{"id":83,"date":"2014-10-16T20:40:39","date_gmt":"2014-10-16T20:40:39","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/fisherlab\/?page_id=83"},"modified":"2020-06-18T12:03:36","modified_gmt":"2020-06-18T12:03:36","slug":"publications","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/fisherlab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"
    \n
  1. Sans\u00f3, M., Parua, P.K., Pinto, D., Svensson, J.P., Pag\u00e9, V., Bitton, D.A., MacKinnon, S., Garcia, P., Hidalgo, E, B\u00e4hler, J., Tanny, J.C. and\u00a0Fisher, R.P.<\/strong>\u00a0Cdk9 and H2Bub1 signal to Clr6-CII\/Rpd3S to suppress aberrant antisense transcription. Nucleic Acids Res. doi: 10.1093\/nar\/gkaa474. Online ahead of print, 2020<\/li>\n
  2. Parua, P.K. and\u00a0Fisher, R.P.<\/strong>\u00a0Dissecting the Pol II transcription cycle and derailing cancer with CDK inhibitors. Nat. Chem. Biol. doi: 10.1038\/s41589-020-0563-4, in press, 2020.<\/li>\n
  3. A Cdk9-PP1 switch regulates the elongation-termination transition of RNA polymerase II. Parua PK, Booth GT, Sans\u00f3 M, Benjamin B, Tanny JC, Lis JT,\u00a0Fisher RP.\u00a0 Nature 2018 Jun;558(7710):460-464. doi: 10.1038\/s41586-018-0214-z. Epub 2018 Jun 13.\u00a0 PMID: 29899453\u00a0https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29899453<\/a><\/li>\n
  4. Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast. Booth GT, Parua PK, Sans\u00f3 M,\u00a0Fisher RP, Lis JT.\u00a0 Nat Commun. 2018 Feb 7;9(1):543. doi: 10.1038\/s41467-018-03006-4.\u00a0 PMID:29416031\u00a0https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29416031<\/a><\/li>\n
  5. Taking Aim at Glycolysis with CDK8 Inhibitors. Fisher RP. Trends Endocrinol Metab. 2018 May;29(5):281-282. doi: 10.1016\/j.tem.2018.02.005. Epub 2018 Feb 20.\u00a0 PMID 29475579\u00a0https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29475579<\/a><\/li>\n
  6. Elagib, K.E., Lu, C.-H., Mosoyan, G., Khalil, S., Zasadzinska, Foltz, D.R., Balogh, P., Gru, A.A., Fuchs, D.A., Rimsza, L.M., Verhoeyen, E., Sans\u00f3, M., Fisher, R.P., Iancu-Rubin, C. and Goldfarb, A.M. Neonatal expression of RNA-binding protein IGF2BP3 regulates the human fetal-adult megakaryocyte transition. J. Clin. Invest. 127: 2365-2377, 2017. PMCID: PMC5451240 https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28481226<\/a><\/li>\n
  7. Kalan, S., Amat, R., Schachter, M.M., Kwiakowski, N., Abraham, B.J., Liang, Y., Zhang, T., Olson, C.M., Larochelle, S., Young, R.A., Gray, N.S. and Fisher, R.P. Activation of the p53 transcriptional program sensitizes cancer cells to Cdk7 inhibitors. Cell Reports 21: 467-481, 2017. PMCID: PMC5687273 https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29020632<\/a><\/li>\n
  8. Rollins, D.A., Kharlyngdoh, J.B., Coppo, M., Tharmalingam, B., Mimouna, S., Guo, Z., Sacta, m.A., Pufall, M.A., Fisher, R.P., Hu, X., Chinenov, Y. and Rogatsky, I. Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages. Nat. Commun. 8: 1739, 2017. PMCID: PMC5700924 https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29170386<\/a><\/li>\n
  9. Fisher, R.P., CDK regulation of transcription by RNAP II: Not over \u2018til it\u2019s over? Transcription 8: 81-90, 2017.PMCID: PMC5423476 https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28005463<\/a><\/li>\n
  10. Sans\u00f3, M., Levin, R.S., Lipp, J.J., Wang, V. Y.-F., Greifenberg, A.K., Quezada, E.M., Ali, A., Ghosh, A., Larochelle, S., Rana, T.M., Geyer, M., Tong, L., Shokat, K.M. and Fisher, R.P. P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates. Genes Dev. 30: 117-131, 2016. PMCID: PMC4701974 https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26728557<\/a><\/li>\n
  11. Fisher, R.P. Getting to S: CDK functions and targets on the path to cell-cycle commitment. F1000Res. 5: 2374, 2016. PMCID: PMC5040153 https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27746911<\/a><\/li>\n
  12. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24385927B\u00f6sken, C.A., Farnung, L., Hintermair, C., Schachter, M.M., Vogel-Bachmayr, K., Blazek, D., Anand, K., Fisher, R.P., Eick, D. and\u00a0 Geyer, M. The structure and substrate specificity of human Cdk12\/Cyclin K. Nat. Commun., 5: 3505, 2014.\u00a0\u00a0\u00a0http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24662513<\/a><\/li>\n
  13. Schachter, M.M., Merrick, K.A., Larochelle, S., Hirschi, A., Zhang, C., Shokat, K.M., Rubin, S.M. and Fisher, R.P. A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression. Mol. Cell 50: 250-260, 2013. PMCID: PMC3677717 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23622515<\/a><\/li>\n
  14. Sans\u00f3, M. and Fisher, R.P. Pause, play, repeat: CDKs push RNAP II\u2019s buttons. Transcription 4: 146-152, 2013. PMCID: PMC3977912 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23756342<\/a><\/li>\n
  15. Schachter, M.M. and Fisher, R.P. The CDK-activating kinase Cdk7: Taking yes for an answer. Cell Cycle 12: 3239-3240, 2013. PMCID: PMC3885630 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24036541<\/a><\/li>\n
  16. Mbogning, J., Nagy, S., Pag\u00e9, V., Schwer, B., Shuman, S., Fisher, R.P. and Tanny, J.C. The PAF complex and Prf1\/Rtf1 delineate distinct Cdk9-dependent pathways regulating transcription elongation in fission yeast. PLoS Genet., 9: e1004029, 2013.\u00a0https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24385927<\/a><\/li>\n
  17. Merrick, K.A. and Fisher, R.P. Why minimal is not optimal: driving the mammalian cell cycle\u2014and drug discovery\u2014with a physiologic CDK control network. Cell Cycle 11: 2600-2605, 2012. PMCID: PMC3409006 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22732498<\/a><\/li>\n
  18. Horiuchi, D., Huskey, N.E., Kusdra, L., Wohlbold, L., Merrick, K.A., Zhang, C., Creasman, K.J., Shokat, K.M., Fisher, R.P. and Goga, A. Chemical-genetic analysis of CDK2 function reveals an important role in cellular transformation by multiple oncogenic pathways. Proc. Natl. Acad. Sci. USA 109: E1019-1027, 2012. PMCID: PMC3340028 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22474407<\/a><\/li>\n
  19. Amour, C.V., Sans\u00f3, M., B\u00f6sken, C.A., Lee, K.M., Larochelle. S., Zhang, C., Shokat, K.M., Geyer, M. and Fisher, R.P. Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) CTD substrate recognition. Mol. Cell. Biol. 32: 2372-2383, 2012. PMCID: PMC3434489 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22508988<\/a><\/li>\n
  20. Sans\u00f3, M., Lee, K.M., Viladevall. L., Jacques, P.-E., Pag\u00e9, V., Nagy, S., Racine, A., St. Amour, C.V., Zhang, C., Shokat, K.M., Schwer, B., Robert, F., Fisher, R.P.* and Tanny, J.C.* A positive feedback loop links opposing functions of P-TEFb\/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast. PLoS Genetics 8: e1002822, 2012. PMCID: PMC3410854 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22876190<\/a><\/li>\n
  21. Wohlbold, L., Merrick, K.A., De, S., Larochelle, S., Allen, J.J., Zhang, C., Petrini, J.H.J. and Fisher, R.P. Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells. PLoS Genetics 8: e1002935, 2012. PMCID: PMC3426557 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22927831<\/a><\/li>\n
  22. Larochelle, S., Amat, R., Glover-Cutter, K., Sans\u00f3, M., Zhang, C., Allen, J.J., Shokat, K.M., Bentley, D.L. and Fisher, R.P. Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II. Nat. Struct. Mol. Biol. 19: 1108-1115, 2012. PMCID: PMC3746743 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23064645<\/a><\/li>\n
  23. Merrick, K.A., Wohlbold, L., Zhang, C., Allen, J.J., Horiuchi, D., Huskey, N.E., Goga, A., Shokat, K.M. and Fisher, R.P. Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation. Mol. Cell 42: 624-636, 2011. PMCID: PMC31190 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21658603<\/a><\/li>\n
  24. Merrick, K.A. and Fisher, R.P. Putting one step before the other: distinct activation pathways for Cdk1 and Cdk2 bring order to the mammalian cell cycle. Cell Cycle 9: 706-714, 2010. PMCID: PMC2851199 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20139727<\/a><\/li>\n
  25. Ray, A., James, M., Larochelle, S., Fisher, R.P. and Blain, S.W. p27Kip1 inhibits cyclin D-cdk4 by two independent modes. Mol. Cell. Biol. 29: 986-999, 2009. PMCID: PMC2643810 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19075005<\/a><\/li>\n
  26. Viladevall, L., St. Amour, C.V., Rosebrock, A., Schneider, S., Zhang, C., Shokat, K.M., Schwer, B., Leatherwood, J.K. and Fisher, R.P. TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast. Mol. Cell 33: 738-751, 2009. PMCID: PMC2693121 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19328067<\/a><\/li>\n
  27. Glover-Cutter, K., Larochelle, S., Erickson, B., Zhang, C., Shokat, K,, Fisher, R.P. and Bentley, D.L. TFIIH-associated Cdk7 kinase functions in phosphorylation of CTD Ser7 residues, promoter-proximal pausing and termination by RNA polymerase II. Mol. Cell. Biol. 29: 5455-5464, 2009. PMCID: PMC2756882 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19667075<\/a><\/li>\n
  28. Wohlbold, L. and Fisher, R.P. Behind the wheel and under the hood: Functions of cyclin-dependent kinases in response to DNA damage. DNA Repair 8: 1018-1024, 2009. PMCID: PMC2725215 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19464967<\/a><\/li>\n
  29. Gerber, H.B., Pikman, Y. and Fisher, R.P. The CDK-Activating Kinase (CAK) Csk1 Is Required for Normal Levels of Homologous Recombination and Resistance to DNA Damage in Fission Yeast. PLoS ONE 3: e1492, 2008. PMCID: PMC2200797 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18231579<\/a><\/li>\n
  30. Sordet, O., Larochelle, S., Nicolas, E. Stevens, E.V., Zhang, C., Shokat, K.M., Fisher, R.P. and Pommier, Y. RNA polymerase II is hyperphosphorylated in response to topoisomerase I-DNA cleavage complexes and is associated with transcription- and BRCA1-dependent degradation of toposiomerase I. J. Mol. Biol. 381: 540-549, 2008. PMCID: PMC2754794 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18588899<\/a><\/li>\n
  31. Merrick, K.A., Larochelle, S., Zhang, C., Allen, J.J., Shokat, K.M. and Fisher, R.P. Distinct activation pathways confer cyclin binding specificity on Cdk1 and Cdk2 in human cells. Mol. Cell 32: 662-672, 2008. PMCID: PMC2643088 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19061641<\/a><\/li>\n
  32. Larochelle, S., Merrick, K.A., Terret, M.-E., Wohlbold, L., Barboza, N.M., Zhang, C., Shokat, K.M., Jallepalli, P.V. and Fisher, R.P. Requirements for Cdk7 in the assembly of Cdk1\/ cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. Mol. Cell 25: 839-850, 2007. PMCID: PMC1858677 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17386261<\/a><\/li>\n
  33. Burkard, M.E., Randall, C.L., Larochelle, S., Zhang, C., Shokat, K.M., Fisher, R.P. and Jallepalli, P.V. Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells. Proc. Natl. Acad. Sci. USA 104: 4383-4388, 2007. PMCID: PMC1838611 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17360533<\/a><\/li>\n
  34. Gamble, M.J. and Fisher, R.P. SET and PARP1 remove DEK from chromatin to permit access by the transcription machinery. Nat. Struct. Mol. Biol. 14: 548-555, 2007. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17529993<\/a><\/li>\n
  35. Larochelle, S., Batliner, J., Gamble, M.J., Barboza, N., Kraybill, B.C., Blethrow, J.D., Shokat, K.M. and Fisher, R.P. Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics. Nat. Struct. Mol. Biol. 13: 55-62, 2006. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16327805<\/a><\/li>\n
  36. Pei, Y., Du, H., Singer, J., St. Amour, C., Granitto, S., Shuman, S. and Fisher, R.P. Cyclin-dependent kinase 9 (Cdk9) of fission yeast is activated by the CDK-activating kinase Csk1, overlaps functionally with the TFIIH-associated kinase Mcs6, and associates with the mRNA cap methyltransferase Pcm1 in vivo. Mol. Cell. Biol. 26: 777-788, 2006. PMCID: PMC1347026 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16428435<\/a><\/li>\n
  37. Wohlbold, L., Larochelle, S., Liao, J.C.-F., Livshits, G., Singer, J., Shokat, K. and Fisher, R.P. The cyclin-dependent kinase (CDK) family member PNQALRE\/ CCRK supports cell proliferation but has no intrinsic CDK-activating kinase (CAK) activity. Cell Cycle 5: 546-554, 2006. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16552187<\/a><\/li>\n
  38. Gamble, M.J., Erdjument-Bromage, H., Tempst, P., Freedman, L.P. and Fisher, R.P. The histone chaperone TAF-I\/SET\/INHAT is required for transcription in vitro of chromatin templates. Mol. Cell. Biol. 25: 797-807, 2005. PMCID: PMC543418 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15632079<\/a><\/li>\n
  39. Lee, K.M., Miklos, I., Du, H., Watt, S., Szilagyi, Z., Saiz, J.E., Madabhushi, R., Penkett, C.J., Sipiczki, M., B\u00e4hler, J. and Fisher, R.P. Impairment of the TFIIH-associated CDK-activating kinase selectively affects cell cycle-regulated gene expression in fission yeast. Mol. Biol. Cell 16: 2734-2745, 2005. PMCID: PMC1142420 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15829570<\/a><\/li>\n
  40. Fisher, R.P. Secrets of a double agent: CDK7 in cell-cycle control and transcription. J. Cell Sci. 118: 5171-5180, 2005. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16280550<\/a><\/li>\n
  41. Saiz, J.E. and Fisher, R.P. A CDK-activating kinase network is required in cell cycle control and transcription in fission yeast. Curr. Biol., 12: 1100-1105, 2002. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12121616<\/a><\/li>\n
  42. Garrett, S., Barton, W.A., Knights, R., Jin, P., Morgan, D.O. and Fisher, R.P. Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop. Mol. Cell. Biol., 21: 88-99, 2001. PMCID: PMC88783 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11113184<\/a><\/li>\n
  43. Larochelle, S., Chen, J., Knights, R., Pandur, J., Morcillo, P. Erdjument-Bromage, H., Tempst, P., Suter, B., and Fisher, R.P. T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activity. EMBO J., 20: 3749-3759, 2001. PMCID: PMC125544 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11447116<\/a><\/li>\n
  44. Pei, Y., Schwer, B., Saiz, J., Fisher, R.P. and Shuman, S. RNA triphosphatase is essential in Schizosaccharomyces pombe and Candida albicans. BMC Microbiology 1: 29, 2001. PMCID: PMC60989 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11737862<\/a><\/li>\n
  45. Lee, K.M., Saiz, J.E., Barton, W.A. and Fisher, R.P. Cdc2 activation in fission yeast depends on Mcs6 and Csk1, two partially redundant Cdk-activating kinases (CAKs). Curr. Biol., 9: 441-444, 1999. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10226032<\/a><\/li>\n
  46. Levine, K., Kiang, L., Jacobson, M., Fisher, R.P. and Cross, F.R. Directed evolution to bypass cyclin requirements for the budding yeast Cdk. Cell, 4: 353-363, 1999. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10518216<\/a><\/li>\n
  47. Larochelle, S., Pandur, J., Fisher, R.P., Salz, H.K. and Suter, B. Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity. Genes Dev., 12: 370-381, 1998. PMCID: PMC316490 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9450931<\/a><\/li>\n
  48. Shiekhattar, R., Mermelstein, F., Fisher, R.P., Drapkin, R., Dynlacht, B., Wessling, H.C., Morgan, D.O. and Reinberg, D. Cdk-activating kinase (CAK) complex is a component of human transcription factor IIH.\u00a0 Nature, 374: 283-287, 1995. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7533895<\/a><\/li>\n
  49. Fisher, R.P., Jin, P., Chamberlin, H.M. and Morgan, D.O. Alternative mechanisms of CAK assembly require an assembly factor or an activating kinase.\u00a0 Cell, 83: 47-57, 1995. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7553872<\/a><\/li>\n
  50. Fisher, R.P. and Morgan, D.O. A novel cyclin associates with MO15\/CDK7 to form the CDK-activating kinase.\u00a0 Cell, 78: 713-724, 1994. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8069918<\/a><\/li>\n<\/ol>\n

     <\/p>\n

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    Sans\u00f3, M., Parua, P.K., Pinto, D., Svensson, J.P., Pag\u00e9, V., Bitton, D.A., MacKinnon, S., Garcia, P., Hidalgo, E, B\u00e4hler, J., Tanny, J.C. and\u00a0Fisher, R.P.\u00a0Cdk9 and H2Bub1 signal to Clr6-CII\/Rpd3S to suppress aberrant antisense transcription. Nucleic Acids Res. doi: 10.1093\/nar\/gkaa474. Online ahead of print, 2020 Parua, P.K. and\u00a0Fisher, R.P.\u00a0Dissecting the Pol II transcription cycle and derailing […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-83","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/fisherlab\/wp-json\/wp\/v2\/pages\/83","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/fisherlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/fisherlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/fisherlab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/fisherlab\/wp-json\/wp\/v2\/comments?post=83"}],"version-history":[{"count":12,"href":"https:\/\/labs.icahn.mssm.edu\/fisherlab\/wp-json\/wp\/v2\/pages\/83\/revisions"}],"predecessor-version":[{"id":240,"href":"https:\/\/labs.icahn.mssm.edu\/fisherlab\/wp-json\/wp\/v2\/pages\/83\/revisions\/240"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/fisherlab\/wp-json\/wp\/v2\/media?parent=83"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}