<\/strong><\/p>\n <\/strong><\/p>\n <\/strong><\/p>\n <\/strong><\/p>\n <\/strong><\/p>\n <\/strong><\/p>\n <\/strong><\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”–et_global_heading_font|600|||||||” text_font_size=”1px” text_line_height=”3em” header_letter_spacing=”62px” header_line_height=”3em” height=”100px” custom_padding=”||0px|||” link_option_url=”https:\/\/share.snipd.com\/snip\/aaf3f2a2-3379-47ea-b78d-3c5d48a8226f” link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n <\/strong><\/p>\n <\/strong><\/p>\n <\/strong><\/p>\n <\/strong><\/p>\n <\/strong><\/p>\n <\/strong><\/p>\n <\/strong><\/p>\n <\/strong><\/p>\n [\/et_pb_text][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/ghaffarilab\/wp-content\/uploads\/sites\/347\/2026\/01\/Screen-Shot-2026-01-06-at-5.37.03-PM.png” title_text=”Screen Shot 2026-01-06 at 5.37.03 PM” url=”https:\/\/stemcellpodcast.com\/ep-310-epithelial-organoids-featuring-dr-hans-clevers” url_new_window=”on” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”–et_global_heading_font|600|||||||” text_font_size=”1px” text_line_height=”3em” header_letter_spacing=”62px” header_line_height=”3em” min_height=”18px” height=”20px” custom_padding=”||0px|||” link_option_url=”https:\/\/stemcellpodcast.com\/ep-310-epithelial-organoids-featuring-dr-hans-clevers” link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/ghaffarilab\/wp-content\/uploads\/sites\/347\/2026\/01\/Screen-Shot-2026-01-06-at-5.37.28-PM.png” title_text=”Screen Shot 2026-01-06 at 5.37.28 PM” url=”https:\/\/stemcellpodcast.com\/ep-310-epithelial-organoids-featuring-dr-hans-clevers” url_new_window=”on” _builder_version=”4.27.4″ _module_preset=”default” min_height=”92.5px” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”–et_global_heading_font|600|||||||” text_font_size=”1px” text_line_height=”2.9em” header_letter_spacing=”82px” header_line_height=”3em” height=”100px” custom_padding=”||0px|||” link_option_url=”https:\/\/www.mountsinai.org\/about\/newsroom\/2025\/mount-sinai-scientists-reverse-aging-in-blood-stem-cells-by-targeting-lysosomal-dysfunction” link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n <\/strong><\/p>\n <\/strong><\/p>\n <\/strong><\/p>\n <\/strong><\/p>\n <\/strong><\/p>\n <\/strong><\/p>\n <\/strong><\/p>\n <\/strong><\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”–et_global_heading_font|600|||||||” text_font_size=”13px” text_line_height=”2.3em” header_line_height=”1.5em” height=”534px” custom_padding=”||29px|||” link_option_url=”https:\/\/www.mountsinai.org\/about\/newsroom\/2025\/mount-sinai-scientists-reverse-aging-in-blood-stem-cells-by-targeting-lysosomal-dysfunction” link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n Ghaffari Lab In the News: Excitement Around New Publication on Reverting Aged Blood Stem Cells to a Young State<\/span>\u00a0<\/strong><\/span><\/p>\n https:\/\/www.24matins.fr\/des-chercheurs-rajeunissent-les-cellules-souches-sanguines-vieillissantes-chez-la-souris-1399111<\/a><\/p>\n https:\/\/www.24matins.es\/rejuvenecimiento-de-celulas-madre-sanguineas-envejecidas-en-ratones-408759<\/a><\/p>\n https:\/\/newstral.com\/de\/article\/de\/1273462646\/blutstammzellen-bei-m%C3%A4usen-neue-methode-zur-verj%C3%BCngung-entdeckt#google_vignette<\/a><\/p>\n https:\/\/www.sciencealert.com\/scientists-restore-aging-blood-stem-cells-to-a-more-youthful-state-in-mice<\/a><\/p>\n https:\/\/www.news-medical.net\/news\/20251124\/Scientists-reverse-aging-in-blood-stem-cells-by-restoring-lysosome-function.aspx<\/a><\/p>\n https:\/\/www.bild.de\/leben-wissen\/medizin\/longevity-forschern-gelingt-es-maeuse-zellen-rueckwaerts-altern-zu-lassen-69284b77acb910e1fd1641ec<\/a><\/p>\n https:\/\/www.yirmidort.tv\/teknoloji\/bilim-insanlari-yaslanan-kan-kok-hucrelerini-genclestirmeyi-basardi-251342<\/a><\/p>\n https:\/\/www.uygurhaberajansi.com\/tip-dunyasinda-devrim-kan-kok-hucrelerini-genclestirme-yontemi-gelistirildi<\/a><\/p>\n https:\/\/scitechdaily.com\/scientists-reverse-blood-stem-cell-aging-by-rewiring-the-cells-recycling-system\/<\/a><\/p>\n https:\/\/drpradeepalbert.com\/lysosomal-dysfunction-the-hidden-driver-of-stem-cell-aging\/<\/a><\/p>\n https:\/\/www.institutimagine.org\/fr\/remonter-le-temps-des-scientifiques-retablissent-certaines-proprietes-des-cellules-souches-agees-en<\/a>\u00a0<\/p>\n https:\/\/www.techno-science.net\/actualite\/rajeunir-scientifiques-retablissent-certaines-proprietes-cellules-souches-agees-N28483.html<\/a>\u00a0<\/p>\n <\/p>\n <\/p>\n <\/p>\n [\/et_pb_text][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/ghaffarilab\/wp-content\/uploads\/sites\/347\/2025\/12\/image-1.png” title_text=”image (1)” url=”https:\/\/iseh.org\/Publications\/Simply-Blood\/Article\/selected-research-on-hsc-metabolism” url_new_window=”on” _builder_version=”4.27.4″ _module_preset=”default” min_height=”602.3px” custom_margin=”60px|||||” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.27.4″ text_font=”||||||||” header_font_size=”26px” min_height=”27px” height=”50px” max_height=”369px” custom_margin=”0px|||3px” custom_padding=”0px||6px|||” link_option_url=”https:\/\/tmrresearchblog.com\/enhancing-stem-cells-potency-aids-in-bone-marrow-transplantation\/” link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n Saghi takes a sabbatical to the Institut Imagine, H\u00f4pital Necker Enfants Malades Paris, France: returns with chocolate and new data and ideas from scRNA-Seq data (2023-2024)<\/strong><\/a><\/p>\n <\/strong><\/p>\n <\/strong><\/p>\n <\/p>\n <\/p>\n [\/et_pb_text][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/ghaffarilab\/wp-content\/uploads\/sites\/347\/2025\/11\/Saghi_MenagerLab.jpg” title_text=”Saghi_MenagerLab” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row module_class=” et_pb_row_fullwidth” _builder_version=”4.27.4″ width=”87.7%” width_tablet=”80%” width_phone=”” width_last_edited=”on|desktop” max_width=”89%” max_width_tablet=”80%” max_width_phone=”” max_width_last_edited=”on|desktop” module_alignment=”center” custom_padding=”67px|0px|27px|0|false|false” make_fullwidth=”on” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”Text” _builder_version=”4.27.4″ text_font=”||||||||” min_height=”72.7px” custom_margin=”0px|||3px” custom_padding=”||0px|||” link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n Remembering Connie Eaves <\/a>(1944-202<\/a>4), <\/a>a Giant in Stem Cell Biology<\/a><\/strong><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_class=” et_pb_row_fullwidth” _builder_version=”4.16″ width=”87.7%” width_tablet=”80%” width_phone=”” width_last_edited=”on|desktop” max_width=”89%” max_width_tablet=”80%” max_width_phone=”” max_width_last_edited=”on|desktop” module_alignment=”center” custom_padding=”21px|0px|27px|0|false|false” make_fullwidth=”on” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/ghaffarilab\/wp-content\/uploads\/sites\/347\/2025\/11\/Screen-Shot-2025-11-07-at-2.43.35-PM.png” _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”-74px|||||” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.27.4″ text_font=”||||||||” min_height=”114.7px” custom_margin=”4px||3px|3px||” custom_padding=”||0px|||” link_option_url=”https:\/\/tmrresearchblog.com\/enhancing-stem-cells-potency-aids-in-bone-marrow-transplantation\/” link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n <\/strong><\/span><\/a><\/p>\n Obituaries published<\/span><\/a> in Nature, Nature Cancer, Stem Cell Reports, American Association for Cancer Research<\/span><\/strong><\/p>\n Obituary published in Experimental Hematology: Remembering Professor Connie Eaves: an exceptional researcher, mentor and friend<\/strong><\/span><\/a><\/p>\n Obituary published in Cell Stem Cell<\/a><\/strong><\/span><\/p>\n Turhan A., Nicolini F., Coulombel L., and S. Ghaffari. Connie Eaves (May 22, 1944\u2013March 7, 2024). <\/strong><\/a>Cell Stem Cell, May 2, 2024.<\/span><\/strong><\/span><\/p>\n Obituary published in Bulletin du Cancer<\/a><\/strong><\/span><\/p>\n Audet J., Berger M., Cashman J., Chalandon Y., Coulombel L., Ghaffari S., Lemoine F., Nicolini F., Schmitt C., Sloma I., Turhan A. Pr. Connie J. Eaves (1944-2024). Bull Cancer<\/strong><\/p>\n <\/p>\n <\/p>\n <\/p>\n [\/et_pb_text][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/ghaffarilab\/wp-content\/uploads\/sites\/347\/2025\/11\/IMG-5033-scaled.jpg” title_text=”IMG-5033″ admin_label=”Image” _builder_version=”4.27.4″ _module_preset=”default” height=”478px” custom_margin=”0px||||false|false” global_colors_info=”{}”][\/et_pb_image][et_pb_text admin_label=”Text” _builder_version=”4.27.4″ text_font=”||||||||” min_height=”72.7px” custom_margin=”0px|||3px” custom_padding=”||0px|||” link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n Saadi Khochbin, Delphine Khochbin, Sophie Rousseaux, John Green, Saghi Ghaffari, Grenoble, France 2017<\/strong><\/span><\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ text_font=”||||||||” custom_margin=”0px|||3px” custom_padding=”0px|||||” link_option_url=”https:\/\/tmrresearchblog.com\/enhancing-stem-cells-potency-aids-in-bone-marrow-transplantation\/” link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n <\/span><\/p>\n Jiajing Qiu’s abstract selected for Best of ASH: Identification of Potent Human Hematopoietic Stem Cells (HSCs) Using Mitochondrial Profile Towards Improving HSC Transplantation<\/span><\/p>\n December 5-8, 2020.<\/span> Jiajing Qiu<\/strong>, Jana Gjini, Saghi Ghaffari. <\/span><\/strong><\/p>\n <\/span><\/p>\n <\/span><\/p>\n <\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n Divide and Rule: Mitochondrial Fission Regulates Quiescence in Hematopoietic Stem Cells.\u00a0<\/a><\/p>\n Tiago C. Luis,\u00a0<\/span>Hannah Lawson,<\/span>\u00a0<\/span>and Kamil R. Kranc. Cell Stem Cell,\u00a0<\/span>Volume<\/span> 26, Issue 3, March 5 2020, Pages 299-301<\/p>\n https:\/\/www.cell.com\/cell-stem-cell\/fulltext\/S1934-5909(20)30062-X<\/a><\/p>\n https:\/\/www.cordobabn.com\/articulo\/salud\/investigadores-logran-potenciar-y-mejorar-la-terapia-de-celulas-madre-para-el-trasplante-de-medula\/20200303195029038639.html<\/a><\/p>\n https:\/\/www.regmednet.com\/users\/346348-ebony-torrington\/posts\/60885-potency-of-hematopoietic-stem-cells-increased-with-new-inhibitor<\/a><\/span><\/strong><\/p>\n https:\/\/medicalxpress.com\/news\/2020-02-approach-stem-cells-bone-marrow.html<\/a><\/span><\/p>\n https:\/\/www.newswise.com\/articles\/moun<\/a><\/span>https:\/\/twitter.com\/JAguirreGhiso\/status\/1233409278347743233<\/a><\/p>\n http:\/\/www.healthnewsdigest.com\/news\/stem%20cell%20issues20\/New-Approach-for-Use-of-Stem-Cells-to-Improve-Bone-Marrow-Transplantation.shtml<\/a><\/p>\n https:\/\/tmrresearchblog.com\/enhancing-stem-cells-potency-aids-in-bone-marrow-transplantation\/<\/a><\/p>\n https:\/\/b-s-h.org.uk\/about-us\/news\/new-approach-to-improve-bone-marrow-transplantation\/<\/a><\/p>\n https:\/\/dailyresearchlist.com\/2020\/02\/28\/researchers-find-a-novel-approach-to-improve-bone-marrow-transplantation\/<\/a><\/p>\n http:\/\/www.masnoticias.mx\/celulas-madre-mejoran-trasplante-de-medula-osea\/<\/a><\/p>\n http:\/\/todotexcoco.com\/celulas-madre-mejoran-trasplante-de-medula-osea-e3TUwe3DQ0NA.html<\/a><\/p>\n https:\/\/www.infosalus.com\/salud-investigacion\/noticia-nuevo-enfoque-uso-celulas-madre-mejorar-trasplante-medula-osea-20200312075845.html<\/a><\/p>\n http:\/\/www.elsiglocoahuila.mx\/coahuila\/noticia\/359192.descubren-que-celulas-madre-mejoran-el-trasplante-de-medula-osea.html<\/a><\/p>\n <\/p>\n August 2018<\/span><\/p>\n https:\/\/amsny.org\/under-the-lens\/nystem-funded-discovery-fuels-research-at-mount-sinai-lab-and-beyond\/<\/a><\/p>\n <\/p>\n <\/p>\n https:\/\/youtu.be\/vov9za2g8bU<\/a>\u00a0<\/span><\/p>\n <\/span><\/p>\n<\/span><\/strong><\/h4>\n
Read the Article Here!<\/u><\/b><\/span><\/a><\/h4>\n
Paper published in Cell Stem Cell, <\/em>Dec 2025, on reversing aging via lysosomal inhibition is discussed in this episode of The Stem Cell Podcast<\/em><\/strong><\/h3>\n
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Listen to the segment focused on the paper here<\/a><\/span><\/span> <\/span><\/strong><\/span><\/strong><\/h4>\n
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Or listen to the whole episode here<\/span><\/strong><\/h4>\n
Press Release: Mount Sinai Scientists Reverse Aging in Blood Stem Cells by Targeting Lysosomal Dysfunction<\/strong><\/h3>\n
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Study published in December 2025 in Cell Stem Cell reveals a lysosome-based approach that reverses aged blood-forming stem cells to a young state and may help prevent age-related blood disorders<\/span><\/strong><\/h4>\n
Best of ASH at the 62nd ASH annual meeting and Exposition.<\/strong>\u00a0<\/span><\/h4>\n
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Virtual Research Advocacy Day,\u00a0December 2020<\/span><\/strong><\/h4>\n
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Potency of hematopoietic stem cells increased with a new inhibitor: towards improving bone marrow\u00a0<\/strong><\/span>transplantation<\/b><\/span><\/h4>\n
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NYSTEM\u00a0<\/strong><\/span><\/h4>\n
Myeloproliferative Neoplasm (MPN) events\u00a0<\/span><\/strong><\/h4>\n