{"id":8,"date":"2016-02-19T18:46:24","date_gmt":"2016-02-19T18:46:24","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/friedmanlab\/?page_id=8"},"modified":"2021-07-15T14:15:04","modified_gmt":"2021-07-15T14:15:04","slug":"projects-and-grants","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/friedmanlab\/projects-and-grants\/","title":{"rendered":"Current Projects"},"content":{"rendered":"<p><a href=\"https:\/\/labs.icahn.mssm.edu\/friedmanlab\/wp-content\/uploads\/sites\/167\/2016\/02\/L_Liver_Research_Lab_Cell_Culture_Flasks.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-35 aligncenter\" src=\"https:\/\/labs.icahn.mssm.edu\/friedmanlab\/wp-content\/uploads\/sites\/167\/2016\/02\/L_Liver_Research_Lab_Cell_Culture_Flasks.jpg\" alt=\"L_Liver_Research_Lab_Cell_Culture_Flasks\" width=\"452\" height=\"230\" srcset=\"https:\/\/labs.icahn.mssm.edu\/friedmanlab\/wp-content\/uploads\/sites\/167\/2016\/02\/L_Liver_Research_Lab_Cell_Culture_Flasks.jpg 452w, https:\/\/labs.icahn.mssm.edu\/friedmanlab\/wp-content\/uploads\/sites\/167\/2016\/02\/L_Liver_Research_Lab_Cell_Culture_Flasks-300x153.jpg 300w\" sizes=\"auto, (max-width: 452px) 100vw, 452px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p>The following is a list of projects being conducted in the Liver Research Laboratory of Dr. Scott Friedman:<\/p>\n<ul>\n<li>Characterization of cell specific gene expression, and cell-cell interactions in mouse models of non-alcoholic steatohepatitis (NASH) and human liver disease.<\/li>\n<\/ul>\n<p style=\"text-align: left\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Investigator: Shuang Wang, PhD<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Epigenetic regulation of stellate cell biology:<\/li>\n<\/ul>\n<p style=\"text-align: left\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Investigator: Shuang Wang, PhD<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Bioinformatics-based identification of novel pro-fibrogenic signaling pathways and druggable targets in hepatic stellate cells.<\/li>\n<\/ul>\n<p style=\"text-align: left\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Investigator: Shuang Wang, PhD<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Antifibrotic activity of clinical candidates for treatment of liver disease in cultured stellate cells, precision cut liver slices and animal models.<\/li>\n<\/ul>\n<p style=\"text-align: left\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Investigators: Dipankar Bhattacharya, MS<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Novel tools to interrogate and manipulate stellate cell function in culture and in vivo.<\/li>\n<\/ul>\n<p style=\"text-align: left\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Investigators:\u00a0 Shuang Wang, PhD and Kenneth Li<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Identification, interactions and targeting of stellate cell surface molecules.<\/li>\n<\/ul>\n<p style=\"text-align: left\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Investigators:\u00a0 James Carter, Vignesh Rajasekaran, Nicholas Venturini<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Novel hepatic stellate cell depletion models to elucidate mechanisms of NASH and liver cancer.<\/li>\n<\/ul>\n<p style=\"text-align: left\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Investigators: Chittampalli Yashaswini, James Carter<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; The following is a list of projects being conducted in the Liver Research Laboratory of Dr. Scott Friedman: Characterization of cell specific gene expression, and cell-cell interactions in mouse models of non-alcoholic steatohepatitis (NASH) and human liver disease. \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Investigator: Shuang Wang, PhD &nbsp; Epigenetic regulation of stellate cell [&hellip;]<\/p>\n","protected":false},"author":545,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-8","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/friedmanlab\/wp-json\/wp\/v2\/pages\/8","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/friedmanlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/friedmanlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/friedmanlab\/wp-json\/wp\/v2\/users\/545"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/friedmanlab\/wp-json\/wp\/v2\/comments?post=8"}],"version-history":[{"count":12,"href":"https:\/\/labs.icahn.mssm.edu\/friedmanlab\/wp-json\/wp\/v2\/pages\/8\/revisions"}],"predecessor-version":[{"id":131,"href":"https:\/\/labs.icahn.mssm.edu\/friedmanlab\/wp-json\/wp\/v2\/pages\/8\/revisions\/131"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/friedmanlab\/wp-json\/wp\/v2\/media?parent=8"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}