{"id":40,"date":"2015-06-04T16:41:35","date_gmt":"2015-06-04T16:41:35","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/garcia-sastre\/?page_id=40"},"modified":"2016-02-12T02:03:21","modified_gmt":"2016-02-12T07:03:21","slug":"research-1","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/garcia-sastre\/research-1\/","title":{"rendered":"Virus-Host Interactions"},"content":{"rendered":"

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Melissa Uccellini, Ph.D<\/h3>\n

My work focuses on the host response to viral infection, mainly using mouse models. Mx1 is specifically upregulated in response to type I and III IFN. We have generated a Mxgfp<\/sup>\u00a0knockin mouse strain in order to track the cells that respond to IFN in vivo<\/i>. We are also studying the TIR-domain containing protein SARM1. We have generated knockout and reporter strains using CRISPR technology in order to study its role in the CNS during viral infection.<\/p>\n

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GFP levels in the spleen of Mxgfp<\/sup> mice injected with PIC at days 1-5 post-treatment.<\/p><\/div>\n<\/div>\n

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Guojun Wang, Ph.D.<\/h3>\n

The generation of fluorescent Influenza A reporter viruses has made it possible to trace the virus both in vitro<\/i> and in vivo<\/i>. This offers new opportunities to study influenza virus replication, tropism, pathogenesis and transmission. My work is focused on constructing and characterizing different subtypes of fluorescent viruses.<\/p>\n<\/div>\n

\"guojun<\/a><\/p>\n

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Michael Schotsaert, Ph.D.<\/h3>\n

Currently licensed influenza vaccines often aim at the induction of virus-neutralizing antibodies that can protect against morbidity induced by infection with a virus if it antigenically matches the vaccine. Immune factors other than neutralizing antibodies also contribute to protection without the need of full virus neutralization. This type of infection-permissive immunity often correlates with protection against a broader range of influenza viruses and understanding the underlying mechanisms is important for pandemic preparedness. My research focuses on infection-permissive immunity using the murine influenza challenge model. Innate and adaptive immune responses upon infection are monitored in vaccinated or virus-exposed mice. We aim at understanding how antiviral immune responses that are induced or boosted by virus infection correlate with the broader protection of the infection-permissive host.<\/p>\n<\/div>\n

\"Flow<\/a>

Flow cytometric analysis of dendritic cell subsets in the murine lung during experimental influenza challenge.<\/p><\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

Melissa Uccellini, Ph.D My work focuses on the host response to viral infection, mainly using mouse models. Mx1 is specifically upregulated in response to type I and III IFN. We have generated a Mxgfp\u00a0knockin mouse strain in order to track the cells that respond to IFN in vivo. We are also studying the TIR-domain containing […]<\/p>\n","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"full-width.php","meta":{"footnotes":""},"class_list":["post-40","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/garcia-sastre\/wp-json\/wp\/v2\/pages\/40","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/garcia-sastre\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/garcia-sastre\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/garcia-sastre\/wp-json\/wp\/v2\/users\/36"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/garcia-sastre\/wp-json\/wp\/v2\/comments?post=40"}],"version-history":[{"count":25,"href":"https:\/\/labs.icahn.mssm.edu\/garcia-sastre\/wp-json\/wp\/v2\/pages\/40\/revisions"}],"predecessor-version":[{"id":958,"href":"https:\/\/labs.icahn.mssm.edu\/garcia-sastre\/wp-json\/wp\/v2\/pages\/40\/revisions\/958"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/garcia-sastre\/wp-json\/wp\/v2\/media?parent=40"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}