My research focuses on how pre-existing immunity to influenza modulates virus-host interactions in the antigen-experienced host. Specifically, I try to dissect the different aspects of both the innate and adaptive branch of the host immune response to vaccination and repeated influenza virus infections, and how these parameters contribute to long-lasting protection. Ultimately, insights gained from my research will translate in development of new and optimization of existing adjuvants and vaccine approaches against influenza.
Choi, A., I. Christopoulou, X. Saelens, A. Garcia-Sastre and M. Schotsaert (2019). TIV Vaccination Modulates Host Responses to Influenza Virus Infection that Correlate with Protection against Bacterial Superinfection. Vaccines (Basel) 7(3).
Choi, A., B. Bouzya, K. D. Cortes Franco, D. Stadlbauer, A. Rajabhathor, R. N. Rouxel, R. Mainil, M. Van der Wielen, P. Palese, A. Garcia-Sastre, B. L. Innis, F. Krammer, M. Schotsaert, C. P. Mallett and R. Nachbagauer (2019). Chimeric Hemagglutinin-Based Influenza Virus Vaccines Induce Protective Stalk-Specific Humoral Immunity and Cellular Responses in Mice. Immunohorizons 3(4): 133-148.
Jacobsen, M. Rajendran, A. Choi, H. Sjursen, K. A. Brokstad, R. J. Cox, P. Palese, F. Krammer, R. Nachbagauer: Influenza hemagglutinin stalk-specifc antibodies in human sera correlate with in vivo activity in a serum transfer mouse challenge model: A surrogate marker for protection. Mbio. (2017). (accepted)
R. Nachbagauer, A. Choi, A. Hirsh, I. Margine, S. Iida, A. Barrera, M. Ferres, R. Albrecht, A. García-Sastre, N. M. Bouvier, K. Ito, R. Medina, P. Palese and F. Krammer: Defining the antibody cross-reactome directed against the influenza virus surface glycoproteins. Nature Immunology. 18. (2017)
R. Nachbagauer*, A. Choi*, R. Izikson, M. M. Cox, P. Palese, and F. Krammer: Age dependence and isotype specificity of influenza virus hemagglutinin stalk-reactive antibodies in humans. MBio. 7. (2016). *R.N and A.C. contributed equally