{"id":227,"date":"2019-08-06T14:45:24","date_gmt":"2019-08-06T14:45:24","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/goosenslab\/?page_id=227"},"modified":"2019-08-14T15:27:10","modified_gmt":"2019-08-14T15:27:10","slug":"template","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/goosenslab\/","title":{"rendered":"Updated Template"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”on|on|on” _builder_version=”3.19.10″ disabled=”on”][et_pb_fullwidth_menu menu_id=”5″ submenu_direction=”downwards” fullwidth_menu=”off” _builder_version=”3.19.10″][\/et_pb_fullwidth_menu][\/et_pb_section][et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”3.19.10″ background_color=”#000000″][et_pb_fullwidth_slider show_pagination=”off” _builder_version=”3.19.10″ animation_style=”slide” animation_direction=”right” auto=”on”][et_pb_slide heading=”Laboratory for Biological Systems in Stress and Disease” use_bg_overlay=”off” use_text_overlay=”off” _builder_version=”3.19.10″ use_background_color_gradient=”on” background_image=”https:\/\/labs.icahn.mssm.edu\/goosenslab\/wp-content\/uploads\/sites\/301\/2019\/08\/Cropped_Mechanical_Bodies.jpg” button_on_hover=”on” background_layout=”light”][\/et_pb_slide][et_pb_slide use_bg_overlay=”off” use_text_overlay=”off” _builder_version=”3.19.10″ use_background_color_gradient=”on” background_image=”https:\/\/labs.icahn.mssm.edu\/goosenslab\/wp-content\/uploads\/sites\/301\/2019\/08\/BrainNetworkSmall.jpg” background_size=”contain” button_on_hover=”on”][\/et_pb_slide][et_pb_slide use_bg_overlay=”off” use_text_overlay=”off” _builder_version=”3.19.10″ use_background_color_gradient=”on” background_image=”https:\/\/labs.icahn.mssm.edu\/goosenslab\/wp-content\/uploads\/sites\/301\/2019\/08\/Cropped_Mechanical_Bodies.jpg”][\/et_pb_slide][\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section fb_built=”1″ module_id=”research” module_class=”research-section” _builder_version=”3.19.10″][et_pb_row _builder_version=”3.0.48″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”3_4″ _builder_version=”3.0.47″ parallax=”off” parallax_method=”on”][et_pb_text admin_label=”research” _builder_version=”3.19.10″]<\/p>\n

The Laboratory for Biological Systems in Stress and Disease studies the systems-level biology of emotional memory and stress in healthy rodents and humans, and examines dysregulation of this biology in animal models of psychiatric disease and human patient populations. We combine modern techniques from systems neurobiology, including optogenetics, in vivo<\/em> recordings, gene transfer, microarrays, and in vivo <\/em>calcium imaging, with classic techniques from neuropharmacology, endocrinology, molecular biology, and behavioral neuroscience to address research questions. Our long-term mission is to advance new frontiers in basic science with high translational relevance and provide new biologically-driven, effective treatments for stress-sensitive disease<\/strong>.<\/p>\n

Our current lines of research focus on 1) Identifying novel circuit mechanisms for associative emotional memory formation and their dysregulation by stress; 2) Understanding the mechanisms by which emotional memory encoding is modulated; and 3) Studies to identify and characterize the endocrine factors that underlie stress-induced vulnerability to disease including rodent models of post-traumatic stress disorder (PTSD), Major Depressive Disorder (MDD), and obesity, and also understand how these factors regulate normal function in the brain and periphery. We focus on biological factors that are either under- or un-studied, an approach that we believe is key to defining new treatments for disease. We also typically perform longitudinal studies which characterize the impact of stress on behavior and physiology in the weeks to months after stress ceases, an approach that we believe is key to understanding the relationship between stress and disease. Finally, we are increasingly performing studies in both animal and human subjects, an approach that we believe is essential for the validation and translation of our findings.<\/p>\n

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Contact Us<\/strong><\/h4>\n

Ki Ann Goosens, Ph.D.<\/h4>\n

Associate Professor
\nDepartment of Psychiatry
\nFriedman Brain Institute
\nCenter for Affective Neuroscience
\nAnnenberg 22-78
\nNew York, NY 10029
\n(212) 241-5959<\/p>\n

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Key Questions<\/strong><\/h4>\n

1) Why does ghrelin remain elevated for so long after chronic stress exposure ceases?<\/p>\n

2) Can ghrelin resistance be reversed? Does reversing it decrease disease vulnerability?<\/p>\n

3) How does ghrelin resistance in the periphery contribute to stress-associated disease?<\/p>\n

4) How does chronic stress impact neuronal ensemble encoding of aversive memories?<\/p>\n

5) How do neuronal ensembles compute ‘contingent’ relationships between cues and outcomes?<\/p>\n

6) Does an inability to predict or time aversive events contribute to anxiety?<\/p>\n

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Sample Recent Publications<\/strong><\/h4>\n

Yousufzai MIUA, Harmatz ES, Shah M, Malik MO,\u00a0Goosens KA<\/b>.Ghrelin is a persistent biomarker for chronic stress exposure in adolescent rats and humans.<\/a>Transl Psychiatry<\/span>. 2018 Apr 11;8(1):74. doi: 10.1038\/s41398-018-0135-5.\u00a0PMID:\u00a0<\/span>29643360 Amadi U, Lim SH, Liu E, Baratta MV,\u00a0Goosens KA<\/b>., Hippocampal Processing of Ambiguity Enhances Fear Memory.\u00a0<\/a>Psychol Sci<\/span>. 2017 Feb;28(2):143-161. doi: 10.1177\/0956797616674055. Epub 2016 Dec 19.\u00a0PMID:<\/span>28182526<\/p>\n

Harmatz ES, Stone L, Lim SH, Lee G, McGrath A, Gisabella B, Peng X, Kosoy E, Yao J, Liu E, Machado NJ, Weiner VS, Slocum W, Cunha RA,\u00a0Goosens KA,\u00a0<\/b>Central Ghrelin Resistance Permits the Overconsolidation of Fear Memory.\u00a0<\/a>Biol Psychiatry<\/span>. 2017 Jun 15;81(12):1003-1013. doi: 10.1016\/j.biopsych.2016.11.009. Epub 2016 Nov 29.\u00a0PMID:<\/span>28010876<\/p>\n

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\n
\n
Gisabella B, Farah S, Peng X, Burgos-Robles A, Lim SH,\u00a0Goosens KA,\u00a0<\/b>Growth hormone biases amygdala network activation after fear learning.<\/a>Transl Psychiatry<\/span>. 2016 Nov 29;6(11):e960. doi: 10.1038\/tp.2016.203.\u00a0PMID:<\/span>27898076<\/div>\n
\u00a0<\/div>\n
Correia SS, McGrath AG, Lee A, Graybiel AM,\u00a0Goosens KA,\u00a0<\/b>Amygdala-ventral striatum circuit activation decreases long-term fear.\u00a0<\/a>Elife<\/span>. 2016 Sep 27;5. pii: e12669. doi: 10.7554\/eLife.12669.\u00a0PMID:<\/span>27671733<\/div>\n
\u00a0<\/div>\n
Baratta MV, Kodandaramaiah SB, Monahan PE, Yao J, Weber MD, Lin PA, Gisabella B, Petrossian N, Amat J, Kim K, Yang A, Forest CR, Boyden ES,\u00a0Goosens KA,\u00a0<\/b>Stress Enables Reinforcement-Elicited Serotonergic Consolidation of Fear Memory.\u00a0<\/a>Biol Psychiatry<\/span>. 2016 May 15;79(10):814-822. doi: 10.1016\/j.biopsych.2015.06.025. Epub 2015 Jul 2.\u00a0PMID:<\/span>26248536<\/div>\n
\u00a0<\/div>\n
Lee G,\u00a0Goosens KA,\u00a0<\/b>Sampling blood from the lateral tail vein of the rat.\u00a0<\/a>J Vis Exp<\/span>. 2015 May 18;(99):e52766. doi: 10.3791\/52766.\u00a0PMID:<\/span>26065632<\/div>\n
\u00a0<\/div>\n
Meyer RM, Burgos-Robles A, Liu E, Correia SS,\u00a0Goosens KA,\u00a0<\/b>A ghrelin-growth hormone axis drives stress-induced vulnerability to enhanced fear.\u00a0<\/a>Mol Psychiatry<\/span>. 2014 Dec;19(12):1284-94. doi: 10.1038\/mp.2013.135. Epub 2013 Oct 15.\u00a0PMID:<\/span>24126924<\/div>\n
\u00a0<\/div>\n
Recent Collaborative Publications<\/strong><\/div>\n
\u00a0<\/div>\n
Novaes LS, Dos Santos NB, Perfetto JG,\u00a0Goosens KA<\/b>, Munhoz CD, Environmental enrichment prevents acute restraint stress-induced anxiety-related behavior but not changes in basolateral amygdala spine density.\u00a0<\/a>Psychoneuroendocrinology<\/span>. 2018 Dec;98:6-10. doi: 10.1016\/j.psyneuen.2018.07.031. Epub 2018 Aug 1.\u00a0PMID:<\/span>30081343<\/div>\n
\u00a0<\/div>\n
Friedman A, Homma D, Bloem B, Gibb LG, Amemori KI, Hu D, Delcasso S, Truong TF, Yang J, Hood AS, Mikofalvy KA, Beck DW, Nguyen N, Nelson ED, Toro Arana SE, Vorder Bruegge RH,\u00a0Goosens KA<\/b>, Graybiel AM, Chronic Stress Alters Striosome-Circuit Dynamics, Leading to Aberrant Decision-Making.<\/a>Cell<\/span>. 2017 Nov 16;171(5):1191-1205.e28. doi: 10.1016\/j.cell.2017.10.017.\u00a0PMID:<\/span>29149606<\/div>\n
\u00a0<\/div>\n
Sim\u00f5es AP, Machado NJ, Gon\u00e7alves N, Kaster MP, Sim\u00f5es AT, Nunes A, Pereira de Almeida L,\u00a0Goosens KA<\/b>, Rial D, Cunha RA, Adenosine A2A<\/sub>\u00a0Receptors in the Amygdala Control Synaptic Plasticity and Contextual Fear Memory.\u00a0<\/a>Neuropsychopharmacology<\/span>. 2016 Nov;41(12):2862-2871. doi: 10.1038\/npp.2016.98. Epub 2016 Jun 17.\u00a0PMID:<\/span>27312408<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Selected Reviews<\/strong><\/h4>\n

Correia SS,\u00a0Goosens KA,\u00a0<\/b>Input-specific contributions to valence processing in the amygdala.\u00a0<\/a>Learn Mem<\/span>. 2016 Sep 15;23(10):534-43. doi: 10.1101\/lm.037887.114. Print 2016 Oct. Review.\u00a0PMID:<\/span>27634144<\/p>\n

Goosens KA,\u00a0<\/b>Hippocampal regulation of aversive memories.\u00a0<\/a>Curr Opin Neurobiol<\/span>. 2011 Jun;21(3):460-6. doi: 10.1016\/j.conb.2011.04.003. Epub 2011 May 3. Review.\u00a0PMID:<\/span>21546244<\/p>\n

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\u00a0<\/div>\n<\/div>\n

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Team<\/h4>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.0.48″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”1_4″ _builder_version=”3.0.47″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.10″ text_text_color=”#ffffff” global_module=”252″ saved_tabs=”all”]<\/p>\n

\n<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Mount Sinai” _builder_version=”3.19.10″]<\/p>\n

JoColl Burgess<\/strong>
Second Year Graduate Student
jocollb@bu.edu<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.0.47″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.10″ text_text_color=”#ffffff” global_module=”253″ saved_tabs=”all”]<\/p>\n

\n<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Mount Sinai” _builder_version=”3.19.10″]<\/p>\n

Seh Hong ‘Chris’ Lim<\/strong>
Graduate Student
chrislsh@bu.edu<\/p>\n

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Alumni<\/h4>\n

Michael Baratta (Asst. Professor, University of Colorado Boulder)<\/p>\n

Vincent C.K. Cheung (Asst. Professor, The Chinese University of Hong Kong)<\/p>\n

Susana Correia (Principal Investigator, Cyclerion)<\/p>\n

Barbara Gisabella (Asst. Professor, University of Mississippi Medical Center)<\/p>\n

Chris Lim (Asst. Professor, Massachusetts General Hospital Institute of Health Professions)<\/p>\n

Anna McGrath (PhD Candidate; Temple University)<\/p>\n

Lauren Stone (MD\/PhD Candidate; Yale University)<\/p>\n

Ugwechi Amadi (Author; Consultant)<\/p>\n

Natalie Petrossian (Research Associate; Beam Therapeutics)<\/p>\n

 <\/p>\n

 <\/p>\n

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Related links<\/h4>\n

Friedman Brain Institute<\/strong>
https:\/\/icahn.mssm.edu\/research\/friedman<\/p>\n

Neuroscience Graduate Program at Mount Sinai<\/strong>
https:\/\/icahn.mssm.edu\/education\/phd\/neuroscience<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.0.47″ parallax=”off” parallax_method=”on”][et_pb_text admin_label=”links” _builder_version=”3.19.10″]<\/p>\n

 <\/p>\n

Center for Affective Neuroscience<\/strong>
https:\/\/icahn.mssm.edu\/research\/affective-neuroscience<\/p>\n

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Location<\/strong>
Annenberg 22-78
ki.goosens@mssm.edu<\/a><\/p>\n

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The Laboratory for Biological Systems in Stress and Disease studies the systems-level biology of emotional memory and stress in healthy rodents and humans, and examines dysregulation of this biology in animal models of psychiatric disease and human patient populations. We combine modern techniques from systems neurobiology, including optogenetics, in vivo recordings, gene transfer, microarrays, and […]<\/p>\n","protected":false},"author":274,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-227","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/goosenslab\/wp-json\/wp\/v2\/pages\/227","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/goosenslab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/goosenslab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/goosenslab\/wp-json\/wp\/v2\/users\/274"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/goosenslab\/wp-json\/wp\/v2\/comments?post=227"}],"version-history":[{"count":22,"href":"https:\/\/labs.icahn.mssm.edu\/goosenslab\/wp-json\/wp\/v2\/pages\/227\/revisions"}],"predecessor-version":[{"id":282,"href":"https:\/\/labs.icahn.mssm.edu\/goosenslab\/wp-json\/wp\/v2\/pages\/227\/revisions\/282"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/goosenslab\/wp-json\/wp\/v2\/media?parent=227"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}