{"id":1210,"date":"2017-10-27T10:56:20","date_gmt":"2017-10-27T14:56:20","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/garcia-sastre\/?page_id=1210"},"modified":"2018-01-18T11:28:43","modified_gmt":"2018-01-18T16:28:43","slug":"maite-sanchez-aparicio-ph-d","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/garcia-sastre\/maite-sanchez-aparicio-ph-d\/","title":{"rendered":"Maite Sanchez-Aparicio, Ph.D."},"content":{"rendered":"

\"\"<\/a><\/p>\n

Research Assistant Professor
\n<\/em>maria.t.sanchez@mssm.edu<\/a><\/p>\n

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\nResearch Interests<\/span>
\n<\/strong>The goal of my work is to understand the mechanisms involved in the innate immune response against viral infections. I am mainly focused on identifying and characterizing the spatio-temporal events in the RIG-I like receptor pathway that lead to the production of type I IFN, and the mechanisms underlying the inhibition of this response by viruses. I currently work on different projects involving different RNA viruses, combining techniques from microscopy, cell biology, virology and biochemistry. In particular, we have developed a Bimolecular Complementary Assay (BiFC) to characterize the interaction between viral and host cell proteins.<\/p>\n

Notable Publications
\n<\/strong><\/span>Aguirre S, Luthra P, Sanchez-Aparicio MT<\/strong>, Maestre AM, Patel J, Lamothe F, Fredericks AC, Tripathi S, Zhu T, Pintado-Silva J, Webb LG, Bernal-Rubio D, Solovyov A, Greenbaum B, Simon V, Basler CF, Mulder LC, Garc\u00eda-Sastre A, Fernandez-Sesma A. Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection. <\/a>Nat Microbiol. 2017 Mar 27<\/p>\n

S\u00e1nchez-Aparicio MT<\/strong>, Garcin D, Rice CM, Kolakofsky D, Garc\u00eda-Sastre A, Baum A. Loss of Sendai virus C protein leads to accumulation of RIG-I immunostimulatory defective interfering RNA. <\/a>J Gen Virol. 2017<\/p>\n

S\u00e1nchez-Aparicio MT<\/strong>, Ayll\u00f3n J, Leo-Macias A, Wolff T, Garc\u00eda-Sastre A. Subcellular Localizations of RIG-I, TRIM25, and MAVS Complexes. <\/a>J Virol. 2017 Jan 3<\/p>\n

Soonthornvacharin S, Rodriguez-Frandsen A, Zhou Y, Galvez F, Huffmaster NJ, Tripathi S, Balasubramaniam VR, Inoue A, de Castro E, Moulton H, Stein DA, S\u00e1nchez-Aparicio MT<\/strong>, De Jesus PD, Nguyen Q, K\u00f6nig R, Krogan NJ, Garc\u00eda-Sastre A, Yoh SM, Chanda SK. Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation. <\/a>Nat Microbiol. 2017 Mar 1<\/p>\n

Versteeg GA, Rajsbaum R, S\u00e1nchez-Aparicio MT<\/strong>, Maestre AM, Valdiviezo J, Shi M, Inn KS, Fernandez-Sesma A, Jung J, Garc\u00eda-Sastre A. The E3-ligase TRIM family of proteins regulates signaling pathways triggered by innate immune pattern-recognition receptors. <\/a>Immunity. 2013 Feb 21<\/p>\n","protected":false},"excerpt":{"rendered":"

Research Assistant Professor maria.t.sanchez@mssm.edu         Research Interests The goal of my work is to understand the mechanisms involved in the innate immune response against viral infections. I am mainly focused on identifying and characterizing the spatio-temporal events in the RIG-I like receptor pathway that lead to the production of type I IFN, […]<\/p>\n","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1210","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/garcia-sastre\/wp-json\/wp\/v2\/pages\/1210","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/garcia-sastre\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/garcia-sastre\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/garcia-sastre\/wp-json\/wp\/v2\/users\/36"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/garcia-sastre\/wp-json\/wp\/v2\/comments?post=1210"}],"version-history":[{"count":10,"href":"https:\/\/labs.icahn.mssm.edu\/garcia-sastre\/wp-json\/wp\/v2\/pages\/1210\/revisions"}],"predecessor-version":[{"id":1645,"href":"https:\/\/labs.icahn.mssm.edu\/garcia-sastre\/wp-json\/wp\/v2\/pages\/1210\/revisions\/1645"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/garcia-sastre\/wp-json\/wp\/v2\/media?parent=1210"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}