{"id":2,"date":"2017-04-03T15:20:50","date_gmt":"2017-04-03T15:20:50","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/?page_id=2"},"modified":"2017-11-29T14:52:54","modified_gmt":"2017-11-29T14:52:54","slug":"sample-page","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/","title":{"rendered":"Welcome to the Garcia-Ocana Laboratory of Pancreatic Beta Cell Biology and Diabetes"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-29 alignleft\" src=\"https:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/wp-content\/uploads\/sites\/225\/2017\/04\/adolfo.jpg\" alt=\"\" width=\"130\" height=\"170\" \/>The Garcia-Ocana Laboratory\u00a0focuses on developing innovative and effective therapies for pancreatic beta cell preservation, immune tolerance and pancreatic beta cell regeneration for the treatment of diabetes.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<div id=\"attachment_43\" class=\"wp-caption alignright\" style=\"width: 300px\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-43 size-medium\" src=\"https:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/wp-content\/uploads\/sites\/225\/2017\/11\/ocana1-300x234.png\" alt=\"\" width=\"300\" height=\"234\" srcset=\"https:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/wp-content\/uploads\/sites\/225\/2017\/11\/ocana1-300x234.png 300w, https:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/wp-content\/uploads\/sites\/225\/2017\/11\/ocana1.png 476w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><p class=\"wp-caption-text\">Pancreatic Islet from an NOD mouse Insulin (green) B220 (red) CD3 (white) DAPI (blue)<\/p><\/div>\n<p>Conventional treatment of patients with diabetes relays on insulin injections. Unfortunately, hypo- and hyperglycemia may frequently occur and result in severe secondary complications. Diabetes is associated with progressive loss of functional pancreatic beta cells. In autoimmune type 1 diabetes (T1D), immune self-tolerance is lost leading to the destruction of pancreatic beta cells. Alternative therapies that enhance at the same time immune tolerance and pancreatic beta cell regeneration and protection could provide a more physiological approach for treating T1D.<\/p>\n<div id=\"attachment_45\" class=\"wp-caption alignleft\" style=\"width: 401px\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-45 size-full\" src=\"https:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/wp-content\/uploads\/sites\/225\/2017\/11\/ocanalabcropped.jpg\" alt=\"\" width=\"401\" height=\"286\" srcset=\"https:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/wp-content\/uploads\/sites\/225\/2017\/11\/ocanalabcropped.jpg 401w, https:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/wp-content\/uploads\/sites\/225\/2017\/11\/ocanalabcropped-300x214.jpg 300w\" sizes=\"auto, (max-width: 401px) 100vw, 401px\" \/><p class=\"wp-caption-text\">Intracellular Signaling in Rodent Beta Cells. Diabetes 2014 63:819-831.<\/p><\/div>\n<p>The pancreatic beta cell adapts to overnutrition, enhanced metabolic demand and insulin resistance by increasing its mass and function. This adaptation is orchestrated by signals derived from nutrient metabolism, growth factors and hormone signaling. Failure to expand in response to metabolic stress leads to excessive work load resulting in beta cell dysfunction, de-differentiation, death and development of type 2 diabetes (T2D).\u00a0 Understanding the mechanisms that regulate pancreatic beta cell adaptation to increased metabolic demand and insulin resistance is of great importance for the development of potential novel T2D modifying treatments.<\/p>\n<p><a href=\"https:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/research\/\">Read more.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Garcia-Ocana Laboratory\u00a0focuses on developing innovative and effective therapies for pancreatic beta cell preservation, immune tolerance and pancreatic beta cell regeneration for the treatment of diabetes. &nbsp; &nbsp; Conventional treatment of patients with diabetes relays on insulin injections. Unfortunately, hypo- and hyperglycemia may frequently occur and result in severe secondary complications. Diabetes is associated with [&hellip;]<\/p>\n","protected":false},"author":146,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-2","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/wp-json\/wp\/v2\/pages\/2","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/wp-json\/wp\/v2\/users\/146"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/wp-json\/wp\/v2\/comments?post=2"}],"version-history":[{"count":18,"href":"https:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/wp-json\/wp\/v2\/pages\/2\/revisions"}],"predecessor-version":[{"id":77,"href":"https:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/wp-json\/wp\/v2\/pages\/2\/revisions\/77"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/wp-json\/wp\/v2\/media?parent=2"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}