{"id":2494,"date":"2022-12-20T11:44:55","date_gmt":"2022-12-20T16:44:55","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/design\/?page_id=2494"},"modified":"2024-02-21T15:55:30","modified_gmt":"2024-02-21T20:55:30","slug":"publications","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/gregoriolab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”Fullwidth Header – Background Title Description – no slider – Section 1 ” module_class=”header-title-desciption-no-slider-section1″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”rgba(0,174,239,0.09)” background_enable_color=”off” background_image=”https:\/\/labs.icahn.mssm.edu\/gregoriolab\/wp-content\/uploads\/sites\/508\/2022\/10\/Rectangle-3.png” parallax=”on” custom_padding=”||||false|false” bottom_divider_style=”ramp2″ bottom_divider_color=”#FFFFFF” bottom_divider_height=”11vw” bottom_divider_arrangement=”above_content” saved_tabs=”all” locked=”off” collapsed=”on”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” border_color_all=”RGBA(0,0,0,0)”][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”10%||8vw||false|false” custom_padding_tablet=”0vw||0vw||true|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet”][et_pb_text admin_label=”Text – Title” _builder_version=”4.9.0″ _module_preset=”b3e3ff14-5f5c-4608-8ecf-1885ce3da7aa” header_font=”||||||||” header_text_color=”#FFFFFF” header_font_size=”48px” header_line_height=”60px” custom_margin=”||10px||false|false” header_font_size_tablet=”40px” header_font_size_phone=”24px” header_font_size_last_edited=”on|desktop”]<\/p>\n

Recent Publications<\/strong><\/h1>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Section 28 – Blog Style Publications” module_class=”section28_blog_style_publications” _builder_version=”4.9.0″ background_color=”#FFFFFF” background_image=”https:\/\/labs.icahn.mssm.edu\/gregoriolab\/wp-content\/uploads\/sites\/508\/2022\/10\/Background-1.png” parallax=”on” parallax_method=”off” custom_padding=”100px||||false|false” global_module=”2511″ saved_tabs=”all” locked=”off” collapsed=”on”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” locked=”off”]<\/p>\n

\"LogoCatalina Vasilescu, Mert Colpan, Tiina H Ojala, Tuula Manninen, Aino Mutka, Kaisa Yl\u00e4nen, Otto Rahkonen, Tuija Poutanen, Laura Martelius, Reena Kumari, Helena Hinterding, Virginia Brilhante, Simo Ojanen, Pekka Lappalainen, Juha Koskenvuo, Christopher J Carroll, Velia M Fowler, Carol C Gregorio, Anu Suomalainen<\/p>\n

<\/em><\/p>\n

Recessive TMOD1 mutation causes childhood cardiomyopathy<\/strong><\/p>\n

Communications Biology – Nature 2024, January 2.<\/p>\n

Link<\/a><\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url_new_window=”on” hover_enabled=”0″ box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” sticky_enabled=”0″]<\/p>\n

\"CellsReiri Sono, Tania M Larrinaga, Alden Huang, Frank Makhlouf, Xuedong Kang, Jonathan Su, Ryan Lau, Valerie A Arboleda, Reshma Biniwale, Gregory A Fishbein, Negar Khanlou, Ming-Sing Si, Gary M Satou, Nancy Halnon, Ucla Congenital Heart Defects-BioCore Faculty, Glen S Van Arsdell, Carol C Gregorio, Stanly Nelson, Marlin Touma<\/em><\/p>\n

 <\/p>\n

Whole-Exome Sequencing Identifies Homozygote Nonsense Variants in LMOD2 Gene Causing Infantile Dilated Cardiomyopathy<\/strong><\/p>\n

Cells – MDPI 2023, May 23.<\/p>\n

Link<\/a><\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”1_3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)”]<\/p>\n

\"National\u00a0Lauren E Schultz, Mert Colpan, Garry E Smith Jr, Rachel M Mayfield, Tania M Larrinaga, Alla S Kostyukova, Carol C Gregorio
<\/em>
A nemaline myopathy-linked mutation inhibits the actin-regulatory functions of tropomodulin and leiomodin<\/strong><\/p>\n

Proceedings of the National Academy of Sciences USA 2023, Nov 21.<\/p>\n

Link<\/a><\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)”]<\/p>\n

\"AmbulatoryMiensheng Chu, Stefanie Mares Novak, Cathleen Cover, Anne A Wang, Ikeotunye Royal Chinyere, Elizabeth B Juneman, Daniela C Zarnescu, Pak Kin Wong, Carol C Gregorio
<\/em>
Increased Cardiac Arrhythmogenesis Associated With Gap Junction Remodeling With Upregulation of RNA-Binding Protein FXR1<\/strong><\/p>\n

Circulation – AHA 2023, Feb 6.<\/p>\n

Link<\/a><\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2020\/01\/2019_Saxena.pdf” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)”]\"European<\/p>\n

Yuen M, Worgan L, Iwanski J, Pappas CT, Joshi H, Churko JM, Arbuckle S, Kirk EP, Zhu Y, Roscioli T, Gregorio CC, Cooper ST
\n<\/em>
\nNeonatal-lethal dilated cardiomyopathy due to a homozygous LMOD2 donor splice-site variant.<\/strong><\/p>\n

European Journal of Human Genetics\u00a02022, Jan 26.<\/p>\n

Link<\/a><\/strong>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2020\/01\/2019_Saxena.pdf” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” locked=”off”]\"Trends \u00a0 Jessika Iwanski, Carol C Gregorio, Mert Colpan
\n<\/em>
\nRedefining actin dynamics of the pointed-end complex in striated muscle\u00a0<\/strong><\/p>\n

Trends in Cell Biology 2021, Jul 12.<\/p>\n

Link<\/a><\/strong>[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2020\/01\/2019_Saxena.pdf” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” locked=”off”]<\/p>\n

\"Logo<\/em><\/p>\n

Mert Colpan, Jessika Iwanski, and Carol C. Gregorio
<\/em>
CAP2 is a regulator of actin pointed end dynamics and myofibrillogenesis in cardiac muscle\u00a0<\/strong><\/p>\n

Communications Biology – Nature 2021, March 19.<\/p>\n

Link<\/a><\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2020\/01\/2019_Saxena.pdf” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” locked=”off”]<\/p>\n

\"PLOSDmitri Tolkatchev,\u00a0Garry E. Smith, Jr.,\u00a0Lauren E. Schultz,\u00a0Mert Colpan,\u00a0Gregory L. Helms,\u00a0Carol C. Gregorio,\u00a0Alla S. Kostyukova
<\/em>
Leiomodin creates a leaky cap at the pointed end of actin-thin filaments<\/strong><\/p>\n

PLoS Biology 2020, Sep 8.<\/p>\n

Link<\/a><\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2020\/01\/2019_Saxena.pdf” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)”]<\/p>\n

\"Science Ahrens-Nicklas RC, Pappas CT, Farman GP, Mayfield RM, Larrinaga TM, Medne L, Ritter A, Krantz ID, Murali C, Lin KY, Berger JH, Yum SW, Carreon CK, Gregorio CC
<\/em>
Disruption of cardiac thin filament assembly arising from a mutation in LMOD2: A novel mechanism of neonatal dilated cardiomyopathy.\u00a0<\/strong><\/p>\n

Science Advances 2019, Sep 04.<\/p>\n

Link<\/a><\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” locked=”off”]<\/p>\n

\"National \u00a0Christopher T Pappas, Rachel M Mayfield, Christine Henderson, Nima Jamilpour, Cathleen Cover, Zachary Hernandez, Kirk R Hutchinson, Miensheng Chu, Ki-Hwan Nam, Jose M Valdez, Pak Kin Wong, Henk L Granzier, Carol C Gregorio
<\/em>
Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality<\/strong><\/p>\n

Proceedings of the National Academy of Sciences USA 2015, Nov 3.<\/p>\n

Link<\/a><\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2020\/01\/2019_Saxena.pdf” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)”]<\/p>\n

\"JCI<\/p>\n

Yuen M, Sandaradura SA, Dowling JJ, Kostyukova AS, Moroz N, Quinlan KG, Lehtokari VL, Ravenscroft G, Todd EJ, Ceyhan-Birsoy O, Gokhin DS, Maluenda J, Lek M, Nolent F, Pappas CT, Novak SM, D’Amico A, Malfatti E, Thomas BP, Gabriel SB, Gupta N, Daly MJ, Ilkovski B, Houweling PJ, Davidson AE, Swanson LC, Brownstein CA, Gupta VA, Medne L, Shannon P, Martin N, Bick DP, Flisberg A, Holmberg E, Van den Bergh P, Lapunzina P, Waddell LB, Sloboda DD, Bertini E, Chitayat D, Telfer WR, Laquerri\u00e8re A, Gregorio CC, Ottenheijm CA, B\u00f6nnemann CG, Pelin K, Beggs AH, Hayashi YK, Romero NB, Laing NG, Nishino I, Wallgren-Pettersson C, Melki J, Fowler VM, MacArthur DG, North KN, Clarke NF
<\/em>
Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.<\/strong><\/p>\n

The Journal of Clinical Investigation 2015, Jan 2.<\/p>\n

Link<\/a><\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2020\/01\/2019_Saxena.pdf” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)”]<\/p>\n

\"nature<\/p>\n

C C Gregorio, A Weber, M Bondad, C R Pennise, V M Fowler
<\/em>
Requirement of pointed-end capping by tropomodulin to maintain actin filament length in embryonic chick cardiac myocytes<\/strong><\/p>\n

Nature 1995, Sep 7.<\/p>\n

Link<\/a><\/strong><\/p>\n

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Gregorio Lab
Icahn School of Medicine
at Mount Sinai
1470 Madison Avenue
Hess, 7th Floor, Room 301
New York, NY 10029<\/p>\n

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Contact Us<\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.9.0″ background_color=”RGBA(0,0,0,0)” background_color_gradient_direction=”38deg” module_alignment=”center” custom_margin=”|auto|-2px|auto||” custom_padding=”0px|||||” locked=”off” collapsed=”on”][et_pb_column type=”1_3″ _builder_version=”4.9.0″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”1.25em” header_font=”||||||||” header_4_font=”|700||on|||||” header_4_font_size=”16px” header_4_letter_spacing=”1px” header_4_line_height=”1.5em” background_layout=”dark” locked=”off”]<\/p>\n

E-mail<\/strong>
<\/strong>fabrizzio.caro@mssm.edu<\/a><\/span><\/p>\n

carol.gregorio@mssm.edu<\/a><\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”1.25em” header_font=”||||||||” header_4_font=”|700||on|||||” header_4_font_size=”16px” header_4_letter_spacing=”1px” header_4_line_height=”1.5em” background_layout=”dark” locked=”off”]<\/p>\n

Mailing Address<\/strong><\/p>\n

Gregorio Lab
Icahn School of Medicine
at Mount Sinai
1470 Madison Ave.
Hess, 7th Floor, Room 301
New York, NY 10029<\/p>\n

Box 1014<\/p>\n

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Lab Address<\/strong><\/p>\n

1470 Madison Ave.
Hess, 7th Floor, Room 301
New York, NY 10029<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Recent PublicationsCatalina Vasilescu, Mert Colpan, Tiina H Ojala, Tuula Manninen, Aino Mutka, Kaisa Yl\u00e4nen, Otto Rahkonen, Tuija Poutanen, Laura Martelius, Reena Kumari, Helena Hinterding, Virginia Brilhante, Simo Ojanen, Pekka Lappalainen, Juha Koskenvuo, Christopher J Carroll, Velia M Fowler, Carol C Gregorio, Anu Suomalainen Recessive TMOD1 mutation causes childhood cardiomyopathy Communications Biology – Nature 2024, January […]<\/p>\n","protected":false},"author":643,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"class_list":["post-2494","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/gregoriolab\/wp-json\/wp\/v2\/pages\/2494","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/gregoriolab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/gregoriolab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/gregoriolab\/wp-json\/wp\/v2\/users\/643"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/gregoriolab\/wp-json\/wp\/v2\/comments?post=2494"}],"version-history":[{"count":26,"href":"https:\/\/labs.icahn.mssm.edu\/gregoriolab\/wp-json\/wp\/v2\/pages\/2494\/revisions"}],"predecessor-version":[{"id":4806,"href":"https:\/\/labs.icahn.mssm.edu\/gregoriolab\/wp-json\/wp\/v2\/pages\/2494\/revisions\/4806"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/gregoriolab\/wp-json\/wp\/v2\/media?parent=2494"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}