Michael Schotsaert, Ph.D.

Postdoctoral Fellow





Flow cytometric analysis of dendritic cell subsets in the murine lung during experimental influenza challenge.


Research Interests
Currently licensed influenza vaccines often aim at the induction of virus-neutralizing antibodies that can protect against morbidity induced by infection with a virus if it antigenically matches the vaccine. Immune factors other than neutralizing antibodies also contribute to protection without the need of full virus neutralization. This type of infection-permissive immunity often correlates with protection against a broader range of influenza viruses and understanding the underlying mechanisms is important for pandemic preparedness. My research focuses on infection-permissive immunity using the murine influenza challenge model. Innate and adaptive immune responses upon infection are monitored in vaccinated or virus-exposed mice. We aim at understanding how antiviral immune responses that are induced or boosted by virus infection correlate with the broader protection of the infection-permissive host.

Notable Publications
Schotsaert M, García-Sastre A. Inactivated influenza virus vaccines: the future of TIV and QIV. Curr Opin Virol. 2017 Apr;23:102-106. doi: 10.1016/j.coviro.2017.04.005. Epub 2017 May 12. Review.

Schotsaert M, Ysenbaert T, Smet A, Schepens B, Vanderschaeghe D, Stegalkina S, Vogel TU, Callewaert N, Fiers W, Saelens X. Long-Lasting Cross-Protection Against Influenza A by Neuraminidase and M2e-based immunization strategies. Sci Rep. 2016 Apr 13;6:24402. doi: 10.1038/srep24402.

Schotsaert M, García-Sastre A. A High-Resolution Look at Influenza Virus Antigenic Drift. J Infect Dis. 2016 Oct 1;214(7):982. doi: 10.1093/infdis/jiw183. Epub 2016 May 6. No abstract available.

Schotsaert M, García-Sastre A. Influenza vaccines: a moving interdisciplinary field. Viruses. 2014 Oct 9;6(10):3809-26. doi: 10.3390/v6103809. Review.

Schotsaert M, Ysenbaert T, Neyt K, Ibañez LI, Bogaert P, Schepens B, Lambrecht BN, Fiers W, Saelens X. Natural and long-lasting cellular immune responses against influenza in the M2e-immune host. Mucosal Immunol. 2013 Mar;6(2):276-87. doi: 10.1038/mi.2012.69. Epub 2012 Jul 18.