{"id":12,"date":"2016-02-19T18:46:55","date_gmt":"2016-02-19T18:46:55","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/friedmanlab\/?page_id=12"},"modified":"2021-07-15T14:13:39","modified_gmt":"2021-07-15T14:13:39","slug":"trainee-publications","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/friedmanlab\/trainee-publications\/","title":{"rendered":"Representative Publications"},"content":{"rendered":"

Representative Recent Publications (out of > 350 total; \u00a0H index \u2013 143)<\/u><\/strong><\/p>\n

Peer reviewed articles<\/em><\/strong><\/p>\n

Tsuchida T, A. Lee YA, Fujiwara N, Ybanez M, Allen B, Martins S, \u00a0Fiel MI, Goossens N, Chou, H, Hoshida Y, Friedman SL<\/u>.\u00a0 A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer.\u00a0 Journal of Hepatology<\/strong>, 69(2):385-395, 2018.<\/a><\/p>\n

Labgaa I,\u00a0 Villacorta-Martin C,\u00a0 D\u2019Avola D, Craig A,\u00a0 von Felden J,\u00a0 Martins-Filho SN,\u00a0 Daniela Sia D, Stueck A,\u00a0 Ward SC, Fiel MI,\u00a0 Mahajan M,\u00a0 Tabrizian P, Thung SN, Ang C, Friedman SL<\/u>,\u00a0\u00a0 Llovet JM, Schwartz M, Villanueva A.\u00a0\u00a0 A pilot study of ultra-deep targeted sequencing of plasma DNA identifies driver mutations in hepatocellular carcinoma. Oncogene<\/strong>, 37(27):3740-3752, 2018.<\/a><\/p>\n

Lee YA,\u00a0 Noon LA, Akat KM, Ybanez MD, Lee T-F, Berres M-L, Fujiwara N, Goossens N, Chou H, Parvin-Nejad F, Khambu B, Kramer EGM, Gordon R, Pfleger C, Germain D, John GR,\u00a0 Campbell KN, Yue Z, Yin X-M, \u00a0Cuervo AM, Czaja MJ, Fiel MI, Hoshida Y, and Friedman SL<\/u>. .<\/sup>Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap.\u00a0 Nature Communications,<\/strong> 9(1):4962, 2018.<\/a><\/p>\n

Amor C, Feucht J, Leibold J, Ho Y-J, Zhu C, Alonso-Curbelo D, Mansilla-Soto J, Boyer JA, Xing Li X, Giavridis T, Kulick A, Houlihan S, Peerschke E, Friedman SL<\/u>, Ponomarev V, Piersigilli A, Sadelain M, Lowe SW.\u00a0 Senolytic CAR T cells reverse senescence-associated pathologies.\u00a0 Nature<\/strong>, 583: 127-132, 2020.<\/a><\/p>\n

Urushima H, Yuasa H, Matsubara T, Kuroda N, Hara Y, Inoue K, Wake K, Sato T, Friedman SL<\/u>, Ikeda K. Activation of hepatic stellate cells requires dissociation of E-cadherin-containing adherens junctions with hepatocytes.\u00a0\u00a0 American Journal of Pathology<\/strong>, S0002-9440(20)30562-9, 2020.<\/a><\/p>\n

Carter JK, Bhattacharya D, Borgerding JN, Fiel MI, Faith JJ, Friedman SL<\/u>. \u00a0<\/sup>Modeling dysbiosis of human NASH in mice: Loss of gut microbiome diversity and overgrowth of Erysipelotrichales. PLoS One, <\/strong>16(1): e0244763, 2021.<\/a><\/p>\n

Bhattacharya D,\u00a0 Basta B,\u00a0 Mato, JM Craig A,\u00a0 Fern\u00e1ndez-Ramos D,\u00a0 Lopitz-Otsoa F, Tsvirkun D, Hayardeny L, Chandar V, Schwartz RE, Villanueva A and Friedman SL<\/u>. \u00a0Aramchol downregulates stearoyl CoA-Desaturase 1 (SCD 1) in hepatic stellate cells to attenuate cellular fibrogenesis.\u00a0 J<\/strong> HEP Reports, <\/strong>in press, <\/strong>2021.<\/a><\/p>\n

Pinyol R, Torrecilla S, Wang H, Montironi C, Piqu\u00e9-Gili M, Torres-Martin M, Wei-Qiang L, Willoughby CE, Ramadori P, Andreu-Oller C, Moeini A, Peix J, Oliveira CP, Alves VA, Boffeta P, Lachenmayer A, Roessler S, Minguez M, Schirmacher P, Dufour J-F, Thung S, Reeves HL, Carrilho FJ, Chang C, Uzilov AV, Heikenw\u00e4lder M, Sanyal A, Friedman SL<\/u>, Sia D, Llovet JM.\u00a0 Molecular characterization of hepatocellular carcinoma in patients with non-alcoholic steatohepatitis. J Hepatology<\/strong>, in press, 2021.<\/a><\/p>\n

Bhattacharya D, Becker C, Readhead B, Goossens N,\u00a0 Novik J, Fiel MI, Cousens LP, <\/em>Magnusson B, Backmark A, Hicks R, Dudley JT and Friedman SL<\/u>.\u00a0 \u00a0<\/sup><\/em>Repositioning of a Novel GABA-B receptor Agonist, AZD3355 (Lesogaberan), for the Treatment of Non-Alcoholic Steatohepatitis.\u00a0 Submitted, 2021.<\/p>\n

\u00a0<\/sup><\/strong><\/p>\n

Review articles<\/em><\/strong><\/p>\n

Friedman SL<\/u>, Neuschwander-Tetri BA, Rinella M and Arun J. Sanyal AJ. \u00a0<\/em>Mechanisms of NAFLD development and therapeutic strategies.\u00a0 Nature Medicine<\/strong>, 4(7):908-922, 2018.<\/a><\/p>\n

Lemoinne S and Friedman SL<\/u>.\u00a0 New and emerging anti-fibrotic therapeutics entering or already in clinical trials in chronic liver diseases. Current Opinion in Pharmacology<\/strong>, 49:60-70, 2019.<\/a><\/p>\n

Wang S and Friedman SL<\/u>.\u00a0 Taming the savage breast from within \u2013 Tcf21, a novel regulator of stellate cell deactivation (invited editorial).\u00a0 Hepatology<\/strong>, 71(4):1150-1153, 2020.<\/a><\/p>\n

Crismale JF, Friedman SL<\/u>. Acute liver injury and decompensated cirrhosis.\u00a0 Med Clin North Am.<\/strong> 104(4):647-662, 2020.<\/a><\/p>\n

Young S, Tariq R, Provenza J, Satapathy, SK, Faisal K, Choudhury A, Friedman SL<\/u>, Singal AK.\u00a0 Prevalence and profile of fatty liver disease in lean adults: a systematic review and meta-analysis.\u00a0 Hepatology Communications<\/strong>, 4 (7):953 – 972, 2020.<\/a><\/p>\n

Asgharpour A,\u00a0\u00a0 <\/sup>Dinani A,\u00a0 <\/sup>Friedman SL<\/u>. \u00a0Basic science to clinical trials in NAFLD & ALD: collaboration with industry.\u00a0 Translational Gastroenterology and Hepatology<\/strong>, 6:5, 2021.<\/a><\/p>\n

Trivedi P, Wang S and Friedman SL<\/u>.\u00a0 The power of plasticity \u2013 metabolic regulation of hepatic stellate cells.\u00a0 Cell Metabolism<\/strong>, S1550-4131(20)30595-7, 2021.<\/a><\/p>\n

Rockey DC and Friedman SL<\/u>.\u00a0 Fibrosis regression after eradication of hepatitis C virus – from bench to bedside.\u00a0 Gastroenterology<\/strong>, in press, 2021.<\/a><\/p>\n

Huisman TM, Dieterich DT,\u00a0 Friedman SL<\/u>. Experimental and investigational targeted therapies for the management of fibrosis in NASH: an update. J Experimental Pharmacology<\/strong>, in press, 2021.<\/a><\/p>\n

Shulman G*, Friedman SL<\/u>*, Loomba R*.\u00a0 Mechanisms and disease consequences of\u00a0nonalcoholic fatty liver disease, Cell,<\/strong> in press, 2021. (* shared equal authorship).<\/a><\/p>\n

\u00a0<\/strong><\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Representative Recent Publications (out of > 350 total; \u00a0H index \u2013 143) Peer reviewed articles Tsuchida T, A. Lee YA, Fujiwara N, Ybanez M, Allen B, Martins S, \u00a0Fiel MI, Goossens N, Chou, H, Hoshida Y, Friedman SL.\u00a0 A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer.\u00a0 […]<\/p>\n","protected":false},"author":545,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-12","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/friedmanlab\/wp-json\/wp\/v2\/pages\/12","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/friedmanlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/friedmanlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/friedmanlab\/wp-json\/wp\/v2\/users\/545"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/friedmanlab\/wp-json\/wp\/v2\/comments?post=12"}],"version-history":[{"count":11,"href":"https:\/\/labs.icahn.mssm.edu\/friedmanlab\/wp-json\/wp\/v2\/pages\/12\/revisions"}],"predecessor-version":[{"id":129,"href":"https:\/\/labs.icahn.mssm.edu\/friedmanlab\/wp-json\/wp\/v2\/pages\/12\/revisions\/129"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/friedmanlab\/wp-json\/wp\/v2\/media?parent=12"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}