{"id":747,"date":"2019-08-07T17:44:12","date_gmt":"2019-08-07T17:44:12","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/foss-feig-lab-beta\/?page_id=747"},"modified":"2021-11-24T21:21:01","modified_gmt":"2021-11-24T21:21:01","slug":"home","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/foss-feig-lab\/","title":{"rendered":"Home"},"content":{"rendered":"

[et_pb_section bb_built=”1″ fullwidth=”on” specialty=”off” next_background_color=”#000000″ _builder_version=”3.19.10″ disabled=”on” disabled_on=”on|on|on” inner_width=”auto” inner_max_width=”1225px”][et_pb_fullwidth_menu _builder_version=”3.19.10″ menu_id=”5″ submenu_direction=”downwards” fullwidth_menu=”off” \/][\/et_pb_section][et_pb_section bb_built=”1″ fullwidth=”on” specialty=”off” next_background_color=”#ffffff” _builder_version=”3.19.10″ prev_background_color=”#ffffff” background_color=”#000000″ inner_width=”auto” inner_max_width=”1225px”][et_pb_fullwidth_slider _builder_version=”4.9.0″ show_pagination=”off” animation_style=”slide” animation_direction=”right” auto=”on”][et_pb_slide _builder_version=”3.19.10″ button_link=”#” url_new_window=”off” link_option_url_new_window=”off” background_color=”#2ea3f2″ use_background_color_gradient=”on” background_color_gradient_start=”#2b87da” background_color_gradient_end=”#29c4a9″ background_color_gradient_type=”linear” background_color_gradient_direction=”180deg” background_color_gradient_direction_radial=”center” background_color_gradient_start_position=”0%” background_color_gradient_end_position=”100%” background_color_gradient_overlays_image=”off” background_image=”https:\/\/labs.icahn.mssm.edu\/foss-feig-lab-beta\/wp-content\/uploads\/sites\/324\/2019\/08\/FF_banner.jpg” parallax=”off” parallax_method=”on” background_size=”cover” background_position=”top_left” background_repeat=”no-repeat” background_blend=”normal” allow_player_pause=”off” background_video_pause_outside_viewport=”on” use_bg_overlay=”off” use_text_overlay=”off” text_border_radius=”3″ alignment=”center” child_filter_hue_rotate=”0deg” child_filter_saturate=”100%” child_filter_brightness=”100%” child_filter_contrast=”100%” child_filter_invert=”0%” child_filter_sepia=”0%” child_filter_opacity=”100%” child_filter_blur=”0px” child_mix_blend_mode=”normal” background_layout=”dark” text_shadow_style=”none” header_text_shadow_style=”none” body_text_shadow_style=”none” button_text_shadow_style=”none” box_shadow_style_button=”none” hover_transition_duration=”300ms” hover_transition_delay=”0ms” hover_transition_speed_curve=”ease” text_shadow_horizontal_length=”0em” text_shadow_vertical_length=”0em” text_shadow_blur_strength=”0em” header_text_shadow_horizontal_length=”0em” header_text_shadow_vertical_length=”0em” header_text_shadow_blur_strength=”0em” body_text_shadow_horizontal_length=”0em” body_text_shadow_vertical_length=”0em” body_text_shadow_blur_strength=”0em” custom_button=”off” button_bg_use_color_gradient=”off” button_bg_color_gradient_overlays_image=”off” button_use_icon=”on” button_on_hover=”on” button_text_shadow_horizontal_length=”0em” button_text_shadow_vertical_length=”0em” button_text_shadow_blur_strength=”0em” heading=”Foss-Feig Laboratory” \/][\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section bb_built=”1″ prev_background_color=”#000000″ next_background_color=”#eaf2f7″ _builder_version=”3.19.10″ module_id=”research” module_class=”research-section” custom_margin=”||-2em|” inner_width=”auto” inner_max_width=”1225px”][et_pb_row][et_pb_column type=”1_4″ custom_padding__hover=”|||” custom_padding=”|||”][et_pb_image _builder_version=”3.19.10″ src=”https:\/\/labs.icahn.mssm.edu\/foss-feig-lab-beta\/wp-content\/uploads\/sites\/324\/2019\/08\/foss-feig-team9.jpg” border_radii=”on|4px|4px|4px|4px” align_last_edited=”on|desktop” align_tablet=”center” \/][et_pb_text _builder_version=”3.19.10″ text_orientation=”left”]<\/p>\n

Principal Investigator<\/b><\/h6>\n

Jennifer Foss-Feig, PhD<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”3_4″ custom_padding__hover=”|||” custom_padding=”|||”][et_pb_text admin_label=”About the Lab” _builder_version=”4.9.0″ text_text_shadow_horizontal_length=”text_text_shadow_style,%91object Object%93″ text_text_shadow_horizontal_length_tablet=”0px” text_text_shadow_vertical_length=”text_text_shadow_style,%91object Object%93″ text_text_shadow_vertical_length_tablet=”0px” text_text_shadow_blur_strength=”text_text_shadow_style,%91object Object%93″ text_text_shadow_blur_strength_tablet=”1px” link_text_shadow_horizontal_length=”link_text_shadow_style,%91object Object%93″ link_text_shadow_horizontal_length_tablet=”0px” link_text_shadow_vertical_length=”link_text_shadow_style,%91object Object%93″ link_text_shadow_vertical_length_tablet=”0px” link_text_shadow_blur_strength=”link_text_shadow_style,%91object Object%93″ link_text_shadow_blur_strength_tablet=”1px” ul_text_shadow_horizontal_length=”ul_text_shadow_style,%91object Object%93″ ul_text_shadow_horizontal_length_tablet=”0px” ul_text_shadow_vertical_length=”ul_text_shadow_style,%91object Object%93″ ul_text_shadow_vertical_length_tablet=”0px” ul_text_shadow_blur_strength=”ul_text_shadow_style,%91object Object%93″ ul_text_shadow_blur_strength_tablet=”1px” ol_text_shadow_horizontal_length=”ol_text_shadow_style,%91object Object%93″ ol_text_shadow_horizontal_length_tablet=”0px” ol_text_shadow_vertical_length=”ol_text_shadow_style,%91object Object%93″ ol_text_shadow_vertical_length_tablet=”0px” ol_text_shadow_blur_strength=”ol_text_shadow_style,%91object Object%93″ ol_text_shadow_blur_strength_tablet=”1px” quote_text_shadow_horizontal_length=”quote_text_shadow_style,%91object Object%93″ quote_text_shadow_horizontal_length_tablet=”0px” quote_text_shadow_vertical_length=”quote_text_shadow_style,%91object Object%93″ quote_text_shadow_vertical_length_tablet=”0px” quote_text_shadow_blur_strength=”quote_text_shadow_style,%91object Object%93″ quote_text_shadow_blur_strength_tablet=”1px” header_text_shadow_horizontal_length=”header_text_shadow_style,%91object Object%93″ header_text_shadow_horizontal_length_tablet=”0px” header_text_shadow_vertical_length=”header_text_shadow_style,%91object Object%93″ header_text_shadow_vertical_length_tablet=”0px” header_text_shadow_blur_strength=”header_text_shadow_style,%91object Object%93″ header_text_shadow_blur_strength_tablet=”1px” header_2_text_shadow_horizontal_length=”header_2_text_shadow_style,%91object Object%93″ header_2_text_shadow_horizontal_length_tablet=”0px” header_2_text_shadow_vertical_length=”header_2_text_shadow_style,%91object Object%93″ header_2_text_shadow_vertical_length_tablet=”0px” header_2_text_shadow_blur_strength=”header_2_text_shadow_style,%91object Object%93″ header_2_text_shadow_blur_strength_tablet=”1px” header_3_text_shadow_horizontal_length=”header_3_text_shadow_style,%91object Object%93″ header_3_text_shadow_horizontal_length_tablet=”0px” header_3_text_shadow_vertical_length=”header_3_text_shadow_style,%91object Object%93″ header_3_text_shadow_vertical_length_tablet=”0px” header_3_text_shadow_blur_strength=”header_3_text_shadow_style,%91object Object%93″ header_3_text_shadow_blur_strength_tablet=”1px” header_4_text_shadow_horizontal_length=”header_4_text_shadow_style,%91object Object%93″ header_4_text_shadow_horizontal_length_tablet=”0px” header_4_text_shadow_vertical_length=”header_4_text_shadow_style,%91object Object%93″ header_4_text_shadow_vertical_length_tablet=”0px” header_4_text_shadow_blur_strength=”header_4_text_shadow_style,%91object Object%93″ header_4_text_shadow_blur_strength_tablet=”1px” header_5_text_shadow_horizontal_length=”header_5_text_shadow_style,%91object Object%93″ header_5_text_shadow_horizontal_length_tablet=”0px” header_5_text_shadow_vertical_length=”header_5_text_shadow_style,%91object Object%93″ header_5_text_shadow_vertical_length_tablet=”0px” header_5_text_shadow_blur_strength=”header_5_text_shadow_style,%91object Object%93″ header_5_text_shadow_blur_strength_tablet=”1px” header_6_text_shadow_horizontal_length=”header_6_text_shadow_style,%91object Object%93″ header_6_text_shadow_horizontal_length_tablet=”0px” header_6_text_shadow_vertical_length=”header_6_text_shadow_style,%91object Object%93″ header_6_text_shadow_vertical_length_tablet=”0px” header_6_text_shadow_blur_strength=”header_6_text_shadow_style,%91object Object%93″ header_6_text_shadow_blur_strength_tablet=”1px” box_shadow_horizontal_tablet=”0px” box_shadow_vertical_tablet=”0px” box_shadow_blur_tablet=”40px” box_shadow_spread_tablet=”0px” vertical_offset_tablet=”0″ horizontal_offset_tablet=”0″ z_index_tablet=”0″]<\/p>\n

About the Lab<\/h4>\n

Here at the Foss-Feig Lab, our research combines clinical assessments with brain-based methods, including EEG and MRI, to examine sensory and perceptual functioning in autism spectrum disorder (ASD). We also study the relation between ASD and other neurodevelopmental disorders, including schizophrenia and psychosis prodrome, as well as monogenic disorders with a prominent ASD phenotype.<\/p>\n

The Foss-Feig Lab is part of the Seaver Autism Center for Research and Treatment\u00a0<\/a>at the\u00a0Icahn School of Medicine at Mount Sinai<\/a>. The Seaver Autism Center is a fully integrated, translational research center that leads progressive studies and provides personalized care to individuals with autism and related rare disorders. As a team, we are dedicated to discovering the biological causes of autism and developing breakthrough treatments. \u00a0<\/p>\n

Learn more<\/a> about the Seaver Autism Center\u2019s translational research approach.<\/p>\n

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Our Research<\/h4>\n

Using multimodal neuroimaging (EEG, MRI), psychophysical testing, eye tracking, and targeted clinical assessments, our research investigates sensory and perceptual processing as they differ between autism spectrum disorder (ASD) and typical development. We also examine the convergence and divergence between ASD and other neurodevelopmental disorders, including schizophrenia, as well as relations between experimental effects and specific patterns of clinical symptoms within the broad ASD population and among individuals exhibiting known genetic mutations that contribute to an ASD phenotype.<\/p>\n

Our work addresses the following central questions:<\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ prev_background_color=”#ffffff” next_background_color=”#f7f7f7″ _builder_version=”3.19.10″ background_color=”#eaf2f7″ module_id=”projects” module_class=”projects-section” inner_width=”auto” inner_max_width=”1225px”][et_pb_row _builder_version=”3.19.10″ text_orientation=”left” width=”80%” max_width=”1225px”][et_pb_column type=”4_4″ custom_padding__hover=”|||” custom_padding=”|||”][et_pb_accordion _builder_version=”3.19.10″ icon_color=”#00aeef” border_radii=”on|4px|4px|4px|4px” box_shadow_style=”preset3″ box_shadow_color=”rgba(0,0,0,0.11)”][et_pb_accordion_item _builder_version=”3.19.10″ title=”Mechanisms of sensory and perceptual processing alterations in ASD” link_option_url_new_window=”off” use_background_color_gradient=”off” background_color_gradient_start=”#2b87da” background_color_gradient_end=”#29c4a9″ background_color_gradient_type=”linear” background_color_gradient_direction=”180deg” background_color_gradient_direction_radial=”center” background_color_gradient_start_position=”0%” background_color_gradient_end_position=”100%” background_color_gradient_overlays_image=”off” parallax=”off” parallax_method=”on” background_size=”cover” background_position=”center” background_repeat=”no-repeat” background_blend=”normal” allow_player_pause=”off” background_video_pause_outside_viewport=”on” text_shadow_style=”none” box_shadow_style=”none” hover_transition_duration=”300ms” hover_transition_delay=”0ms” hover_transition_speed_curve=”ease” text_shadow_horizontal_length=”0em” text_shadow_vertical_length=”0em” text_shadow_blur_strength=”0em”]<\/p>\n

Question 1: Mechanisms of sensory and perceptual processing alterations in ASD<\/strong><\/h4>\n
\"\"Sensory processing difficulties affect up to 90% of individuals with ASD. In fact, many families report that, on a day-to-day basis, they are among the most impairing parts of autism. And yet, sensory symptoms are diverse: different modalities (sight, hearing, touch) may be affected or unaffected, and individuals with ASD may be over-sensitive, under-sensitive, or have significant sensory cravings. From basic science, much is known about how sensory systems are organized in the brain and about what brain pathways, neurotransmitters, and interactions between populations of brain cells affect sensory functioning. This body of knowledge allows us to ask questions and uncover the brain-basis of sensory symptoms in ASD. Sensory systems are also among the first to develop in the brain and lay the foundation upon which more complex brain functions are built. In that sense, sensory processing differences may not only be important symptoms to understand in their own right, but may also give us clues to how social, communication, and behavioral differences in ASD develop.<\/div>\n
 <\/div>\n
In the lab, we ask several questions about sensory functioning in ASD. How are visual and auditory systems affected? Can we detect differences in the brain with EEG and\/or with MRI that can give us clues about how, where, and when breakdowns in sensory processing occur? Is there something about the timing of how sensory input is processed that makes perception more difficult for individuals with ASD? How do sensory symptoms interact and integrate information? Can we probe differences in core brain-related mechanisms and circuitry using sensory stimuli and well-validated experimental approaches? Why do some individuals with ASD have unique visual processing strengths? How do sensory processing differences relate to other core symptoms in ASD? Can sensory symptoms be changed with treatment, and can we measure it<\/div>\n

[\/et_pb_accordion_item][et_pb_accordion_item _builder_version=”3.19.10″ title=”Overlap between ASD and schizophrenia” link_option_url_new_window=”off” use_background_color_gradient=”off” background_color_gradient_start=”#2b87da” background_color_gradient_end=”#29c4a9″ background_color_gradient_type=”linear” background_color_gradient_direction=”180deg” background_color_gradient_direction_radial=”center” background_color_gradient_start_position=”0%” background_color_gradient_end_position=”100%” background_color_gradient_overlays_image=”off” parallax=”off” parallax_method=”on” background_size=”cover” background_position=”center” background_repeat=”no-repeat” background_blend=”normal” allow_player_pause=”off” background_video_pause_outside_viewport=”on” text_shadow_style=”none” box_shadow_style=”none” hover_transition_duration=”300ms” hover_transition_delay=”0ms” hover_transition_speed_curve=”ease” text_shadow_horizontal_length=”0em” text_shadow_vertical_length=”0em” text_shadow_blur_strength=”0em”]<\/p>\n

Question 2: Overlap between ASD and schizophrenia<\/strong><\/h4>\n
\"\"Autism and schizophrenia were once considered the same disorder. We now understand that there are many differences between the two and most people with ASD do not have schizophrenia or psychosis. However, research has repeatedly shown that there are genes and brain differences that ASD and schizophrenia have in common. Many symptoms, such as social difficulties and sensory processing differences, trouble both people with ASD and people with schizophrenia. Moreover, a small but important subset of children and adults with ASD will show psychosis symptoms. Clinicians will sometimes wonder whether these individuals may have both ASD and schizophrenia or psychosis at the same time, and right now there is still little research on the topic.<\/div>\n
 <\/div>\n
This line of research asks several questions. How are brain functioning and sensory processing alike or different in those diagnosed with ASD versus those diagnosed with schizophrenia? Are there alterations in brain pathways and neurochemical interactions that ASD and schizophrenia have in common? Are children with ASD at higher than average risk for developing psychosis? If so, can we identify particular symptom patterns or differences in brain functioning that might help us predict which kids with ASD are at higher risk? Do those children with ASD where psychosis questions are raised actually progress to having a true psychotic illness? Can our concept of symptoms in ASD benefit from thinking about positive and negative symptoms like those in schizophrenia clinical service and research do?<\/div>\n

[\/et_pb_accordion_item][et_pb_accordion_item _builder_version=”3.19.10″ title=”Genetics-first approach to understanding mechanisms and developing biomarkers for ASD” link_option_url_new_window=”off” use_background_color_gradient=”off” background_color_gradient_start=”#2b87da” background_color_gradient_end=”#29c4a9″ background_color_gradient_type=”linear” background_color_gradient_direction=”180deg” background_color_gradient_direction_radial=”center” background_color_gradient_start_position=”0%” background_color_gradient_end_position=”100%” background_color_gradient_overlays_image=”off” parallax=”off” parallax_method=”on” background_size=”cover” background_position=”center” background_repeat=”no-repeat” background_blend=”normal” allow_player_pause=”off” background_video_pause_outside_viewport=”on” text_shadow_style=”none” box_shadow_style=”none” hover_transition_duration=”300ms” hover_transition_delay=”0ms” hover_transition_speed_curve=”ease” text_shadow_horizontal_length=”0em” text_shadow_vertical_length=”0em” text_shadow_blur_strength=”0em”]<\/p>\n

Question 3: Genetics-first approach to understanding mechanisms and developing biomarkers for ASD<\/strong><\/h4>\n
\"\"In the past decade, researchers have made large advances in understanding genes that contribute to autism. We now know of many specific genetic alterations (deletions, mutations, etc) that can confer high risk for ASD in affected individuals. Many of the genes that cause autism affect particular brain pathways, and basic science has told us much about the specific aspects of neurotransmitter, synapse, and cell structure and function that are directly impacted by these genetic alterations. Individuals sharing the same genetic alterations tend to have symptoms in common, making them a less heterogeneous group than we typically see in research and clinical work with individuals with ASD where the genetic origin is unknown. The Seaver Autism Center for Research and Treatment has an international reputation for its work in rare genetic syndromes associated with ASD, including Phelan McDermid syndrome, FOXP1 syndrome, and Fragile X syndrome. Our colleagues at Seaver are also conducting several clinical trials in these syndromes, which offers us the unique opportunity to explore how different interventions affect measurable aspects of brain functioning and behavior.<\/div>\n
 <\/div>\n

In this line of research, we collaborate with colleagues at Seaver to explore several research avenues. First, how is brain functioning and behavior different in individuals with genetic disorders? How is sensory functioning impacted, and how do social and attentional symptoms present? Second, how do differences in brain functioning in those with genetic syndromes compare to those in individuals with ASD with unknown cause (\u201cidiopathic ASD\u201d)? Are there groups of individuals with idiopathic ASD whose behavior and brain functioning looks similar to that associated with a specific genetic disorder? If so, might this give us clues into neural alterations that are affecting a broader portion of individuals with ASD, even when we don\u2019t know the specific cause? Third, can we develop biomarkers for ASD starting in genetic syndromes? Are there brain-based alterations that are reliable across time and individuals and that can easily be measured regardless of a child\u2019s functioning level or the research or clinical setting? Do these markers help us know which children will benefit from a specific treatment? When we do treat children, do these biomarkers show change? Can this work inform biomarkers and treatment approaches for ASD more broadly?<\/p>\n

[\/et_pb_accordion_item][\/et_pb_accordion][et_pb_slider _builder_version=”3.19.10″ text_orientation=”left” width=”80%” max_width=”1225px”][et_pb_slide _builder_version=”3.19.10″ button_link=”#” url_new_window=”off” link_option_url_new_window=”off” background_color=”#ffffff” use_background_color_gradient=”off” background_color_gradient_start=”#2b87da” background_color_gradient_end=”#29c4a9″ background_color_gradient_type=”linear” background_color_gradient_direction=”180deg” background_color_gradient_direction_radial=”center” background_color_gradient_start_position=”0%” background_color_gradient_end_position=”100%” background_color_gradient_overlays_image=”off” parallax=”off” parallax_method=”on” background_size=”cover” background_position=”center” background_repeat=”no-repeat” background_blend=”normal” allow_player_pause=”off” background_video_pause_outside_viewport=”on” use_bg_overlay=”off” use_text_overlay=”off” text_border_radius=”3″ alignment=”center” child_filter_hue_rotate=”0deg” child_filter_saturate=”100%” child_filter_brightness=”100%” child_filter_contrast=”100%” child_filter_invert=”0%” child_filter_sepia=”0%” child_filter_opacity=”100%” child_filter_blur=”0px” child_mix_blend_mode=”normal” background_layout=”dark” text_shadow_style=”none” header_text_shadow_style=”none” body_text_shadow_style=”none” custom_button=”off” button_bg_use_color_gradient=”off” button_bg_color_gradient_overlays_image=”off” button_use_icon=”on” button_on_hover=”on” button_text_shadow_style=”none” box_shadow_style_button=”none” hover_transition_duration=”300ms” hover_transition_delay=”0ms” hover_transition_speed_curve=”ease” text_shadow_horizontal_length=”0em” text_shadow_vertical_length=”0em” text_shadow_blur_strength=”0em” header_text_shadow_horizontal_length=”0em” header_text_shadow_vertical_length=”0em” header_text_shadow_blur_strength=”0em” body_text_shadow_horizontal_length=”0em” body_text_shadow_vertical_length=”0em” body_text_shadow_blur_strength=”0em” button_text_shadow_horizontal_length=”0em” button_text_shadow_vertical_length=”0em” button_text_shadow_blur_strength=”0em”]<\/p>\n

[wds id=”1″]<\/p>\n

[\/et_pb_slide][\/et_pb_slider][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ prev_background_color=”#eaf2f7″ next_background_color=”#eaf2f7″ _builder_version=”3.19.10″ background_color=”#f7f7f7″ module_id=”publications” module_class=”publications-section” disabled=”on” disabled_on=”on|on|on” inner_width=”auto” inner_max_width=”1225px”][et_pb_row _builder_version=”3.19.10″ text_orientation=”left” width=”80%” max_width=”1225px”][et_pb_column type=”4_4″ custom_padding__hover=”|||” custom_padding=”|||”][et_pb_text admin_label=”Recent Projects” _builder_version=”3.19.10″]<\/p>\n

Recent Publications<\/h3>\n

[\/et_pb_text][et_pb_accordion _builder_version=”3.19.10″ icon_color=”#00aeef” border_radii=”on|3px|3px|3px|3px”][et_pb_accordion_item _builder_version=”3.19.10″ title=”2019″ link_option_url_new_window=”off” use_background_color_gradient=”off” background_color_gradient_start=”#2b87da” background_color_gradient_end=”#29c4a9″ background_color_gradient_type=”linear” background_color_gradient_direction=”180deg” background_color_gradient_direction_radial=”center” background_color_gradient_start_position=”0%” background_color_gradient_end_position=”100%” background_color_gradient_overlays_image=”off” parallax=”off” parallax_method=”on” background_size=”cover” background_position=”center” background_repeat=”no-repeat” background_blend=”normal” allow_player_pause=”off” background_video_pause_outside_viewport=”on” text_shadow_style=”none” box_shadow_style=”none” hover_transition_duration=”300ms” hover_transition_delay=”0ms” hover_transition_speed_curve=”ease”]<\/p>\n

Foss-Feig, J. H.<\/strong>, Velthorst, E., Smith, L., Reichenberg, A., Addington, J., Cadenhead, K. S., \u2026 & Seidman, L. J. (2019). Clinical Profiles and Conversion Rates Among Young Individuals With Autism Spectrum Disorder Who Present to Clinical High Risk for Psychosis Services. Journal of the American Academy of Child & Adolescent Psychiatry.pubmed<\/a><\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item _builder_version=”3.19.10″ title=”2018″ link_option_url_new_window=”off” use_background_color_gradient=”off” background_color_gradient_start=”#2b87da” background_color_gradient_end=”#29c4a9″ background_color_gradient_type=”linear” background_color_gradient_direction=”180deg” background_color_gradient_direction_radial=”center” background_color_gradient_start_position=”0%” background_color_gradient_end_position=”100%” background_color_gradient_overlays_image=”off” parallax=”off” parallax_method=”on” background_size=”cover” background_position=”center” background_repeat=”no-repeat” background_blend=”normal” allow_player_pause=”off” background_video_pause_outside_viewport=”on” text_shadow_style=”none” box_shadow_style=”none” hover_transition_duration=”300ms” hover_transition_delay=”0ms” hover_transition_speed_curve=”ease”]<\/p>\n

Foss-Feig, J.H.<\/strong>, Stavropoulos, K.K.M., McPartland, J.C., Wallace, M.T., Stone, W.L., & Key, A.F. (2018). Neural response to auditory gap detection: Biomarker for sensory and communicative functioning impairment in autism spectrum disorder? Developmental Neuropsychology.pubmed<\/a><\/p>\n

Kang, E., Keifer, C.M., Levy, E.J., Foss-Feig, J.H.<\/strong>, McPartland, J.P., & Lerner, M.D. (2018). Atypicality of the N170 Event-Related Potential in Autism Spectrum Disorder: A Meta-Analysis. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.pubmed<\/a><\/p>\n

Stavropoulos KKM, Viktorinova M, Naples A, Foss-Feig J<\/strong>, McPartland JC. (2018). Autistic traits modulate conscious and nonconscious face perception. Soc Neurosci. 13(1):40-51. pubmed<\/a><\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item _builder_version=”3.19.10″ title=”2017″ link_option_url_new_window=”off” use_background_color_gradient=”off” background_color_gradient_start=”#2b87da” background_color_gradient_end=”#29c4a9″ background_color_gradient_type=”linear” background_color_gradient_direction=”180deg” background_color_gradient_direction_radial=”center” background_color_gradient_start_position=”0%” background_color_gradient_end_position=”100%” background_color_gradient_overlays_image=”off” parallax=”off” parallax_method=”on” background_size=”cover” background_position=”center” background_repeat=”no-repeat” background_blend=”normal” allow_player_pause=”off” background_video_pause_outside_viewport=”on” text_shadow_style=”none” box_shadow_style=”none” hover_transition_duration=”300ms” hover_transition_delay=”0ms” hover_transition_speed_curve=”ease”]<\/p>\n

Failla MD, Peters BR, Karbasforoushan H, Foss-Feig JH<\/strong>, Schauder KB, Heflin BH, Cascio CJ. (2017). Intrainsular connectivity and somatosensory responsiveness in young children with ASD. Mol Autism. 2017 Jun 13;8:25. pubmed<\/a><\/p>\n

Foss-Feig JH<\/strong>, Adkinson BD, Ji JL, Yang G, Srihari VH, McPartland JC, Krystal JH, Murray JD, Anticevic A. (2017). Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders. Biol Psychiatry. 2017 May 15;81(10):848-861. pubmed<\/a><\/p>\n

Foss-Feig JH<\/strong>, Schauder KB, Key AP, Wallace MT, Stone WL. (2017). Audition-specific temporal processing deficits associated with language function in children with autism spectrum disorder. Autism Res. 2017 Nov;10(11):1845-1856. pubmed <\/a><\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item _builder_version=”3.19.10″ title=”2016″ link_option_url_new_window=”off” use_background_color_gradient=”off” background_color_gradient_start=”#2b87da” background_color_gradient_end=”#29c4a9″ background_color_gradient_type=”linear” background_color_gradient_direction=”180deg” background_color_gradient_direction_radial=”center” background_color_gradient_start_position=”0%” background_color_gradient_end_position=”100%” background_color_gradient_overlays_image=”off” parallax=”off” parallax_method=”on” background_size=”cover” background_position=”center” background_repeat=”no-repeat” background_blend=”normal” allow_player_pause=”off” background_video_pause_outside_viewport=”on” text_shadow_style=”none” box_shadow_style=”none” hover_transition_duration=”300ms” hover_transition_delay=”0ms” hover_transition_speed_curve=”ease”]<\/p>\n

Foss-Feig JH<\/strong>, McGugin RW, Gauthier I, Mash LE, Ventola P, Cascio CJ. (2016). A functional neuroimaging study of fusiform response to restricted interests in children and adolescents with autism spectrum disorder. J Neurodev Disord. 2016 Apr 14;8:15. pubmed<\/a><\/p>\n

Stavropoulos, K.K.M., Viktorinova, M., Naples, A., Foss-Feig, J.<\/strong>, & McPartland, J.C. (2016). Autistic traits modulate conscious and nonconscious face perception. Social Neuroscience. pubmed<\/a><\/p>\n

Foss-Feig JH<\/strong>, McPartland JC, Anticevic A, Wolf J. (2016). Re-conceptualizing ASD Within a Dimensional Framework: Positive, Negative, and Cognitive Feature Clusters. J Autism Dev Disord. 2016 Jan;46(1):342-351. pubmed<\/a><\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item _builder_version=”3.19.10″ title=”2014″ link_option_url_new_window=”off” use_background_color_gradient=”off” background_color_gradient_start=”#2b87da” background_color_gradient_end=”#29c4a9″ background_color_gradient_type=”linear” background_color_gradient_direction=”180deg” background_color_gradient_direction_radial=”center” background_color_gradient_start_position=”0%” background_color_gradient_end_position=”100%” background_color_gradient_overlays_image=”off” parallax=”off” parallax_method=”on” background_size=”cover” background_position=”center” background_repeat=”no-repeat” background_blend=”normal” allow_player_pause=”off” background_video_pause_outside_viewport=”on” text_shadow_style=”none” box_shadow_style=”none” hover_transition_duration=”300ms” hover_transition_delay=”0ms” hover_transition_speed_curve=”ease”]<\/p>\n

Pryweller JR, Schauder KB, Anderson AW, Heacock JL, Foss-Feig JH<\/strong>, Newsom CR, Loring WA, Cascio CJ. (2014). White matter correlates of sensory processing in autism spectrum disorders. Neuroimage Clin. 2014 Oct 13;6:379-87. pubmed<\/a><\/p>\n

Cascio CJ, Foss-Feig JH<\/strong>, Heacock J, Schauder KB, Loring WA, Rogers BP, Pryweller JR, Newsom CR, Cockhren J, Cao A, Bolton S. (2014). Affective neural response to restricted interests in autism spectrum disorders. J Child Psychol Psychiatry. 2014;55(2):162-71. pubmed<\/a><\/p>\n

Nichols CM, Iba\u00f1ez LV, Foss-Feig JH<\/strong>, Stone WL.(2014). Social smiling and its components in high-risk infant siblings without later ASD symptomatology. J Autism Dev Disord. 44(4):894-902. pubmed<\/a><\/p>\n

Ventola, P., Friedman, H. E., Anderson, L. C., Wolf, J. M., Oosting, D., Foss-Feig, J.<\/strong>, McDonald N., Volkmar F., Pelphrey, K. A. (2014). Improvements in social and adaptive functioning following short-duration PRT program: A clinical replication. Journal of autism and developmental disorders, 1-9. pubmed<\/a><\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item _builder_version=”3.19.10″ title=”2013″ link_option_url_new_window=”off” use_background_color_gradient=”off” background_color_gradient_start=”#2b87da” background_color_gradient_end=”#29c4a9″ background_color_gradient_type=”linear” background_color_gradient_direction=”180deg” background_color_gradient_direction_radial=”center” background_color_gradient_start_position=”0%” background_color_gradient_end_position=”100%” background_color_gradient_overlays_image=”off” parallax=”off” parallax_method=”on” background_size=”cover” background_position=”center” background_repeat=”no-repeat” background_blend=”normal” allow_player_pause=”off” background_video_pause_outside_viewport=”on” text_shadow_style=”none” box_shadow_style=”none” hover_transition_duration=”300ms” hover_transition_delay=”0ms” hover_transition_speed_curve=”ease”]<\/p>\n

Foss-Feig JH<\/strong>, Tadin D, Schauder KB, Cascio CJ. (2013). A substantial and unexpected enhancement of motion perception in autism. J Neurosci. 8;33(19):8243-9. pubmed<\/a><\/p>\n

Malesa, E.E., Foss-Feig, J.H.<\/strong>, Yoder, P.J., Warren, Z.E., Walden, T.A., and Stone, W.L. (2013). Language and social outcomes at school age for later-born siblings of children with autism spectrum disorders. Autism. 17(5):558-70, pubmed<\/a><\/p>\n

Woynaroski TG, Kwakye LD, Foss-Feig JH<\/strong>, Stevenson RA, Stone WL, Wallace MT. (2013). Multisensory speech perception in children with autism spectrum disorders. J Autism Dev Disord. 43(12):2891-902. pubmed<\/a><\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item _builder_version=”3.19.10″ title=”2012″ link_option_url_new_window=”off” use_background_color_gradient=”off” background_color_gradient_start=”#2b87da” background_color_gradient_end=”#29c4a9″ background_color_gradient_type=”linear” background_color_gradient_direction=”180deg” background_color_gradient_direction_radial=”center” background_color_gradient_start_position=”0%” background_color_gradient_end_position=”100%” background_color_gradient_overlays_image=”off” parallax=”off” parallax_method=”on” background_size=”cover” background_position=”center” background_repeat=”no-repeat” background_blend=”normal” allow_player_pause=”off” background_video_pause_outside_viewport=”on” text_shadow_style=”none” box_shadow_style=”none” hover_transition_duration=”300ms” hover_transition_delay=”0ms” hover_transition_speed_curve=”ease”]<\/p>\n

Cascio CJ, Foss-Feig JH<\/strong>, Heacock JL, Newsom CR, Cowan RL, Benningfield MM, Rogers BP, Cao A. (2012). Response of neural reward regions to food cues in autism spectrum disorders. J Neurodev Disord. 17;4(1):9. pubmed<\/a><\/p>\n

Cascio CJ, Foss-Feig JH<\/strong>, Burnette CP, Heacock JL, Cosby AA. (2012). The rubber hand illusion in children with autism spectrum disorders: delayed influence of combined tactile and visual input on proprioception. Autism. 16(4):406-19. pubmed<\/a><\/p>\n

Foss-Feig JH<\/strong>, Heacock JL, Cascio CJ. (2012). Tactile responsiveness patterns and their association with core features in autism spectrum disorders. Res Autism Spectr Disord. 6(1):337-344. pubmed<\/a><\/p>\n

Murphy, E., Foss-Feig, J.<\/strong>, Kenworthy, L., Gaillard, W.D., and Vaidya, C. (2012). Atypical functional connectivity of the amygdala in childhood autism spectrum disorders during spontaneous attention to eye-gaze. Autism Research and Treatment. pubmed<\/a><\/p>\n

Warren ZE, Foss-Feig JH<\/strong>, Malesa EE, Lee EB, Taylor JL, Newsom CR, Crittendon J, Stone WL. (2012). Neurocognitive and behavioral outcomes of younger siblings of children with autism spectrum disorder at age five. J Autism Dev Disord. 42(3):409-18. pubmed<\/a><\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item _builder_version=”3.19.10″ title=”2011″ link_option_url_new_window=”off” use_background_color_gradient=”off” background_color_gradient_start=”#2b87da” background_color_gradient_end=”#29c4a9″ background_color_gradient_type=”linear” background_color_gradient_direction=”180deg” background_color_gradient_direction_radial=”center” background_color_gradient_start_position=”0%” background_color_gradient_end_position=”100%” background_color_gradient_overlays_image=”off” parallax=”off” parallax_method=”on” background_size=”cover” background_position=”center” background_repeat=”no-repeat” background_blend=”normal” allow_player_pause=”off” background_video_pause_outside_viewport=”on” text_shadow_style=”none” box_shadow_style=”none” hover_transition_duration=”300ms” hover_transition_delay=”0ms” hover_transition_speed_curve=”ease”]<\/p>\n

Gordon, E. M., Lee, P. S., Maisog, J. M., Foss-Feig, J.<\/strong>, Billington, M. E., VanMeter, J., and Vaidya, C. J. (2011). Strength of default mode resting-state connectivity relates to white matter integrity in children. Developmental Science, 14, 738-751. pubmed<\/a><\/p>\n

Kwakye LD, Foss-Feig JH<\/strong>, Cascio CJ, Stone WL, Wallace MT. (2011). Altered auditory and multisensory temporal processing in autism spectrum disorders. Front Integr Neurosci. 5;4:129. pubmed<\/a><\/p>\n

Vaidya, C.J., Foss-Feig, J.<\/strong>, Shook, D., Kaplan, L., Kenworthy, L., and Gaillard, W.D. (2011). Controlling attention to gaze and arrows in childhood: A fMRI study of typical development and Autism Spectrum Disorders. Developmental Science, 14, 911-924. pubmed<\/a><\/p>\n

Warren Z, Veenstra-VanderWeele J, Stone W, Bruzek JL, Nahmias AS, Foss-Feig JH<\/strong>, Jerome RN, Krishnaswami S, Sathe NA, Glasser AM, Surawicz T, McPheeters ML. (2011). Therapies for Children With Autism Spectrum Disorders. Rockville (MD): Agency for Healthcare Research and Quality (US). pubmed<\/a><\/p>\n

Warren Z, McPheeters ML, Sathe N, Foss-Feig JH<\/strong>, Glasser A, Veenstra-Vanderweele J. (2011). A systematic review of early intensive intervention for autism spectrum disorders. Pediatrics. 127(5):e1303-11. pubmed<\/a><\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item _builder_version=”3.19.10″ title=”2010″ link_option_url_new_window=”off” use_background_color_gradient=”off” background_color_gradient_start=”#2b87da” background_color_gradient_end=”#29c4a9″ background_color_gradient_type=”linear” background_color_gradient_direction=”180deg” background_color_gradient_direction_radial=”center” background_color_gradient_start_position=”0%” background_color_gradient_end_position=”100%” background_color_gradient_overlays_image=”off” parallax=”off” parallax_method=”on” background_size=”cover” background_position=”center” background_repeat=”no-repeat” background_blend=”normal” allow_player_pause=”off” background_video_pause_outside_viewport=”on” text_shadow_style=”none” box_shadow_style=”none” hover_transition_duration=”300ms” hover_transition_delay=”0ms” hover_transition_speed_curve=”ease”]<\/p>\n

Foss-Feig JH<\/strong>, Kwakye LD, Cascio CJ, Burnette CP, Kadivar H, Stone WL, Wallace MT. (2010). An extended multisensory temporal binding window in autism spectrum disorders. Exp Brain Res. 203(2):381-9. pubmed<\/a><\/p>\n

Stollstorff, M., Foss-Feig, J.<\/strong>, Cook, E.H., Stein, M.A., Gaillard, W.D., and Vaidya, C.J. (2010). Neural response to working memory load varies by dopamine transporter genotype in children. Neuroimage, 53, 970-977. pubmed<\/a><\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item _builder_version=”3.19.10″ title=”2007 -2009″ link_option_url_new_window=”off” use_background_color_gradient=”off” background_color_gradient_start=”#2b87da” background_color_gradient_end=”#29c4a9″ background_color_gradient_type=”linear” background_color_gradient_direction=”180deg” background_color_gradient_direction_radial=”center” background_color_gradient_start_position=”0%” background_color_gradient_end_position=”100%” background_color_gradient_overlays_image=”off” parallax=”off” parallax_method=”on” background_size=”cover” background_position=”center” background_repeat=”no-repeat” background_blend=”normal” allow_player_pause=”off” background_video_pause_outside_viewport=”on” text_shadow_style=”none” box_shadow_style=”none” hover_transition_duration=”300ms” hover_transition_delay=”0ms” hover_transition_speed_curve=”ease”]<\/p>\n

Lee, P.S., Yerys, B.E., Della Rosa, A., Foss-Feig, J.H.<\/strong>, Barnes, K.A., James, J.D., VanMeter, J., Vaidya, C.J., Gaillard, W.D., and Kenworthy, L.E. (2009). Functional connectivity of the inferior frontal cortex changes with age in children with autism spectrum disorders: A fcMRI study of response inhibition. Cerebral Cortex, 19, 1787-1794. pubmed<\/a><\/p>\n

Lee, P.S., Foss-Feig, J.<\/strong>, Henderson, J., Kenworthy, L., Gilotty, L., Gaillard, W.D., and Vaidya, C.J. (2007). Atypical neural substrates of Embedded Figure Task performance in children with autism spectrum disorders. Neuroimage, 38, 184-193. pubmed<\/a><\/p>\n

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Current Openings<\/h3>\n

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\n

Interested in joining the lab? We are always looking for talented people to join our team. Check out the opportunities that we offer for:
Undergraduate Students
Graduate Students
Postdoctoral Students<\/p>\n

To apply:
Please send a cover letter stating your interest and a resume to christopher.mclaughlin@mssm.edu<\/a>. Please, be sure to indicate the type of position that you are interested in.<\/p>\n

UNDERGRADUATE STUDENTS<\/strong>
Research assistants get hands-on experience in the following areas:
Assisting in running EEG and eye-tracking studies
Clinical exposure to individuals with neurodevelopmental disorders
Observation of clinical assessments
Data processing, entry, and analysis
Participant recruitment and screening
Attending bi-weekly lab meetings
Presenting research and writing abstracts
Development and maintenance of experimental paradigms<\/p>\n

GRADUATE STUDENTS<\/strong>
Qualified applicants should visit the Icahn School of Medicine at Mount Sinai Graduate School of Biomedical Sciences<\/a> PhD Program\u2019s home page.<\/p>\n

POSTDOCTORAL FELLOW<\/strong>
Interested applicants should contact Dr. Jennifer Foss-Feig<\/a> to inquire about positions.<\/p>\n<\/div>\n

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\n<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Mount Sinai” _builder_version=”3.19.10″]<\/p>\n

Mount Sinai<\/strong>
Associate Scientist
mount.sinai@mssm.edu<\/a>\u00a0<\/p>\n

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Current Openings<\/h3>\n

[\/et_pb_text][et_pb_text admin_label=”Mount Sinai” _builder_version=”3.19.10″]<\/p>\n

Mount Sinai<\/strong>
Associate Scientist
mount.sinai@mssm.edu<\/a>\u00a0<\/p>\n

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\n<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Mount Sinai” _builder_version=”3.19.10″]<\/p>\n

Mount Sinai<\/strong>
Associate Scientist
mount.sinai@mssm.edu<\/a>\u00a0<\/p>\n

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[\/et_pb_text][et_pb_text admin_label=”Mount Sinai” _builder_version=”3.19.10″]<\/p>\n

Mount Sinai<\/strong>
Associate Scientist
mount.sinai@mssm.edu<\/a>\u00a0<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ prev_background_color=”#eaf2f7″ next_background_color=”#000000″ _builder_version=”3.19.10″ background_color=”#ffffff” border_color_bottom=”#00aeef” module_id=”links” module_class=”links-section” background_image=”https:\/\/labs.icahn.mssm.edu\/foss-feig-lab-beta\/wp-content\/uploads\/sites\/324\/2019\/08\/word-cloud.png” disabled=”on” disabled_on=”on|on|on” inner_width=”auto” inner_max_width=”1225px”][et_pb_row admin_label=”team” _builder_version=”3.19.10″ custom_margin=”||-50px|”][et_pb_column type=”4_4″ custom_padding__hover=”|||” custom_padding=”|||”][et_pb_text admin_label=”In The News” _builder_version=”3.19.10″ custom_margin=”||-3em|”]<\/p>\n

In The News<\/h3>\n

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Autism Science Foundation Undergraduate Research Award <\/strong>
Congratulations to Christina Layton a recipient of the Autism Science Foundation Undergraduate Summer Research Award. Read more…<\/a><\/p>\n

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\nPresentations<\/strong>
Emily Isenstein presented a poster entitled \u201cElectrophysiological Evidence of Auditory Habituation Abnormalities in Young Adults With Phelan-Mcdermid Syndrome\u201d at the Society for Biological Psychiatry conference in May 2018.<\/p>\n

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Participant Recruitment<\/strong>
We are currently recruiting for our research studies. Want to participate? Find out how…<\/a><\/p>\n

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Recent Papers<\/strong>
Dr. Jennifer Foss-Feig’s article on temporal processing deficits in ASD was published in the 11th issue of Autism Research volume 10. Read more…<\/a><\/p>\n

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\nFoss-Feig Lab<\/strong>
Seaver Autism Center for Research and Treatment
Icahn School of Medicine at Mount Sinai
Department of Psychiatry<\/p>\n

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Contact Us<\/strong>
One Gustave L. Levy Place
New York, NY 10029
Telephone: (212) 241-0961
Email: fossfeiglab@mssm.edu<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ custom_padding__hover=”|||” custom_padding=”|||”][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div> Principal Investigator Jennifer Foss-Feig, PhD About the LabHere at the Foss-Feig Lab, our research combines clinical assessments with brain-based methods, including EEG and MRI, to examine sensory and perceptual functioning in autism spectrum disorder (ASD). We also study the relation between ASD and other neurodevelopmental disorders, including schizophrenia and psychosis prodrome, as well as […]<\/p>\n","protected":false},"author":274,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-747","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/foss-feig-lab\/wp-json\/wp\/v2\/pages\/747","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/foss-feig-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/foss-feig-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/foss-feig-lab\/wp-json\/wp\/v2\/users\/274"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/foss-feig-lab\/wp-json\/wp\/v2\/comments?post=747"}],"version-history":[{"count":42,"href":"https:\/\/labs.icahn.mssm.edu\/foss-feig-lab\/wp-json\/wp\/v2\/pages\/747\/revisions"}],"predecessor-version":[{"id":1129,"href":"https:\/\/labs.icahn.mssm.edu\/foss-feig-lab\/wp-json\/wp\/v2\/pages\/747\/revisions\/1129"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/foss-feig-lab\/wp-json\/wp\/v2\/media?parent=747"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}