{"id":1349,"date":"2022-10-13T17:37:32","date_gmt":"2022-10-13T21:37:32","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/design\/?page_id=1349"},"modified":"2024-12-09T15:03:23","modified_gmt":"2024-12-09T20:03:23","slug":"home","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/ferraralab\/","title":{"rendered":"Home"},"content":{"rendered":"

[et_pb_section bb_built=”1″ admin_label=”Fullwidth Video over Background – Section 9″ disabled_on=”off|off|off” module_class=”fullwidth-video-over-background-section-9″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”#ededed” background_image=”https:\/\/labs.icahn.mssm.edu\/ferraralab2\/wp-content\/uploads\/sites\/492\/2022\/10\/4.png” height_last_edited=”on|desktop” max_height=”100%” custom_margin=”||4%||false|false” custom_padding=”0px||0px||false|false” locked=”off” collapsed=”off” next_background_color=”rgba(0,174,239,0.09)”][et_pb_row _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_video src=”https:\/\/www.youtube.com\/watch?v=wwr5y222FME?autoplay=1″ _builder_version=”4.9.0″ _module_preset=”default”]<\/p>\n

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[\/et_pb_video][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ admin_label=”Header Title Description – Section – Header – Fullwidth Slider ” fullwidth=”on” disabled_on=”off|off|off” module_id=”header-title-description-slider-section1″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”rgba(0,174,239,0.09)” background_enable_color=”off” background_image=”https:\/\/labs.icahn.mssm.edu\/ferraralab2\/wp-content\/uploads\/sites\/492\/2022\/07\/ai-002-1.jpg” parallax=”on” custom_padding=”||||false|false” bottom_divider_style=”ramp2″ bottom_divider_color=”#FFFFFF” bottom_divider_height=”11vw” locked=”off” collapsed=”off” prev_background_color=”#ededed” next_background_color=”#ffffff”][et_pb_fullwidth_slider arrows_custom_color=”#D80B8C” dot_nav_custom_color=”#D80B8C” _builder_version=”4.9.0″ _module_preset=”default” min_height=”386.1px” animation_style=”fade”][et_pb_slide heading=”Welcome to the MAGIC Consortium & Ferrara Lab!” _builder_version=”4.9.0″ _module_preset=”default” header_text_align=”left” body_text_align=”left” background_image=”https:\/\/labs.icahn.mssm.edu\/ferraralab2\/wp-content\/uploads\/sites\/492\/2022\/07\/ai-002-1.jpg” background_enable_image=”on” text_orientation=”left” custom_padding=”|||80px|false|false” sticky_transition=”on”][\/et_pb_slide][et_pb_slide heading=”Projects” _builder_version=”4.9.0″ _module_preset=”default” header_text_align=”left” body_text_align=”left” background_image=”https:\/\/labs.icahn.mssm.edu\/ferraralab2\/wp-content\/uploads\/sites\/492\/2022\/07\/ai-002-1.jpg” background_enable_image=”on” text_orientation=”left” custom_padding=”|||80px|false|false” sticky_transition=”on”]<\/p>\n

The current projects in the Ferrara Laboratory investigate graft versus host disease (GVHD) using two different approaches: Biomarkers of GVHD and Mechanisms of GVHD Pathophysiology<\/span>.<\/p>\n

[\/et_pb_slide][et_pb_slide heading=”Biomarkers ” _builder_version=”4.9.0″ _module_preset=”default” header_text_align=”left” body_text_align=”left” background_image=”https:\/\/labs.icahn.mssm.edu\/ferraralab2\/wp-content\/uploads\/sites\/492\/2022\/07\/ai-002-1.jpg” background_enable_image=”on” text_orientation=”left” custom_padding=”|||80px|false|false” sticky_transition=”on”]<\/p>\n

In these projects, we aim to use novel and established proteomic techniques to identify and validate biomarkers of GVHD, and subsequently combine these into predictive algorithms.<\/span><\/p>\n

[\/et_pb_slide][et_pb_slide heading=”Mechanisms of GVHD Pathophysiology” _builder_version=”4.9.0″ _module_preset=”default” header_text_align=”left” body_text_align=”left” background_image=”https:\/\/labs.icahn.mssm.edu\/ferraralab2\/wp-content\/uploads\/sites\/492\/2022\/07\/ai-002-1.jpg” background_enable_image=”on” text_orientation=”left” custom_padding=”|||80px|false|false” sticky_transition=”on”]<\/p>\n

These projects aim to dissect the biological pathways of GVHD at the cellular and molecular levels, using both\u00a0<\/span>in vitro<\/em>\u00a0assays and\u00a0<\/span>in vivo<\/em>\u00a0murine models.<\/span><\/p>\n

[\/et_pb_slide][\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section bb_built=”1″ admin_label=”Two Column Image and Text over Button – Section 6 (Collections)” module_class=”section6_two_col_img_txt_over_btn” _builder_version=”4.9.0″ custom_margin=”30px||100px||false|false” custom_margin_tablet=”100px||||false|false” custom_margin_last_edited=”on|desktop” custom_padding=”0px|0px|0px|0px|false|false” custom_css_main_element=”padding: 0px !important;” locked=”off” collapsed=”on” prev_background_color=”rgba(0,174,239,0.09)” next_background_color=”#00AEEF”][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.9.0″ module_alignment=”center” min_height=”665.8px” custom_margin=”|auto|0px|auto||” custom_padding=”0px||0px|||” box_shadow_style=”preset1″ box_shadow_color=”#58595B” collapsed=”off”][et_pb_column type=”1_2″ _builder_version=”4.9.0″ use_background_color_gradient=”on” background_color_gradient_start=”#ff6a88″ background_color_gradient_end=”#ff99ac” background_color_gradient_direction=”35deg” background_image=”https:\/\/labs.icahn.mssm.edu\/ferraralab2\/wp-content\/uploads\/sites\/492\/2022\/08\/Rectangle-3-copy-5.jpg” custom_padding=”|5%||5%” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/ferraralab\/wp-content\/uploads\/sites\/492\/2023\/08\/3.png” title_text=”3″ align=”center” src_last_edited=”on|desktop” align_tablet=”center” align_last_edited=”on|desktop” _builder_version=”4.9.0″ background_enable_image=”off” background_size=”initial” width=”100%” custom_margin=”-20px||19px|||” custom_padding=”|||” animation_style=”zoom” animation_direction=”left” animation_intensity_zoom=”10%” animation_starting_opacity=”100%”]<\/p>\n

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[\/et_pb_image][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/ferraralab\/wp-content\/uploads\/sites\/492\/2023\/08\/1.png” title_text=”1″ _builder_version=”4.9.0″ _module_preset=”default” custom_margin=”||-18px|||” animation_style=”zoom”]<\/p>\n

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[\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.9.0″ background_image=”https:\/\/labs.icahn.mssm.edu\/ferraralab2\/wp-content\/uploads\/sites\/492\/2022\/08\/ai-008-bwSm-1.png” background_position=”center_right” custom_padding=”40px|40px|40px|40px|true|true” custom_padding__hover=”|||”][et_pb_text disabled_on=”off|off|off” _builder_version=”4.9.0″ header_font=”|700|||||||” header_text_color=”#141414″ header_font_size=”36px” header_3_font=”|700|||||||” header_3_text_color=”#2b2b2b” header_3_font_size=”28px” header_3_line_height=”1.5em” min_height=”49.6px” custom_margin=”||10px|” custom_padding=”0%|36px|0px|0px|false|false”]<\/p>\n

BMT, GVHD, and MAGIC<\/strong><\/span><\/h1>\n

[\/et_pb_text][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#000000″ text_line_height=”22px” header_font=”||||” header_text_color=”#000000″ header_4_text_color=”#FFFFFF” header_5_text_color=”#FFFFFF” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”816px” min_height=”320.4px” custom_margin=”-9px||-77px|||” custom_padding=”0.3%|22px|0%||false|false” animation_style=”slide” animation_direction=”top” animation_intensity_slide=”4%”]<\/p>\n

The Ferrara Laboratory investigates the immunobiology of allogeneic hematopoietic stem cell transplantation, commonly referred to as bone marrow transplantation (BMT).\u00a0<\/span>First utilized over 50 years ago, allogeneic BMT represents one of the earliest forms of stem cell therapy, cancer immunotherapy, and personalized medicine. Much of the success of allogeneic BMT in treating hematologic malignancies derives from the powerful graft versus leukemia effect exerted by donor T cells. But donor T cells also mediate graft versus host disease (GVHD), the major toxicity of BMT, which can be lethal.<\/p>\n

Using pioneering proteomic techniques, the lab has identified and validated unexpected biomarkers for skin, gut, and steroid-resistant GVHD. We have used exceptionally large and informative biorepositories to meld the most informative biomarkers into the first algorithm that predicts lethal GVHD prior to the onset of symptoms. The capacity of biomarkers to guide therapy is the driving force that led to the establishment in\u00a02014 of MAGIC (Mount Sinai Acute GVHD International Consortium),\u00a0a consortium of twenty-five BMT centers in the USA, Europe and Asia that conducts clinical trials to prevent and treat acute GVHD.<\/span><\/p>\n

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[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ admin_label=”Two Column Image and Text over Button – Section 4″ module_class=”section4_two_col_img_txt_over_btn” _builder_version=”3.22″ background_color=”#00AEEF” background_image=”https:\/\/labs.icahn.mssm.edu\/ferraralab2\/wp-content\/uploads\/sites\/492\/2022\/12\/Background-1ALT.png” parallax=”on” width=”100%” custom_margin=”30px||||false|false” custom_padding=”80px|0px|63px|0px||” mix_blend_mode=”multiply” bottom_divider_style=”ramp2″ bottom_divider_color=”#FFFFFF” bottom_divider_height=”150px” bottom_divider_flip=”horizontal” bottom_divider_arrangement=”above_content” locked=”off” collapsed=”on” prev_background_color=”#ffffff” next_background_color=”#ffffff”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”|||” custom_padding=”|||”][et_pb_column type=”1_2″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/ferraralab\/wp-content\/uploads\/sites\/492\/2023\/08\/2-2.png” title_text=”2″ disabled_on=”off|off|off” _builder_version=”4.9.0″ animation_style=”slide” animation_direction=”left” animation_intensity_slide=”10%” box_shadow_style=”preset1″ box_shadow_color=”#58595B” always_center_on_mobile=”off”]<\/p>\n

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[\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”22px” header_font=”||||” header_text_color=”#FFFFFF” header_4_text_color=”#FFFFFF” header_5_text_color=”#FFFFFF” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”700px” custom_margin=”-51px|||||” custom_padding=”0px|||||” animation_style=”slide” animation_direction=”top” animation_intensity_slide=”4%”]<\/p>\n

Serum Biomarkers of GVHD<\/strong><\/h1>\n

In these projects, we aim to use novel and established proteomic techniques to identify and validate biomarkers of GVHD, and subsequently combine these into predictive algorithms. Such algorithms will further be tested in innovative clinical trials, to prospectively assess their capacity to help diagnose and treat acute GVHD. Specific projects include:<\/span><\/p>\n

    \n
  1. The development of a biomarker algorithm to identify patients at high risk of developing acute GVHD prior to the onset of clinical symptoms. Such an algorithm would then facilitate a clinical trial of pre-emptive treatment of acute GVHD for high-risk patients.<\/span><\/li>\n
  2. The\u00a0use of biomarkers in real-time to stratify patients with diagnosed acute GVHD into those at high risk for severe disease. These patients are then eligible for a trial of monoclonal antibody therapy in addition to high dose steroids as primary treatment.<\/span><\/li>\n<\/ol>\n

    Our biomarker projects are collaborative, using patient data and samples from twenty-five bone marrow transplant centers across the USA, Europe and Asia. Together, these centers comprise MAGIC (M<\/u><\/strong>ount Sinai\u00a0<\/span>A<\/u><\/strong>cute\u00a0<\/span>G<\/u><\/strong>VHD\u00a0<\/span>I<\/u><\/strong>nternational\u00a0<\/span>C<\/u><\/strong>onsortium), under the leadership of Dr. Ferrara.<\/p>\n

      <\/ol>\n

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      Mechanisms of GVHD Pathophysiology<\/strong><\/span><\/h1>\n

      These projects aim to dissect the biological pathways of GVHD at the cellular and molecular levels, using both\u00a0in vitro<\/em>\u00a0assays and\u00a0in vivo<\/em>\u00a0murine models. There is synergy to be found with the biomarker work, since biomarkers of GVHD may play an active role in the pathophysiology of GVHD and may represent potential therapeutic targets. Current projects include:<\/p>\n

      \u00a0<\/p>\n

        \n
      1. Paneth cells, an important epithelial component of the intestinal stem cell niche, are targets of GVHD. Interestingly, serum Reg3\u03b1 and its murine orthologue Reg3\u03b3, produced by the Paneth cells, are strong predictive biomarkers of intestinal acute GVHD. We are exploring the role of Reg3\u03b3 in
        \n","protected":false},"excerpt":{"rendered":"

        The current projects in the Ferrara Laboratory investigate graft versus host disease (GVHD) using two different approaches: Biomarkers of GVHD and Mechanisms of GVHD Pathophysiology.In these projects, we aim to use novel and established proteomic techniques to identify and validate biomarkers of GVHD, and subsequently combine these into predictive algorithms.These projects aim to dissect the […]<\/p>\n","protected":false},"author":545,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

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        Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>

        [\/et_pb_slide][et_pb_slide heading=\"Two\" _builder_version=\"4.9.0\" _module_preset=\"default\" header_text_align=\"left\" body_text_align=\"left\" background_image=\"https:\/\/labs.icahn.mssm.edu\/ferraralab2\/wp-content\/uploads\/sites\/492\/2022\/07\/ai-002-1.jpg\" background_enable_image=\"on\" text_orientation=\"left\" custom_padding=\"|||80px|false|false\" sticky_transition=\"on\"]<\/p>

        Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>

        [\/et_pb_slide][et_pb_slide heading=\"Three\" _builder_version=\"4.9.0\" _module_preset=\"default\" header_text_align=\"left\" body_text_align=\"left\" background_image=\"https:\/\/labs.icahn.mssm.edu\/ferraralab2\/wp-content\/uploads\/sites\/492\/2022\/07\/ai-002-1.jpg\" background_enable_image=\"on\" text_orientation=\"left\" custom_padding=\"|||80px|false|false\" sticky_transition=\"on\"]<\/p>

        Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>

        [\/et_pb_slide][\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section fb_built=\"1\" custom_padding_last_edited=\"on|tablet\" disabled_on=\"on|on|on\" admin_label=\"Fullwidth Two Column Header and Image (no slider) - Section 1 (Desktop only)\" module_class=\"section1_header_no_slider\" _builder_version=\"4.9.0\" _module_preset=\"default\" background_color=\"#00aeef\" background_image=\"https:\/\/labs.icahn.mssm.edu\/ferraralab2\/wp-content\/uploads\/sites\/492\/2022\/10\/Background-2.png\" parallax=\"on\" custom_margin=\"||30px||false|false\" custom_padding=\"||||false|false\" custom_padding_tablet=\"0px||0px||false|false\" custom_padding_phone=\"\" bottom_divider_style=\"slant\" bottom_divider_color=\"#FFFFFF\" bottom_divider_arrangement=\"above_content\" custom_css_main_element=\"padding: 0px !important;\" locked=\"on\" collapsed=\"on\" disabled=\"on\"][et_pb_row column_structure=\"2_5,3_5\" disabled_on=\"off|off|off\" _builder_version=\"4.9.0\" _module_preset=\"default\" background_color=\"RGBA(0,0,0,0)\" module_alignment=\"right\" custom_padding=\"||||false|false\" border_color_all=\"RGBA(0,0,0,0)\" collapsed=\"on\"][et_pb_column type=\"2_5\" _builder_version=\"4.9.0\" _module_preset=\"default\" custom_padding=\"10%||8vw||false|false\" custom_padding_tablet=\"0vw||0vw||true|false\" custom_padding_phone=\"\" custom_padding_last_edited=\"on|desktop\"][et_pb_text admin_label=\"Title - Text\" _builder_version=\"4.9.0\" _module_preset=\"da86b6f0-f83c-4c7c-bdd8-3019777ddffe\" text_font=\"||||||||\" text_text_color=\"#FFFFFF\" text_font_size=\"20px\" text_line_height=\"32px\" header_text_align=\"left\" header_text_color=\"#FFFFFF\" header_font_size=\"48px\" header_line_height=\"60px\" custom_margin=\"||2%||false|false\" text_font_size_tablet=\"15px\" text_font_size_phone=\"14px\" text_font_size_last_edited=\"on|desktop\" header_font_size_tablet=\"40px\" header_font_size_phone=\"24px\" header_font_size_last_edited=\"on|phone\" custom_css_main_element=\"\/*margin-right: 8vw!important;*\/\"]<\/p>

        Welcome to the Rendl Lab<\/h1>

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        Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>

        [\/et_pb_text][\/et_pb_column][et_pb_column type=\"3_5\" _builder_version=\"4.9.0\" _module_preset=\"default\" background_color=\"RGBA(0,0,0,0)\"][et_pb_image src=\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2022\/07\/210629-Nivi-graduation-scaled.jpg\" align=\"right\" force_fullwidth=\"on\" _builder_version=\"4.9.0\" _module_preset=\"default\" custom_margin=\"80px|0px|0px|0px|false|false\" custom_padding=\"20px|0px|0px|0px|false|false\" box_shadow_style=\"preset1\" box_shadow_spread=\"15px\"][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_2,1_2\" disabled_on=\"on|on|on\" _builder_version=\"4.9.0\" _module_preset=\"default\" disabled=\"on\" collapsed=\"on\"][et_pb_column type=\"1_2\" _builder_version=\"4.9.0\" _module_preset=\"default\"][et_pb_blurb title=\"Welcome to the Rendl Lab\" admin_label=\"Blurb - Left Side Content\" _builder_version=\"4.9.0\" _module_preset=\"default\" header_text_color=\"#FFFFFF\" body_text_color=\"#FFFFFF\" custom_margin=\"80px||||false|false\"]<\/p>

        Welcome to the Rendl Lab<\/h1>

        Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>

        [\/et_pb_blurb][\/et_pb_column][et_pb_column type=\"1_2\" _builder_version=\"4.9.0\" _module_preset=\"default\"][et_pb_blurb image=\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2022\/07\/210629-Nivi-graduation-scaled.jpg\" icon_alignment=\"right\" admin_label=\"Blurb - Right-Side Image\" _builder_version=\"4.9.0\" _module_preset=\"default\" custom_margin=\"80px|-40%|0px||false|false\" custom_margin_tablet=\"|0%|||false|false\" custom_margin_phone=\"|0%|||false|false\" custom_margin_last_edited=\"on|phone\"][\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" admin_label=\"Header and Image (no slider) - Section 1 (Tablet and Mobile only)\" module_class=\"section1_header_no_slider_mobile\" _builder_version=\"4.9.0\" background_color=\"#00AEEF\" background_image=\"https:\/\/labs.icahn.mssm.edu\/ferraralab2\/wp-content\/uploads\/sites\/492\/2022\/10\/Background-2.png\" parallax=\"on\" width=\"100%\" custom_margin=\"||30px||false|false\" custom_padding=\"80px|0px|63px|0px||\" mix_blend_mode=\"multiply\" bottom_divider_color=\"#FFFFFF\" bottom_divider_height=\"150px\" bottom_divider_flip=\"horizontal\" locked=\"on\" collapsed=\"on\" disabled=\"on\"][et_pb_row column_structure=\"1_2,1_2\" _builder_version=\"3.25\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" custom_margin=\"|||\" custom_padding=\"|||\"][et_pb_column type=\"1_2\" _builder_version=\"3.25\" background_position=\"top_left\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.9.0\" _module_preset=\"default\" header_text_color=\"#FFFFFF\" header_line_height=\"1.7em\"]<\/p>

        Welcome to the Rendl Lab<\/strong><\/h1>

        [\/et_pb_text][et_pb_text _builder_version=\"4.9.0\" _module_preset=\"default\" text_text_color=\"#FFFFFF\"]<\/p>

        Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>

        [\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_2\" _builder_version=\"3.25\" background_position=\"top_left\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_image src=\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2022\/07\/210629-Nivi-graduation-scaled.jpg\" title_text=\"AdobeStock_436735485\" disabled_on=\"off|off|off\" _builder_version=\"4.9.0\" animation_style=\"slide\" animation_direction=\"left\" animation_intensity_slide=\"10%\" box_shadow_style=\"preset1\" box_shadow_blur=\"30px\" box_shadow_color=\"#58595B\" always_center_on_mobile=\"off\"][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" admin_label=\"Two Column Image and Text over Button - Section 6 (Collections)\" module_class=\"section6_two_col_img_txt_over_btn\" _builder_version=\"4.9.0\" custom_margin=\"30px||100px||false|false\" custom_margin_tablet=\"100px||||false|false\" custom_margin_phone=\"\" custom_margin_last_edited=\"on|desktop\" custom_padding=\"0px|0px|0px|0px|false|false\" custom_css_main_element=\"padding: 0px !important;\" locked=\"on\" collapsed=\"on\"][et_pb_row column_structure=\"1_2,1_2\" make_equal=\"on\" _builder_version=\"4.9.0\" module_alignment=\"center\" custom_margin=\"|auto|0px|auto||\" custom_padding=\"0px||0px|||\" box_shadow_style=\"preset1\" box_shadow_color=\"#58595B\" collapsed=\"off\"][et_pb_column type=\"1_2\" _builder_version=\"4.9.0\" use_background_color_gradient=\"on\" background_color_gradient_start=\"#ff6a88\" background_color_gradient_end=\"#ff99ac\" background_color_gradient_direction=\"35deg\" background_image=\"https:\/\/labs.icahn.mssm.edu\/ferraralab2\/wp-content\/uploads\/sites\/492\/2022\/08\/Rectangle-3-copy-5.jpg\" custom_padding=\"|5%||5%\" custom_padding__hover=\"|||\"][et_pb_image src=\"https:\/\/labs.icahn.mssm.edu\/ferraralab2\/wp-content\/uploads\/sites\/492\/2022\/08\/AdobeStock_182052860.png\" title_text=\"AdobeStock_182052860\" align=\"center\" align_tablet=\"center\" align_phone=\"\" align_last_edited=\"on|desktop\" _builder_version=\"4.9.0\" background_enable_image=\"off\" background_size=\"initial\" custom_margin=\"-20px||-20px|\" custom_padding=\"|||\" animation_style=\"zoom\" animation_direction=\"left\" animation_intensity_zoom=\"10%\" animation_starting_opacity=\"100%\"][\/et_pb_image][\/et_pb_column][et_pb_column type=\"1_2\" _builder_version=\"4.9.0\" background_image=\"https:\/\/labs.icahn.mssm.edu\/ferraralab2\/wp-content\/uploads\/sites\/492\/2022\/08\/ai-008-bwSm-1.png\" background_position=\"center_right\" custom_padding=\"40px|40px|40px|40px|true|true\" custom_padding__hover=\"|||\"][et_pb_text disabled_on=\"off|off|off\" _builder_version=\"4.9.0\" header_font=\"|700|||||||\" header_text_color=\"#141414\" header_font_size=\"36px\" header_3_font=\"|700|||||||\" header_3_text_color=\"#2b2b2b\" header_3_font_size=\"28px\" header_3_line_height=\"1.5em\" custom_margin=\"||10px|\" custom_padding=\"5%||||false|false\"]<\/p>

        Birth of the Hair Follicle Niche<\/strong><\/h1>

        [\/et_pb_text][et_pb_text _builder_version=\"4.9.0\" text_font=\"||||||||\" text_text_color=\"#000000\" text_line_height=\"22px\" header_font=\"||||\" header_text_color=\"#000000\" header_4_text_color=\"#FFFFFF\" header_5_text_color=\"#FFFFFF\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" max_width=\"700px\" custom_padding=\"2%||5%||false|false\" animation_style=\"slide\" animation_direction=\"top\" animation_intensity_slide=\"4%\"]<\/p>

        A central question in stem cell research is how cells specialize during organ development to become adult tissue-regenerative stem cells and their instructive niche. During hair follicle development, epidermal progenitors in nascent hair placodes receive niche signals from specialized cell clusters located underneath that are called Dermal Condensates.<\/p>

        [\/et_pb_text][et_pb_text disabled_on=\"on|on|on\" _builder_version=\"4.9.0\" text_font=\"||||||||\" text_text_color=\"#141414\" text_line_height=\"1.9em\" header_font=\"||||||||\" header_2_font=\"||||||||\" module_alignment=\"center\" custom_margin=\"||30px|\" disabled=\"on\"]<\/p>

        Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ornare suspendisse sed nisi lacus sed viverra tellus in.<\/p>

        [\/et_pb_text][et_pb_button button_text=\"Lorem ipsum dolor sit amet\" disabled_on=\"on|on|on\" _builder_version=\"4.9.0\" custom_button=\"on\" button_text_size=\"16px\" button_text_color=\"#FFFFFF\" button_bg_color=\"#00AEEF\" button_border_width=\"0px\" button_border_radius=\"0px\" button_font=\"||||||||\" button_icon=\"%%20%%\" button_icon_color=\"#FFFFFF\" button_on_hover=\"off\" custom_margin=\"20px|||\" custom_padding=\"12px|28px|12px|28px\" box_shadow_style=\"preset1\" box_shadow_vertical=\"10px\" box_shadow_blur=\"30px\" box_shadow_color=\"#58595B\" button_letter_spacing_hover=\"2px\" disabled=\"on\" locked=\"off\" button_text_size__hover_enabled=\"off\" button_one_text_size__hover_enabled=\"off\" button_two_text_size__hover_enabled=\"off\" button_text_color__hover_enabled=\"off\" button_one_text_color__hover_enabled=\"off\" button_two_text_color__hover_enabled=\"off\" button_border_width__hover_enabled=\"off\" button_one_border_width__hover_enabled=\"off\" button_two_border_width__hover_enabled=\"off\" button_border_color__hover_enabled=\"off\" button_one_border_color__hover_enabled=\"off\" button_two_border_color__hover_enabled=\"off\" button_border_radius__hover_enabled=\"off\" button_one_border_radius__hover_enabled=\"off\" button_two_border_radius__hover_enabled=\"off\" button_letter_spacing__hover_enabled=\"on\" button_letter_spacing__hover=\"2px\" button_one_letter_spacing__hover_enabled=\"off\" button_two_letter_spacing__hover_enabled=\"off\" button_bg_color__hover_enabled=\"off\" button_one_bg_color__hover_enabled=\"off\" button_two_bg_color__hover_enabled=\"off\"][\/et_pb_button][et_pb_button button_url=\"https:\/\/labs.icahn.mssm.edu\/design\/option1-research\" button_text=\"Find Out More\" _builder_version=\"4.9.0\" _module_preset=\"default\" custom_button=\"on\" button_text_color=\"#FFFFFF\" button_bg_color=\"#00AEEF\" button_border_radius=\"0px\" box_shadow_style=\"preset1\" locked=\"off\"][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" admin_label=\"Two Column Image and Text over Button - Section 4\" module_class=\"section4_two_col_img_txt_over_btn\" _builder_
        version=\"4.9.0\" background_color=\"#00AEEF\" background_image=\"https:\/\/labs.icahn.mssm.edu\/ferraralab2\/wp-content\/uploads\/sites\/492\/2022\/12\/Background-1ALT.png\" parallax=\"on\" width=\"100%\" custom_margin=\"30px||||false|false\" custom_padding=\"80px|0px|63px|0px||\" mix_blend_mode=\"multiply\" bottom_divider_style=\"ramp2\" bottom_divider_color=\"#FFFFFF\" bottom_divider_height=\"150px\" bottom_divider_flip=\"horizontal\" bottom_divider_arrangement=\"above_content\" locked=\"on\" collapsed=\"on\"][et_pb_row column_structure=\"1_2,1_2\" _builder_version=\"3.25\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" custom_margin=\"|||\" custom_padding=\"|||\"][et_pb_column type=\"1_2\" _builder_version=\"3.25\" background_position=\"top_left\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_image src=\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2022\/08\/Stalled-follicles_03MR-2560x1440-1.jpg\" title_text=\"AdobeStock_436735485\" disabled_on=\"off|off|off\" _builder_version=\"4.9.0\" animation_style=\"slide\" animation_direction=\"left\" animation_intensity_slide=\"10%\" box_shadow_style=\"preset1\" box_shadow_color=\"#58595B\" always_center_on_mobile=\"off\"][\/et_pb_image][\/et_pb_column][et_pb_column type=\"1_2\" _builder_version=\"3.25\" background_position=\"top_left\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.9.0\" text_font=\"||||||||\" text_text_color=\"#FFFFFF\" text_line_height=\"22px\" header_font=\"||||\" header_text_color=\"#FFFFFF\" header_4_text_color=\"#FFFFFF\" header_5_text_color=\"#FFFFFF\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" max_width=\"700px\" animation_style=\"slide\" animation_direction=\"top\" animation_intensity_slide=\"4%\"]<\/p>

        Formation and Function of Stem Cell Niches<\/strong><\/h4>

        Stem cells and their immediate environment, also called stem cell niche, are critical for the growth and continuous renewal of our organs, and are also key for new growth and repair during regeneration. Unlocking the secrets of how specialized niche cells operate to activate stem cells and progenitors holds great promise for regenerative medicine.<\/p>

        Our laboratory aims to answer these fundamental questions in stem cell biology by utilizing the hair follicle mini-organ as a powerful model system. Deciphering how niche cells govern stem cell and progenitor functions in the hair follicle will also provide a rational basis for developing hair regenerative therapies. Fundamental questions towards this goal are:<\/p>

        1. How do niche cells acquire the stem cell-inducing properties?<\/li>
        2. What are the niche signals that control tissue growth and regeneration?<\/li>
        3. How do niche cells control progenitor death and tissue reorganization?<\/li><\/ol>

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          Growth Control and Regeneration<\/strong><\/h1>

          How is tissue growth, homeostasis and renewal by stem cells regulated throughout life? Understanding the core molecular controls is fundamental for realizing the therapeutic potential of the instructive niche (Rezza et al, Current Topics in Developmental Biology 2014). After initial morphogenesis of hair follicles, the Dermal Condensate gives rise to the adult follicle inductive niche, the Dermal Papilla. Dermal Papilla cells signal to progenitors in the follicle bulb to control continuous production and outgrowth of hair. They are also critical for activating stem cells to regenerate a new follicle during the hair growth cycle. Remarkably, isolated niche cells can induce new hair formation after cell transplantation into skin in mice, a yet unrealized goal in human.<\/p>

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          Tissue Regression and Reorganization<\/strong><\/h1>

          How tissues regenerate from stem cells and how different organs balance cell loss with new growth is under intensive investigation in the regenerative biology field. In the natural hair growth cycle after years of continuous hair growth, follicles enter a wave of massive progenitor death along the hair axis that \u2013 as we are just beginning to unravel \u2013 is controlled by the niche microenvironment. During this follicle regression, the Dermal Papilla niche needs to relocate from the base of growing hair bulbs to the stem cell reservoir in the upper follicle for new growth activation.<\/p>

          [\/et_pb_text][et_pb_button button_url=\"https:\/\/labs.icahn.mssm.edu\/design\/option1-research\" button_text=\"Find Out More\" _builder_version=\"4.9.0\" _module_preset=\"default\" custom_button=\"on\" button_text_color=\"#d80b8c\" button_bg_color=\"#FFFFFF\" button_border_radius=\"0px\" box_shadow_style=\"preset1\" locked=\"off\"][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"off|off|on\" admin_label=\"One Column Image Over Title Over Text Over Button - Section 4 (Mobile and Tablet Only)\" module_class=\"section4_one_col_img_over_title_over_txt_over_btn_mobile_tablet\" _builder_version=\"4.9.0\" background_color=\"#00AEEF\" use_background_color_gradient=\"on\" background_color_gradient_start=\"#00aeef\" background_color_gradient_end=\"#d80b8c\" background_color_gradient_direction=\"33deg\" background_image=\"https:\/\/labs.icahn.mssm.edu\/ferraralab2\/wp-content\/uploads\/sites\/492\/2022\/10\/Background-1.png\" parallax=\"on\" width=\"100%\" custom_margin=\"||100px||false|false\" custom_padding=\"80px|0px|63px|0px||\" bottom_divider_color=\"#FFFFFF\" bottom_divider_height=\"150px\" bottom_divider_flip=\"horizontal\" bottom_divider_arrangement=\"above_content\" locked=\"off\" collapsed=\"on\"][et_pb_row column_structure=\"1_2,1_2\" _builder_version=\"3.25\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" custom_margin=\"|||\" custom_padding=\"|||\"][et_pb_column type=\"1_2\" _builder_version=\"3.25\" background_position=\"top_left\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_image src=\"https:\/\/labs.icahn.mssm.edu\/ferraralab2\/wp-content\/uploads\/sites\/492\/2022\/08\/2021-Hero-Shot-2-smallest-scaled-3.png\" title_text=\"2021-Hero-Shot-2-smallest-scaled-3\" disabled_on=\"off|off|off\" _builder_version=\"4.9.0\" animation_style=\"slide\" animation_direction=\"left\" animation_intensity_slide=\"10%\" box_shadow_style=\"preset1\" box_shadow_color=\"#58595B\" always_center_on_mobile=\"off\"][\/et_pb_image][\/et_pb_column][et_pb_column type=\"1_2\" _builder_version=\"3.25\" background_position=\"top_left\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.9.0\" text_font=\"||||||||\" text_text_color=\"#FFFFFF\" text_line_height=\"22px\" header_font=\"||||\" header_text_color=\"#FFFFFF\" header_4_text_color=\"#FFFFFF\" header_5_text_color=\"#FFFFFF\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" max_width=\"700px\" animation_style=\"slide\" animation_direction=\"top\" animation_intensity_slide=\"4%\"]<\/p>

          Tissue Regression and Reorganization<\/strong><\/h1>

          How tissues regenerate from stem cells and how different organs balance cell loss with new growth is under intensive investigation in the regenerative biology field. In the natural hair growth cycle after years of continuous hair growth, follicles enter a wave of massive progenitor death along the hair axis that \u2013 as we are just beginning to unravel \u2013 is controlled by the niche microenvironment. During this follicle regression, the Dermal Papilla niche needs to relocate from the base of growing hair bulbs to the stem cell reservoir in the upper follicle for new growth activation.<\/p>

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