{"id":118,"date":"2016-09-19T16:27:23","date_gmt":"2016-09-19T16:27:23","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/gelblab\/?page_id=118"},"modified":"2021-06-23T15:46:04","modified_gmt":"2021-06-23T15:46:04","slug":"team","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/gelblab\/team\/","title":{"rendered":"Team"},"content":{"rendered":"

Investigator :<\/h1>\n

\"\" \u00a0 \u00a0<\/a>Bruce D Gelb\u00a0 \u00a0MD<\/strong>\u00a0 Professor<\/p>\n

\u00a0bruce.gelb@mssm.edu<\/em><\/span><\/h5>\n

DIRECTOR MINDICH CHILD HEALTH AND DEVELOPMENT INSTITUTE<\/p>\n

PROFESSOR | Pediatrics, Cardiology<\/p>\n

PROFESSOR | Genetics and Genomic Sciences<\/p>\n

Research Topics:<\/strong><\/h2>\n

Cardiovascular, Gene Discovery, Human Genetics and Genetic Disorders, Signal Transduction, Stem Cells.<\/p>\n

<\/h1>\n

Faculty :<\/h1>\n

\"\" \u00a0 \u00a0<\/a>Amy Kontorovich\u00a0 MD PhD<\/strong>\u00a0Assistant Professor<\/p>\n

amy.kontorovich@mountsinai.org<\/em><\/span><\/p>\n

Myocarditis, most often caused by viral infection, is associated with considerable morbidity and mortality in adults and children, causing more than 10% of cases of dilated cardiomyopathy and sudden cardiac death in adults. Little is known about the pathogenesis of viral infection or replication in human myocardium. We have overcome this challenge by developing an in vitro model of myocarditis using human induced pluripotent stem cells. Cardiotropic viruses are quite common in the environment, with over half the population seropositive for coxsackievirus, yet most infected individuals have no apparent clinical manifestations and the vast majority never develop myocarditis. Human genetic variation may therefore be important in the phenotypic evolution of myocarditis and may determine the fate of disease in infected individuals. Hence, we are investigating genetic factors that underlie individual predilection towards versus protection from myocardial injury following viral infection.<\/span><\/p>\n

 <\/p>\n

Resident:<\/h1>\n

 <\/p>\n

\"\" \u00a0 <\/a>Felix Richter<\/strong>\u00a0\u00a0MD PhD<\/strong> Pediatrics Resident Physician<\/p>\n

felix.richter@mssm.edu<\/a><\/span><\/div>\n
Felix Richter is a current Pediatrics Resident Physician and graduate of the ISMMS MD\/PhD program. He conducted his thesis work on the genetics of congenital heart disease (CHD) under the mentorship of Bruce Gelb, MD, and Eric Schadt, PhD, demonstrating a role for noncoding de novo variation in CHD (Richter, et al, Nature Genetics, 2020). His past research has spanned whole genome sequencing, RNAseq, embryology, pediatrics, neuropsychiatric traits, cardiology, and Covid-19. As a member of the Gelb Lab, Felix is continuing his work on noncoding variation in larger cohorts and with ever-improving algorithms.<\/div>\n

<\/h1>\n

Post-Doctoral Fellows:<\/h1>\n

 <\/p>\n

\"\"<\/a> \u00a0 \u00a0<\/strong>Nelson Rodriguez<\/strong>\u00a0 \u00a0<\/strong>PhD<\/strong><\/p>\n

nelson.rodriguez@mssm.edu<\/em><\/span><\/p>\n

I utilize gene editing tools and iPSC technology to study mutations associated with congenital heart disease in children.<\/p>\n

 <\/p>\n

\"\" \u00a0 \u00a0<\/a>Kimberly Stephens\u00a0 PhD<\/strong><\/p>\n

kimberly.stephens2@mssm.edu<\/span><\/p>\n

I utilize a Drosophila model to test potential therapeutics on RASopathies<\/p>\n

 <\/p>\n

 <\/p>\n

Graduate Students:<\/h1>\n

 <\/p>\n

\"Clifford<\/a>\u00a0 \u00a0 \u00a0 Clifford Liu<\/strong><\/p>\n

\u00a0 \u00a0 \u00a0 clifford.liu@icahn.mssm.edu<\/span><\/p>\n

I am an MD\/PhD student in the Development, Regeneration, and Stem Cells training track. My thesis work is focused on elucidating allele-specific\u00a0mechanisms of hypertrophic cardiomyopathy in Noonan syndrome and related disorders. Additionally, I am interested in understanding the mechanisms hat cardiac valve defects in Noonan syndrome. Utilizing iPSC technology, atranscriptomics.\u00a0 I hope to uncover the mechanisms central to the\u00a0pathogenesis of these diseases. Outside the Lab, I enjoy working out and exploring the diverse New York City food scene.<\/p>\n

 <\/p>\n

\"\"<\/a>\u00a0 \u00a0Cindy Wang<\/strong><\/p>\n

\u00a0 \u00a0 \u00a0 \u00a0cindy.wang@icahn.mssm.edu<\/span><\/p>\n

I am a masters student in the Gelb Lab. My thesis is based on using CRIMIC technology to test the impact of RASopathy allels when expressed at physiologic levels.<\/p>\n

<\/h2>\n

Lab Members:<\/h1>\n

 <\/p>\n

\"\" \u00a0 \u00a0<\/a>Simon Ng<\/strong><\/p>\n

simon.hg1@mssm.edu<\/em><\/span><\/p>\n

Investigation of human genetic disposition of acute viral myocarditis using human iPSC-derived cardiomyocyte models.<\/p>\n

 <\/p>\n

\"\" \u00a0 \u00a0 <\/a>Priyal Agrawal<\/strong><\/p>\n

priyal.agrawal@mssm.edu<\/span><\/p>\n

I am involved in the screening and enrollment of subjects for clinical research studies such as GEMINI, Congenital Heart Disease Genetic NEtwork Study and Undiagnosed Disease Program.<\/p>\n

 <\/p>\n

 <\/p>\n

\"\" \u00a0 \u00a0 \u00a0<\/a>Sereene Kurzum<\/strong><\/p>\n

sereene.kurzum@mssm.edu<\/span><\/p>\n

I am an Associate Researcher with the Gelb Lab. My research focuses on the genetic and molecular causes and effects of the RASopathies as modeled in Drosophila.<\/p>\n

 <\/p>\n

Lab Management :<\/strong><\/h1>\n

\"jian's<\/a><\/p>\n

Jian Zhang<\/span><\/h3>\n

MD<\/span><\/p>\n

jian.zhang@mssm.edu<\/em><\/span><\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

Previous Lab Member:<\/h1>\n

 <\/p>\n

\"\" \u00a0 \u00a0 \u00a0<\/a>Se-Yeon PhD<\/strong><\/p>\n

\"\" \u00a0 \u00a0 <\/a>Tara Keshavarz Shirazi<\/em><\/strong><\/p>\n

\"\" \u00a0 \u00a0<\/a>Angelika Nitzl<\/strong><\/p>\n

\"\" \u00a0 \u00a0 \u00a0<\/a>Jared Gatto\u00a0<\/strong><\/p>\n

\"\"<\/a>\u00a0\u00a0 \u00a0 \u00a0<\/a>Nihir Patel\u00a0 \u00a0 MSc<\/strong><\/p>\n

\"\"\u00a0 \u00a0 \u00a0 <\/a>Meghan Mac Neal\u00a0 \u00a0MGC. MSc.<\/strong><\/p>\n

 <\/p>\n

 <\/p>\n

Devendran, Anichavezhi\u00a0 \u00a0PhD<\/strong><\/p>\n

 <\/p>\n

Past Trainees:<\/h1>\n

 <\/p>\n

\"\"<\/a>\u00a0 \u00a0Beccy Josowitz\u00a0 MD PhD<\/strong><\/p>\n

 <\/p>\n

\"\" \u00a0 <\/a>Sonia Mulero Navarro\u00a0 PhD<\/b><\/p>\n

 <\/p>\n

\"\"\u00a0 \u00a0 <\/a><\/strong>Jonathan Edward\u00a0 MD<\/strong><\/p>\n

 <\/p>\n

\"\" \u00a0 <\/a>Dhandapany Perundurai\u00a0 \u00a0PhD<\/strong><\/p>\n

 <\/p>\n

\"\"<\/a>\u00a0 \u00a0 <\/a>Kathryn Manheimer Ryn Manheimer\u00a0 PhD<\/strong><\/p>\n

 <\/p>\n

<\/div>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

<\/h4>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Investigator : \u00a0 \u00a0Bruce D Gelb\u00a0 \u00a0MD\u00a0 Professor \u00a0bruce.gelb@mssm.edu DIRECTOR MINDICH CHILD HEALTH AND DEVELOPMENT INSTITUTE PROFESSOR | Pediatrics, Cardiology PROFESSOR | Genetics and Genomic Sciences Research Topics: Cardiovascular, Gene Discovery, Human Genetics and Genetic Disorders, Signal Transduction, Stem Cells. Faculty : \u00a0 \u00a0Amy Kontorovich\u00a0 MD PhD\u00a0Assistant Professor amy.kontorovich@mountsinai.org Myocarditis, most often caused by viral […]<\/p>\n","protected":false},"author":705,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-118","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/gelblab\/wp-json\/wp\/v2\/pages\/118","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/gelblab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/gelblab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/gelblab\/wp-json\/wp\/v2\/users\/705"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/gelblab\/wp-json\/wp\/v2\/comments?post=118"}],"version-history":[{"count":104,"href":"https:\/\/labs.icahn.mssm.edu\/gelblab\/wp-json\/wp\/v2\/pages\/118\/revisions"}],"predecessor-version":[{"id":382,"href":"https:\/\/labs.icahn.mssm.edu\/gelblab\/wp-json\/wp\/v2\/pages\/118\/revisions\/382"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/gelblab\/wp-json\/wp\/v2\/media?parent=118"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}