Research Assistant Professor
My work is focused on the interactions between the influenza A virus and its various hosts. We recently unveiled the role of two adaptations in the hemagglutinin protein of the pandemic H1N1 influenza A virus that is able to alter viral replication and pathogenicity in a wide variety of in vitro and in vivo models. This provides us with a better insight with regards to the ability of the virus to adapt and go through various reassortments. My research is also focused on the repurposing of current therapeutic compounds in order to find new therapies against the Ebola virus disease. This has led to discovery of several candidates that we are now further testing to confirm newly discovered antiviral properties. Finally, I am currently establishing a collection of primary cells that will serve as novel in vivo platforms for the study of classical and recent influenza viruses, as well as other emerging viruses.
Sun W, He S, Martínez-Romero C, Kouznetsova J, Tawa G1, Xu M, Shinn P, Fisher E, Long Y, Motabar O, Yang S, Sanderson PE, Williamson PR, García-Sastre A, Qiu X, Zheng W. Synergistic drug combination effectively blocks Ebola virus infection. Antiviral Res. 2017 Jan;137:165-172. doi: 10.1016/j.antiviral.2016.11.017. Epub 2016 Nov 24.
Martínez-Romero C, García-Sastre A. Against the clock towards new Ebola virus therapies. Virus Res. 2015 Nov 2;209:4-10. doi: 10.1016/j.virusres.2015.05.025. Epub 2015 Jun 6.
Kouznetsova J, Sun W, Martínez-Romero C, Tawa G, Shinn P, Chen CZ, Schimmer A, Sanderson P, McKew JC, Zheng W, García-Sastre A. Identification of 53 compounds that block Ebola virus-like particle entry via a repurposing screen of approved drugs. Emerg Microbes Infect. 2014 Dec;3(12):e84. doi: 10.1038/emi.2014.88. Epub 2014 Dec 17.
Rajsbaum R, Versteeg GA, Schmid S, Maestre AM, Belicha-Villanueva A, Martínez-Romero C, Patel JR, Morrison J, Pisanelli G, Miorin L, Laurent-Rolle M, Moulton HM, Stein DA, Fernandez-Sesma A, tenOever BR, García-Sastre A. Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response. Immunity. 2014 Jun 19;40(6):880-95. doi: 10.1016/j.immuni.2014.04.018. Epub 2014 May 29.
Martínez-Romero C, de Vries E, Belicha-Villanueva A, Mena I, Tscherne DM, Gillespie VL, Albrecht RA, de Haan CA, García-Sastre A. Substitutions T200A and E227A in the hemagglutinin of pandemic 2009 influenza A virus increase lethality but decrease transmission. J Virol. 2013 Jun;87(11):6507-11. doi: 10.1128/JVI.00262-13. Epub 2013 Mar 27.