{"id":2494,"date":"2022-12-20T11:44:55","date_gmt":"2022-12-20T16:44:55","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/design\/?page_id=2494"},"modified":"2024-12-09T15:27:50","modified_gmt":"2024-12-09T20:27:50","slug":"contact-us","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/ferraralab\/contact-us\/","title":{"rendered":"Contact Us"},"content":{"rendered":"

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Contact Us<\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.9.0″ background_color=”RGBA(0,0,0,0)” background_color_gradient_direction=”38deg” module_alignment=”center” custom_margin=”|auto|-2px|auto||” custom_padding=”0px|||||” locked=”off” collapsed=”on”][et_pb_column type=”1_2″ _builder_version=”4.9.0″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”1.25em” header_font=”||||||||” header_4_font=”|700||on|||||” header_4_font_size=”16px” header_4_letter_spacing=”1px” header_4_line_height=”1.5em” background_layout=”dark” locked=”off”]<\/p>\n

E-mail
<\/strong>james.ferrara@mssm.edu<\/p>\n

Phone
<\/strong>212-824-9339<\/p>\n

<\/b><\/p>\n

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Lab Address <\/strong>
Hess Center for Science and Medicine<\/span>
1470 Madison Avenue<\/span>
6th Floor<\/span>
New York, NY 10029<\/span><\/p>\n

<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Contact Us E-mailjames.ferrara@mssm.edu Phone212-824-9339 Lab Address Hess Center for Science and Medicine1470 Madison Avenue6th FloorNew York, NY 10029<\/p>\n","protected":false},"author":545,"featured_media":0,"parent":0,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":" \r\n \r\n \r\n \r\n \r\n body {\r\n font-family: 'Proxima Nova', sans-serif;\r\n }\r\n .text-orange-800 {\r\n color: rgb(154 52 18);\r\n }\r\n .bg-orange-100 {\r\n background-color: rgb(255 237 213);\r\n }\r\n \r\n Manhattan Risk and MAGIC Composite Score Calculator<\/title>\r\n <div class=\"container mx-auto p-4 pt-1\">\r\n <div class=\"flex justify-between\">\r\n <img class=\"h-1\/6 w-1\/6\" src=\"https:\/\/erap-dev-002.mssm.edu\/UI\/Img\/MAGIC-logo.PNG\" alt=\"MAGIC\">\r\n <img class=\"h-1\/6 w-1\/6\" src=\"https:\/\/labs.icahn.mssm.edu\/ferraralab2\/wp-content\/uploads\/sites\/492\/2022\/08\/ISMMS_Web_ExtremeHoriz_Web_RGB.png\">\r\n <\/div>\r\n <h1 class=\"text-3xl font-bold mb-5 text-center\"><span class=\"\">Manhattan Risk and MAGIC Composite Score Calculator<\/span><\/h1>\r\n <h5 class=\"text-sm italic mb\">Enter aGVHD staging for each target organ at the initiation of systemic treatment<\/h5>\r\n <div class=\"grid grid-cols-1 md:grid-cols-2 lg:grid-cols-2 gap-4\">\r\n <!-- Skin -->\r\n <div class=\"bg-white rounded-lg p-4\">\r\n <h3 class=\"font-bold underline\">Skin<\/h3>\r\n <div>\r\n <label class=\"flex items-center group cursor-pointer\">\r\n \r\n <span class=\"transition-all duration-300 group-hover:underline ml-2\">Stage 0 - no GVHD rash<\/span>\r\n <\/label>\r\n <label class=\"flex items-center group cursor-pointer\">\r\n \r\n <span class=\"transition-all duration-300 group-hover:underline ml-2\">Stage 1 - <25% BSA<\/span>\r\n <\/label>\r\n <label class=\"flex items-center group cursor-pointer\">\r\n \r\n <span class=\"transition-all duration-300 group-hover:underline ml-2\">Stage 2 - 25-50% BSA<\/span>\r\n <\/label>\r\n <label class=\"flex items-center group cursor-pointer\">\r\n \r\n <span class=\"transition-all duration-300 group-hover:underline ml-2\">Stage 3 - >50% BSA<\/span>\r\n <\/label>\r\n <label class=\"flex items-center group cursor-pointer\">\r\n \r\n <span class=\"transition-all duration-300 group-hover:underline ml-2\">Stage 4 - Generalized rash (>50% BSA) with bullous formation and\/or desquamation >5%<\/span>\r\n <\/label>\r\n <\/div>\r\n <\/div>\r\n <!-- Liver -->\r\n <div class=\"bg-white rounded-lg p-4\">\r\n <h3 class=\"font-bold underline\">Liver<\/h3>\r\n <div>\r\n <label class=\"flex items-center group cursor-pointer\">\r\n \r\n <span class=\"transition-all duration-300 group-hover:underline ml-2\">Stage 0 - Total Bilirubin <2.0 mg\/dl or non-GVHD hyperbilirubinemia<\/span>\r\n <\/label>\r\n <label class=\"flex items-center group cursor-pointer\">\r\n \r\n <span class=\"transition-all duration-300 group-hover:underline ml-2\">Stage 1 - Total Bilirubin 2.0-3.0 mg\/dl<\/span>\r\n <\/label>\r\n <label class=\"flex items-center group cursor-pointer\">\r\n \r\n <span class=\"transition-all duration-300 group-hover:underline ml-2\">Stage 2 - Total Bilirubin 3.1-6.0 mg\/dl<\/span>\r\n <\/label>\r\n <label class=\"flex items-center group cursor-pointer\">\r\n \r\n <span class=\"transition-all duration-300 group-hover:underline ml-2\">Stage 3 - Total Bilirubin 6.1-15.0 mg\/dl<\/span>\r\n <\/label>\r\n <label class=\"flex items-center group cursor-pointer\">\r\n \r\n <span class=\"transition-all duration-300 group-hover:underline ml-2\">Stage 4 - Total Bilirubin >15.0 mg\/dl<\/span>\r\n <\/label>\r\n <\/div>\r\n <\/div>\r\n\r\n <!-- Upper GI -->\r\n <div class=\"bg-white rounded-lg p-4\">\r\n <h3 class=\"font-bold underline\">Upper GI<\/h3>\r\n <div>\r\n <label class=\"flex items-center group cursor-pointer\">\r\n \r\n <span class=\"transition-all duration-300 group-hover:underline ml-2\">Stage 0 - no persistent N\/V\/A or N\/V\/A from non-GVHD causes<\/span>\r\n <\/label>\r\n <label class=\"flex items-center group cursor-pointer\">\r\n \r\n <span class=\"transition-all duration-300 group-hover:underline ml-2\">Stage 1 - persistent N\/V\/A<\/span>\r\n <\/label>\r\n <\/div>\r\n <\/div>\r\n\r\n <!-- Lower GI -->\r\n <div class=\"bg-white rounded-lg p-4\">\r\n <div class=\"flex items-center\">\r\n <span class=\"flex-grow font-bold underline\">Lower GI<\/span>\r\n <span class=\"ml-2\">\r\n <span id=\"toggleOff\" class=\"cursor-pointer text-gray-600\">Adult <i class=\"fa fa-solid fa-toggle-off fa-lg\"><\/i><\/span>\r\n <span id=\"toggleOn\" class=\"cursor-pointer text-gray-600 hidden\">Child <50kg <i class=\"fa fa-solid fa-toggle-on fa-lg\"><\/i><\/span>\r\n <\/span>\r\n <\/div>\r\n <div>\r\n <label class=\"flex items-center group cursor-pointer\">\r\n \r\n <span class=\"transition-all duration-300 group-hover:underline ml-2\" id=\"lgi0\">Stage 0 - Diarrhea <500 ml\/day or non-GVHD diarrhea<\/span>\r\n <\/label>\r\n <label class=\"flex items-center group cursor-pointer\">\r\n \r\n <span class=\"transition-all duration-300 group-hover:underline ml-2\" id=\"lgi1\">Stage 1 - Diarrhea 500-999 ml\/day<\/span>\r\n <\/label>\r\n <label class=\"flex items-center group cursor-pointer\">\r\n \r\n <span class=\"transition-all duration-300 group-hover:underline ml-2\" id=\"lgi2\">Stage 2 - Diarrhea 1000-1500 ml\/day<\/span>\r\n <\/label>\r\n <label class=\"flex items-center group cursor-pointer\">\r\n \r\n <span class=\"transition-all duration-300 group-hover:underline ml-2\" id=\"lgi3\">Stage 3 - Diarrhea >1500 ml\/day<\/span>\r\n <\/label>\r\n <label class=\"flex items-center group cursor-pointer\">\r\n \r\n <span class=\"transition-all duration-300 group-hover:underline ml-2\" id=\"lgi4\">Stage 4 - Severe abdominal pain with or without ileus or grossly bloody stool (volume independent)<\/span>\r\n <\/label>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <div class=\"bg-white rounded-lg mt-4 p-4\">\r\n <h3 class=\"font-bold underline\">Legend\/Help Text:<\/h3>\r\n <ul class=\"list-disc ml-4\">\r\n <li>N\/V\/A - Nausea, Vomiting, Anorexia<\/li>\r\n <li>Persistent N\/V\/A\r\n <ol class=\"list-decimal ml-8\">\r\n <li>Nausea lasting >3 days <span class=\"font-bold\">and\/or<\/span><\/li>\r\n <li>>2 vomiting episodes per day for at least 2 days <span class=\"font-bold\">and\/or<\/span><\/li>\r\n <li>Anorexia with weight loss<\/li>\r\n <\/ol>\r\n <li id=\"lgi-help\">If diarrhea is reported in episodes: 1 episode = 200 mL<\/li>\r\n <\/ul>\r\n <\/div>\r\n <!-- Score -->\r\n <div class=\"mt-4 mb-8\" id=\"risk\">\r\n <div class=\"bg-blue-100 text-blue-800 rounded-lg p-4 mb-4 hidden\" id=\"risk_low\">\r\n <h2 class=\"text-xl text-center\">The Manhattan Risk is: <span class=\"font-bold\">Low<\/span><\/h2>\r\n <h2 class=\"text-base text-center\">Estimated Day 28 ORR: <span class=\"font-bold\">77%<\/span><\/h2>\r\n <h2 class=\"text-base text-center\">Estimated 6-month NRM: <span class=\"font-bold\">7.0%<\/span><\/h2>\r\n <\/div>\r\n\r\n <div class=\"bg-orange-100 text-orange-800 rounded-lg p-4 mb-4 hidden\" id=\"risk_intermediate\">\r\n <h2 class=\"text-xl text-center\">The Manhattan Risk is: <span class=\"font-bold\">Intermediate<\/span><\/h2>\r\n <h2 class=\"text-base text-center\">Estimated Day 28 ORR: <span class=\"font-bold\">70%<\/span><\/h2>\r\n <h2 class=\"text-base text-center\">Estimated 6-month NRM: <span class=\"font-bold\">15%<\/span><\/h2>\r\n <\/div>\r\n\r\n <div class=\"bg-red-100 text-red-800 rounded-lg p-4 mb-4 hidden\" id=\"risk_high\">\r\n <h2 class=\"text-xl text-center\">The Manhattan Risk is: <span class=\"font-bold\">High<\/span><\/h2>\r\n <h2 class=\"text-base text-center\">Estimated Day 28 ORR: <span class=\"font-bold\">49%<\/span><\/h2>\r\n <h2 class=\"text-base text-center\">Estimated 6-month NRM: <span class=\"font-bold\">36%<\/span><\/h2>\r\n <\/div>\r\n\r\n <div class=\"bg-gray-300 text-gray-800 rounded-lg p-4 mb-4 hidden\" id=\"risk_na\">\r\n <h2 class=\"text-xl text-center\"><span class=\"font-bold\">Not applicable<\/span><\/h2>\r\n <\/div>\r\n <\/div>\r\n \r\n <div id=\"composite\" class=\"hidden\">\r\n <h5 class=\"text-sm italic mb\">Enter Ann Arbor (AA) scoring at the initiation of systemic treatment below to calculate MAGIC Composite Score<\/h5>\r\n <div class=\"bg-white rounded-lg mt-4 p-4\">\r\n <h3 class=\"font-bold underline\">AA Score<\/h3>\r\n <div>\r\n <label class=\"flex items-center group cursor-pointer\">\r\n \r\n <span class=\"transition-all duration-300 group-hover:underline ml-2\">1<\/span>\r\n <\/label>\r\n <label class=\"flex items-center group cursor-pointer\">\r\n \r\n <span class=\"transition-all duration-300 group-hover:underline ml-2\">2<\/span>\r\n <\/label>\r\n <label class=\"flex items-center group cursor-pointer\">\r\n \r\n <span class=\"transition-all duration-300 group-hover:underline ml-2\">3<\/span>\r\n <\/label>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"mt-4 mb-8\" id=\"score\">\r\n <div class=\"bg-blue-100 text-blue-800 rounded-lg p-4 mb-4 hidden\" id=\"score1\">\r\n <h2 class=\"text-xl text-center\">The MAGIC Composite Score is: <span class=\"font-bold\">1<\/span><\/h2>\r\n <h2 class=\"text-base text-center\">Estimated Day 28 ORR: <span class=\"font-bold\">80%<\/span><\/h2>\r\n <h2 class=\"text-base text-center\">Estimated 6-month NRM: <span class=\"font-bold\">5.7%<\/span><\/h2>\r\n <\/div>\r\n\r\n <div class=\"bg-orange-100 text-orange-800 rounded-lg p-4 mb-4 hidden\" id=\"score2\">\r\n <h2 class=\"text-xl text-center\">The MAGIC Composite Score is: <span class=\"font-bold\">2<\/span><\/h2>\r\n <h2 class=\"text-base text-center\">Estimated Day 28 ORR: <span class=\"font-bold\">63%<\/span><\/h2>\r\n <h2 class=\"text-base text-center\">Estimated 6-month NRM: <span class=\"font-bold\">29%<\/span><\/h2>\r\n <\/div>\r\n\r\n <div class=\"bg-red-100 text-red-800 rounded-lg p-4 mb-4 hidden\" id=\"score3\">\r\n <h2 class=\"text-xl text-center\">The MAGIC Composite Score is: <span class=\"font-bold\">3<\/span><\/h2>\r\n <h2 class=\"text-base text-center\">Estimated Day 28 ORR: <span class=\"font-bold\">30%<\/span><\/h2>\r\n <h2 class=\"text-base text-center\">Estimated 6-month NRM: <span class=\"font-bold\">52%<\/span><\/h2>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n\r\n var organs = {skin: undefined, liver: undefined, uppergi: undefined, lowergi: undefined};\r\n var risk = undefined;\r\n const toggleOn = document.getElementById('toggleOn');\r\n const toggleOff = document.getElementById('toggleOff');\r\n const lgi0 = document.getElementById('lgi0');\r\n const lgi1 = document.getElementById('lgi1');\r\n const lgi2 = document.getElementById('lgi2');\r\n const lgi3 = document.getElementById('lgi3');\r\n const lgiHelp = document.getElementById('lgi-help');\r\n const riskLow = document.getElementById('risk_low');\r\n const riskIntermediate = document.getElementById('risk_intermediate');\r\n const riskHigh = document.getElementById('risk_high');\r\n const riskNa = document.getElementById('risk_na');\r\n const composite = document.getElementById('composite');\r\n const aaScore = document.getElementsByName('aa_score');\r\n const score1 = document.getElementById('score1');\r\n const score2 = document.getElementById('score2');\r\n const score3 = document.getElementById('score3');\r\n \r\n function clearAAScore() {\r\n for (var i = 0; i typeof value !== 'undefined');\r\n if (allDefined) {\r\n if ((['1', '2'].includes(organs['skin']) && organs['liver'] == '0' && organs['uppergi'] == '0' && organs['lowergi'] == '0') ||\r\n (organs['uppergi'] == '1' && organs['liver'] == '0' && organs['skin'] == '0' && organs['lowergi'] == '0') ||\r\n (organs['skin'] == '1' && organs['uppergi'] == '1' && organs['liver'] == '0' && organs['lowergi'] == '0')) {\r\n riskLow.classList.toggle('hidden', false);\r\n riskIntermediate.classList.toggle('hidden', true);\r\n riskHigh.classList.toggle('hidden', true);\r\n riskNa.classList.toggle('hidden', true);\r\n composite.classList.toggle('hidden', false);\r\n risk = 'low';\r\n } \r\n else if ((organs['skin'] == '2' && organs['uppergi'] == '1' && organs['liver'] == '0' && organs['lowergi'] == '0') ||\r\n (['1', '2'].includes(organs['lowergi']) && ['0', '1'].includes(organs['uppergi']) && organs['skin'] == '0' && organs['liver'] == '0') ||\r\n (['1', '2', '3'].includes(organs['skin']) && organs['lowergi'] == '1' && ['0', '1'].includes(organs['uppergi']) && organs['liver'] == '0') ||\r\n (organs['skin'] == '3' && ['0', '1'].includes(organs['uppergi']) && organs['liver'] == '0' && organs['lowergi'] == '0')) {\r\n riskLow.classList.toggle('hidden', true);\r\n riskIntermediate.classList.toggle('hidden', false);\r\n riskHigh.classList.toggle('hidden', true);\r\n riskNa.classList.toggle('hidden', true);\r\n composite.classList.toggle('hidden', false);\r\n risk = 'intermediate';\r\n } \r\n else if ((['1', '2', '3'].includes(organs['skin']) && ['2', '3'].includes(organs['lowergi']) && ['0', '1'].includes(organs['uppergi']) && organs['liver'] == '0') ||\r\n (organs['lowergi'] == '3' && ['0', '1'].includes(organs['uppergi']) && organs['skin'] == '0' && organs['liver'] == '0') ||\r\n ([organs['skin'], organs['lowergi']].includes('4') && ['0', '1'].includes(organs['uppergi']) && organs['liver'] == '0') ||\r\n (['1', '2', '3', '4'].includes(organs['liver']) && (['0', '1', '2', '3', '4'].includes(organs['skin']) || ['0', '1'].includes(organs['uppergi']) || ['0', '1', '2', '3', '4'].includes(organs['lowergi'])))) {\r\n riskLow.classList.toggle('hidden', true);\r\n riskIntermediate.classList.toggle('hidden', true);\r\n riskHigh.classList.toggle('hidden', false);\r\n riskNa.classList.toggle('hidden', true);\r\n composite.classList.toggle('hidden', false);\r\n risk = 'high';\r\n } \r\n else if (organs['skin'] == '0' && organs['liver'] == '0' && organs['uppergi'] == '0' && organs['lowergi'] == '0') {\r\n riskLow.classList.toggle('hidden', true);\r\n riskIntermediate.classList.toggle('hidden', true);\r\n riskHigh.classList.toggle('hidden', true);\r\n riskNa.classList.toggle('hidden', false);\r\n composite.classList.toggle('hidden', true);\r\n risk = 'na';\r\n }\r\n document.getElementById('risk').scrollIntoView({block: 'start', behavior: 'smooth'});\r\n } \r\n }\r\n \r\n function toggleChildOn() {\r\n toggleOn.classList.toggle('hidden');\r\n toggleOff.classList.toggle('hidden');\r\n lgi0.textContent = \"Stage 0 - Diarrhea 30 ml\/kg\/day\";\r\n lgiHelp.textContent = \"If diarrhea is reported in episodes: 1 episode = 3ml\/kg\";\r\n }\r\n\r\n function toggleChildOff() {\r\n toggleOn.classList.toggle('hidden');\r\n toggleOff.classList.toggle('hidden');\r\n lgi0.textContent = \"Stage 0 - Diarrhea 1500 ml\/day\";\r\n lgiHelp.textContent = \"If diarrhea is reported in episodes: 1 episode = 200 mL\";\r\n } 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