Peer Reviewed Original Contributions

Cheng Z, Naga Srikanth Garikipati V, Truongcao MM, Cimini M, Huang G, Wang C, Benedict C, Gonzalez C, Mallaredy V, Goukassian DA, Verma SK, Kishore R. Serum-Derived Small Extracellular Vesicles From Diabetic Mice Impair Angiogenic Property of Microvascular Endothelial Cells: Role of EZH2. J Am Heart Assoc. 2021 May 18;10(10):e019755. Epub 2021 May 14. PMID: 33988033

Garikipati VNS, Arakelyan A, Blakely EA, Chang PY, Truongcao MM, Cimini M, Malaredy V, Bajpai A, Addya S, Bisserier M, Brojakowska A, Eskandari A, Khlgatian MK, Hadri L, Fish KM, Kishore R, Goukassian DA. Long-Term Effects of Very Low Dose Particle Radiation on Gene Expression in the Heart: Degenerative Disease Risks. Cells. 2021 Feb 13;10(2):387. PMID: 33668521

Hamouche W, Bisserier M, Brojakowska A, Eskandari A, Fish K, Goukassian DA, Hadri L. Pathophysiology and pharmacological management of pulmonary and cardiovascular features of COVID-19. J Mol Cell Cardiol. 2021 Apr;153:72-85. Epub 2020 Dec 26. PMID: 33373644

Garikipati VNS, Verma SK, Cheng Z, Liang D, Truongcao MM, Cimini M, Yue Y, Huang G, Wang C, Benedict C, Tang Y, Mallaredy V, Ibetti J, Grisanti L, Schumacher SM, Gao E, Rajan S, Wilusz JE, Goukassian D, Houser SR, Koch WJ, Kishore R. Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis. Nat Commun. 2019 Sep 20;10(1):4317. PMID: 31541092

Cimini M, Garikipati VNS, de Lucia C, Cheng Z, Wang C, Truongcao MM, Lucchese AM, Roy R, Benedict C, Goukassian DA, Koch WJ, Kishore R. Podoplanin neutralization improves cardiac remodeling and function after acute myocardial infarction. JCI Insight. 2019 Jul 9;5(15):e126967. PMID: 31287805

*Quintana-Villamandos B, Goukassian DA, Sasi SP, Delgado-Baeza E. Short-Term Treatment with Esmolol Reverses Left Ventricular Hypertrophy in Adult Spontaneously Hypertensive Rats via Inhibition of Akt/NF-κB and NFATc4. Biomed Res Int. 2018 Feb 18;2018:2691014

*Sano S, Oshima K, Wang Y, MacLauchlan S, Katanasaka Y, Sano M, Zuriaga MA, Yoshiyama M, Goukassian DA, Cooper MA, Fuster JJ, Walsh K. Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome. J Am Coll Cardiol. 2018 Feb 27;71(8):875-886, 2018

*Verma SK, Garikipati VNS, Krishnamurthy P, Schumacher SM, Grisanti LA, Cimini M, Cheng Z, Khan M, Yue Y, Benedict C, Truongcao MM, Rabinowitz JE, Goukassian DA, Tilley D, Koch WJ, Kishore R. Interleukin-10 Inhibits Bone Marrow Fibroblast Progenitor Cell-Mediated Cardiac Fibrosis in Pressure-Overloaded Myocardium. Circulation. 2017 Sep 5;136(10):940-953

*Sasi SP, Yan X, Zuriaga-Herrero M, Gee H, Lee J, Mehrzad R, Song J, Onufrak J, Morgan J, Enderling H, Walsh K, Kishore R, Goukassian DA. Different Sequences of Fractionated Low Dose Proton and Single Iron-Radiation-Induced Divergent Biological Responses in the Heart. Radiat Res. 2017 Aug;188(2):191-203.

*Garikipati VN, Verma SK, Jolardarashi D, Cheng Z, Ibetti J, Cimini M, Tang Y, Khan M, Yue Y, Benedict C, Nickoloff E, Trungcao MM, Gao E, Krishnamurthy P, Goukassian DA, Koch WJ, Kishore R. Therapeutic Inhibition of miR-375 Attenuates Post-MI Inflammatory Response and Left Ventricular Dysfunction via PDK-1-AKT Signaling Axis. Cardiovasc Res. 2017 Jul 1;113(8):938-949

*Yue Y, Garikipati VNS, Verma SK, Goukassian DA, Kishore R. Interleukin-10 Deficiency Impairs Reparative Properties of Bone Marrow-Derived Endothelial Progenitor Cell Exosomes. Tissue Eng Part A. 2017 Jun 15. doi: 10.1089/ten.TEA.2017.0084

*He S, Zhao T, Guo H, Meng Y, Qin G, Goukassian DA, Han J, Gao X, Zhu Y. Coordinated Activation of VEGF/VEGFR-2 and PPARδ Pathways by a Multi-Component Chinese Medicine DHI Accelerated Recovery from Peripheral Arterial Disease in Type 2 Diabetic Mice. PLoS One. 2016 Dec 8;11(12):e0167305

*Muralidharan S, Sasi SP, Zuriaga MA, Hirschi KK, Porada CD, Coleman MA, Walsh K, Yan X, Goukassian DA. Ionizing particle radiation as a modulator of endogenous bone marrow cell reprogramming: implications for hematological cancers. Front. Oncol., 14 October 2015, http://dx.doi.org/10.3389/fonc.2015.00231

*Coleman MA, Sasi SP, Onufrak J, Natarajan M, Manickam K, Schwab J, Muralidharan S, Peterson LE, Alekseyev YO, Yan X, Goukassian DA. Low-dose radiation affects cardiac physiology: gene networks and molecular signaling in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2015 Dec 1;309(11):H1947-63, 2015.

*Sasi SP, Park D, Muralidharan S, Wage J, Kiladjian A, Onufrak J, Enderling H, Yan X, Goukassian DA. Particle Radiation-Induced Nontargeted Effects in Bone-Marrow-Derived Endothelial Progenitor Cells. Stem Cells Int. 2015:496512, 2015.

*Zhou J, Cheng M, Boriboun C, Ardehali MM, Jiang C, Liu Q, Han S, Goukassian DA, Tang YL, Zhao TC, Zhao M, Cai L, Richard S, Kishore R, Qin G. Inhibition of Sam68 triggers adipose tissue browning. J Endocrinol. Jun;225(3):181-9, 2015

*Sasi SP, Rahimi L, Yan X, Silver M, Qin G, Losordo DW, Kishore R, Goukassian DA. Genetic Deletion of TNFR2 Augments Inflammatory Response and Blunts Satellite Cell-Mediated Recovery Responses in Hind Limb Ischemia Model. FASEB J, Apr;29(4):1208-19, 2015

*Yan X, Sasi SP, Gee H, Lee J, Yang Y, Mehrzad R, Onufrak J, Song J, Enderling H, Rahimi L, Morgan J, Wilson PF, Carrozza J, Walsh K, Kishore R, Goukassian DA. Cardiovascular risks associated with low dose ionizing particle radiation. PLoS One. Oct 22;9(10):e110269, 2014

*Sasi SP, Song J, Park D, Enderling H, McDonald JT, Gee H, Garrity B, Shtifman A, Yan X, Walsh K, Natarajan M, Kishore R, Goukassian DA. TNF-TNFR2/p75 Signaling Inhibits Early and Increases Delayed Non-Targeted Effects in Bone Marrow-Derived Endothelial Progenitor Cells. J Biol Chem. May 16;289(20):14178-93, 2014.

Sasi SP, Bae S, Song J, Perepletchikov A, Schneider D, Carrozza J, Yan X, Kishore R, Enderling H, Goukassian DA. Therapeutic non-toxic doses of TNF induce significant regression in TNFR2-p75 knockdown Lewis lung carcinoma tumor implants. PLoS One. 9(3):e92373, 2014.

*Bian Y, Silver M, Ho KKL, Marchionni MA, Kang PM, Goukassian DA, Carrozza J, Morgan JP, Yan X. Neuregulin1 Improved Cardiac function in Doxorubicin-Treated Mice with Cardiomyocyte-Specific Overexpression of a Dominant-Negative PI3Kp110α. J Cardiovasc Dis Diagn 1:120, 2013

*Zhou J, Cheng M, Liao YH, Hu Y, Wu M, Wang Q, Qin B, Wang H, Zhu Y, Gao XM, Goukassian D, Zhao TC, Tang YL, Kishore R, Qin G. Rosuvastatin enhances angiogenesis via eNOS-dependent mobilization of endothelial progenitor cells. PLoS One. May 21;8(5):e63126, 2013.

*Shtifman A, Pezone MJ, Sasi SP, Agarwal A, Gee H, Song J, Perepletchikov A, Yan X, Kishore R, Goukassian DA. Divergent modification of low-dose (56)Fe-particle and proton radiation on skeletal muscle. Radiat Res. Nov;180(5):455-64, 2013.

*Klement G.L., Goukassian D.A., Hlatky L., Carrozza J., Morgan J.P., Yan X. Cancer Therapy Targeting the HER2-PI3K Pathway: Potential Impact on the Heart. Frontiers in Pharmacology, 3:113, 2012.

*Goukassian D.A., Gilchrest B.A. Topical Application of Thymidine Dinucleotide to Newborn Mice Reduces and Delays Development of UV-Induced Melanomas. Journal of Investigative Dermatology, 132: pp. 2664-6, 2012.

*Sasi SP, Yan X, Enderling H, Park D, Gilbert HY, Curry C, Coleman C, Hlatky L, Qin G, Kishore R, Goukassian D.A. Breaking the ‘Harmony’ of TNF-α Signaling for Cancer Treatment. Oncogene, 567, pp 1-11, 2011.

*Coleman C, Levine D, Kishore R, Qin R, Thorne T, Lambers E, Sasi SP, Yaar M, Gilchrest BA, Goukassian DA. Inhibition of Melanoma Angiogenesis by Telomere Homolog Oligonucleotides. Journal of Oncology, 2010: 2010:928628.

*Zattra E, Coleman C, Arad S, Helms E, Levine D, Bord E, Guillaume A, El-Hajahmad M, Zwart E, van Steeg H, Gonzalez S, Kishore R, Goukassian DA. Polypodium Leucotomos Extract Decreases UV-induced Cox-2 Expression and Inflammation, Enhances DNA Repair, and Decreases Mutagenesis in Hairless Mice. Am J Pathol. 175(5):1952-61, 2009.

*Arad S, Zattra E, Hebert J, Epstein EH, Jr, Goukassian DA, Gilchrest BA. Topical pTT Treatment Reduces UV-induced BCC Development in Ptch-1 +/- Mice. American Journal of Pathology. 172(5):1248-55.2008.

*Aprahamian T, Takemura Y, Goukassian D.A., Walsh K.  Ageing is Associated with Diminished Apoptotic Cell Clearance in Vivo.  Clin Exp Immunol 152(3): 448-55, 2008

*Astner S, Wu A, Chen J, Philips N, Rius-Diaz F, Parrado C, Mihm MC, Goukassian D.A., Pathak MA, Gonzalez S. Dietary Lutein/ Zeaxanthin Partially Reduces Photoaging and Photocarcinogenesis in Chronically UVB-Irradiated Skh-1 Hairless Mice. Skin Pharmacol Physiol, 20: pp. 283-91, 2007

*Arad S., Konnikov N., Goukassian D.A., Gilchrest B.A. Quantification of Inducible SOS-like Photoprotective Responses in Human Skin. J of Investigative Dermatology, 127(11):2629-36. 2007

*Rajasingh J., Bord E., Qin G., Ii M., Silver M., Hamada H., Ahluwalia D., Goukassian D.A., Zhu Y., Losordo D.W., Kishore R. Enhanced Voluntary Alcohol Consumption After Estrogen Supplementation Negates Estrogen-mediated Vascular Repair in Ovariectomized Mice. Endocrinology 148(8): pp. 3618-24, 2007

*Goukassian D.A., Qin G., Dolan C., Murayama T., Silver M., Curry C., Eaton E., Luedemann C., Ma H., Asahara T., Zak V., Mehta S., Burg A., Thorne T., Kishore R., Losordo D.W. Tumor Necrosis Factor-alpha Receptor p75 is Required in Ischemia-induced Neovascularization. Circulation 115(6): pp. 752-62, 2007.

*Rajasingh J., Bord E., Luedemann C., Asai J., Thorne T., Qin G., Goukassian D.A., Zhu Y., Losordo D.W., Kishore R. IL-10-induced TNF-alpha mRNA Destabilization is Mediated via IL10 Suppression of p38 MAP Kinase Activation and Inhibition of HuR Expression. FASEB J, 20(12): pp. 2112-4, 2006

*Arad S., Konnikov N., Goukassian D.A. Gilchrest B.A. T-oligo Augment UV-induced Protective Responses in Human Skin. FASEB J, 20(11): pp. 1895-7, 2006.

*Qin G, Kishore R, Dolan CM, Silver M, Wecker A, Luedemann CN, Thorne T, Hanley A, Curry C, Heyd L, Dinesh D, Kearney M, Martelli F, Murayama T, Goukassian DA, Zhu Y, Losordo DW. Cell Cycle Regulator E2F1 Modulates Angiogenesis via p53-dependent Transcriptional Control of VEGF. PNAS. 103(29): 11015-20, 2006.

*Qin G, Ii M, Silver M, Wecker A, Bord E, Ma H, Gavin M, Goukassian DA, Yoon YS, Papayannopoulou T, Asahara T, Kearney M, Thorne T, Curry C, Eaton L, Heyd L, Dinesh D, Kishore R, Zhu Y, Losordo DW. Functional Disruption of {alpha}4 Integrin Mobilizes Bone Marrow-derived Endothelial Progenitors and Augments Ischemic Neovascularization. J Exp Med. 203(1): 153-63, 2006.

*Kusano KF, Pola R, Murayama T, Curry C, Kawamoto A, Iwakura A, Shintani S, Ii M, Asai J, Tkebuchava T, Thorne T, Takenaka H, Aikawa R, Goukassian D.A., von Samson P, Hamada H, Yoon YS, Silver M, Eaton E, Ma H, Heyd L, Kearney M, Munger W, Porter JA, Kishore R, Losordo DW. Sonic Hedgehog Myocardial Gene Therapy: Tissue Repair Through Transient Reconstitution of Embryonic Signaling. Nature Medicine. 11(11):1197-204, 2005.

*Marwaha V, Chen YH, Helms E, Arad S, Inoue H, Bord E, Kishore R, Sarkissian RD, Gilchrest BA, Goukassian DA. T-oligo Treatment Decreases Constitutive and UVB-induced COX-2 Levels Through p53- and NFkappaB-dependent Repression of the COX-2 Promoter. J Biol Chem. 280(37):32379-88, 2005.

*Luedemann C, Bord E, Qin G, Zhu Y, Goukassian D.A., Losordo DW, Kishore R. Ethanol Modulation of TNF-alpha Biosynthesis and Signaling in Endothelial Cells: Synergistic Augmentation of TNF-alpha Mediated Endothelial Cell Dysfunctions by Chronic Ethanol. Alcohol Clin Exp Res. Jun;29(6):930-8, 2005.

*Kishore R, Qin G, Luedemann C, Bord E, Hanley A, Silver M, Gavin M, Yoon YS, Goukassian D.A., Losordo DW. The Cytoskeletal Protein Ezrin Regulates EC Proliferation and Angiogenesis via TNF-alpha-induced Transcriptional Repression of Cyclin A. J Clin Invest. Jul;115(7):1785-96, 2005.

*Middlekamp-Hup M.A., Pathak M.A., Parrado C., Goukassian D.A., Rius-Diaz F., Mihm M.C., Fitzpatrick T.B., Gonzalez S. Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin. Journal of American Academy of Dermatology 51, pp.910-918, 2004.

*Goukassian D.A., Helms, E., van Steeg H., van Oostrom C., Bhawan J., Gilchrest B.A. Topical DNA Oligonucleotide Therapy Reduces UV-Induced Mutations and Photocarcinogenesis in Hairless Mice. PNAS 101, pp. 3933-3938. 2004.

Kishore, R., Luedemann, C., Bord, E., Goukassian, D., Losordo, D.W. Tumor Necrosis Factor Mediated E2F1 Suppression in Endothelial Cells. Differential Requirement of c-Jun N-Terminal Kinase and p38 Mitogen-Activated Protein Kinase Signal Transduction Pathways. Circulation Research 93: 932-940, 2003.

Gonzales S., Astner S., An W., Goukassian D.A., Pathak M.A. Dietary Lutein/Zeaxanthin Decreases Ultraviolet B-Induced Epidermal Hyperproliferation and Acute Inflammation in Hairless Mice. Journal of Investigative Dermatology, 121: pp. 399-405, 2003.

Goukassian D.A., Kishore R., Dolan C., Leutemann C., Krasinski K., Ma H., Hanley A., Asahara T., Isner J., and Losordo D.W. Engineering the Response to Vascular Injury: Divergent Effects of Deregulated E2F1 Expression on Vascular Smooth Muscle Cells and Endothelial Cells Result in Endothelial Recovery and Inhibition of Neointimal Growth. Circ Research, 93: pp. 162-169, 2003.

Goukassian D.A., Bagheri S., El-Keeb L., Eller M.S., Gilchrest B.A., DNA Oligonucleotide Treatment Corrects the Age-Associated Decline in DNA Repair Capacity. FASEB J, 16, pp. 754756, 2002.

Andres, Urena, J., Poch, E., Chen, D. Goukassian, D.A. Role of Sp1 in the Induction of p27 Gene Expression in Vascular Smooth Muscle Cells In Vitro and After Balloon AngioplastyArteriosclerosis Thrombosis and Vascular Biology 21, pp. 342-347, 2001.

Goukassian D.A., Sanz-Gonzalez, Silvia M., Perez-Rogers, Ignacio, Font de Mora, Jaime, Urena, Jesus, Andres, Vicente. Inhibition of the Cyclin D1/E2F Pathway by PCA-4230, a Potent Repressor of Cellular Proliferation-British Journal of Pharmacology, 1327: pp. 1597-1605 2001.

Goukassian D.A., Asahara T., Schratzberger P., Silver M., Murayama T., Isner J., Andres V., Overexpression of p27 kip1 by Doxycycline-Regulated Adenoviral Vectors Inhibits Endothelial Cell Proliferation and Migration and Impairs Angiogenesis in Response to Tissue Ischemia. FASEB J, 15, pp. 1877-1885, 2001.

Goukassian D.A., Gad F., Yaar M., Eller M.S., Nehal U., Gilchrest B.A. Mechanisms and Implications of the Age Associated Decrease in DNA Repair Capacity. FASEB J, 14, 10, 13251334, 2000.

Goukassian D.A., Eller M.S. Yaar M. and Gilchrest, B.A.-Thymidine Dinucleotide Mimics the Effect of Solar Simulated Irradiation on p53 and p53-regulated proteins. Journal of Investigative Dermatology, 112, 1, pp.25-31, 1999.

Hara M., Yaar M., Byers H.R., Goukassian D.A., Fine R.A. and Gilchrest B.A. Kinesin Participates in Melanosomal Transfer Along Melanocyte Dendrites. Journal of Investigative Dermatology, 114, 3, pp. 438-443, 1999.

 

Other Peer Reviewed Publications

*Goukassian D.A., Gilchrest B.A. The Interdependence of Skin Aging, Skin Cancer, and DNA Repair Capacity: A Novel Perspective with Therapeutic Implications. Rejuven. Res. 7(3):175-85, 2004.Invited Contributions
*Goukassian D.A. Mending the Rift: DNA Repair and Aging. Geriatrics and Aging. 8(8): 57-60, 2005.
*Kishore R,Tkebuchava T, Sasi SP, Silver M, Gilbert H-Y, Yoon Y-S, Park H-Y, Thorne, T, Losordo W, Goukassian DA. Tumor Necrosis Factor-α Signaling Via TNFR1/p55 is Deleterious whereas TNFR2/p75 Signaling is Protective in Adult Infarct Myocardium. Publisher Springer, Adv Exp Med and Biol 691, Chapter 45: pp. 433-48, 2011.

Books and Book Chapters

Suvorova X.N. and Goukassian D.A.- Textbook for Physicians “Complications of Atopic Dermatitis by Secondary Infection and its Treatment”. -Moscow, 1993.
*Goukassian D.A. Morgan J, Yan X. Neuregulin1-ErbB Signaling in Doxorubicin-Induced Cardiotoxicity. Publisher Intech, Ed.: Manuela Fiuza, Book Chapter in: Cardiotoxicity of Oncologic Treatments. pp. 65-88, 2012.

Non-Peer Reviewed Publications

*Sasi SP, Gee H, Lee J, Yang Y, Song J, Carrozza J, Yan X., Goukassian DA. Radiation associated cardiovascular risks for future deep-space missions. J Radiat Res. Mar 1;55 Suppl 1:i37-i39, 2014.
*Sasi SP, Song J, Enderling H, Yan X, Goukassian DA. TNF-α and IL-1α but not MCP-1 and Rantes increase significantly the formation of p-H2AX foci in naive BM-derived TNFR1/p55KO EPCs. J Radiat Res. Mar 1;55 Suppl 1:i122-i123, 2014.