#8221; button_font=&#8221;Roboto|700||on|||||&#8221; button_use_icon=&#8221;off&#8221; background_layout=&#8221;dark&#8221; custom_margin=&#8221;|-70px||&#8221; global_colors_info=&#8221;{}&#8221;]<br \/>\n[\/et_pb_button][\/et_pb_column][et_pb_column type=&#8221;1_5&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_button button_url=&#8221;https:\/\/labs.icahn.mssm.edu\/harellab\/contact-us\/&#8221; url_new_window=&#8221;on&#8221; button_text=&#8221;Contact Us&#8221; _builder_version=&#8221;4.16&#8243; custom_button=&#8221;on&#8221; button_text_size=&#8221;14px&#8221; button_text_color=&#8221;#ffffff&#8221; button_bg_color=&#8221;#267ff8&#8243; button_border_color=&#8221;#267ff8&#8243; button_letter_spacing=&#8221;1px&#8221; button_font=&#8221;Roboto|700||on|||||&#8221; button_use_icon=&#8221;off&#8221; background_layout=&#8221;dark&#8221; custom_margin=&#8221;|-70px||&#8221; global_colors_info=&#8221;{}&#8221;]<br \/>\n[\/et_pb_button][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Non-Invasive Cervical Stimulation for ALS Background Individuals with amyotrophic lateral sclerosis (ALS) have reduced connections in the nerve circuits between the brain and the hands. We are testing different combinations of magnetic and electrical brain and spinal cord stimulation to better understand how nerve circuits interact with each other in ALS, and also to see [&hellip;]<\/p>\n","protected":false},"author":403,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-482","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/pages\/482","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/users\/403"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/comments?post=482"}],"version-history":[{"count":24,"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/pages\/482\/revisions"}],"predecessor-version":[{"id":2513,"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/pages\/482\/revisions\/2513"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/media?parent=482"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}