{"id":11,"date":"2020-02-10T13:50:49","date_gmt":"2020-02-10T18:50:49","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/ghaffarilab\/?page_id=11"},"modified":"2026-02-13T13:34:52","modified_gmt":"2026-02-13T18:34:52","slug":"publications","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/ghaffarilab\/publications\/","title":{"rendered":"PUBLICATIONS"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; custom_margin=&#8221;||-2px|||&#8221; custom_padding=&#8221;54px||0px|||&#8221; collapsed=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; min_height=&#8221;33px&#8221; custom_margin=&#8221;||-4px|||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h1><span style=\"color: #7c7c7c\"><strong>KEY PUBLICATIONS<\/strong><\/span><\/h1>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; width=&#8221;88.3%&#8221; module_alignment=&#8221;center&#8221; min_height=&#8221;3000px&#8221; max_height=&#8221;5000px&#8221; custom_margin=&#8221;|0px||0px|false|false&#8221; custom_padding=&#8221;0px|0px|0px|0px|false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; text_font_size=&#8221;16px&#8221; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; width=&#8221;100%&#8221; module_alignment=&#8221;right&#8221; min_height=&#8221;3000px&#8221; max_height=&#8221;5000px&#8221; custom_margin=&#8221;||47px|0px|false|false&#8221; custom_padding=&#8221;||0px|1px||&#8221; inline_fonts=&#8221;Acme,Aclonica,Noto Sans&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3><span style=\"text-decoration: underline;font-size: 22px;font-weight: normal\"><strong>2024-2025<\/strong><\/span><\/h3>\n<p><span style=\"text-decoration: underline;font-size: 22px;font-weight: normal\"><strong><\/strong><\/span><\/p>\n<p style=\"text-align: justify\">Arif<sup> <\/sup>T.*, Qiu J.*, Khademian H., Lohithakshan A., Menon, A., Menon<sup> <\/sup>V., Slavinsky, M., Batignes M., Lin<sup> <\/sup>M., Sebra R., Beaumont K., Benson D.L., Tzavaras<sup> <\/sup>N., M\u00e9nager M., and S. Ghaffari. <span style=\"font-family: inherit;font-weight: normal;color: #000000\"><b>Reversing lysosomal dysfunction r<\/b><b style=\"font-size: 16px\">estores youthful state in aged hematopoietic stem cells.<\/b><strong style=\"font-size: medium\">\u00a0<\/strong><span style=\"font-size: 16px\">Cell Stem Cell, Dec 4, 2025<\/span><span style=\"font-size: 16px\">.<\/span><\/span><\/p>\n<p style=\"text-align: justify\">Bigarella C., Liang R., Bourova-Flin E., Chuffart F., Qiu J., Khatun J., Batignes M., Menon A., Slavinsky M., Lin M., Rimmel\u00e9 P., Mi J., Wang J., Menon V., Menager M., Chipuk, J. Khochbin S., Rousseaux S., and S. Ghaffari.<span style=\"color: #000000\"><strong> Mitochondrial remodeling promotes pre-Leukemic stem cell generation from blood forming progenitor cells lacking both FOXO3 and TP53<\/strong><\/span><strong style=\"color: #000000;font-size: 16px\">\u00a0<\/strong><span style=\"color: #000000;font-size: 16px\">(<\/span><em style=\"color: #000000;font-size: 16px\">In revision<\/em><span style=\"color: #000000;font-size: 16px\">).<\/span><\/p>\n<p style=\"text-align: justify\">Menon V., Slavinsky M., Hermine O., and S. Ghaffari. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.19600\"><strong style=\"color: #000000;font-size: medium\">Mitochondrial regulation of erythropoiesis in homeostasis and disease. <\/strong><\/a><span style=\"color: #000000\">British Journal of Haematology, June 30, 2024.<\/span><span style=\"text-decoration: underline;font-size: 22px;font-weight: normal;color: #000000\"><strong><\/strong><\/span><\/p>\n<p><span style=\"color: #000000\"><\/span><\/p>\n<p><span style=\"text-decoration: underline;font-size: 22px;font-weight: normal\"><\/span><\/p>\n<h3><span style=\"text-decoration: underline;font-size: 22px;font-weight: normal;color: #000000\"><strong>2023<\/strong><\/span><\/h3>\n<p><span style=\"text-decoration: underline;font-size: 22px;font-weight: normal\"><strong><\/strong><\/span><\/p>\n<h1 style=\"text-align: justify\"><span style=\"font-size: medium;font-weight: normal;font-family: inherit\"><span class=\"cit\">Liang R.*, Lin M.*, Menon V., Qiu, J., Menon A., Breda L., Arif T., Rivella S., and S. Ghaffari. <\/span><strong><span class=\"cit\"><a href=\"https:\/\/doi.org\/10.1101\/2022.03.03.482874\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">Elevated CDKN1a (p21) mediates \u03b2-thalassemia erythroid apoptosis but its loss does not improve \u03b2-thalassemic erythropoiesis.\u00a0<\/span><\/a><\/span><\/strong><span class=\"cit\" style=\"color: #000000\">Blood Advances, Nov 16, 2023.<\/span><\/span><\/h1>\n<p><span style=\"text-decoration: underline;font-size: 22px;font-weight: normal\"><strong><\/strong><\/span><\/p>\n<p>Kalair A., Pavan M., Alpert N., Ghaffari S., and E. Taioli.\u00a0<span style=\"font-size: medium;color: #000000\"><a href=\"https:\/\/journals.plos.org\/plosone\/article\/authors?id=10.1371\/journal.pone.0293027\" style=\"color: #000000\"><strong>Blood inflammatory markers and mortality in the US population: a health and retirement survey (HRS) ana<\/strong><\/a><\/span><span style=\"color: #000000\"><span style=\"font-size: medium\"><span style=\"color: #000000\"><a href=\"https:\/\/journals.plos.org\/plosone\/article\/authors?id=10.1371\/journal.pone.0293027\" style=\"color: #000000\"><strong>lysis. <\/strong><\/a><\/span>PLOS ONE, Oct 16, 2023.<\/span><\/span><span style=\"font-weight: normal\"><\/span><\/p>\n<p><span style=\"font-weight: normal\"><\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-weight: normal\">S. <\/span><span style=\"font-weight: normal\">Ghaffari.\u00a0<span style=\"color: #000000\"><a style=\"color: #000000\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36473018\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Hematopoietic stem cell quiescence exposed using mitochondrial membrane potential.<\/strong><\/a>\u00a0<span style=\"color: #000000\">Current Opinion in Hematology,<\/span><\/span><span style=\"color: #000000\"><span class=\"cit\">\u00a0Jan 1, 2023.\u00a0<\/span><\/span><\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-weight: normal\"><span style=\"color: #000000\"><span class=\"cit\"><\/span><\/span><\/span><\/p>\n<h3><span style=\"text-decoration: underline;font-size: 22px;font-weight: normal;color: #000000\"><strong><\/strong><\/span><\/h3>\n<h3><span style=\"text-decoration: underline;font-size: 22px;font-weight: normal;color: #000000\"><strong>2022<\/strong><\/span><\/h3>\n<p><span style=\"text-decoration: underline;font-size: 22px;font-weight: normal;color: #000000\"><strong><\/strong><\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-size: medium;font-weight: normal\">Qiu J. and S. Ghaffari. <span style=\"color: #000000\"><a style=\"color: #000000\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35908627\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Mitochondrial deep dive into hematopoietic stem cell dormancy: not much glycolysis but plenty of sluggish lysosomes.<\/strong><\/a> Experimental Hematology online, July 29, 2022.<\/span><\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-weight: normal\"><span style=\"font-size: 16px\">Qiu J., Menon V., Tzavaras N., Liang R., and S.<\/span>\u00a0Ghaffari<span style=\"font-size: 16px\">. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36595934\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\"><strong>A protocol for identifying and analyzing\u00a0 mouse and human quiescent hematopoietic stem cells using flow cytometry and confocal imaging.<\/strong><\/span><\/a><\/span><span style=\"color: #000000\">\u00a0STAR Protocols,\u00a0<span class=\"cit\">Dec 16, 2022.<\/span><\/span><\/span><\/p>\n<h3><span style=\"text-decoration: underline;font-weight: normal\"><span style=\"color: #000000;text-decoration: underline\"><strong><\/strong><\/span><\/span><\/h3>\n<h3><span style=\"text-decoration: underline;font-weight: normal\"><span style=\"color: #000000;text-decoration: underline\"><strong><\/strong><\/span><\/span><\/h3>\n<h3><span style=\"text-decoration: underline;font-weight: normal\"><span style=\"color: #000000;text-decoration: underline\"><strong><\/strong><\/span><\/span><\/h3>\n<h3><span style=\"text-decoration: underline;font-weight: normal\"><span style=\"color: #000000;text-decoration: underline\"><strong>2020 &#8211; 2021<\/strong><\/span><\/span><\/h3>\n<p><span style=\"text-decoration: underline;font-weight: normal\"><span style=\"color: #000000;text-decoration: underline\"><strong><\/strong><\/span><\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-size: medium;font-weight: normal\">Liang R.<sup>*<\/sup>, Arif T.<sup>*<\/sup>, Kalmykova S., Kasianov\u00a0A., Lin\u00a0M., Menon\u00a0V., Qiu\u00a0J., Bernitz\u00a0J., Moore\u00a0K., Lin\u00a0F., Benson D., Tzavaras\u00a0N., Mahajan\u00a0M., Papatsenko\u00a0D., and S. Ghaffari.\u00a0<span style=\"color: #0c71c3\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1934590920300138\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\"><strong>Restraining lysosomal activity preserves <\/strong><strong>\u00a0hematopoietic s<\/strong><\/span><\/a><strong><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1934590920300138\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">tem cell quiescence and potency.<\/span><\/a>\u00a0<\/strong><\/span><span style=\"color: #000000\">Cell Stem Cell,\u00a0Mar 5, 2020. <\/span><\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-size: medium;font-weight: normal\">Ghaffari S.<span style=\"color: #e27c00\">\u00a0<\/span><strong><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1934590921000679\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">Lysosomal regulation of metabolism in quiescent hematopoietic stem cells: more than just autophagy. <\/span><\/a><\/strong><span style=\"color: #000000\">Cell Stem Cell,\u00a0<\/span><span style=\"color: #000000\">Mar 4, 2021.<\/span><\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-size: medium;font-weight: normal\">Qiu J., Gjini J., Arif T., Moore K., Lin M., and S. Ghaffari.<strong>\u00a0<span style=\"color: #000000\"><a style=\"color: #000000\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33710339\/\" target=\"_blank\" rel=\"noopener noreferrer\">Using mitochondrial activity to select for potent human hematopoietic stem cells<\/a>. <\/span><\/strong><span style=\"color: #000000\">Blood Adv., Mar 23, 2021.\u00a0<\/span><\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-size: medium;font-weight: normal\">Liang R., Menon V., Qiu J., Arif T., Renuse S., Lin M., Nowak R., Hartmann B., Tzavaras N., Benson D., Chipuk J., Fribourg M.,\u00a0 Pandey A., Fowler V., and S. Ghaffari.<strong><span style=\"color: #000000\"><a style=\"color: #000000\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34032849\/\" target=\"_blank\" rel=\"noopener noreferrer\"> Mitochondrial localization and moderated activity are key to murine erythroid enuclea<span style=\"color: #000000\">tion<\/span><\/a>. <\/span><\/strong><span style=\"color: #000000\">Blood Adv.,<\/span><strong><span style=\"color: #000000\">\u00a0<\/span><\/strong><span style=\"color: #000000\"><span class=\"cit\"><span style=\"color: #000000\">May 25, 2<\/span>021.<\/span><\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\"><span style=\"font-size: medium\">Menon V. and S. Ghaffari.<\/span><a style=\"font-family: 'Noto Sans';font-size: medium;font-weight: normal\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33440185\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\"><strong> Erythroid enucleation: A gateway into a \u201cbloody\u201d world.<\/strong><\/span><\/a><span style=\"font-size: medium\">\u00a0<\/span><span style=\"color: #000000\">Experimental<\/span><span style=\"color: #000000;font-size: medium\">\u00a0Hematology, Mar, 2021.\u00a0<\/span><\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-size: medium;font-weight: normal\">Tremblay D., Rapp J., Alpert N., Lieberman-Cribbin W., Mascarenhas J., Taioli E., and S. Ghaffari.<strong><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/jha2.167\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\"> Mild anemia as a single independent predictor of mortality in patients with COVID-19.<\/span><\/a><\/strong><span style=\"color: #000000\"> eJHaem,\u00a0<\/span><span style=\"color: #000000\"><span class=\"epub-date\">May 6, 2021.<\/span><span class=\"epub-date\">\u00a0<\/span><\/span><\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-size: medium;font-weight: normal\">Rapp J., Tremblay D., Alpert N., Lieberman-Cribbin W., Mascarenhas J., Taioli E., and S. Ghaffari.<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/jmv.27011\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\"><strong> Red cell distribution width is associated with mortality in non-anemic patients with COVID-19.<\/strong><\/span> <\/a><span style=\"color: #000000\">Journal of Medical Virology, Apr 10, 2021.\u00a0<\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\">\u00a0<\/span><\/p>\n<h3><span style=\"text-decoration: underline;font-weight: normal\"><strong>2019<\/strong><\/span><\/h3>\n<p><span style=\"text-decoration: underline;font-weight: normal\"><strong><\/strong><\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-size: medium;font-weight: normal\">Filippi MD. and S. Ghaffari. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30808633\" target=\"_blank\" rel=\"noopener noreferrer\"><strong><span style=\"color: #e27c00\"><span style=\"color: #000000\">Mitochondria in the maintenance of hematopoietic stem cells: new perspectives and opportunities. <\/span><\/span><\/strong><span style=\"color: #e27c00\"><span style=\"color: #000000\">Blood,<\/span><\/span><\/a><span style=\"color: #000000\">\u00a0May 2, 2019.<\/span><\/span><\/p>\n<p><span style=\"font-size: medium;font-weight: normal\">Liang R., Menon V., and S. Ghaffari. <span style=\"color: #0c71c3\"><span style=\"color: #000000\"><strong><a style=\"color: #000000\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30414157\" target=\"_blank\" rel=\"noopener noreferrer\">Following transcriptome to uncover FOXO biological functions. <\/a><\/strong>Methods in Molecular Biology,<\/span><\/span><span style=\"color: #000000\">\u00a02019.<\/span><\/span><\/p>\n<h3><\/h3>\n<p><span style=\"font-weight: normal\">\u00a0<\/span><\/p>\n<h3><span style=\"text-decoration: underline;font-weight: normal\"><strong>2018<\/strong><\/span><\/h3>\n<p><span style=\"text-decoration: underline;font-weight: normal\"><strong><\/strong><\/span><\/p>\n<p><span style=\"font-weight: normal\"><span style=\"color: #808080\">Liu J., Duan Z., Guo W., Zeng L., Wu Y., Chen Y., Tai F., Wang Y., Lin Y., Zhang Q., He Y., Deng J., Stewart R., Wang C., Lin P., Ghaffari S., Evers B., Liu S., Zhou M., Zhou B., and J. Shi.<\/span><strong style=\"color: #000000\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6281582\/pdf\/41467_2018_Article_7258.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">\u00a0<span style=\"color: #000000\">Targeting the BRD4\/FOXO3a\/CDK6 axis sensitizes AKT inhibition in luminal breast cancer.\u00a0<\/span><\/a><\/strong><span style=\"color: #000000\"><a style=\"color: #000000\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6281582\/pdf\/41467_2018_Article_7258.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><span role=\"menubar\">Nature Communication<\/span><\/a><span role=\"menubar\"><a style=\"color: #000000\" title=\"Nature communications.\" role=\"menuitem\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30518851#\">,\u00a0<\/a><\/span><\/span><span style=\"color: #000000\">Dec 5, 2018.\u00a0<\/span><\/span><\/p>\n<p><span style=\"color: #000000;font-weight: normal\"><span style=\"color: #808080\">Liang R. and S. Ghaffari.<span style=\"color: #000000\">\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29433739\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\"><strong>Stem cells seen through the FOXO lens: an evolving paradigm.<\/strong><\/span>\u00a0<span style=\"color: #000000\">Current Topics in Developmental Biology,<\/span><\/a><span style=\"color: #000000\">\u00a02018.\u00a0<\/span><\/span><\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-weight: normal\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29782339\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #808080\">Menon V. and S. Ghaffari.<\/span> <span style=\"color: #000000\"><strong>Transcription factors FOXO in the regulation of homeostatic hematopoiesis.<\/strong><\/span>\u00a0<span style=\"color: #000000\">Current Opinions in Hematology,\u00a0<\/span><\/a><span style=\"color: #000000\"><a style=\"color: #000000\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29782339\/\" target=\"_blank\" rel=\"noopener noreferrer\">July 2018.<\/a><\/span><\/span><\/p>\n<h3><\/h3>\n<p><span style=\"font-weight: normal\">\u00a0<\/span><\/p>\n<h3><span style=\"text-decoration: underline;font-weight: normal\"><strong><\/strong><\/span><\/h3>\n<h3><span style=\"text-decoration: underline;font-weight: normal\"><strong>2017<\/strong><\/span><\/h3>\n<p><span style=\"text-decoration: underline;font-weight: normal\"><strong><\/strong><\/span><\/p>\n<p><span style=\"font-weight: normal\"><span style=\"color: #808080\">Bigarella C.L., Li J., Rimmel\u00e9 P., Liang R., Izac B., Sobol, R.W., and S. Ghaffari.<\/span><strong>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27994057\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">FOXO3 is essential for protecting hematopoietic stem and progenitor cells from oxidative DNA damage. <\/span><\/a><\/strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27994057\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">Journal of Biological Chemistry<\/span><\/a>,\u00a0<span style=\"color: #000000\">2017.<\/span><\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"color: #333333;font-weight: normal\"><span style=\"color: #808080\">Liang R. and S. Ghaffari.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28639090\" target=\"_blank\" rel=\"noopener noreferrer\"><strong><span style=\"color: #000000\">Mitochondria and FOXO3 in stem cell homeostasis, a window into hematopoietic stem cell fate determination. <\/span><\/strong><span style=\"color: #000000\">Journal of Bioenergetics and Biomembranes,<\/span><\/a><span style=\"color: #000000\">\u00a0Jun 21, 2017.<\/span><\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\">\u00a0<\/span><\/p>\n<h3><span style=\"text-decoration: underline;font-weight: normal\"><strong>2016<\/strong><\/span><\/h3>\n<p><span style=\"text-decoration: underline;font-weight: normal\"><strong><\/strong><\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-weight: normal\">Liang R., Rimmel\u00e9 P., Bigarella C.L., Yalcin S., and S. Ghaffari.\u00a0<strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26929388\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">Evidence for AKT-independent regulation of FOXO1 and FOXO3 in hematopoietic stem and progenitor Cells. <\/span><\/a><\/strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26929388\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">Cell Cycle,<\/span><\/a><span style=\"color: #000000\">\u00a0Feb 29, 2016.<\/span><\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-weight: normal\"><span style=\"color: #808080\"><a style=\"color: #808080\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26940015\" target=\"_blank\" rel=\"noopener noreferrer\">Liang R. and\u00a0S. Ghaffari. <\/a><\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27442953\" target=\"_blank\" rel=\"noopener noreferrer\"><strong><span style=\"color: #000000\">Advances in understanding the mechanisms of erythropoiesis homeostasis and disease. <\/span><\/strong><span style=\"color: #000000\">British Journal of Haematology<\/span><\/a><span style=\"color: #000000\">,\u00a02016.<\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\">\u00a0<\/span><\/p>\n<h3><span style=\"text-decoration: underline;font-weight: normal\"><strong>2015<\/strong><\/span><\/h3>\n<p><span style=\"text-decoration: underline;font-weight: normal\"><strong><\/strong><\/span><\/p>\n<p><span style=\"font-weight: normal\">Rimmel\u00e9 P*., Liang R*., Bigarella C*., Zhang A., Sadek H., and S. Ghaffari.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26209246\" target=\"_blank\" rel=\"noopener noreferrer\"><strong><span style=\"color: #000000\">Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3. <\/span><\/strong><span style=\"color: #000000\">EMBO Reports<\/span><\/a><span style=\"color: #000000\">, Sep 2015.<\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\">Liang R*., Camprecios G*., Kou Y., McGrath K., Nowak R., Catherman S., Bigarella C.L., Rimmel\u00e9 P., Zhang X., <span style=\"color: #666666\"><a style=\"color: #666666\" title=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Gnanapragasam MN[Author]&amp;cauthor=true&amp;cauthor_uid=26452208\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Gnanapragasam%20MN%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=26452208\">Gnanapragasam M.N.<\/a>,<\/span> Bieker J.J., Papatsenko D., Ma\u2019yan A., Bresnick E., Fowler V., Palis J., and S. Ghaffari.<span style=\"color: #000000\"><a style=\"color: #000000\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26452208\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u00a0<\/a><\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26452208\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong><span style=\"color: #000000\">A systems approach identifies essential FOXO3\u2019s functions at key steps of terminal erythropoiesis. <\/span><\/strong><span style=\"color: #000000\">PLoS Genetics, Oct 9,<\/span><span style=\"color: #000000\">\u00a0<\/span><\/a><span style=\"color: #000000\">2015.<\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\">Price J., Idoyaga J., Salmon H., Hogstad B., Bigarella C., Ghaffari S., Leboeuf M., and M. Merad.\u00a0<a href=\"https:\/\/www.nature.com\/articles\/ni.3270\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\"><strong>CDKN1A regulates Langerhans cell survival and promotes Treg cell generation upon exposure to ionizing irradiation.<\/strong>\u00a0Nature Immunology, Oct<\/span><\/a><span style=\"color: #000000\"> 2015.<\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\">\u00a0<\/span><\/p>\n<h3><span style=\"text-decoration: underline;font-weight: normal\"><strong>2014<\/strong><\/span><\/h3>\n<p><span style=\"text-decoration: underline;font-weight: normal\"><strong><\/strong><\/span><\/p>\n<p><span style=\"font-weight: normal\"><span style=\"color: #000000\"><span style=\"color: #808080\">Rimmel\u00e9 P., Bigarella C.L., Liang R., Izac B., Dieguez-Gonzalez R., Barbet G., Donovan M., Brugnara C., Blander J.M., Sinclair D.A., and S. Ghaffari.<\/span> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25068121\" target=\"_blank\" rel=\"noopener noreferrer\"><strong><span style=\"color: #000000\">Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells.<\/span> <\/strong><\/a><\/span><span style=\"color: #000000\"><a style=\"color: #000000\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25068121\" target=\"_blank\" rel=\"noopener noreferrer\">Stem Cell Reports,\u00a0<\/a>2014.<\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\"><span style=\"font-size: 16px;color: #808080\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0In the news:\u00a0<\/span><a style=\"font-family: 'Noto Sans';font-size: 16px\" href=\"https:\/\/www.sciencedaily.com\/releases\/2014\/06\/140609205023.htm\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\"><strong>Protein that keeps blood stem cells healthy as they age identified by researchers<\/strong>. Science Daily,<\/span><\/a><span style=\"color: #000000;font-size: 16px\">\u00a0<\/span><span style=\"font-size: 16px;color: #808080\"><span style=\"color: #000000\">June 9, 2014.<\/span>\u00a0<\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\"><span style=\"color: #000000\"><span style=\"color: #808080\">S.\u00a0Ghaffari.<\/span>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24421322\" target=\"_blank\" rel=\"noopener noreferrer\"><strong><span style=\"color: #000000\">PIAS adds methyl-bias to HSC-differentiation.<\/span> <\/strong><\/a><\/span><span style=\"color: #000000\"><a style=\"color: #000000\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24421322\" target=\"_blank\" rel=\"noopener noreferrer\">EMBO Journal.\u00a0<\/a>2014.\u00a0<\/span><\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-weight: normal\"><span style=\"font-size: 16px\">Rimmel\u00e9 P., Lofek S., and S. Ghaffari. <\/span><strong style=\"font-family: 'Noto Sans';font-size: 16px\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25163926\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">Resveratrol increases the bone marrow hematopoietic stem and progenitor cell capacity<\/span>. <\/a><\/strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25163926\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">American Journal of Hematology,<\/span><\/a> <span style=\"font-size: 16px;color: #000000\">2014.<\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\">Bigarella, C.*, Liang R.*, and S. Ghaffari.\u00a0<strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25371358\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">Stem cells and the impact of ROS signaling. <\/span><\/a><\/strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25371358\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">Development, 2014.<\/span><\/a><\/span><\/p>\n<p><span style=\"font-weight: normal\">Zhang X., Camprecios G., Yalcin S., Mungamuri S.H., Barminko J., Rimmele P., Liang R., Baron M., Brugnara C., Papatsenko D., Rivella S., and S. Ghaffari. <strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24966026\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">FOXO3-mTOR metabolic cooperation in the regulation of erythroid cell maturation and homeostasis. <\/span><\/a><\/strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24966026\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">American Journal of Hematology<\/span><\/a><span style=\"color: #000000\">,<\/span>\u00a0<span style=\"color: #000000\">2014.<\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\">McIver S.C., Kang Y.A., DeVilbiss A.W., O\u2019Driscoll C.A., Ouellette J.N., Pope N.J., Camprecios G., Chang C-J, Yang D., Bouhassira E.E., S. Ghaffari, and E.H. Bresnick. <a href=\"https:\/\/ashpublications.org\/blood\/article\/124\/14\/2285\/33116\/The-exosome-complex-establishes-a-barricade-to\" target=\"_blank\" rel=\"noopener noreferrer\"><strong><span style=\"color: #000000\">The Exosome complex establishes a barricade to erythroid maturation.\u00a0<\/span><\/strong><span style=\"color: #000000\">Blood<\/span><\/a><span style=\"color: #000000\"><a href=\"https:\/\/ashpublications.org\/blood\/article\/124\/14\/2285\/33116\/The-exosome-complex-establishes-a-barricade-to\" target=\"_blank\" rel=\"noopener noreferrer\">,<\/a> 2014.<\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\">Liang R. and S. Ghaffari. <strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24383555\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">Stem cells, redox signaling, and stem cell aging.<\/span> <\/a><\/strong><span style=\"color: #000000\"><a style=\"color: #000000\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24383555\">Antioxidant and Redox Signaling<\/a>,\u00a0Apr 20, 2014.<\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\">\u00a0<\/span><\/p>\n<h3><span style=\"text-decoration: underline;font-weight: normal\"><strong>2011 &#8211; 2013<\/strong><\/span><\/h3>\n<p><span style=\"text-decoration: underline;font-weight: normal\"><strong><\/strong><\/span><\/p>\n<p><span style=\"font-weight: normal\"><span style=\"font-size: 16px\">Ramos P., Casu C., Gardenghi S., Breda L., Crielaard B., Guy E., Marongiu M.F., Gupta R., Levine R.L., Abdel-Wahab O., Ebert B.L., Van Rooijen N., Ghaffari S., Grady R.W., Giardina P.J., and S. Rivella. <\/span><a style=\"font-family: 'Noto Sans';font-size: 16px\" href=\"https:\/\/www.nature.com\/articles\/nm.3126\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\"><strong>Macrophages support pathological erythropoiesis in polycythemia vera and -thalassemia.<\/strong><\/span><strong>\u00a0<\/strong><\/a><span style=\"font-size: 16px;color: #000000\"><a style=\"color: #000000\" href=\"https:\/\/www.nature.com\/articles\/nm.3126\">Nature Medicine<\/a>, Mar 17, 2013.<\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\">Zhang X., Yalcin S., Lee D.F., Lee S-M, Yeh T.Y.J., Jie S., Kennedy M., Sellers R., Landthaler, M., Tuschl T, Chi N.W., Lemischka I., Keller G., and S. Ghaffari.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21804543\" target=\"_blank\" rel=\"noopener noreferrer\"><strong><span style=\"color: #000000\">FOXO1 is an essential regulator of pluripotency in human embryonic stem cells.<\/span><\/strong><span style=\"color: #000000\"> Nature Cell Biology, July 21, 2011.<\/span><\/a><\/span><\/p>\n<p><span style=\"font-weight: normal\">Zhang X., Rielland M., Yalcin S., and S. Ghaffari. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21443463\" target=\"_blank\" rel=\"noopener noreferrer\"><strong><span style=\"color: #000000\">Regulation and function of FoxO transcription factors in normal and cancer stem cells: what have we learned? <\/span><\/strong><span style=\"color: #000000\">Current Drug Targets<\/span><\/a><span style=\"color: #000000\">, Aug 1, 2011.<\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\">S. Ghaffari.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22162726\" target=\"_blank\" rel=\"noopener noreferrer\"><strong><span style=\"color: #000000\">Cancer, stem cells and cancer stem cells: old ideas, new developments. <\/span><\/strong><span style=\"color: #000000\">F1000 Medicine Reports, Dec 1,<\/span><\/a><span style=\"color: #000000\"> 2011.<\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\">Rimmel\u00e9 P., Zhang X., and S. Ghaffari.<strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22480644\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\"> FoxO proteins in the control of stem cells. <\/span><\/a><\/strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22480644\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">Revue M\u00e9decine Sciences. <\/span><\/a><span style=\"color: #000000\">2012.<\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\"><span style=\"color: #000000\"><\/span><\/span><\/p>\n<h3><\/h3>\n<h3><span style=\"text-decoration: underline;font-weight: normal\"><strong>2006 &#8211; 2010<\/strong><\/span><\/h3>\n<p><span style=\"text-decoration: underline;font-weight: normal\"><strong><\/strong><\/span><\/p>\n<p><span style=\"font-weight: normal\"><span style=\"color: #808080\">Yalcin S., Marinkovic D., Mungamuri S.K., Zhang X., Tong W., and S. Ghaffari.<\/span> <strong style=\"color: #000000\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21113129\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">ROS-mediated amplification of AKT\/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-\/-) mice. <\/span><\/a><\/strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21113129\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">EMBO Journal,\u00a0<\/span><\/a><span style=\"color: #000000\">Nov 26, 2010.<\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\"><span style=\"color: #808080\">Yu D., dos Santos C.O., Zhao G., Jiang J., Amigo J.D., Khandros E., Dore L.C., Yao Y., D\u2019Souza J., Zhang Z., Ghaffari S., Choi J., Friend S., Tong W., Orange J.S., Paw B.H., and M.J. Weiss.<\/span> <strong><span style=\"color: #000000\"><a style=\"color: #000000\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20679398%20\" target=\"_blank\" rel=\"noopener noreferrer\">miR-451 protects against erythroid oxidant stress by repressing 14-3-3z.<\/a> <\/span><\/strong><span style=\"color: #000000\"><span role=\"menubar\"><a role=\"menuitem\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2912560\/#\" style=\"color: #000000\">Genes and Development,\u00a0<\/a><\/span><\/span><span style=\"color: #000000\">2010.\u00a0<\/span><\/span><\/p>\n<p><span style=\"color: #808080;font-weight: normal\">Yalcin S., Zhang X., Marinkovic D., Luciano J.P., Sarkar A., Brugnara C., Vercherat C., Taneja R., and S. Ghaffari. <strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18424439\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. <\/span><\/a><\/strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18424439\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">Journal of Biological Chemistry,<\/span><\/a><span style=\"color: #000000\">\u00a02008.<\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\">Marinkovic D., ZhangX., Yalcin S., Brugnara C., Huber T., and\u00a0S. Ghaffari. <strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17671650\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">Foxo3 is required for the regulation of oxidative stress in erythropoiesis. <\/span><\/a><\/strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17671650\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">Journal of Clinical Investigation<\/span><\/a><span style=\"color: #000000\">, 2007.<\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\">Sun H., Ghaffari S.,<strong>\u00a0<\/strong>and R. Taneja. <strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23641148\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">bHLH-Orange transcription factors in development and cancer.<\/span> <\/a><\/strong><span style=\"color: #000000\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23641148\" target=\"_blank\" rel=\"noopener noreferrer\" style=\"color: #000000\">Translational Oncogenomics,<\/a>\u00a02007.<\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\">S.\u00a0Ghaffari. <strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18707226\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">Oxidative stress in the regulation of normal and neoplastic hematopoiesis.\u00a0(Forum Issue). <\/span><\/a><\/strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18707226\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">Antioxidants &amp; Redox Signaling<\/span><\/a><span style=\"color: #000000\">, 2008.\u00a0<\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\">Jagani Z., Song K., Kutok J.L., Dewar M.R., Melet A., Santos T., Grassian A., Ghaffari S., Wu C., Ren R., Rodin H.Y., Miller K., Khosravi-Far R. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19654305\" target=\"_blank\" rel=\"noopener noreferrer\"><strong><span style=\"color: #000000\">Proteasome inhibition causes regression of leukemia and abrogates BCR-ABL-induced evasion of apoptosis in part through regulation of forkhead tumor suppressors.<\/span><\/strong><span style=\"color: #000000\"> Cancer Research,<\/span><\/a><span style=\"color: #000000\">\u00a02009.<\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\">Vercherat C., Chung T.K., Yalcin S., Gulbagci N., Gopinadhan S., Ghaffari S., and R. Taneja. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19679564\" target=\"_blank\" rel=\"noopener noreferrer\"><strong><span style=\"color: #000000\">Stra13 regulates oxidative stress mediated skeletal muscle degeneration. <\/span><\/strong><span style=\"color: #000000\">Human Molecular Genetics<\/span><\/a><span style=\"color: #000000\">, 2009.<\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\">Pervaiz S., Taneja R., and S. Ghaffari. <strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19650689\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">Oxidative stress regulation of stem and progenitor cells. (Forum Issue). <\/span><\/a><\/strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19650689\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">Antioxidants &amp; Redox Signaling<\/span><\/a><span style=\"color: #000000\">, 2009.\u00a0<\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\">\u00a0<\/span><\/p>\n<h3><span style=\"text-decoration: underline;font-weight: normal\"><strong>2003 &#8211; 2005<\/strong><\/span><\/h3>\n<p><span style=\"text-decoration: underline;font-weight: normal\"><strong><\/strong><\/span><\/p>\n<p><span style=\"font-weight: normal\"><span style=\"color: #000000\"><a class=\"view\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1895894\/\"><span style=\"color: #808080\">Zhao W., Kitidis C., Fleming M.D., Lodish H.F., and S. Ghaffari.\u00a0<\/span><\/a><strong><span style=\"color: #000000\"><a class=\"view\" style=\"color: #000000\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1895894\/\" target=\"_blank\" rel=\"noopener noreferrer\">Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase\/AKT signaling pathway<\/a><\/span><span style=\"color: #000000\"><a class=\"view\" style=\"color: #000000\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1895894\/\" target=\"_blank\" rel=\"noopener noreferrer\">.<\/a><\/span><a class=\"view\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1895894\/\">\u00a0<\/a><\/strong><\/span><span style=\"color: #000000\"><a class=\"view\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1895894\/\" style=\"color: #000000\">Blood, Feb 1,\u00a0<\/a><a class=\"view\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1895894\/\" style=\"color: #000000\"><span class=\"citation-publication-date\">2006<\/span><\/a>.<\/span><\/span><\/p>\n<p><span style=\"color: #000000;font-weight: normal\"><span style=\"color: #808080\"><span class=\"doi\">Ghaffari S., Kitidis C., Zhao W., Marinkovic D., Fleming M.D., Luo B., Marszalek J., and H F. Lodish.<\/span><strong><span class=\"doi\">\u00a0<a class=\"view\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1895702\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">AKT induces erythroid-cell maturation of JAK2-deficient fetal liver progenitor cells and is required for Epo regulation of erythroid-cell differentiation. <\/span><\/a><\/span><\/strong><span class=\"doi\"><a class=\"view\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1895702\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">Blood,<\/span><\/a><\/span><span class=\"doi\"><span style=\"color: #000000\">\u00a0Mar 1,\u00a0<\/span><\/span><span style=\"color: #000000\"><span class=\"doi\"><span class=\"citation-publication-date\">2006.<\/span><\/span><\/span><\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\"><span class=\"doi\">Ghaffari S., Jagani Z., Kitidis C., Lodish H.F., and R. Khosravi-Far.\u00a0<\/span><strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12750477\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">Cytokines and BCR-ABL mediate suppression of TRAIL-induced apoptosis through inhibition of forkhead FOXO3a transcription factor. <\/span><\/a><\/strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12750477\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #000000\">Proceedings of the National Academy of Science<\/span><\/a>,\u00a0<span style=\"color: #000000\"><span class=\"citation-publication-date\">May 27, 2003.<\/span><\/span><\/span><\/p>\n<p><span style=\"font-weight: normal\"><span style=\"color: #000000\"><span class=\"citation-publication-date\"><\/span><\/span><\/span><\/p>\n<p><span style=\"font-family: 'Noto Sans';font-weight: normal\"><span style=\"color: #000000\"><span class=\"citation-publication-date\"><\/span><\/span><\/span><\/p>\n<p><span style=\"font-family: 'Noto Sans';font-weight: normal\"><span class=\"\"><\/span><\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>KEY PUBLICATIONS2024-2025 Arif T.*, Qiu J.*, Khademian H., Lohithakshan A., Menon, A., Menon V., Slavinsky, M., Batignes M., Lin M., Sebra R., Beaumont K., Benson D.L., Tzavaras N., M\u00e9nager M., and S. Ghaffari. Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells.\u00a0Cell Stem Cell, Dec 4, 2025. Bigarella C., Liang R., Bourova-Flin E., [&hellip;]<\/p>\n","protected":false},"author":391,"featured_media":0,"parent":0,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<p>2019 \u00a0 Liang R, Menon V and Ghaffari S. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30414157\" target=\"_blank\" rel=\"noopener\">Following Transcriptome to Uncover FOXO Biological Functions.<\/a> Methods Mol Biol. 2019;1890:219-227. doi: 10.1007\/978-1-4939-8900-3_18.<\/p>","_et_gb_content_width":"","footnotes":""},"class_list":["post-11","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/ghaffarilab\/wp-json\/wp\/v2\/pages\/11","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/ghaffarilab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/ghaffarilab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/ghaffarilab\/wp-json\/wp\/v2\/users\/391"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/ghaffarilab\/wp-json\/wp\/v2\/comments?post=11"}],"version-history":[{"count":192,"href":"https:\/\/labs.icahn.mssm.edu\/ghaffarilab\/wp-json\/wp\/v2\/pages\/11\/revisions"}],"predecessor-version":[{"id":2176,"href":"https:\/\/labs.icahn.mssm.edu\/ghaffarilab\/wp-json\/wp\/v2\/pages\/11\/revisions\/2176"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/ghaffarilab\/wp-json\/wp\/v2\/media?parent=11"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}