{"id":3010,"date":"2022-12-21T12:17:26","date_gmt":"2022-12-21T17:17:26","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/design\/?page_id=3010"},"modified":"2024-01-25T10:55:06","modified_gmt":"2024-01-25T15:55:06","slug":"research","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/gregoriolab\/","title":{"rendered":"Research"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”Fullwidth Header – Background Title Description – no slider – Section 1″ module_class=”header-title-desciption-no-slider-section1″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”rgba(0,174,239,0.09)” background_enable_color=”off” background_image=”https:\/\/labs.icahn.mssm.edu\/gregoriolab\/wp-content\/uploads\/sites\/508\/2022\/10\/Rectangle-3.png” parallax=”on” custom_padding=”||||false|false” bottom_divider_style=”ramp2″ bottom_divider_color=”#FFFFFF” bottom_divider_height=”11vw” bottom_divider_arrangement=”above_content” saved_tabs=”all” locked=”off” collapsed=”on”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” border_color_all=”RGBA(0,0,0,0)”][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”10%||8vw||false|false” custom_padding_tablet=”0vw||0vw||true|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet”][et_pb_text admin_label=”Text – Title” _builder_version=”4.9.0″ _module_preset=”b3e3ff14-5f5c-4608-8ecf-1885ce3da7aa” header_font=”||||||||” header_text_color=”#FFFFFF” header_font_size=”48px” header_line_height=”60px” custom_margin=”||10px||false|false” custom_padding=”0px|||||” header_font_size_tablet=”40px” header_font_size_phone=”24px” header_font_size_last_edited=”on|desktop”]<\/p>\n

Gregorio Laboratory<\/b><\/h1>\n

 
\n[\/et_pb_text][et_pb_text admin_label=”Text – Description” _builder_version=”4.9.0″ _module_preset=”da86b6f0-f83c-4c7c-bdd8-3019777ddffe” text_font=”||||||||” text_text_color=”#FFFFFF” text_font_size=”20px” text_line_height=”32px” width=”100%” custom_margin=”|-73px||||” custom_padding=”|8px||||” text_font_size_tablet=”15px” text_font_size_phone=”14px” text_font_size_last_edited=”on|desktop”]<\/p>\n

The Cardiovascular Research Institute<\/strong><\/span><\/h2>\n

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The research in this laboratory is focused on identifying the components and molecular mechanisms regulating actin architecture in cardiac and skeletal muscle during normal development and disease.<\/span><\/h3>\n

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Control of actin filament lengths and dynamics is important for cell motility and architecture and is regulated in part by capping proteins that block elongation and depolymerization at both the fast-growing (barbed) and slow-growing (pointed) ends of the filaments.<\/h3>\n

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Striated muscle is an ideal model system to test for the functional properties of various actin regulatory proteins due to the precise organization and polarity of cytoskeletal components within repeating sarcomeric units.<\/span><\/h3>\n

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For example, the ~1 mm long actin filaments are easily resolved by light microscopy; thus we can make filaments longer and\/or shorter and see the alterations by fluorescent microscopy in live myocytes.<\/span><\/h3>\n

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Using this system we can combine advanced cell biological and biochemical approaches with direct tests of physiological function in live beating muscle cells.<\/span><\/h3>\n

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The research objectives of the laboratory can be broadly summarized as follows:<\/strong><\/h2>\n

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1.\u00a0 \u00a0Understanding the cellular mechanisms involved in the assembly, regulation and maintenance of contractile proteins in cardiac muscle in health and disease;<\/span><\/p>\n

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2.\u00a0 \u00a0Deciphering the mechanisms critical for precisely specifying and maintaining the lengths of actin filaments. Actin is an indispensable structural element of cells and is the major component of heart muscle. Changes in actin, caused by genetic mutations, which have been identified in humans, are a frequent cause of several forms of cardiomyopathy. We are determining how genetic defects in this protein affect muscle force generation and muscle contraction, leading to sudden cardiac death.<\/span><\/p>\n

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3.\u00a0 \u00a0Investigating how striated muscle cells maintain their shape, drive contraction, and generate mechanical force through the efficient integration of microfilament, microtubule and intermediate filament (IF) function.<\/span><\/p>\n

<\/span><\/p>\n

4.\u00a0 \u00a0Discovery of novel models of de novo cardiac muscle assembly, with special emphasis on differentiating murine embryonic stem (ES) cells to study the functional properties of specific cytoskeletal proteins (via \u201cknock out\u201d and \u201cknock in\u201d approaches) during all stages of heart muscle development.<\/span><\/p>\n

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Contact Us<\/strong><\/p>\n

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Contact Us
<\/a><\/span>Recent News
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<\/a>Submit Inquiry
<\/a>Resources
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Accessibility<\/a><\/span><\/p>\n

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E-mail
<\/strong>labname@mssm.edu<\/p>\n

Phone
<\/strong>Tel: 555-555-5555<\/p>\n

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Lab Address <\/strong>
1470 Madison Avenue
Hess, 7th Floor, Room 301
New York, NY 10029<\/p>\n

Mailing Address <\/strong><\/p>\n

Gregorio Lab
Icahn School of Medicine
at Mount Sinai
1470 Madison Avenue
Hess, 7th Floor, Room 301
New York, NY 10029<\/p>\n

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Contact Us<\/strong><\/p>\n

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E-mail<\/strong>
<\/strong>fabrizzio.caro@mssm.edu<\/a><\/span><\/p>\n

carol.gregorio@mssm.edu<\/a><\/span><\/p>\n

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Mailing Address<\/strong><\/p>\n

Gregorio Lab
Icahn School of Medicine
at Mount Sinai
1470 Madison Ave.
Hess, 7th Floor, Room 301
New York, NY 10029<\/p>\n

Box 1014<\/p>\n

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Lab Address<\/strong><\/p>\n

1470 Madison Ave.
Hess, 7th Floor, Room 301
New York, NY 10029<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Gregorio Laboratory   The Cardiovascular Research Institute The research in this laboratory is focused on identifying the components and molecular mechanisms regulating actin architecture in cardiac and skeletal muscle during normal development and disease. Control of actin filament lengths and dynamics is important for cell motility and architecture and is regulated in part by capping […]<\/p>\n","protected":false},"author":643,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"class_list":["post-3010","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/gregoriolab\/wp-json\/wp\/v2\/pages\/3010","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/gregoriolab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/gregoriolab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/gregoriolab\/wp-json\/wp\/v2\/users\/643"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/gregoriolab\/wp-json\/wp\/v2\/comments?post=3010"}],"version-history":[{"count":17,"href":"https:\/\/labs.icahn.mssm.edu\/gregoriolab\/wp-json\/wp\/v2\/pages\/3010\/revisions"}],"predecessor-version":[{"id":4789,"href":"https:\/\/labs.icahn.mssm.edu\/gregoriolab\/wp-json\/wp\/v2\/pages\/3010\/revisions\/4789"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/gregoriolab\/wp-json\/wp\/v2\/media?parent=3010"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}