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\u00b7 People with amyotrophic lateral sclerosis (ALS) have reduced nerve connections between the brain and the hands that resemble those of people with SCI. Activating spared nerve connections could be a way to improve recovery.<\/p>\n
\u00b7 We are testing different combinations of magnetic and electrical brain and spinal cord stimulation to see if we can improve hand function by activating spared nerve connections in people with ALS.<\/p>\n
\u00b7 We will first determine each individual\u2019s best timing for pairs of brain and cervical spinal cord stimulation, then determine each individual\u2019s best frequency, and then compare the effects of 1 week of repetitive stim plus functional hand exercises versus 1 week of repetitive stim without hand exercises.<\/p>\n
\u00b7 The goal is to measure the safety and duration of effects in the hope of achieving lasting benefit up to 2 weeks.<\/p>\n
\u00b7 Note: This is a research study testing for temporary changes in nerve transmission and volitional motor function. This is not a cure for ALS. There is no guarantee of long-term benefit from this study. Any benefits seen in this study will be implemented in future studies attempting to augment that effect.<\/p>\n
<\/p>\n
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\n[\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_accordion open_toggle_text_color=”#267ff8″ open_toggle_background_color=”#ffffff” closed_toggle_text_color=”#1f2430″ closed_toggle_background_color=”#ffffff” icon_color=”#267ff8″ _builder_version=”4.27.4″ toggle_font=”Roboto|500|||||||” body_font=”Roboto|300|||||||” body_text_color=”#51596c” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][et_pb_accordion_item title=”Eligibility Criteria (summary)” open=”on” _builder_version=”4.27.4″ global_colors_info=”{}”]<\/p>\n
\u00b7 Age 18-85 years old with a diagnosis of ALS.<\/p>\n
\u00b7 Ability to at least slightly move muscles of left or right hand<\/p>\n
\u00b7 No history of severe traumatic brain injury (TBI); not ventilator-dependent; no implanted stimulators or cardiac pacemaker\/defibrillator, no epilepsy.<\/p>\n
\u00b7 Other eligibility criteria will be screened in person to make sure it is safe for you to participate<\/p>\n
[\/et_pb_accordion_item][et_pb_accordion_item title=”Procedures” _builder_version=”4.27.4″ global_colors_info=”{}” open=”off”]<\/p>\n
\u00b7 This study involves a significant time commitment: up to 18 visits, 3-4 hours each, over a period of up to 4 months.<\/p>\n
\u00b7 Scheduling is flexible. You do not need to complete all visits.<\/p>\n
[\/et_pb_accordion_item][et_pb_accordion_item title=”What you should know” _builder_version=”4.27.4″ hover_enabled=”0″ global_colors_info=”{}” open=”off” sticky_enabled=”0″]<\/p>\n
\u00b7 Electrical and magnetic stimulation can feel like a \u2018shock\u2019 or \u2018bite\u2019 that is temporarily uncomfortable, especially at higher pulse strength.<\/p>\n
o If you ever had an \u201cEMG\u201d or \u201cnerve conduction study\u201d previously, you will already be familiar with this sensation. However, there are no needles used in this study.<\/p>\n
\u00b7 We have never observed a serious adverse event from study procedures during more than 10 years of stimulation studies.<\/p>\n
\u00b7 If you are uncomfortable at any time for any reason, we can stop the procedures. There is no obligation!!<\/p>\n
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Investigator<\/strong> Study ID Contact<\/strong> Clinicaltrials.gov Identifier<\/strong><\/p>\n NCT06172621<\/p>\n <\/strong><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_5,1_5,3_5″ _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”-70px||” global_colors_info=”{}”][et_pb_column type=”1_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_button button_url=”https:\/\/labs.icahn.mssm.edu\/harellab\/our-research\/” button_text=”Back to Studies” _builder_version=”4.16″ custom_button=”on” button_text_size=”14px” button_text_color=”#ffffff” button_bg_color=”#267ff8″ button_border_color=”#267ff8″ button_letter_spacing=”1px” button_font=”Roboto|700||on|||||” button_use_icon=”off” background_layout=”dark” custom_margin=”|-70px||” global_colors_info=”{}”] Spinal Cord Associative Plasticity for Amyotrophic Lateral Sclerosis (ALS) Background \u00b7 People with amyotrophic lateral sclerosis (ALS) have reduced nerve connections between the brain and the hands that resemble those of people with SCI. Activating spared nerve connections could be a way to improve recovery. \u00b7 We are testing different combinations of magnetic and electrical […]<\/p>\n","protected":false},"author":403,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-2315","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/pages\/2315","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/users\/403"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/comments?post=2315"}],"version-history":[{"count":13,"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/pages\/2315\/revisions"}],"predecessor-version":[{"id":2613,"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/pages\/2315\/revisions\/2613"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/media?parent=2315"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Noam Y. Harel, MD, PhD<\/p>\n
<\/strong>ALS SCAP + HAND<\/p>\n
Sig Sigafose or Francisco Castano<\/p>\n
\n[\/et_pb_button][\/et_pb_column][et_pb_column type=”1_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_button button_url=”https:\/\/labs.icahn.mssm.edu\/harellab\/contact-us\/” url_new_window=”on” button_text=”Contact Us” _builder_version=”4.16″ custom_button=”on” button_text_size=”14px” button_text_color=”#ffffff” button_bg_color=”#267ff8″ button_border_color=”#267ff8″ button_letter_spacing=”1px” button_font=”Roboto|700||on|||||” button_use_icon=”off” background_layout=”dark” global_colors_info=”{}”]
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