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Most individuals with injury or disease of the spinal cord have residual nerve connections, even if they have trouble moving their muscles.<\/p>\n
To strengthen these connections, we conduct multiple studies using different combinations of physical exercises, magnetic stimulation, electrical stimulation, ischemic conditioning, and medications.<\/p>\n
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Call for participants! <\/span><\/strong><\/span><\/p>\n Veterans and non-Veterans are eligible<\/strong> for our research studies.<\/p>\n People with spinal cord injury, amyotrophic lateral sclerosis, or uninjured volunteers are welcome to participate in our studies. For information about specific research projects and eligibility criteria please check out our studies below:<\/p>\n <\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”on|desktop” admin_label=”Video” _builder_version=”4.16″ custom_margin=”-50px||” custom_padding=”40px|40px|100px|40px|false|true” custom_padding_tablet=”0px||” custom_padding_phone=”” global_colors_info=”{}” use_background_color_gradient__hover=”off” use_background_color_gradient__hover_enabled=”off” background_color_gradient_start__hover=”#2b87da” background_color_gradient_start__hover_enabled=”#2b87da” background_color_gradient_end__hover=”#29c4a9″ background_color_gradient_end__hover_enabled=”#29c4a9″ background_color_gradient_type__hover=”linear” background_color_gradient_type__hover_enabled=”linear” 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testosterone replacement therapy (iTRT) on restoration of central nervous system (CNS) excitability and cardiovascular function in men with chronic spinal cord injury (SCI) and Amyotrophic lateral sclerosis (ALS) compared to uninjured volunteers. Additionally, we will examine the relationships among testosterone concentrations, neural function, and cardiovascular function. The iTRT has already gained U.S. Food and Drug Administration (FDA) approval.<\/span><\/p>\n <\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_4,1_4″ _builder_version=”4.16″ custom_margin=”-90px||40px” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_button button_url=”https:\/\/labs.icahn.mssm.edu\/harellab\/the-role-of-androgens-in-neurophysiological-and-autonomic-function-in-male-veterans\/” button_text=”READ ABOUT STUDY” _builder_version=”4.16″ _module_preset=”default” background_layout=”dark” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_button 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quote_line_height__hover=”1em” quote_line_height__hover_enabled=”1em” quote_text_shadow_style__hover=”none” quote_text_shadow_style__hover_enabled=”none” quote_text_shadow_color__hover=”rgba(0,0,0,0.4)” quote_text_shadow_color__hover_enabled=”rgba(0,0,0,0.4)” text_orientation__hover=”left” text_orientation__hover_enabled=”left” background_layout__hover=”light” background_layout__hover_enabled=”light” max_width__hover=”100%” max_width__hover_enabled=”100%”]<\/p>\n This is a follow-up of the \u2018Spinal Cord Associative Plasticity (SCAP)\u2019 study. In people with chronic cervical SCI, we will systematically test parameters of brain and cervical spinal cord stimulation such as pulse frequency, number of bouts of SCAP per session, time interval between bouts of SCAP, and the effect of combining SCAP with functional hand exercises. The goal is to determine each participant\u2019s optimal individualized method for delivering repetitive SCAP along with functional hand exercises to obtain a more lasting effect of at least 24 hours.<\/p>\n <\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_4,1_4″ _builder_version=”4.16″ min_height=”154px” custom_margin=”-90px||40px” custom_padding=”40px|||||” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_button button_url=”https:\/\/labs.icahn.mssm.edu\/harellab\/finding-the-best-combination-of-brain-and-spinal-cord-stimulation-with-hand-training-after-spinal-cord-injury\/” button_text=”Read about study” _builder_version=”4.16″ custom_button=”on” button_text_size=”14px” button_text_color=”#ffffff” 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link_text_shadow_style__hover=”none” link_text_shadow_style__hover_enabled=”none” link_text_shadow_color__hover=”rgba(0,0,0,0.4)” link_text_shadow_color__hover_enabled=”rgba(0,0,0,0.4)” ul_font_size__hover=”14px” ul_font_size__hover_enabled=”14px” ul_letter_spacing__hover=”0px” ul_letter_spacing__hover_enabled=”0px” ul_line_height__hover=”1em” ul_line_height__hover_enabled=”1em” ul_text_shadow_style__hover=”none” ul_text_shadow_style__hover_enabled=”none” ul_text_shadow_color__hover=”rgba(0,0,0,0.4)” ul_text_shadow_color__hover_enabled=”rgba(0,0,0,0.4)” ol_font_size__hover=”14px” ol_font_size__hover_enabled=”14px” ol_letter_spacing__hover=”0px” ol_letter_spacing__hover_enabled=”0px” ol_line_height__hover=”1em” ol_line_height__hover_enabled=”1em” ol_text_shadow_style__hover=”none” ol_text_shadow_style__hover_enabled=”none” ol_text_shadow_color__hover=”rgba(0,0,0,0.4)” ol_text_shadow_color__hover_enabled=”rgba(0,0,0,0.4)” quote_font_size__hover=”14px” quote_font_size__hover_enabled=”14px” quote_letter_spacing__hover=”0px” quote_letter_spacing__hover_enabled=”0px” quote_line_height__hover=”1em” quote_line_height__hover_enabled=”1em” quote_text_shadow_style__hover=”none” quote_text_shadow_style__hover_enabled=”none” quote_text_shadow_color__hover=”rgba(0,0,0,0.4)” quote_text_shadow_color__hover_enabled=”rgba(0,0,0,0.4)” text_orientation__hover=”left” text_orientation__hover_enabled=”left” background_layout__hover=”light” background_layout__hover_enabled=”light” max_width__hover=”100%” max_width__hover_enabled=”100%”]<\/p>\n This is a follow-up of the \u2018Spinal Cord Associative Plasticity (SCAP)\u2019 study. In people with chronic cervical SCI, we will systematically test parameters of brain and cervical spinal cord stimulation such as pulse frequency, number of bouts of SCAP per session, time interval between bouts of SCAP, and the effect of combining SCAP with functional hand exercises. The goal is to determine each participant\u2019s optimal individualized method for delivering repetitive SCAP along with functional hand exercises to obtain a more lasting effect of at least 24 hours.<\/p>\n <\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_4,1_4″ _builder_version=”4.16″ min_height=”154px” custom_margin=”-90px||40px” custom_padding=”40px|||||” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_button button_url=”https:\/\/labs.icahn.mssm.edu\/harellab\/spinal-cord-associative-plasticity-for-amyotrophic-lateral-sclerosis\/” button_text=”Read about study” _builder_version=”4.16″ custom_button=”on” button_text_size=”14px” button_text_color=”#ffffff” button_bg_color=”#267ff8″ button_border_width=”0px” button_border_color=”rgba(0,0,0,0)” button_letter_spacing=”1px” button_font=”Roboto|700||on|||||” button_use_icon=”off” custom_padding=”8px|12px|8px|12px|true|true” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/harellab\/wp-content\/uploads\/sites\/355\/2026\/02\/istockphoto-1276620416-612×612-1.jpg” title_text=”istockphoto-1276620416-612×612″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text 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header_text_shadow_color__hover=”rgba(0,0,0,0.4)” header_text_shadow_color__hover_enabled=”rgba(0,0,0,0.4)” text_font_size__hover=”14px” text_font_size__hover_enabled=”14px” text_letter_spacing__hover=”0px” text_letter_spacing__hover_enabled=”0px” text_line_height__hover=”1.7em” text_line_height__hover_enabled=”1.7em” text_text_shadow_style__hover=”none” text_text_shadow_style__hover_enabled=”none” text_text_shadow_color__hover=”rgba(0,0,0,0.4)” text_text_shadow_color__hover_enabled=”rgba(0,0,0,0.4)” link_font_size__hover=”14px” link_font_size__hover_enabled=”14px” link_letter_spacing__hover=”0px” link_letter_spacing__hover_enabled=”0px” link_line_height__hover=”1em” link_line_height__hover_enabled=”1em” link_text_shadow_style__hover=”none” link_text_shadow_style__hover_enabled=”none” link_text_shadow_color__hover=”rgba(0,0,0,0.4)” link_text_shadow_color__hover_enabled=”rgba(0,0,0,0.4)” ul_font_size__hover=”14px” ul_font_size__hover_enabled=”14px” ul_letter_spacing__hover=”0px” ul_letter_spacing__hover_enabled=”0px” ul_line_height__hover=”1em” ul_line_height__hover_enabled=”1em” ul_text_shadow_style__hover=”none” ul_text_shadow_style__hover_enabled=”none” ul_text_shadow_color__hover=”rgba(0,0,0,0.4)” ul_text_shadow_color__hover_enabled=”rgba(0,0,0,0.4)” ol_font_size__hover=”14px” ol_font_size__hover_enabled=”14px” ol_letter_spacing__hover=”0px” ol_letter_spacing__hover_enabled=”0px” ol_line_height__hover=”1em” ol_line_height__hover_enabled=”1em” ol_text_shadow_style__hover=”none” ol_text_shadow_style__hover_enabled=”none” ol_text_shadow_color__hover=”rgba(0,0,0,0.4)” ol_text_shadow_color__hover_enabled=”rgba(0,0,0,0.4)” quote_font_size__hover=”14px” quote_font_size__hover_enabled=”14px” quote_letter_spacing__hover=”0px” quote_letter_spacing__hover_enabled=”0px” quote_line_height__hover=”1em” quote_line_height__hover_enabled=”1em” quote_text_shadow_style__hover=”none” quote_text_shadow_style__hover_enabled=”none” quote_text_shadow_color__hover=”rgba(0,0,0,0.4)” quote_text_shadow_color__hover_enabled=”rgba(0,0,0,0.4)” text_orientation__hover=”left” text_orientation__hover_enabled=”left” background_layout__hover=”light” background_layout__hover_enabled=”light” max_width__hover=”100%” max_width__hover_enabled=”100%”]<\/p>\n There is a high prevalence of depression in the SCI population; however, members of the SCI community have been left out of psychedelic research studies. Psilocybin belongs to a class of drugs called psychedelics. Psilocybin is produced in nature by some species of mushrooms and has been <\/span>designated a breakthrough therapy for major depressive disorders by the Food and Drug Administration (FDA).\u00a0<\/span><\/i><\/b>This study will evaluate the safety and therapeutic potential of psilocybin for the treatment of depression in Veterans with spinal cord injury (SCI). Under the leadership of Dr. Jill Wecht, participants with chronic SCI will receive one of three psilocybin doses and will be followed longitudinally for up to one year. Outcomes will include safety and tolerability, depressive symptoms, pain, muscle spasticity, and quality of life. The goal is to determine whether psilocybin can provide a safe and effective treatment for depression in individuals with SCI and to challenge the assumption that depression is an unavoidable consequence of spinal cord injury.<\/span><\/p>\n <\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_4,1_4″ _builder_version=”4.16″ min_height=”113.3px” custom_margin=”-90px||40px” custom_padding=”40px|||||” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_button button_url=”https:\/\/labs.icahn.mssm.edu\/harellab\/dylan-arnero\/” button_text=”Contact Us” _builder_version=”4.27.4″ custom_button=”on” button_text_size=”14px” button_text_color=”#ffffff” button_bg_color=”#267ff8″ button_border_width=”0px” button_border_color=”rgba(0,0,0,0)” button_letter_spacing=”1px” button_font=”Roboto|700||on|||||” button_use_icon=”off” custom_padding=”8px|12px|8px|12px|true|true” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Our Research Most individuals with injury or disease of the spinal cord have residual nerve connections, even if they have trouble moving their muscles. To strengthen these connections, we conduct multiple studies using different combinations of physical exercises, magnetic stimulation, electrical stimulation, ischemic conditioning, and medications.Call for participants! The Neurorehabilitation Program currently has several studies […]<\/p>\n","protected":false},"author":403,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-296","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/pages\/296","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/users\/403"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/comments?post=296"}],"version-history":[{"count":125,"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/pages\/296\/revisions"}],"predecessor-version":[{"id":2608,"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/pages\/296\/revisions\/2608"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/media?parent=296"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}The Neurorehabilitation Program currently has several studies seeking volunteers.<\/h4>\n
Pairing brain and spinal stimulation to achieve Spinal Cord Associative Plasticity (SCAP)<\/h4>\n
The Role of Androgens in Neurophysiological and Autonomic Function in Male Veterans with Spinal Cord Injury<\/h4>\n
Finding the Best Combination of Brain and Spinal Cord Stimulation with Hand Training after Spinal Cord Injury<\/h4>\n
Spinal Cord Associative Plasticity for Amyotrophic Lateral Sclerosis (ALS)<\/h4>\n
Safety, Tolerability, and Outcomes of Psilocybin in Veterans with SCI\u00a0\u00a0<\/h4>\n