[et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”off|off|off” admin_label=”Header Title Description – Section – Header – Fullwidth Slider ” module_id=”header-title-description-slider-section1″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”rgba(0,174,239,0.09)” background_enable_color=”off” background_image=”https:\/\/labs.icahn.mssm.edu\/greenbaum-lab-new\/wp-content\/uploads\/sites\/573\/2022\/07\/ai-002-1.jpg” parallax=”on” custom_padding=”||||false|false” bottom_divider_style=”ramp2″ bottom_divider_color=”#FFFFFF” bottom_divider_height=”11vw” locked=”off” collapsed=”on”][et_pb_fullwidth_slider arrows_custom_color=”#D80B8C” dot_nav_custom_color=”#D80B8C” _builder_version=”4.9.0″ _module_preset=”default” hover_enabled=”0″ sticky_enabled=”0″][et_pb_slide heading=”Greenbaum Lab” _builder_version=”4.9.0″ _module_preset=”default” header_text_align=”left” body_text_align=”left” background_image=”https:\/\/labs.icahn.mssm.edu\/greenbaum-lab-new\/wp-content\/uploads\/sites\/573\/2022\/07\/ai-002-1.jpg” background_enable_image=”on” text_orientation=”left” custom_padding=”|||80px|false|false” hover_enabled=”0″ sticky_transition=”on” sticky_enabled=”0″][\/et_pb_slide][\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”on|tablet” disabled_on=”on|on|on” admin_label=”Fullwidth Two Column Header and Image (no slider) – Section 1 (Desktop only)” module_class=”section1_header_no_slider” _builder_version=”4.9.0″ _module_preset=”default” background_color=”#00aeef” background_image=”https:\/\/labs.icahn.mssm.edu\/greenbaum-lab-new\/wp-content\/uploads\/sites\/573\/2022\/10\/Background-2.png” parallax=”on” custom_margin=”||30px||false|false” custom_padding=”||||false|false” custom_padding_tablet=”0px||0px||false|false” custom_padding_phone=”” bottom_divider_style=”slant” bottom_divider_color=”#FFFFFF” bottom_divider_arrangement=”above_content” custom_css_main_element=”padding: 0px !important;” disabled=”on” locked=”on” collapsed=”on”][et_pb_row column_structure=”2_5,3_5″ disabled_on=”off|off|off” _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” module_alignment=”right” custom_padding=”||||false|false” border_color_all=”RGBA(0,0,0,0)” collapsed=”on”][et_pb_column type=”2_5″ _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”10%||8vw||false|false” custom_padding_tablet=”0vw||0vw||true|false” custom_padding_phone=”” custom_padding_last_edited=”on|desktop”][et_pb_text admin_label=”Title – Text” _builder_version=”4.9.0″ _module_preset=”da86b6f0-f83c-4c7c-bdd8-3019777ddffe” text_font=”||||||||” text_text_color=”#FFFFFF” text_font_size=”20px” text_line_height=”32px” header_text_align=”left” header_text_color=”#FFFFFF” header_font_size=”48px” header_line_height=”60px” custom_margin=”||2%||false|false” text_font_size_tablet=”15px” text_font_size_phone=”14px” text_font_size_last_edited=”on|desktop” header_font_size_tablet=”40px” header_font_size_phone=”24px” header_font_size_last_edited=”on|phone” custom_css_main_element=”\/*margin-right: 8vw!important;*\/”]<\/p>\n
[\/et_pb_text][et_pb_text admin_label=”Description – Text” _builder_version=”4.9.0″ _module_preset=”da86b6f0-f83c-4c7c-bdd8-3019777ddffe” text_font=”||||||||” text_text_color=”#FFFFFF” text_font_size=”20px” text_line_height=”32px” header_text_align=”left” custom_margin=”||||false|false” text_font_size_tablet=”15px” text_font_size_phone=”14px” text_font_size_last_edited=”on|desktop” custom_css_main_element=”\/*margin-right: 9vw!important;*\/”]<\/p>\n
Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>\n
[\/et_pb_text][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2022\/07\/210629-Nivi-graduation-scaled.jpg” align=”right” force_fullwidth=”on” _builder_version=”4.9.0″ _module_preset=”default” custom_margin=”80px|0px|0px|0px|false|false” custom_padding=”20px|0px|0px|0px|false|false” box_shadow_style=”preset1″ box_shadow_spread=”15px”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ disabled_on=”on|on|on” _builder_version=”4.9.0″ _module_preset=”default” disabled=”on” collapsed=”on”][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_blurb title=”Welcome to the Rendl Lab” admin_label=”Blurb – Left Side Content” _builder_version=”4.9.0″ _module_preset=”default” header_text_color=”#FFFFFF” body_text_color=”#FFFFFF” custom_margin=”80px||||false|false”]<\/p>\n
Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>\n
[\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_blurb image=”https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2022\/07\/210629-Nivi-graduation-scaled.jpg” icon_alignment=”right” admin_label=”Blurb – Right-Side Image” _builder_version=”4.9.0″ _module_preset=”default” custom_margin=”80px|-40%|0px||false|false” custom_margin_tablet=”|0%|||false|false” custom_margin_phone=”|0%|||false|false” custom_margin_last_edited=”on|phone”][\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|on” admin_label=”Header and Image (no slider) – Section 1 (Tablet and Mobile only)” module_class=”section1_header_no_slider_mobile” _builder_version=”4.9.0″ background_color=”#00AEEF” background_image=”https:\/\/labs.icahn.mssm.edu\/greenbaum-lab-new\/wp-content\/uploads\/sites\/573\/2022\/10\/Background-2.png” parallax=”on” width=”100%” custom_margin=”||30px||false|false” custom_padding=”80px|0px|63px|0px||” mix_blend_mode=”multiply” bottom_divider_color=”#FFFFFF” bottom_divider_height=”150px” bottom_divider_flip=”horizontal” disabled=”on” locked=”on” collapsed=”on”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”|||” custom_padding=”|||”][et_pb_column type=”1_2″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” header_text_color=”#FFFFFF” header_line_height=”1.7em”]<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_text_color=”#FFFFFF”]<\/p>\n
Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>\n
[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2022\/07\/210629-Nivi-graduation-scaled.jpg” title_text=”AdobeStock_436735485″ disabled_on=”off|off|off” _builder_version=”4.9.0″ animation_style=”slide” animation_direction=”left” animation_intensity_slide=”10%” box_shadow_style=”preset1″ box_shadow_blur=”30px” box_shadow_color=”#58595B” always_center_on_mobile=”off”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Two Column Image and Text over Button – Section 6 (Collections)” module_class=”section6_two_col_img_txt_over_btn” _builder_version=”4.9.0″ custom_margin=”30px||100px||false|false” custom_margin_tablet=”100px||||false|false” custom_margin_phone=”” custom_margin_last_edited=”on|desktop” custom_padding=”0px|0px|0px|0px|false|false” custom_css_main_element=”padding: 0px !important;” locked=”off” collapsed=”off”][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.9.0″ module_alignment=”center” custom_margin=”|auto|0px|auto||” custom_padding=”0px||0px|||” box_shadow_style=”preset1″ box_shadow_color=”#58595B” collapsed=”off”][et_pb_column type=”1_2″ _builder_version=”4.9.0″ use_background_color_gradient=”on” background_color_gradient_start=”#ff6a88″ background_color_gradient_end=”#ff99ac” background_color_gradient_direction=”35deg” background_image=”https:\/\/labs.icahn.mssm.edu\/greenbaum-lab-new\/wp-content\/uploads\/sites\/573\/2022\/08\/Rectangle-3-copy-5.jpg” custom_padding=”|5%||5%” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/greenbaum-lab-new\/wp-content\/uploads\/sites\/573\/2022\/08\/AdobeStock_182052860.png” title_text=”AdobeStock_182052860″ align=”center” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.9.0″ background_enable_image=”off” background_size=”initial” custom_margin=”-20px||-20px|” custom_padding=”|||” animation_style=”zoom” animation_direction=”left” animation_intensity_zoom=”10%” animation_starting_opacity=”100%” disabled_on=”off|off|off”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.9.0″ background_image=”https:\/\/labs.icahn.mssm.edu\/greenbaum-lab-new\/wp-content\/uploads\/sites\/573\/2022\/08\/ai-008-bwSm-1.png” background_position=”center_right” custom_padding=”40px|40px|40px|40px|true|true” custom_padding__hover=”|||”][et_pb_text disabled_on=”off|off|off” _builder_version=”4.9.0″ header_font=”|700|||||||” header_text_color=”#141414″ header_font_size=”39px” header_3_font=”|700|||||||” header_3_text_color=”#2b2b2b” header_3_font_size=”28px” header_3_line_height=”1.5em” custom_margin=”||10px|” custom_padding=”5%||||false|false” hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#000000″ text_line_height=”22px” header_font=”||||” header_text_color=”#000000″ header_4_text_color=”#FFFFFF” header_5_text_color=”#FFFFFF” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”700px” custom_padding=”2%||5%||false|false” animation_style=”slide” animation_direction=”top” animation_intensity_slide=”4%” disabled_on=”on|on|on” disabled=”on”]<\/p>\n
A central question in stem cell research is how cells specialize during organ development to become adult tissue-regenerative stem cells and their instructive niche. During hair follicle development, epidermal progenitors in nascent hair placodes receive niche signals from specialized cell clusters located underneath that are called Dermal Condensates.<\/p>\n
[\/et_pb_text][et_pb_text disabled_on=”on|on|on” _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#141414″ text_line_height=”1.9em” header_font=”||||||||” header_2_font=”||||||||” module_alignment=”center” custom_margin=”||30px|” disabled=”on”]<\/p>\n
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ornare suspendisse sed nisi lacus sed viverra tellus in.<\/p>\n
[\/et_pb_text][et_pb_button button_text=”Lorem ipsum dolor sit amet” disabled_on=”on|on|on” _builder_version=”4.9.0″ custom_button=”on” button_text_size=”16px” button_text_color=”#FFFFFF” button_bg_color=”#00AEEF” button_border_width=”0px” button_border_radius=”0px” button_font=”||||||||” button_icon=”%%20%%” button_icon_color=”#FFFFFF” button_on_hover=”off” custom_margin=”20px|||” custom_padding=”12px|28px|12px|28px” box_shadow_style=”preset1″ box_shadow_vertical=”10px” box_shadow_blur=”30px” box_shadow_color=”#58595B” button_letter_spacing_hover=”2px” disabled=”on” locked=”off” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”2px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_button][et_pb_button button_url=”https:\/\/labs.icahn.mssm.edu\/design\/option1-research” button_text=”Find Out More” _builder_version=”4.9.0″ _module_preset=”default” custom_button=”on” button_text_color=”#FFFFFF” button_bg_color=”#00AEEF” button_border_radius=”0px” box_shadow_style=”preset1″ locked=”off” disabled_on=”on|on|on” disabled=”on”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Two Column Image and Text over Button – Section 4″ module_class=”section4_two_col_img_txt_over_btn” _builder_version=”3.22″ background_color=”#00AEEF” background_image=”https:\/\/labs.icahn.mssm.edu\/greenbaum-lab-new\/wp-content\/uploads\/sites\/573\/2022\/12\/Background-1ALT.png” parallax=”on” width=”100%” custom_margin=”30px||||false|false” custom_padding=”80px|0px|63px|0px||” mix_blend_mode=”multiply” bottom_divider_style=”ramp2″ bottom_divider_color=”#FFFFFF” bottom_divider_height=”150px” bottom_divider_flip=”horizontal” bottom_divider_arrangement=”above_content” locked=”off” collapsed=”on” disabled_on=”on|on|on” disabled=”on”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”|||” custom_padding=”|||”][et_pb_column type=”1_2″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2022\/08\/Stalled-follicles_03MR-2560×1440-1.jpg” title_text=”AdobeStock_436735485″ disabled_on=”off|off|off” _builder_version=”4.9.0″ animation_style=”slide” animation_direction=”left” animation_intensity_slide=”10%” box_shadow_style=”preset1″ box_shadow_color=”#58595B” always_center_on_mobile=”off”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”22px” header_font=”||||” header_text_color=”#FFFFFF” header_4_text_color=”#FFFFFF” header_5_text_color=”#FFFFFF” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”700px” animation_style=”slide” animation_direction=”top” animation_intensity_slide=”4%”]<\/p>\n
Stem cells and their immediate environment, also called stem cell niche, are critical for the growth and continuous renewal of our organs, and are also key for new growth and repair during regeneration. Unlocking the secrets of how specialized niche cells operate to activate stem cells and progenitors holds great promise for regenerative medicine.<\/p>\n
Our laboratory aims to answer these fundamental questions in stem cell biology by utilizing the hair follicle mini-organ as a powerful model system. Deciphering how niche cells govern stem cell and progenitor functions in the hair follicle will also provide a rational basis for developing hair regenerative therapies. Fundamental questions towards this goal are:<\/p>\n
[\/et_pb_text][et_pb_button button_url=”https:\/\/labs.icahn.mssm.edu\/design\/option1-research” button_text=”Find Out More ” _builder_version=”4.9.0″ _module_preset=”default” custom_button=”on” button_text_color=”#d80b8c” button_bg_color=”#FFFFFF” button_border_radius=”0px” box_shadow_style=”preset1″][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ fullwidth=”on” admin_label=”Paralax Background fullwidth Image – Section 3″ module_class=”section3_paralax_bg_fullwidth_img” _builder_version=”4.9.0″ _module_preset=”default” locked=”off” collapsed=”on” disabled_on=”on|on|on” disabled=”on”][et_pb_fullwidth_image title_text=”3″ _builder_version=”4.9.0″ _module_preset=”default” background_image=”https:\/\/labs.icahn.mssm.edu\/greenbaum-lab-new\/wp-content\/uploads\/sites\/573\/2022\/10\/3.png” parallax=”on” parallax_method=”off” min_height=”217.5px” custom_margin=”-2px|||||” filter_opacity=”20%”][\/et_pb_fullwidth_image][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Two Column Title Over Text Next to Image – Section 5″ module_class=”section5_two_col_title_over_txt_next_to_img” _builder_version=”4.9.0″ _module_preset=”default” locked=”off” collapsed=”on” disabled_on=”on|on|on” disabled=”on”][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” admin_label=”5 (Module)” _builder_version=”4.9.0″ background_color=”#FFFFFF” background_size=”initial” background_position=”top_left” background_repeat=”repeat” module_alignment=”center” custom_padding=”6px||3px|||” global_module=”956″][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_text_color=”#00AEEF” header_font=”|700|||||||” header_text_color=”#00AEEF” header_font_size=”36px” module_alignment=”center” custom_padding=”10%||10%||true|false”]<\/p>\n
How is tissue growth, homeostasis and renewal by stem cells regulated throughout life? Understanding the core molecular controls is fundamental for realizing the therapeutic potential of the instructive niche (Rezza et al, Current Topics in Developmental Biology 2014). After initial morphogenesis of hair follicles, the Dermal Condensate gives rise to the adult follicle inductive niche, the Dermal Papilla. Dermal Papilla cells signal to progenitors in the follicle bulb to control continuous production and outgrowth of hair. They are also critical for activating stem cells to regenerate a new follicle during the hair growth cycle. Remarkably, isolated niche cells can induce new hair formation after cell transplantation into skin in mice, a yet unrealized goal in human.<\/p>\n
[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/greenbaum-lab-new\/wp-content\/uploads\/sites\/573\/2022\/07\/ai-008.png” title_text=”ai-008″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”#FFFFFF”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|on” admin_label=”Two Column Image with Title and Text Over Button – Section 4 (Desktop Only)” module_class=”section4_two_col_img_next_to_title_over_txt_over_btn_desktop” _builder_version=”4.9.0″ _module_preset=”default” background_color=”#00AEEF” use_background_color_gradient=”on” background_color_gradient_start=”#00aeef” background_color_gradient_end=”#d80b8c” background_color_gradient_direction=”33deg” background_image=”https:\/\/labs.icahn.mssm.edu\/greenbaum-lab-new\/wp-content\/uploads\/sites\/573\/2022\/10\/Background-2.png” parallax=”on” module_alignment=”center” height=”558px” custom_margin=”||200px||false|false” locked=”off” collapsed=”on” disabled=”on”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/greenbaum-lab-new\/wp-content\/uploads\/sites\/573\/2022\/08\/2021-Hero-Shot-2-smallest-scaled-3.png” title_text=”2021-Hero-Shot-2-smallest-scaled-3″ _builder_version=”4.9.0″ _module_preset=”default” width=”91%” max_width=”91%” min_height=”550px” height=”550px” max_height=”550px” custom_padding=”40px||||false|false”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_text_color=”#FFFFFF” header_text_align=”center” header_text_color=”#FFFFFF” text_orientation=”center” custom_padding=”||||false|false”]<\/p>\n
How tissues regenerate from stem cells and how different organs balance cell loss with new growth is under intensive investigation in the regenerative biology field. In the natural hair growth cycle after years of continuous hair growth, follicles enter a wave of massive progenitor death along the hair axis that \u2013 as we are just beginning to unravel \u2013 is controlled by the niche microenvironment. During this follicle regression, the Dermal Papilla niche needs to relocate from the base of growing hair bulbs to the stem cell reservoir in the upper follicle for new growth activation.<\/p>\n
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How tissues regenerate from stem cells and how different organs balance cell loss with new growth is under intensive investigation in the regenerative biology field. In the natural hair growth cycle after years of continuous hair growth, follicles enter a wave of massive progenitor death along the hair axis that \u2013 as we are just beginning to unravel \u2013 is controlled by the niche microenvironment. During this follicle regression, the Dermal Papilla niche needs to relocate from the base of growing hair bulbs to the stem cell reservoir in the upper follicle for new growth activation.<\/p>\n
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