{"id":3794,"date":"2023-03-23T16:07:53","date_gmt":"2023-03-23T20:07:53","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/design\/?page_id=3794"},"modified":"2025-02-09T12:40:47","modified_gmt":"2025-02-09T17:40:47","slug":"option-two","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/guttmanlab\/","title":{"rendered":"Home"},"content":{"rendered":"

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Our Mission<\/strong><\/p>\n

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The Laboratory of Inflammatory Skin Diseases has major focus on atopic dermatitis, also known as eczema, alopecia areata, and other inflammatory skin diseases. The lab has made paradigm-shifting discoveries on the immunologic basis of AD\/eczema in humans, opening the door to new therapeutics.\u00a0Our work on atopic dermatitis\/eczema has contributed directly to many of the recently developed treatments for this disease, earning us a unique place as one of the leading labs in dermatology and immunology worldwide. We have also shown that Atopic dermatitis is a complex disease with distinct phenotypes based on ethnicity, age and other factors: Atopic dermatitis in Asian and African American patients is different from atopic dermatitis in European American patients, with important therapeutic implications.\u00a0<\/span><\/p>\n

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Lorem ipsum dolor sit amet<\/strong><\/h2>\n

Stem cells and their immediate environment, also called stem cell niche, are critical for the growth and continuous renewal of our organs, and are also key for new growth and repair during regeneration. Unlocking the secrets of how specialized niche cells operate to activate stem cells and progenitors holds great promise for regenerative medicine.<\/p>\n

Our laboratory aims to answer these fundamental questions in stem cell biology by utilizing the hair follicle mini-organ as a powerful model system. Deciphering how niche cells govern stem cell and progenitor functions in the hair follicle will also provide a rational basis for developing hair regenerative therapies.<\/p>\n

[\/et_pb_text][et_pb_button button_url=”https:\/\/labs.icahn.mssm.edu\/design\/option1-research” button_text=”Find Out More ” _builder_version=”4.9.0″ _module_preset=”default” custom_button=”on” button_text_color=”#d80b8c” button_bg_color=”#FFFFFF” button_border_radius=”0px” button_on_hover=”off” custom_padding=”15px|50px|15px||false|false” hover_transition_duration=”0ms”]<\/p>\n

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Our Approach<\/strong><\/p>\n

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Our lab has developed the only comprehensive molecular maps of AD, defining skin differentiation and immune-circuits characterizing this disease. The lab\u2019s work has established the reversibility of the AD phenotype and defined a series of biomarkers that are now accelerating testing of novel pathway-specific drugs for AD.\u00a0We are now testing (both clinically and mechanistically) multiple targeted-therapeutics for atopic dermatitis. Our work has also recently extended into studying alopecia areata, in which our findings are also translated to novel therapeutic targets.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ global_parent=”956″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image global_parent=”956″ src=”https:\/\/labs.icahn.mssm.edu\/brunnerlab2\/wp-content\/uploads\/sites\/534\/2022\/07\/ai-008.png” title_text=”ai-008″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”#FFFFFF” \/][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ admin_label=”Option2 Section20″ disabled_on=”off|off|off” module_class=”Option2-Section20″ _builder_version=”4.9.0″ background_color=”#00AEEF” background_enable_image=”off” width=”100%” module_alignment=”center” custom_margin=”||||false|false” custom_padding=”0px|0px|0px|0px|false|false” mix_blend_mode=”multiply” bottom_divider_color=”#FFFFFF” bottom_divider_height=”150px” bottom_divider_flip=”horizontal” bottom_divider_arrangement=”above_content” hover_enabled=”0″ locked=”off” collapsed=”off” scroll_fade_enable=”on” sticky_enabled=”0″ prev_background_color=”#ffffff” next_background_color=”#000000″][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.9.0″ background_color=”RGBA(0,0,0,0)” background_size=”initial” background_position=”top_left” background_repeat=”repeat” width=”79.7%” module_alignment=”center” min_height=”100%” height=”100%” max_height=”100%” custom_margin=”0px|0px|0px|0px|false|false” custom_padding=”0px|0px|0px|0px|false|false”][et_pb_column type=”1_2″ admin_label=”Content Column” _builder_version=”4.9.0″ background_position=”top_left” custom_padding=”80px||40px||false|false” custom_padding__hover=”|||”][et_pb_video src=”https:\/\/www.youtube.com\/watch?v=WlXuSoHh_Jc” _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”|||0px||”]<\/p>\n

[\/et_pb_video][\/et_pb_column][et_pb_column type=”1_2″ admin_label=”Image Column” _builder_version=”4.9.0″ background_position=”top_left” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_text_color=”#FFFFFF” text_font_size=”29px” custom_padding=”34px|||||”]<\/p>\n

“Spotlighting Alopecia” with Dr. Guttman<\/strong><\/p>\n

[\/et_pb_text][et_pb_text module_class=”Option2-Section20-TextModule Option2-Section20-TextModule_981-1400″ _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#FFFFFF” text_font_size=”18px” text_line_height=”22px” header_font=”||||” header_text_color=”#FFFFFF” header_2_text_align=”left” header_2_text_color=”#FFFFFF” header_2_line_height=”1.2em” header_3_text_color=”#FFFFFF” header_4_text_color=”#FFFFFF” header_5_text_color=”#FFFFFF” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”100%” module_alignment=”left” custom_padding=”|0px||0px|false|false” custom_padding_tablet=”|12%||12%|false|false” custom_padding_phone=”|||12%|false|false” custom_padding_last_edited=”on|desktop” animation_direction=”top” hover_transition_duration=”0ms” header_2_line_height_phone=”1em” header_2_line_height_last_edited=”on|phone”]<\/p>\n

Stem cells and their immediate environment, also called stem cell niche, are critical for the growth and continuous renewal of our organs, and are also key for new growth and repair during regeneration. Unlocking the secrets of how specialized niche cells operate to activate stem cells and progenitors holds great promise for regenerative medicine. Our laboratory aims to answer these fundamental questions in stem cell biology by utilizing the hair follicle mini-organ as a powerful model system.<\/p>\n

[\/et_pb_text][et_pb_button button_url=”https:\/\/profiles.mountsinai.org\/emma-guttman” url_new_window=”on” button_text=”Find Out More ” module_class=”Option2-Section20-BtnModule Option2-Section20-BtnModule_981-1400″ _builder_version=”4.9.0″ _module_preset=”default” custom_button=”on” button_text_color=”#d80b8c” button_bg_color=”#FFFFFF” button_border_radius=”0px” button_on_hover=”off” custom_margin=”50px||0px|180px|false|false” custom_margin_tablet=”|||12%|false|false” custom_margin_phone=”50px||0px|12%|false|false” custom_margin_last_edited=”on|tablet” custom_padding=”15px|50px|15px||false|false” hover_transition_duration=”0ms”]<\/p>\n

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Amet venenatis urna cursus eget nunc scelerisque viverra mauris. Varius duis at consectetur lorem donec massa sapien. Fermentum iaculis eu non diam phasellus vestibulum lorem sed risus. Tempor id eu nisl nunc mi ipsum faucibus. Dictumst quisque sagittis purus sit amet volutpat. Sapien et ligula ullamcorper malesuada proin. Risus commodo viverra maecenas accumsan lacus vel facilisis volutpat est.<\/p>\n

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Amet venenatis urna cursus eget nunc scelerisque viverra mauris. Varius duis at consectetur lorem donec massa sapien. Fermentum iaculis eu non diam phasellus vestibulum lorem sed risus. Tempor id eu nisl nunc mi ipsum faucibus. Dictumst quisque sagittis purus sit amet volutpat. Sapien et ligula ullamcorper malesuada proin. Risus commodo viverra maecenas accumsan lacus vel facilisis volutpat est.<\/p>\n

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Amet venenatis urna cursus eget nunc scelerisque viverra mauris. Varius duis at consectetur lorem donec massa sapien. Fermentum iaculis eu non diam phasellus vestibulum lorem sed risus. Tempor id eu nisl nunc mi ipsum faucibus. Dictumst quisque sagittis purus sit amet volutpat. Sapien et ligula ullamcorper malesuada proin. Risus commodo viverra maecenas accumsan lacus vel facilisis volutpat est.<\/p>\n

[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ admin_label=”Option2 Section19″ disabled_on=”off|off|off” _builder_version=”4.9.0″ _module_preset=”default” background_color=”#FFFFFF” background_image=”https:\/\/labs.icahn.mssm.edu\/brunnerlab2\/wp-content\/uploads\/sites\/534\/2022\/07\/ai-008.png” background_size=”contain” background_position=”top_left” custom_padding=”61px||100px||false|false” hover_enabled=”0″ locked=”off” collapsed=”off” scroll_fade_enable=”on” sticky_enabled=”0″ prev_background_color=”#00AEEF” next_background_color=”#EEEEEE”][et_pb_row column_structure=”3_4,1_4″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”#221F72″ module_alignment=”center” custom_padding=”80px|40px|27px|40px|false|false”][et_pb_column type=”3_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_blurb title=”American Association Spring Gala 2024″ content_max_width=”768px” _builder_version=”4.9.0″ _module_preset=”default” header_font=”|600|||||||” header_text_color=”#000000″ header_font_size=”24px” body_text_color=”#000000″ body_font_size=”18px” background_color=”#FFFFFF” custom_margin=”-33px||24px||false|false” custom_padding=”22px|5px|40px|40px|false|false” custom_css_blurb_content=”\/*margin-left: 60px !important;||margin-right: 0px !important;*\/” box_shadow_style=”preset1″]<\/p>\n

Dr. Emma Guttman received the Inaugural Therapeutic Innovation Award at the American Skin Association (ASA) Spring Gala at the Plaza Hotel in New York City on Thursday evening, April 4, 2024. It was presented by Howard P. Milstein, Chairman of the ASA. The award was in recognition of Dr. Guttman\u2019s work in helping to unravel the molecular and cellular mechanisms driving inflammatory skin diseases including atopic dermatitis (AD) and alopecia areata.<\/span><\/p>\n

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[\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ admin_label=”Option2 Section17″ module_class=”Option2-Section17″ _builder_version=”4.9.0″ background_color=”#EEEEEE” background_enable_image=”off” width=”100%” module_alignment=”center” custom_margin=”||||false|false” custom_padding=”40px|0px|40px|0px|false|false” mix_blend_mode=”multiply” bottom_divider_color=”#FFFFFF” bottom_divider_height=”150px” bottom_divider_flip=”horizontal” bottom_divider_arrangement=”above_content” hover_enabled=”0″ custom_css_main_element=”padding-bottom: 40px !important;” locked=”off” collapsed=”on” scroll_fade_enable=”on” sticky_enabled=”0″ prev_background_color=”#FFFFFF” next_background_color=”#00AEEF”][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.9.0″ background_color=”RGBA(0,0,0,0)” background_size=”initial” background_position=”top_left” background_repeat=”repeat” module_alignment=”center” custom_margin=”0px|0px|0px|0px|false|false” custom_padding=”0px|0px|40px|0px|false|false” collapsed=”on”][et_pb_column type=”1_2″ _builder_version=”4.9.0″ background_position=”top_left” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_video src=”https:\/\/www.youtube.com\/watch?v=J2JuWVPZtQI” _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”11px|||||”]<\/p>\n

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2024 Jacobi Medallion Award<\/strong><\/h2>\n<\/div>\n<\/div>\n

[\/et_pb_text][et_pb_text admin_label=”Body text” _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#000000″ text_font_size=”18px” text_line_height=”22px” header_font=”||||” header_text_color=”#000000″ header_4_text_color=”#FFFFFF” header_5_text_color=”#FFFFFF” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”90%” custom_margin=”||36px|||” animation_direction=”top”]<\/p>\n

Dr. Emma Guttman was honored on March 14, with the Jacobi Medallion at the 2024 Jacobi Medallion Ceremony at The Plaza Hotel.<\/p>\n

This prestigious award honors a member of the Mount Sinai community who, through long-term service (typically 10 years or more), has made exceptional contributions to the fields of clinical medicine or biomedical research, or has exemplified extraordinary dedication to Mount Sinai.<\/p>\n

[\/et_pb_text][et_pb_button button_url=”https:\/\/health.mountsinai.org\/blog\/2024-jacobi-medallion-award-ceremony\/” url_new_window=”on” button_text=”Full Press Release” _builder_version=”4.9.0″ _module_preset=”default” custom_button=”on” button_text_color=”#FFFFFF” button_bg_color=”#00AEEF” button_border_radius=”0px” button_on_hover=”off” custom_padding=”15px|50px|15px||false|false” hover_transition_duration=”0ms”]<\/p>\n

[\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ admin_label=”Option2 Section25 \u2013 Fullwidth Footer \u2013 Local” disabled_on=”off|off|off” module_class=”footer-section” _builder_version=”4.9.0″ background_color=”#00AEEF” background_enable_image=”off” max_width=”100%” max_width_last_edited=”on|phone” module_alignment=”center” custom_margin=”0px|||176px|false|false” custom_padding=”3px|0px|0px|0px|false|false” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”14%” animation_starting_opacity=”100%” hover_enabled=”0″ saved_tabs=”all” locked=”off” collapsed=”on” scroll_fade_enable=”on” sticky_enabled=”0″ prev_background_color=”#EEEEEE” next_background_color=”rgba(0,174,239,0.09)”][et_pb_row _builder_version=”4.9.0″ background_color=”RGBA(0,0,0,0)” background_color_gradient_direction=”38deg” module_alignment=”center” custom_margin=”|auto||147px||” locked=”off” collapsed=”off”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_social_media_follow _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” text_orientation=”center” custom_margin=”||0px|||”][et_pb_social_media_follow_network social_network=”linkedin” url=”https:\/\/www.linkedin.com\/school\/icahnmountsinai\/%20″ use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” follow_button=”off” url_new_window=”on”]linkedin[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=”facebook” url=”https:\/\/www.facebook.com\/IcahnMountSinai” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” follow_button=”off” url_new_window=”on”]facebook[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=”twitter” url=”https:\/\/twitter.com\/icahnmountsinai” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” follow_button=”off” url_new_window=”on”]twitter[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=”youtube” url=”https:\/\/www.youtube.com\/user\/MountSinaiSchool” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” follow_button=”off” url_new_window=”on”]youtube[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=”instagram” url=”https:\/\/www.instagram.com\/icahnmountsinai\/” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” follow_button=”off” url_new_window=”on”]instagram[\/et_pb_social_media_follow_network][\/et_pb_social_media_follow][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.9.0″ background_color=”RGBA(0,0,0,0)” background_color_gradient_direction=”38deg” module_alignment=”center” custom_margin=”|auto|-2px|auto||” custom_padding=”0px|||||” locked=”off” collapsed=”on”][et_pb_column type=”1_2″ _builder_version=”4.9.0″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_text_color=”#FFFFFF” text_font_size=”20px” custom_margin=”||24px|||”]<\/p>\n

Clinic Information<\/strong><\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_text_color=”#FFFFFF” custom_margin=”22px|||||” custom_padding=”14px|||||”]<\/p>\n

Address<\/strong>: 5 E 98th Street, Dermatology Suite, New York, NY 10029<\/p>\n

Phone<\/strong>: 212-241-9728<\/p>\n

Clinic Hours<\/strong>: 8am \u2013 12pm Mondays and Thursday<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.9.0″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_text_color=”#FFFFFF” text_font_size=”20px” custom_margin=”||19px|||”]<\/p>\n

Interested in participating in our Clinical Trial?<\/strong><\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_text_color=”#FFFFFF” custom_padding=”17px|||||”]<\/p>\n

Phone<\/strong>: 212-241-3288<\/p>\n

Email<\/strong>: giselle.singer@mssm.edu<\/p>\n

Clinic Hours<\/strong>: 8am \u2013 5pm on Mondays \u2013 Fridays<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ admin_label=”Header Title Description – Section – Header – Fullwidth Slider ” fullwidth=”on” disabled_on=”on|on|on” module_id=”header-title-description-slider-section1″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”rgba(0,174,239,0.09)” background_enable_color=”off” background_image=”https:\/\/labs.icahn.mssm.edu\/brunnerlab2\/wp-content\/uploads\/sites\/534\/2022\/07\/ai-002-1.jpg” parallax=”on” custom_padding=”||||false|false” bottom_divider_style=”ramp2″ bottom_divider_color=”#FFFFFF” bottom_divider_height=”11vw” disabled=”on” locked=”on” collapsed=”on” prev_background_color=”#00AEEF”][et_pb_fullwidth_slider arrows_custom_color=”#D80B8C” dot_nav_custom_color=”#D80B8C” _builder_version=”4.9.0″ _module_preset=”default”][et_pb_slide heading=”One” _builder_version=”4.9.0″ _module_preset=”default” header_text_align=”left” body_text_align=”left” background_image=”https:\/\/labs.icahn.mssm.edu\/brunnerlab2\/wp-content\/uploads\/sites\/534\/2022\/07\/ai-002-1.jpg” background_enable_image=”on” text_orientation=”left” custom_padding=”|||80px|false|false” sticky_transition=”on”]<\/p>\n

Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>\n

[\/et_pb_slide][et_pb_slide heading=”Two” _builder_version=”4.9.0″ _module_preset=”default” header_text_align=”left” body_text_align=”left” background_image=”https:\/\/labs.icahn.mssm.edu\/brunnerlab2\/wp-content\/uploads\/sites\/534\/2022\/07\/ai-002-1.jpg” background_enable_image=”on” text_orientation=”left” custom_padding=”|||80px|false|false” sticky_transition=”on”]<\/p>\n

Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>\n

[\/et_pb_slide][et_pb_slide heading=”Three” _builder_version=”4.9.0″ _module_preset=”default” header_text_align=”left” body_text_align=”left” background_image=”https:\/\/labs.icahn.mssm.edu\/brunnerlab2\/wp-content\/uploads\/sites\/534\/2022\/07\/ai-002-1.jpg” background_enable_image=”on” text_orientation=”left” custom_padding=”|||80px|false|false” sticky_transition=”on”]<\/p>\n

Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>\n

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Our Mission The Laboratory of Inflammatory Skin Diseases has major focus on atopic dermatitis, also known as eczema, alopecia areata, and other inflammatory skin diseases. The lab has made paradigm-shifting discoveries on the immunologic basis of AD\/eczema in humans, opening the door to new therapeutics.\u00a0Our work on atopic dermatitis\/eczema has contributed directly to many of […]<\/p>\n","protected":false},"author":545,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"class_list":["post-3794","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/guttmanlab\/wp-json\/wp\/v2\/pages\/3794","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/guttmanlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/guttmanlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/guttmanlab\/wp-json\/wp\/v2\/users\/545"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/guttmanlab\/wp-json\/wp\/v2\/comments?post=3794"}],"version-history":[{"count":42,"href":"https:\/\/labs.icahn.mssm.edu\/guttmanlab\/wp-json\/wp\/v2\/pages\/3794\/revisions"}],"predecessor-version":[{"id":5229,"href":"https:\/\/labs.icahn.mssm.edu\/guttmanlab\/wp-json\/wp\/v2\/pages\/3794\/revisions\/5229"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/guttmanlab\/wp-json\/wp\/v2\/media?parent=3794"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}