Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes. Rizi Ai, Teresina Laragione, Deepa Hammaker, David L. Boyle, Andre Wildberg, Keisuke Maeshima, Emanuele Palescandolo, Vinod Krishna, David Pocalyko, John W. Whitaker, Yuchen Bai, Sunil Nagpal, Kurtis E. Bachman, Richard I. Ainsworth, Mengchi Wang, Bo Ding, Percio S. Gulko, Wei Wang & Gary S. Firestein. Nature Communications. Article number: 1921 (2018)
doi:10.1038/s41467-018-04310-9. Published: 15 May 2018

Suppression and resolution of autoimmune arthritis by rhesus θ-defensin-1, an immunomodulatory macrocyclic peptide. Justin B. Schaal , Dat Q. Tran , Akshay Subramanian, Reshma Patel, Teresina Laragione, Kevin D. Roberts, Katie Trinh, Prasad Tongaonkar, Patti A. Tran, Dmitriy Minond, Gregg B. Fields, Paul Beringer, André J. Ouellette, Percio S. Gulko, Michael E. Selsted
Published: November 16, 2017 https://doi.org/10.1371/journal.pone.0187868

The cation channel Trpv2 is a new suppressor of arthritis severity, joint damage, and synovial fibroblast invasion. Laragione T, Cheng KF, Tanner MR, He M, Beeton C, Al-Abed Y, Gulko PS. Clin Immunol. 2015 Jun;158(2):183-92. doi: 10.1016/j.clim.2015.04.001. Epub 2015 Apr 11.

KCa1.1 inhibition attenuates fibroblast-like synoviocyte invasiveness and ameliorates disease in rat models of rheumatoid arthritis. Tanner MR, Hu X, Huq R, Tajhya RB, Sun L, Khan FS, Laragione T, Horrigan FT, Gulko PS, Beeton C. Arthritis Rheumatol. 2015 Jan;67(1):96-106. doi: 10.1002/art.38883.

Analyses of synovial tissues from arthritic and protected congenic rat strains reveal a new core set of genes associated with disease severity. Brenner M, Laragione T, Gulko PS. Physiol Genomics. 2013 Nov 15;45(22):1109-22. doi: 10.1152/physiolgenomics.00108.2013. Epub 2013 Sep 17.

Arthritis severity locus Cia4 is an early regulator of IL-6, IL-1β, and NF-κB activators’ expression in pristane-induced arthritis. Brenner M, Laragione T, Gulko PS. Physiol Genomics. 2013 Jul 2;45(13):552-64. doi: 10.1152/physiolgenomics.00029.2013. Epub 2013 May 21

Whole-genome sequences of DA and F344 rats with different susceptibilities to arthritis, autoimmunity, inflammation and cancer. Guo X, Brenner M, Zhang X, Laragione T, Tai S, Li Y, Bu J, Yin Y, Shah AA, Kwan K, Li Y, Jun W, Gulko PS.Genetics. 2013 Aug;194(4):1017-28. doi: 10.1534/genetics.113.153049. Epub 2013 May 20.

http://www.ncbi.nlm.nih.gov/pubmed/?term=gulko+p