Selected publications (last 3 years):<\/p>\n
1. <\/b>J.C. Alvarez-Perez, S. Ernst, C. Demerci, G.P. Casinelli, J.M.D. Mellado-Gil, R.C. Vasavada, A. Garcia-Ocana. Hepatocyte Growth Factor\/c-Met signaling is required for \u00df-cell regeneration. Diabetes<\/i><\/b> 63:216-223, 2014.<\/p>\n
2. <\/b>J.C. Alvarez-Perez, T. C. Rosa, G. P. Casinelli, S. R. Valle, J. Lakshmipathi, C. Rosselot, F. Rausell-Palamos, R.C. Vasavada, and A. Garc\u00eda-Ocana. Hepatocyte growth factor (HGF) ameliorates hyperglycemia and corrects beta cell mass in IRS2 deficient mice. Mol Endo<\/i><\/b> 28:2038-48, 2014.<\/p>\n
3. <\/b>Garc\u00eda-Mart\u00edn A, Maycas M, Ardura JA, Lozano D, L\u00f3pez-Herrad\u00f3n A, Portal-N\u00fa\u00f1ez S, A Garc\u00eda-Oca\u00f1a, Esbrit P. Roles of the nuclear localization signal 88-107 sequence of parathyroid hormone-related protein (PTHrP) in osteoblastic cells. Mol Endo<\/i><\/b> 28:925\u2013934, 2014.<\/p>\n
4. <\/b>A. Garc\u00eda-Oca\u00f1a and A. F. Stewart. \u201cRAS\u201dling \u03b2 cells to proliferate for diabetes: why do we need MEN? J Clin Invest<\/i><\/b>, 124:3698-3700, 2014.<\/p>\n
5. <\/b>E. Bernal-Mizrachi, R. Kulkarni, D.K. Scott, F. Mauvais-Jarvis, A.F. Stewart and A. Garcia-Oca\u00f1a. Human \u00df-Cell Proliferation and Intracellular Signaling Part 2: Driving in the Dark without a Roadmap. Diabetes<\/i><\/b> 63:819-831, 2014.<\/p>\n
6. <\/b>A. Maffei, A.M. Segal, J.C. Alvarez-Perez , A. Garcia-Oca\u00f1a, and P. Harris. Anti-incretin, anti-proliferative action of dopamine on \u03b2-cells. Mol Endo<\/i><\/b> 29:542-557, 2015.<\/p>\n
7. <\/b>S. Ljubicic, K. Polak, J.M. Wiwczar, B. Szlyk, Y. Chang, J.C. Alvarez-Perez, G.H. Bird, L.D. Walensky, A. Garcia-Oca\u00f1a, N.N. Danial. Phospho-BAD Mimetic Strategies Protect \u00df-Cells and Restore Functional \u00df-Cell Mass in Diabetes. Cell Rep<\/i><\/b>, 10: 497\u2013504, 2015.<\/p>\n
8. <\/b>P. Wang, J.C. Alvarez-Perez, D.P. Felsenfeld, H. Liu, S. Sivendran, A. Bender, R.Sanchez, A. Kumar, D.K. Scott, A. Garcia-Oca\u00f1a, A.F. Stewart. Induction of Rodent and Human Pancreatic Beta Cell Replication by Inhibitors of Dual Specificity, Tyrosine-Regulated Kinase 1a. Nat Medicine<\/i><\/b>, 21:383-388, 2015.<\/p>\n
9. <\/b>P. Wang, N. Fiaschi-Taesch, R.C. Vasavada, D.K. Scott, A. Garcia-Oca\u00f1a, and A.F. Stewart.\u00a0 Advances and Challenges in Human Beta Cell Replication for Diabetes. Nat Rev Endo<\/i><\/b>, 11:201-212, 2015.<\/p>\n
10. <\/b>A.F. Stewart, M.A. Hussain, A. Garc\u00eda-Oca\u00f1a, R.C. Vasavada, A. Bhushan, E. Bernal-Mizrachi and R.N. Kulkarni. Human Beta Cell Proliferation and Intracellular Signaling: Part 3. Diabetes<\/i><\/b> 64:1872-85, 2015.<\/p>\n
11. <\/b>E. Shroff, L. Eberlin, V. Dang, A. Gouw, M. Gabay, S. Adam, D.L. Bellovin, P. Tran, W. Philbrick, A. Garcia-Ocana, S. Casey, Y. Li, C. Dang, R. Zare, D. Felsher. MYC Oncogene Overexpression Drives Renal Cell Carcinoma in a Mouse Model through Glutamine Metabolism. Proc Natl Acad Sci USA <\/i><\/b>112:6539-44, 2015.<\/p>\n
12. <\/b>N.K. Guthalu, R. Fenutria, I. Pollack, A. Garcia-Oca\u00f1a, J. Penninger, R.C. Vasavada. Osteoprotegerin and Denosumab stimulate human beta cell proliferation through inhibition of the Receptor Activator of NF-\u03baB Ligand pathway. Cell Metab<\/i><\/b>, 22:77-85, 2015.<\/p>\n
13. <\/b>T.V. Sanchez-Encinales, I. Cozar-Castellano, A. Garcia-Oca\u00f1a*, G. Perdomo*. Targeted delivery of HGF to the skeletal muscle improves glucose homeostasis in diet induced-obese mice. J Physiol Biochem <\/i><\/b>71:795-805, 2015. *Co-corresponding authors.<\/p>\n
14. <\/b>T. Zhang, D.H. Kim, X. Xiao, S. Lee, Z. Gong, R. Muzumdar, V. Calabuig-Navarro, J. Yamauchi, H. Harashima, R. Wang, R. Bottino, J. Carlos Alvarez-Perez, A. Garcia-Oca\u00f1a, G. Gittes, H. Dong. FoxO1 Plays An Important Role in Regulating Beta-Cell Compensation for Insulin Resistance in Male Mice. Endocrinology<\/i><\/b> 157:1055-70, 2016.<\/p>\n
15. <\/b>Y-C. Lai, D.M. Tabima, J.J. Dube, K.S. Hughan, R.R. Vanderpool, D.A. Goncharov, C.M. St Croix, A. Garcia-Oca\u00f1a, E.A. Goncharova, S.P. Tofovic, A.L. Mora, M.T. Gladwin. SIRT3-AMPK activation by nitrite and metformin improves hyperglycemia and normalizes pulmonary hypertension in heart failure with preserved ejection fraction (PH-HFpEF). Circulation<\/i><\/b>, 133:717-31, 2016.<\/p>\n
16. <\/b>R.E. Stamateris, R.B. Sharma, C.P. O\u2019Donnell, A. Garcia-Ocana, and L.C. Alonso. Glucose induces pancreatic beta cell cyclin D2 expression and activates proliferation via a pathway involving IRS2 and mTORC1. Diabetes <\/i><\/b>65:981-995, 2016.<\/p>\n
17. <\/b>J. Lakshmipathi, J.C. Alvarez-Perez, C. Rosselot, G.P. Casinelli, R. Stamateris, F. Rausell-Palamos, C. O\u2019Donnell, R.C. Vasavada, D.K. Scott, L.C. Alonso, A. Garcia-Oca\u00f1a. PKC-\u03b6 is essential for pancreatic beta cell replication during insulin resistance by regulating mTOR and cyclin-D2. Diabetes <\/i><\/b>65:1283-1296, 2016.<\/p>\n
18. <\/b>A. Mozar, H. Lin, K. Williams, C. Chin, N.G. Kondegowda, A.F. Stewart, A. Garcia-Oca\u00f1a, R.C. Vasavada. Parathyroid Hormone-Related Peptide (1-36) Enhances Beta Cell Regeneration and Increases Beta Cell Mass in a Mouse Model of Partial Pancreatectomy. PLOS One<\/i><\/b>, 11(7):e0158414, 2016.<\/p>\n
19. <\/b>A.I. Sacaan, S. Thibault, M. Hong, N.K. Guthalu, T. Nichols , R. Li, C. Rosselot, W. Evering, R. Fenutria, A.Vitsky, T. Brown, M. Finkelstein, A. Garcia-Oca\u00f1a, N. Khan, A.F. Stewart, R.C. Vasavada. The Effects of Inhibition of Cyclin-Dependent Kinase 4\/6 on Glucose and Pancreatic Beta Cell Homeostasis in Young and Aged Rats. Molecular Cancer Research<\/i><\/b>, 2017 Jul 31. doi: 10.1158\/1541-7786.MCR-17-0172. [Epub ahead of print].<\/p>\n
20. <\/b>S.D. Meriney, T.B. Tarr, K.S. Ojala, M. Wu, Y. Li, D. Lacomis, A. Garcia-Ocana, M. Liang, G. Valdomir, and P. Wipf. Lambert-Eaton Myasthenic Syndrome: mouse passive-transfer model illuminates disease pathology and facilitates testing therapeutic leads. Annals of the New York Academy of Sciences<\/i><\/b>, 2017, in press.<\/p>\n
<\/p>\n","protected":false},"excerpt":{"rendered":"
Selected publications (last 3 years): 1. J.C. Alvarez-Perez, S. Ernst, C. Demerci, G.P. Casinelli, J.M.D. Mellado-Gil, R.C. Vasavada, A. Garcia-Ocana. Hepatocyte Growth Factor\/c-Met signaling is required for \u00df-cell regeneration. Diabetes 63:216-223, 2014. 2. J.C. Alvarez-Perez, T. C. Rosa, G. P. Casinelli, S. R. Valle, J. Lakshmipathi, C. Rosselot, F. Rausell-Palamos, R.C. Vasavada, and A. Garc\u00eda-Ocana. […]<\/p>\n","protected":false},"author":228,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-10","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/wp-json\/wp\/v2\/pages\/10","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/wp-json\/wp\/v2\/users\/228"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/wp-json\/wp\/v2\/comments?post=10"}],"version-history":[{"count":4,"href":"https:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/wp-json\/wp\/v2\/pages\/10\/revisions"}],"predecessor-version":[{"id":67,"href":"https:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/wp-json\/wp\/v2\/pages\/10\/revisions\/67"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/garciaocana-lab\/wp-json\/wp\/v2\/media?parent=10"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}