{"id":2257,"date":"2023-12-06T20:54:45","date_gmt":"2023-12-06T20:54:45","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/harellab\/?page_id=2257"},"modified":"2026-03-18T16:57:35","modified_gmt":"2026-03-18T16:57:35","slug":"finding-the-best-combination-of-brain-and-spinal-cord-stimulation-with-hand-training-after-spinal-cord-injury","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/harellab\/finding-the-best-combination-of-brain-and-spinal-cord-stimulation-with-hand-training-after-spinal-cord-injury\/","title":{"rendered":"Finding the Best Combination of Brain and Spinal Cord Stimulation with Hand Training after Spinal Cord Injury"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; custom_margin=&#8221;40px|40px|50px|40px|false|true&#8221; custom_padding=&#8221;0px||0px||true&#8221; border_radii=&#8221;|||60px|&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;3_5,2_5&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;Roboto|300|||||||&#8221; text_text_color=&#8221;#1f2430&#8243; text_font_size=&#8221;22px&#8221; text_line_height=&#8221;1.5em&#8221; header_font=&#8221;||||||||&#8221; header_text_color=&#8221;#1f2430&#8243; header_2_font=&#8221;Roboto|700|||||||&#8221; header_2_text_color=&#8221;#1f2430&#8243; header_2_font_size=&#8221;62px&#8221; custom_margin=&#8221;|-225px||&#8221; custom_padding=&#8221;10%|0px||&#8221; animation_style=&#8221;fade&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Finding the Best Combination of Brain and Spinal Cord Stimulation with Hand Training after Spinal Cord Injury<\/h2>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.16&#8243; 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ol_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; ol_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; quote_font_size__hover=&#8221;14px&#8221; quote_font_size__hover_enabled=&#8221;14px&#8221; quote_letter_spacing__hover=&#8221;0px&#8221; quote_letter_spacing__hover_enabled=&#8221;0px&#8221; quote_line_height__hover=&#8221;1em&#8221; quote_line_height__hover_enabled=&#8221;1em&#8221; quote_text_shadow_style__hover=&#8221;none&#8221; quote_text_shadow_style__hover_enabled=&#8221;none&#8221; quote_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; quote_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; text_orientation__hover=&#8221;left&#8221; text_orientation__hover_enabled=&#8221;left&#8221; background_layout__hover=&#8221;light&#8221; background_layout__hover_enabled=&#8221;light&#8221; max_width__hover=&#8221;100%&#8221; max_width__hover_enabled=&#8221;100%&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<h2>Background<\/h2>\n<ul>\n<li>People with cervical spinal cord injury (SCI) have reduced nerve connections between the brain and the hands. Activating spared nerve connections could be a way to improve recovery.<\/li>\n<li>We are testing different combinations of magnetic and electrical brain and spinal cord stimulation plus arm\/hand exercises to see if we can optimize temporary improvements in hand function for each participant.<\/li>\n<li>The goal is to determine each participant\u2019s optimal individualized method for delivering repetitive stimulation along with functional hand exercises to obtain a more lasting effect of at least 24 hours.<\/li>\n<li>Note: This is a research study. This study is testing for temporary changes (up to several days) in nerve transmission and hand function. If we see temporary changes in this study, then future studies would focus on how to prolong that effect.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/harellab\/wp-content\/uploads\/sites\/355\/2023\/12\/GAM-TMS-scaled.jpeg&#8221; alt=&#8221;Brain Stimulation with Neuronavigation&#8221; title_text=&#8221;GAM TMS&#8221; align=&#8221;right&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;&#8221; align_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;4.16&#8243; max_width=&#8221;112%&#8221; module_alignment=&#8221;right&#8221; custom_margin=&#8221;40px|0px||&#8221; custom_padding=&#8221;0px|0px|0px|52px|true|&#8221; animation_style=&#8221;fade&#8221; custom_css_before=&#8221;z-index: 99;||&#8221; custom_css_main_element=&#8221;z-index: 99;||&#8221; custom_css_after=&#8221;z-index: 99;||&#8221; border_radii=&#8221;||60px|60px|60px&#8221; box_shadow_style=&#8221;preset1&#8243; box_shadow_color=&#8221;rgba(0,0,0,0.13)&#8221; global_colors_info=&#8221;{}&#8221;]<br \/>\n[\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_accordion open_toggle_text_color=&#8221;#267ff8&#8243; open_toggle_background_color=&#8221;#ffffff&#8221; closed_toggle_text_color=&#8221;#1f2430&#8243; closed_toggle_background_color=&#8221;#ffffff&#8221; icon_color=&#8221;#267ff8&#8243; _builder_version=&#8221;4.27.4&#8243; toggle_font=&#8221;Roboto|500|||||||&#8221; body_font=&#8221;Roboto|300|||||||&#8221; body_text_color=&#8221;#51596c&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_accordion_item title=&#8221;Eligibility Criteria (summary)&#8221; open=&#8221;on&#8221; _builder_version=&#8221;4.27.4&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>Age 18-85 years old with chronic cervical SCI, occurred greater than 12 months ago.<\/li>\n<li>Ability to at least slightly move muscles of left or right hand and fingers.<\/li>\n<li>No history of severe traumatic brain injury (TBI); not ventilator-dependent; no implanted stimulators or cardiac pacemaker\/defibrillator, no epilepsy.<\/li>\n<li>Other eligibility criteria will be screened in person to make sure it is safe for you to participate<\/li>\n<\/ul>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;Procedures&#8221; _builder_version=&#8221;4.27.4&#8243; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221;]<\/p>\n<ul>\n<li>This study involves a significant time commitment: 53 visits over a period of 6-9 months.<\/li>\n<li>Scheduling is flexible. You do not need to complete all visits.<\/li>\n<\/ul>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;What you should know&#8221; _builder_version=&#8221;4.27.4&#8243; global_colors_info=&#8221;{}&#8221; open=&#8221;off&#8221;]<\/p>\n<ul>\n<li>Electrical and magnetic stimulation can feel like a \u2018shock\u2019 that is temporarily uncomfortable at higher pulse strength.<\/li>\n<li>We have never observed a serious adverse event from study procedures during more than 10 years of stimulation studies.<\/li>\n<li>If you are uncomfortable at any time for any reason, we can stop the procedures. There is no obligation!!<\/li>\n<\/ul>\n<p>[\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;Roboto|300|||||||&#8221; text_text_color=&#8221;#51596c&#8221; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.6em&#8221; header_font=&#8221;Roboto|700|||||||&#8221; header_text_color=&#8221;#1f2430&#8243; header_font_size=&#8221;48px&#8221; header_2_font=&#8221;Work Sans|700|||||||&#8221; header_2_font_size=&#8221;40px&#8221; header_2_line_height=&#8221;1.4em&#8221; header_3_font=&#8221;Roboto|700|||||||&#8221; header_3_text_color=&#8221;#1f2430&#8243; header_3_font_size=&#8221;48px&#8221; header_3_line_height=&#8221;1.5em&#8221; background_color=&#8221;#dbf0fa&#8221; custom_margin=&#8221;30px||30px||true&#8221; custom_padding=&#8221;20px||20px|30px&#8221; animation_style=&#8221;fade&#8221; text_font_size_tablet=&#8221;16px&#8221; text_font_size_phone=&#8221;14px&#8221; text_font_size_last_edited=&#8221;on|phone&#8221; header_2_font_size_tablet=&#8221;30px&#8221; header_2_font_size_phone=&#8221;22px&#8221; header_2_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221; header_font_size__hover=&#8221;30px&#8221; header_font_size__hover_enabled=&#8221;30px&#8221; header_letter_spacing__hover=&#8221;0px&#8221; header_letter_spacing__hover_enabled=&#8221;0px&#8221; header_text_shadow_style__hover=&#8221;none&#8221; header_text_shadow_style__hover_enabled=&#8221;none&#8221; header_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; header_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; text_font_size__hover=&#8221;14px&#8221; text_font_size__hover_enabled=&#8221;14px&#8221; text_letter_spacing__hover=&#8221;0px&#8221; text_letter_spacing__hover_enabled=&#8221;0px&#8221; text_line_height__hover=&#8221;1.7em&#8221; text_line_height__hover_enabled=&#8221;1.7em&#8221; text_text_shadow_style__hover=&#8221;none&#8221; text_text_shadow_style__hover_enabled=&#8221;none&#8221; text_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; text_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; link_font_size__hover=&#8221;14px&#8221; link_font_size__hover_enabled=&#8221;14px&#8221; link_letter_spacing__hover=&#8221;0px&#8221; link_letter_spacing__hover_enabled=&#8221;0px&#8221; link_line_height__hover=&#8221;1em&#8221; link_line_height__hover_enabled=&#8221;1em&#8221; link_text_shadow_style__hover=&#8221;none&#8221; link_text_shadow_style__hover_enabled=&#8221;none&#8221; link_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; link_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; ul_font_size__hover=&#8221;14px&#8221; ul_font_size__hover_enabled=&#8221;14px&#8221; ul_letter_spacing__hover=&#8221;0px&#8221; ul_letter_spacing__hover_enabled=&#8221;0px&#8221; ul_line_height__hover=&#8221;1em&#8221; ul_line_height__hover_enabled=&#8221;1em&#8221; ul_text_shadow_style__hover=&#8221;none&#8221; ul_text_shadow_style__hover_enabled=&#8221;none&#8221; ul_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; ul_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; ol_font_size__hover=&#8221;14px&#8221; ol_font_size__hover_enabled=&#8221;14px&#8221; ol_letter_spacing__hover=&#8221;0px&#8221; ol_letter_spacing__hover_enabled=&#8221;0px&#8221; ol_line_height__hover=&#8221;1em&#8221; ol_line_height__hover_enabled=&#8221;1em&#8221; ol_text_shadow_style__hover=&#8221;none&#8221; ol_text_shadow_style__hover_enabled=&#8221;none&#8221; ol_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; ol_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; quote_font_size__hover=&#8221;14px&#8221; quote_font_size__hover_enabled=&#8221;14px&#8221; quote_letter_spacing__hover=&#8221;0px&#8221; quote_letter_spacing__hover_enabled=&#8221;0px&#8221; quote_line_height__hover=&#8221;1em&#8221; quote_line_height__hover_enabled=&#8221;1em&#8221; quote_text_shadow_style__hover=&#8221;none&#8221; quote_text_shadow_style__hover_enabled=&#8221;none&#8221; quote_text_shadow_color__hover=&#8221;rgba(0,0,0,0.4)&#8221; quote_text_shadow_color__hover_enabled=&#8221;rgba(0,0,0,0.4)&#8221; text_orientation__hover=&#8221;left&#8221; text_orientation__hover_enabled=&#8221;left&#8221; background_layout__hover=&#8221;light&#8221; background_layout__hover_enabled=&#8221;light&#8221; max_width__hover=&#8221;100%&#8221; max_width__hover_enabled=&#8221;100%&#8221;]<\/p>\n<p><strong>Investigator<\/strong><br \/>Noam Y. Harel, MD, PhD<\/p>\n<p><strong>Study ID<br \/><\/strong>SCI SCAP+HAND<\/p>\n<p><strong>Contact<\/strong><br \/>Sig Sigafose or Francisco Castano<\/p>\n<p><strong>Clinicaltrials.gov Identifier<\/strong><span><\/span><\/p>\n<p>NCT06104735<strong><\/strong><\/p>\n<p><strong><\/strong><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_5,1_5,3_5&#8243; _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;-70px||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_5&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_button button_url=&#8221;https:\/\/labs.icahn.mssm.edu\/harellab\/our-research\/&#8221; button_text=&#8221;Back to Studies&#8221; _builder_version=&#8221;4.16&#8243; custom_button=&#8221;on&#8221; button_text_size=&#8221;14px&#8221; button_text_color=&#8221;#ffffff&#8221; button_bg_color=&#8221;#267ff8&#8243; button_border_color=&#8221;#267ff8&#8243; button_letter_spacing=&#8221;1px&#8221; button_font=&#8221;Roboto|700||on|||||&#8221; button_use_icon=&#8221;off&#8221; background_layout=&#8221;dark&#8221; custom_margin=&#8221;|-70px||&#8221; global_colors_info=&#8221;{}&#8221;]<br \/>\n[\/et_pb_button][\/et_pb_column][et_pb_column type=&#8221;1_5&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_button button_url=&#8221;https:\/\/labs.icahn.mssm.edu\/harellab\/contact-us\/&#8221; url_new_window=&#8221;on&#8221; button_text=&#8221;Contact Us&#8221; _builder_version=&#8221;4.16&#8243; custom_button=&#8221;on&#8221; button_text_size=&#8221;14px&#8221; button_text_color=&#8221;#ffffff&#8221; button_bg_color=&#8221;#267ff8&#8243; button_border_color=&#8221;#267ff8&#8243; button_letter_spacing=&#8221;1px&#8221; button_font=&#8221;Roboto|700||on|||||&#8221; button_use_icon=&#8221;off&#8221; background_layout=&#8221;dark&#8221; global_colors_info=&#8221;{}&#8221;]<br \/>\n[\/et_pb_button][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Finding the Best Combination of Brain and Spinal Cord Stimulation with Hand Training after Spinal Cord InjuryBackground People with cervical spinal cord injury (SCI) have reduced nerve connections between the brain and the hands. Activating spared nerve connections could be a way to improve recovery. We are testing different combinations of magnetic and electrical brain [&hellip;]<\/p>\n","protected":false},"author":403,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-2257","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/pages\/2257","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/users\/403"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/comments?post=2257"}],"version-history":[{"count":17,"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/pages\/2257\/revisions"}],"predecessor-version":[{"id":2618,"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/pages\/2257\/revisions\/2618"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/harellab\/wp-json\/wp\/v2\/media?parent=2257"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}