{"id":88,"date":"2017-01-17T20:47:40","date_gmt":"2017-01-17T20:47:40","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/giannarellilab\/?page_id=88"},"modified":"2019-10-08T18:59:49","modified_gmt":"2019-10-08T18:59:49","slug":"publications","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/giannarellilab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”3.19.10″][et_pb_fullwidth_header title=”Publications” subhead=”Most recent publications” _builder_version=”3.19.10″ title_font=”||||||||” content_font=”||||||||” subhead_font=”||||||||” subhead_font_size=”19px” subhead_font_size_last_edited=”on|desktop” background_color=”#00c1fc”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.0.47″][et_pb_row _builder_version=”3.0.48″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″ _builder_version=”3.0.47″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.10″ text_font=”||||||||” text_text_color=”#000000″ header_font=”||||||||” header_text_color=”#000000″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”]<\/p>\n

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  1. Dawn M. Fernandez, Adeeb H. Rahman, Nicolas Fernandez, Aleksey Chudnovskiy, El-ad David Amir, Letizia Amadori, Nayaab S. Khan, Christine Wong, Roza Shamailova, Christopher Hill, Zichen Wang, Romain Remark, Jennifer R. Li, Christian Pina, Christopher Faries, Ahmed J. Awad, Noah Moss, Johan L.M. Bjorkegren, Seunghee Kim-Schulze, Sacha Gnjatic, Avi Ma\u2019ayan, J. Mocco, Peter Faries, Miriam Merad, Chiara Giannarelli<\/strong>.\u00a0 Single-cell Immune Landscape of Human Atherosclerotic Plaques.<\/em> Nature Medicine 721688. 2019 Oct.\u00a0doi: 10.1038\/s41591-019-0590-4\u00a0\u00a0<\/span><\/a><\/li>\n
  2. Dawn M. Fernandez, Adeeb H. Rahman, Nicolas Fernandez, Aleksey Chudnovskiy, El-ad David Amir, Letizia Amadori, Nayaab S. Khan, Christine Wong, Roza Shamailova, Christopher Hill, Zichen Wang, Romain Remark, Jennifer R. Li, Christian Pina, Christopher Faries, Ahmed J. Awad, Noah Moss, Johan L.M. Bjorkegren, Seunghee Kim-Schulze, Sacha Gnjatic, Avi Ma\u2019ayan, J. Mocco, Peter Faries, Miriam Merad, Chiara Giannarelli<\/strong>.\u00a0Immune Profiling of Atherosclerotic Plaques Identifies Innate and Adaptive Dysregulations Associated with Ischemic Cerebrovascular Events.<\/em> bioRxiv 721688. 2019 Aug.\u00a0doi: 10.1101\/721688.\u00a0<\/span><\/a><\/li>\n
  3. Glicksberg, Benjamin S; Amadori, Letizia; Akers, Nicholas K; Sukhavasi, Katyayani; Franz\u00e9n, Oscar; Li, Li; Belbin, Gillian M; Akers, Kristin L; Shameer, Khader; Badgeley, Marcus A; Johnson, Kipp W; Readhead, Ben; Darrow, Bruce J; Kenny, Eimear E; Betsholtz, Christer; Ermel, Raili; Skogsberg, Josefin; Ruusalepp, Arno; Schadt, Eric E; Dudley, Joel T; Ren, Hongxia; Kovacic, Jason C; Giannarelli, Chiara<\/strong>; Li, Shuyu D; Bj\u00f6rkegren, Johan L M; Chen, Rong. Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits.<\/em> BMC Medical Genomics. 2019 Jul;12(Suppl 6):108. doi: 10.1186\/s12920-019-0542-3.\u00a0PMID: 31345219.<\/a><\/span><\/li>\n
  4. Zeng, Lingyao; Talukdar, Husain A; Koplev, Simon;\u00a0Giannarelli, Chiara<\/strong>; Ivert, Torbj\u00f6rn; Gan, Li-Ming; Ruusalepp, Arno; Schadt, Eric E; Kovacic, Jason C; Lusis, Aldons J; Michoel, Tom; Schunkert, Heribert; Bj\u00f6rkegren, Johan L M. Contribution of Gene Regulatory Networks to Heritability of Coronary Artery Disease.<\/em> Journal of the American College of Cardiology. 2019 Jun;73(23):2946-2957. doi: 10.1016\/j.jacc.2019.03.520.\u00a0PMID: 31196451.<\/a><\/span><\/li>\n
  5. Giannarelli, Chiara<\/strong>; Wong, Christine K.\u00a0Crosstalk Between Inflammatory Cells to Promote Cardioprotective Angiogenesis.<\/em> Journal of the American College of Cardiology. 2019 Jun;73(23):3003-3005. doi: 10.1016\/j.jacc.2019.04.014.\u00a0PMID: 31196458.<\/a><\/span><\/li>\n
  6. Alique, Matilde; Bodega, Guillermo; Giannarelli, Chiara<\/strong>; Carracedo, Julia; Ram\u00edrez, Rafael. MicroRNA-126 regulates Hypoxia-Inducible Factor-1\u03b1 which inhibited migration, proliferation, and angiogenesis in replicative endothelial senescence.<\/em> Scientific Reports. 2019 May;9(1):7381. doi: 10.1038\/s41598-019-43689-3.\u00a0PMID: 31089163.<\/a><\/span><\/li>\n
  7. Frades, Itziar; Readhead, Ben; Amadori, Letizia; Koplev, Simon; Talukdar, Husain A; Crane, Heidi M; Crane, Paul K; Kovacic, Jason C; Dudley, Joel T; Giannarelli, Chiara<\/strong>; Bj\u00f6rkegren, Johan L M; Peter, Inga.\u00a0Systems Pharmacology Identifies an Arterial Wall Regulatory Gene Network Mediating Coronary Artery Disease Side Effects of Antiretroviral Therapy.<\/em> Circulation: Genomic and Precision Medicine. 2019 May;12(6):e002390.\u00a0doi: 10.1161\/circgen.118.002390.\u00a0PMID: 31059280.<\/a><\/span><\/li>\n
  8. Fernandez-Jimenez, Rodrigo; Jaslow, Risa; Bansilal, Sameer; Santana, Maribel; Diaz-Munoz, Raquel; Latina, Jacqueline; Soto, Ana V; Vedanthan, Rajesh; Al-Kazaz, Mohamed;\u00a0Giannarelli, Chiara<\/strong>; Kovacic, Jason C; Bagiella, Emilia; Kasarskis, Andrew; Fayad, Zahi A; Hajjar, Roger J; Fuster, Valentin.\u00a0Child Health Promotion in Underserved Communities: The FAMILIA Trial.<\/em> Journal of the American College of Cardiology. 2019 Apr;73(16):2011-2021. doi: 10.1016\/j.jacc.2019.01.057.\u00a0PMID: 31023422.\u00a0<\/a><\/span><\/li>\n
  9. Williams, Jesse W; Giannarelli, Chiara<\/strong>; Rahman, Adeeb; Randolph, Gwendalyn J; Kovacic, Jason C.\u00a0Macrophage Biology, Classification, and Phenotype in Cardiovascular Disease: JACC Macrophage in CVD Series (Part 1).<\/em> Journal of the American College of Cardiology. 2018 Oct;72(18):2166-2180. Review. doi: 10.1016\/j.jacc.2018.08.2148.\u00a0PMID: 30360826.\u00a0<\/a><\/span><\/li>\n
  10. Giannarelli, Chiara<\/strong>; Fernandez, Dawn M.\u00a0Manipulating Macrophage Polarization to Fix the Broken Heart: Challenges and Hopes.<\/em> Journal of the American College of Cardiology. 2018 Aug;72(8):905-907.\u00a0doi: 10.1016\/j.jacc.2018.06.019.\u00a0PMID: 30115229.<\/a><\/span><\/li>\n
  11. Fernandez, Dawn M.; Clemente, Jose C.; Giannarelli, Chiara<\/strong>.\u00a0Physical Activity, Immune System, and the Microbiome in Cardiovascular Disease. Frontiers in Physiology.<\/em> 2018 Jun;9(JUN):763.\u00a0doi: 10.3389\/fphys.2018.00763.\u00a0PMID: 30013482.<\/a><\/span><\/li>\n
  12. Franz\u00e9n, Oscar; Ermel, Raili; Sukhavasi, Katyayani; Jain, Rajeev; Jain, Anamika; Betsholtz, Christer;\u00a0Giannarelli, Chiara<\/strong>; Kovacic, Jason C; Ruusalepp, Arno; Skogsberg, Josefin; Hao, Ke; Schadt, Eric E; Bj\u00f6rkegren, Johan L M.\u00a0Global analysis of A-to-I RNA editing reveals association with common disease variants.<\/em>\u00a0PeerJ. 2018 Mar;6(3):e4466.\u00a0doi: 10.7717\/peerj.4466. PMID: 29527417.<\/a><\/span><\/li>\n
  13. Marco Di Paolo; Stefania Fornaro; Benedetta Guidi; Valentina Bugelli; Michele Figus;\u00a0Chiara Giannarelli<\/strong>; Marco Tuccori.\u00a0Acute myocardial infarction following off label retrobulbar injection of desmopressin for non-arteritic anterior ischemic optic neuropathy (NAION). causal correlation or coincidence?<\/em>\u00a0Romanian Journal of Legal Medicine. 2017 June;25(2):165-168. doi: 10.4323\/rjlm.2017.165.<\/a><\/span><\/li>\n
  14. Bansilal, Sameer; Vedanthan, Rajesh; Kovacic, Jason C; Soto, Ana Victoria; Latina, Jacqueline; Bj\u00f6rkegren, Johan L M; Jaslow, Risa; Santana, Maribel; Sartori, Samantha; Giannarelli, Chiara<\/strong>; Mani, Venkatesh; Hajjar, Roger; Schadt, Eric; Kasarskis, Andrew; Fayad, Zahi A; Fuster, Valentin.\u00a0Rationale and Design of Family-Based Approach in a Minority Community Integrating Systems-Biology for Promotion of Health (FAMILIA).<\/em> American Heart Journal. 2017 May;187:170-181.\u00a0doi: 10.1016\/j.ahj.2017.02.020.\u00a0PMID: 28454800<\/a>.<\/span><\/li>\n
  15. Giannarelli, Chiara<\/strong>; Rodriguez, David T; Zafar, M Urooj; Christoffel, Daniel; Vialou, Vincent; Pe\u00f1a, Catherine; Badimon, Ana; Hodes, Georgia F; Mury, Pauline; Rabkin, Jacklyn; Alique, Matilde; Villa, Giulia; Argmann, Carmen; Nestler, Eric J; Russo, Scott J; Badimon, Juan J.\u00a0Susceptibility to chronic social stress increases plaque progression, vulnerability and platelet activation.<\/em> Thromb Haemost. 2017 Apr;117(4):816-818.\u00a0doi: 10.1160\/th16-10-0817.\u00a0PMID:28078352.<\/a><\/span><\/li>\n
  16. Bruno, Rosa Maria; Cartoni, Giulia; Stea, Francesco; Armenia, Sabina; Bianchini, Elisabetta; Buralli, Simona;\u00a0Giannarelli, Chiara<\/strong>; Taddei, Stefano; Ghiadoni, Lorenzo.\u00a0Carotid and aortic stiffness in essential hypertension and their relation with target organ damage: the CATOD study.<\/em> Journal of Hypertension. 2017 Feb;35(2):310-318.\u00a0doi: 10.1097\/hjh.0000000000001167.\u00a0PMID: 27841779.\u00a0<\/a><\/span><\/li>\n
  17. Fruzzetti F, Ghiadoni L, Virdis A, De Negri F, Perini D, Bucci F,\u00a0Giannarelli<\/strong>\u00a0C, Gadducci A, Taddei S. Adolescents with Classical Polycystic Ovary Syndrome Have Alterations in the Surrogate Markers of Cardiovascular Disease but Not in the Endothelial Function. The Possible Benefits of Metformin.<\/em> J Pediatr Adolesc Gynecol. 2016 Oct;29(5):489-95. doi: 10.1016\/j.jpag.2016.03.004. PubMed PMID: 27018756; PubMed Central PMCID: PMC5003746.<\/a><\/span><\/li>\n
  18. Franz\u00e9n O, Ermel R, Cohain A, Akers NK, Di Narzo A, Talukdar HA, Foroughi-Asl H, Giambartolomei C, Fullard JF, Sukhavasi K, K\u00f6ks S, Gan LM, Giannarelli C<\/strong>, Kovacic JC, Betsholtz C, Losic B, Michoel T, Hao K, Roussos P, Skogsberg J, Ruusalepp A, Schadt EE, Bj\u00f6rkegren JL. Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases.<\/em> Science. 2016 Aug 19;353(6301):827-30. doi: 10.1126\/science.aad6970. PubMed PMID: 27540175.<\/a><\/span><\/li>\n
  19. Talukdar HA, Foroughi Asl H, Jain RK, Ermel R, Ruusalepp A, Franz\u00e9n O, Kidd BA, Readhead B, Giannarelli C<\/strong>, Kovacic JC, Ivert T, Dudley JT, Civelek M, Lusis AJ, Schadt EE, Skogsberg J, Michoel T, Bj\u00f6rkegren JL. Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease.<\/em> Cell Syst. 2016 Mar 23;2(3):196-208. doi: 10.1016\/j.cels.2016.02.002. PubMed PMID: 27135365; PubMed Central PMCID: PMC4855300.<\/a><\/span><\/li>\n
  20. Chen J, Yaniz-Galende E, Kagan HJ, Liang L, Hekmaty S, Giannarelli C<\/strong>, Hajjar R. Abnormalities of capillary microarchitecture in a rat model of coronary ischemic congestive heart failure.<\/em> Am J Physiol Heart Circ Physiol. 2015 Apr 15;308(8):H830-40. doi: 10.1152\/ajpheart.00583.2014. PubMed PMID: 25659485; PubMed Central PMCID: PMC4398862.<\/a><\/span><\/li>\n
  21. Cornejo MC, Cho SK, Giannarelli C<\/strong>, Iatridis JC, Purmessur D. Soluble factors from the notochordal-rich intervertebral disc inhibit endothelial cell invasion and vessel formation in the presence and absence of pro-inflammatory cytokines. Osteoarthritis Cartilage.<\/em> 2015 Mar;23(3):487-96. doi: 10.1016\/j.joca.2014.12.010. PubMed PMID: 25534363; PubMed Central PMCID: PMC4411226.<\/a><\/span><\/li>\n
  22. Zafar MU, Vorchheimer DA, Tewar MP, Giannarelli C<\/strong>, Crippa M, Sartori S, Rodriguez D, Baber U, Mehran R, Badimon JJ. Ticagrelor reduces thrombus formation more than clopidogrel, even when co-administered with bivalirudin.<\/em> Thromb Haemost. 2014 Nov;112(5):1069-70. doi: 10.1160\/TH14-03-0269. PubMed PMID: 25104302; PubMed Central PMCID: PMC4807433.<\/a><\/span><\/li>\n
  23. Giannarelli C<\/strong>, Alique M, Rodriguez DT, Yang DK, Jeong D, Calcagno C, Hutter R, Millon A, Kovacic JC, Weber T, Faries PL, Soff GA, Fayad ZA, Hajjar RJ, Fuster V, Badimon JJ. Alternatively spliced tissue factor promotes plaque angiogenesis through the activation of hypoxia-inducible factor-1\u03b1 and vascular endothelial growth factor signaling.<\/em> Circulation. 2014 Oct 7;130(15):1274-86. doi: 10.1161\/CIRCULATIONAHA.114.006614. PubMed PMID: 25116956.<\/a><\/span><\/li>\n
  24. Hutter R, Huang L, Speidl WS, Giannarelli C<\/strong>, Trubin P, Bauriedel G, Klotman ME, Fuster V, Badimon JJ, Klotman PE. Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheroma.<\/em> Circulation. 2013 Nov 26;128(22):2351-63. doi: 10.1161\/CIRCULATIONAHA.113.004634. PubMed PMID: 24043300; PubMed Central PMCID: PMC3917564.<\/a><\/span><\/li>\n
  25. Zhao S, Nishimura T, Chen Y, Azeloglu EU, Gottesman O,\u00a0Giannarelli C<\/strong>, Zafar MU, Benard L, Badimon JJ, Hajjar RJ, Goldfarb J, Iyengar R. Systems pharmacology of adverse event mitigation by drug combinations.<\/em> Sci Transl Med. 2013 Oct 9;5(206):206ra140. doi: 10.1126\/scitranslmed.3006548. PubMed PMID: 24107779; PubMed Central PMCID: PMC3963511.<\/a><\/span><\/li>\n
  26. Bianchini E, Giannarelli C<\/strong>, Bruno RM, Armenia S, Landini L, Faita F, Gemignani V, Taddei S, Ghiadoni L. Functional and structural alterations of large arteries: methodological issues.<\/em> Curr Pharm Des. 2013;19(13):2390-400. Review. PubMed PMID: 23173588.<\/a><\/span><\/li>\n
  27. Zafar MU, Santos-Gallego C, Vorchheimer DA, Viles-Gonzalez JF, Elmariah S, Giannarelli C<\/strong>, Sartori S, Small DS, Jakubowski JA, Fuster V, Badimon JJ. Platelet function normalization after a prasugrel loading-dose: time-dependent effect of platelet supplementation.<\/em> J Thromb Haemost. 2013 Jan;11(1):100-6. doi: 10.1111\/jth.12058. PubMed PMID: 23137352; PubMed Central PMCID: PMC4802976.<\/a><\/span><\/li>\n
  28. Giannarelli C<\/strong>, Bianchini E, Bruno RM, Magagna A, Landini L, Faita F, Gemignani V, Penno G, Taddei S, Ghiadoni L. Local carotid stiffness and intima-media thickness assessment by a novel ultrasound-based system in essential hypertension.<\/em> Atherosclerosis. 2012 Aug;223(2):372-7. doi: 10.1016\/j.atherosclerosis.2012.05.027. PubMed PMID: 22727194.<\/a><\/span><\/li>\n
  29. Giannarelli C<\/strong>, Cimmino G, Ibanez B, Chiesa G, Garcia-Prieto J, Santos-Gallego CG, Alique-Aguilar M, Fuster V, Sirtori C, Badimon JJ. Acute ApoA-I Milano administration induces plaque regression and stabilisation in the long term.<\/em> Thromb Haemost. 2012 Dec;108(6):1246-8. doi: 10.1160\/TH12-08-0556. PubMed PMID: 23093000.<\/a><\/span><\/li>\n
  30. Ibanez B, Giannarelli C<\/strong>, Cimmino G, Santos-Gallego CG, Alique M, Pinero A, Vilahur G, Fuster V, Badimon L, Badimon JJ. Recombinant HDL(Milano) exerts greater anti-inflammatory and plaque stabilizing properties than HDL(wild-type).<\/em> Atherosclerosis. 2012 Jan;220(1):72-7. doi: 10.1016\/j.atherosclerosis.2011.10.006. PubMed PMID: 22030095.<\/a><\/span><\/li>\n
  31. Giannarelli C<\/strong>, Cimmino G, Connolly TM, Ibanez B, Ruiz JM, Alique M, Zafar MU, Fuster V, Feuerstein G, Badimon JJ. Synergistic effect of liver X receptor activation and simvastatin on plaque regression and stabilization: an magnetic resonance imaging study in a model of advanced atherosclerosis.<\/em> Eur Heart J. 2012 Jan;33(2):264-73. doi: 10.1093\/eurheartj\/ehr136. PubMed PMID: 21606082.<\/a><\/span><\/li>\n
  32. Giannarelli C<\/strong>, Klein RS, Badimon JJ. Cardiovascular implications of HIV-induced dyslipidemia.<\/em> Atherosclerosis. 2011 Dec;219(2):384-9. doi: 10.1016\/j.atherosclerosis.2011.06.003. Review. PubMed PMID: 21722900.<\/a><\/span><\/li>\n
  33. Cimmino, Giovanni; Ibanez, Borja; Giannarelli, Chiara<\/strong>; Prat-Gonz\u00e1lez, Susanna; Hutter, Randolph; Garcia, Mario; Sanz, Javier; Fuster, Valentin; Badimon, Juan J.\u00a0Carvedilol administration in acute myocardial infarction results in stronger inhibition of early markers of left ventricular remodeling than metoprolol.<\/em>\u00a0International Journal of Cardiology. 2011 Dec;153(3):256-261.\u00a0doi: 10.1016\/j.ijcard.2010.08.018.\u00a0PMID: 20864196.\u00a0<\/a><\/span><\/li>\n
  34. Santos-Gallego CG, Giannarelli C<\/strong>, Badim\u00f3n JJ. Experimental models for the investigation of high-density lipoprotein-mediated cholesterol efflux.<\/em> Curr Atheroscler Rep. 2011 Jun;13(3):266-76. doi: 10.1007\/s11883-011-0177-0. Review. PubMed PMID: 21484293.<\/a><\/span><\/li>\n
  35. Cimmino G, Giannarelli C<\/strong>, Chen W, Alique M, Santos-Gallego CG, Fuster V, Hajjar RJ, Walsh CE, Badimon JJ. Adeno-associated virus serotype 8 ApoA-I gene transfer reduces progression of atherosclerosis in ApoE-KO mice: comparison of intramuscular and intravenous administration.<\/em> J Cardiovasc Pharmacol. 2011 Mar;57(3):325-33. doi: 10.1097\/FJC.0b013e3182092841. PubMed PMID: 21164355.<\/a><\/span><\/li>\n
  36. Giannarelli C<\/strong>, Ibanez B, Cimmino G, Garcia Ruiz JM, Faita F, Bianchini E, Zafar MU, Fuster V, Garcia MJ, Badimon JJ. Contrast-enhanced ultrasound imaging detects intraplaque neovascularization in an experimental model of atherosclerosis.<\/em> JACC Cardiovasc Imaging. 2010 Dec;3(12):1256-64. doi: 10.1016\/j.jcmg.2010.09.017. PubMed PMID: 21163454.<\/a><\/span><\/li>\n
  37. Giannarelli C<\/strong>, Zafar MU, Badimon JJ. Prostanoid and TP-receptors in atherothrombosis: is there a role for their antagonism?<\/em> Thromb Haemost. 2010 Nov;104(5):949-54. doi: 10.1160\/TH10-03-0195. Review. PubMed PMID: 20886180.<\/a><\/span><\/li>\n<\/ol>\n

    [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

    Dawn M. Fernandez, Adeeb H. Rahman, Nicolas Fernandez, Aleksey Chudnovskiy, El-ad David Amir, Letizia Amadori, Nayaab S. Khan, Christine Wong, Roza Shamailova, Christopher Hill, Zichen Wang, Romain Remark, Jennifer R. Li, Christian Pina, Christopher Faries, Ahmed J. Awad, Noah Moss, Johan L.M. Bjorkegren, Seunghee Kim-Schulze, Sacha Gnjatic, Avi Ma\u2019ayan, J. Mocco, Peter Faries, Miriam Merad, […]<\/p>\n","protected":false},"author":200,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

    1: Franz\u00e9n O, Ermel R, Cohain A, Akers NK, Di Narzo A, Talukdar HA, Foroughi-Asl H, Giambartolomei C, Fullard JF, Sukhavasi K, K\u00f6ks S, Gan LM, Giannarelli C<\/strong>, Kovacic JC, Betsholtz C, Losic B, Michoel T, Hao K, Roussos P, Skogsberg J, Ruusalepp A, Schadt EE, Bj\u00f6rkegren JL. Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases. Science. 2016 Aug 19;353(6301):827-30. doi: 10.1126\/science.aad6970. PubMed PMID: 27540175.<\/p>

    2: Talukdar HA, Foroughi Asl H, Jain RK, Ermel R, Ruusalepp A, Franz\u00e9n O, Kidd BA, Readhead B, Giannarelli C<\/strong>, Kovacic JC, Ivert T, Dudley JT, Civelek M, Lusis AJ, Schadt EE, Skogsberg J, Michoel T, Bj\u00f6rkegren JL. Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease. Cell Syst. 2016 Mar 23;2(3):196-208. doi: 10.1016\/j.cels.2016.02.002. PubMed PMID: 27135365; PubMed Central PMCID: PMC4855300.<\/p>

    3: Fruzzetti F, Ghiadoni L, Virdis A, De Negri F, Perini D, Bucci F, Giannarelli<\/strong> C, Gadducci A, Taddei S. Adolescents with Classical Polycystic Ovary Syndrome Have Alterations in the Surrogate Markers of Cardiovascular Disease but Not in the Endothelial Function. The Possible Benefits of Metformin. J Pediatr Adolesc Gynecol. 2016 Oct;29(5):489-95. doi: 10.1016\/j.jpag.2016.03.004. PubMed PMID: 27018756; PubMed Central PMCID: PMC5003746.<\/p>

    4: Chen J, Yaniz-Galende E, Kagan HJ, Liang L, Hekmaty S, Giannarelli C<\/strong>, Hajjar R. Abnormalities of capillary microarchitecture in a rat model of coronary ischemic congestive heart failure. Am J Physiol Heart Circ Physiol. 2015 Apr 15;308(8):H830-40. doi: 10.1152\/ajpheart.00583.2014. PubMed PMID: 25659485; PubMed Central PMCID: PMC4398862.<\/p>

    5: Cornejo MC, Cho SK, Giannarelli C<\/strong>, Iatridis JC, Purmessur D. Soluble factors from the notochordal-rich intervertebral disc inhibit endothelial cell invasion and vessel formation in the presence and absence of pro-inflammatory cytokines. Osteoarthritis Cartilage. 2015 Mar;23(3):487-96. doi: 10.1016\/j.joca.2014.12.010. PubMed PMID: 25534363; PubMed Central PMCID: PMC4411226.<\/p>

    6: Giannarelli C<\/strong>, Alique M, Rodriguez DT, Yang DK, Jeong D, Calcagno C, Hutter R, Millon A, Kovacic JC, Weber T, Faries PL, Soff GA, Fayad ZA, Hajjar RJ, Fuster V, Badimon JJ. Alternatively spliced tissue factor promotes plaque angiogenesis through the activation of hypoxia-inducible factor-1\u03b1 and vascular endothelial growth factor signaling. Circulation. 2014 Oct 7;130(15):1274-86. doi: 10.1161\/CIRCULATIONAHA.114.006614. PubMed PMID: 25116956.<\/p>

    7: Zafar MU, Vorchheimer DA, Tewar MP, Giannarelli C<\/strong>, Crippa M, Sartori S, Rodriguez D, Baber U, Mehran R, Badimon JJ. Ticagrelor reduces thrombus formation more than clopidogrel, even when co-administered with bivalirudin. Thromb Haemost. 2014 Nov;112(5):1069-70. doi: 10.1160\/TH14-03-0269. PubMed PMID: 25104302; PubMed Central PMCID: PMC4807433.<\/p>

    8: Zhao S, Nishimura T, Chen Y, Azeloglu EU, Gottesman O, Giannarelli C<\/strong>, Zafar MU, Benard L, Badimon JJ, Hajjar RJ, Goldfarb J, Iyengar R. Systems pharmacology of adverse event mitigation by drug combinations. Sci Transl Med. 2013 Oct 9;5(206):206ra140. doi: 10.1126\/scitranslmed.3006548. PubMed PMID: 24107779; PubMed Central PMCID: PMC3963511.<\/p>

    9: Hutter R, Huang L, Speidl WS, Giannarelli C<\/strong>, Trubin P, Bauriedel G, Klotman ME, Fuster V, Badimon JJ, Klotman PE. Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheroma. Circulation. 2013 Nov 26;128(22):2351-63. doi: 10.1161\/CIRCULATIONAHA.113.004634. PubMed PMID: 24043300; PubMed Central PMCID: PMC3917564.<\/p>

    10: Bianchini E, Giannarelli C<\/strong>, Bruno RM, Armenia S, Landini L, Faita F, Gemignani V, Taddei S, Ghiadoni L. Functional and structural alterations of large arteries: methodological issues. Curr Pharm Des. 2013;19(13):2390-400. Review. PubMed PMID: 23173588.<\/p>

    11: Zafar MU, Santos-Gallego C, Vorchheimer DA, Viles-Gonzalez JF, Elmariah S, Giannarelli C<\/strong>, Sartori S, Small DS, Jakubowski JA, Fuster V, Badimon JJ. Platelet function normalization after a prasugrel loading-dose: time-dependent effect of platelet supplementation. J Thromb Haemost. 2013 Jan;11(1):100-6. doi: 10.1111\/jth.12058. PubMed PMID: 23137352; PubMed Central PMCID: PMC4802976.<\/p>

    12: Giannarelli C<\/strong>, Cimmino G, Ibanez B, Chiesa G, Garcia-Prieto J, Santos-Gallego CG, Alique-Aguilar M, Fuster V, Sirtori C, Badimon JJ. Acute ApoA-I Milano administration induces plaque regression and stabilisation in the long term. Thromb Haemost. 2012 Dec;108(6):1246-8. doi: 10.1160\/TH12-08-0556. PubMed PMID: 23093000.<\/p>

    13: Giannarelli C<\/strong>, Bianchini E, Bruno RM, Magagna A, Landini L, Faita F, Gemignani V, Penno G, Taddei S, Ghiadoni L. Local carotid stiffness and intima-media thickness assessment by a novel ultrasound-based system in essential hypertension. Atherosclerosis. 2012 Aug;223(2):372-7. doi: 10.1016\/j.atherosclerosis.2012.05.027. PubMed PMID: 22727194.<\/p>

    14: Ibanez B, Giannarelli C<\/strong>, Cimmino G, Santos-Gallego CG, Alique M, Pinero A, Vilahur G, Fuster V, Badimon L, Badimon JJ. Recombinant HDL(Milano) exerts greater anti-inflammatory and plaque stabilizing properties than HDL(wild-type). Atherosclerosis. 2012 Jan;220(1):72-7. doi: 10.1016\/j.atherosclerosis.2011.10.006. PubMed PMID: 22030095.<\/p>

    15: Giannarelli C<\/strong>, Klein RS, Badimon JJ. Cardiovascular implications of HIV-induced dyslipidemia. Atherosclerosis. 2011 Dec;219(2):384-9. doi: 10.1016\/j.atherosclerosis.2011.06.003. Review. PubMed PMID: 21722900.<\/p>

    16: Giannarelli C<\/strong>, Cimmino G, Connolly TM, Ibanez B, Ruiz JM, Alique M, Zafar MU, Fuster V, Feuerstein G, Badimon JJ. Synergistic effect of liver X receptor activation and simvastatin on plaque regression and stabilization: an magnetic resonance imaging study in a model of advanced atherosclerosis. Eur Heart J. 2012 Jan;33(2):264-73. doi: 10.1093\/eurheartj\/ehr136. PubMed PMID: 21606082.<\/p>

    17: Santos-Gallego CG, Giannarelli C<\/strong>, Badim\u00f3n JJ. Experimental models for the investigation of high-density lipoprotein-mediated cholesterol efflux. Curr Atheroscler Rep. 2011 Jun;13(3):266-76. doi: 10.1007\/s11883-011-0177-0. Review. PubMed PMID: 21484293.<\/p>

    18: Cimmino G, Giannarelli C<\/strong>, Chen W, Alique M, Santos-Gallego CG, Fuster V, Hajjar RJ, Walsh CE, Badimon JJ. Adeno-associated virus serotype 8 ApoA-I gene transfer reduces progression of atherosclerosis in ApoE-KO mice: comparison of intramuscular and intravenous administration. J Cardiovasc Pharmacol. 2011 Mar;57(3):325-33. doi: 10.1097\/FJC.0b013e3182092841. PubMed PMID: 21164355.<\/p>

    19: Giannarelli C<\/strong>, Ibanez B, Cimmino G, Garcia Ruiz JM, Faita F, Bianchini E, Zafar MU, Fuster V, Garcia MJ, Badimon JJ. Contrast-enhanced ultrasound imaging detects intraplaque neovascularization in an experimental model of atherosclerosis. JACC Cardiovasc Imaging. 2010 Dec;3(12):1256-64. doi: 10.1016\/j.jcmg.2010.09.017. PubMed PMID: 21163454.<\/p>

    20: Giannarelli C<\/strong>, Zafar MU, Badimon JJ. Prostanoid and TP-receptors in atherothrombosis: is there a role for their antagonism? Thromb Haemost. 2010 Nov;104(5):949-54. doi: 10.1160\/TH10-03-0195. Review. PubMed PMID: 20886180.<\/p>","_et_gb_content_width":"","footnotes":""},"class_list":["post-88","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/giannarellilab\/wp-json\/wp\/v2\/pages\/88","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/giannarellilab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/giannarellilab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/giannarellilab\/wp-json\/wp\/v2\/users\/200"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/giannarellilab\/wp-json\/wp\/v2\/comments?post=88"}],"version-history":[{"count":15,"href":"https:\/\/labs.icahn.mssm.edu\/giannarellilab\/wp-json\/wp\/v2\/pages\/88\/revisions"}],"predecessor-version":[{"id":676,"href":"https:\/\/labs.icahn.mssm.edu\/giannarellilab\/wp-json\/wp\/v2\/pages\/88\/revisions\/676"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/giannarellilab\/wp-json\/wp\/v2\/media?parent=88"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}