{"id":3010,"date":"2022-12-21T12:17:26","date_gmt":"2022-12-21T17:17:26","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/design\/?page_id=3010"},"modified":"2026-03-31T15:23:57","modified_gmt":"2026-03-31T19:23:57","slug":"research","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/ferlandlab\/research\/","title":{"rendered":"Research"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”Fullwidth Header – Background Title Description – no slider – Section 1″ module_class=”header-title-desciption-no-slider-section1″ _builder_version=”4.27.4″ _module_preset=”default” background_color=”rgba(0,174,239,0.09)” background_enable_color=”off” background_image=”https:\/\/labs.icahn.mssm.edu\/ferlandlab\/wp-content\/uploads\/sites\/515\/2026\/02\/MAX_rGT34_BLA1-scaled.jpg” parallax=”on” custom_padding=”||||false|false” bottom_divider_style=”ramp2″ bottom_divider_color=”#FFFFFF” bottom_divider_height=”11vw” bottom_divider_arrangement=”above_content” saved_tabs=”all” locked=”off” collapsed=”on” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.27.4″ _module_preset=”default” background_enable_color=”off” border_color_all=”RGBA(0,0,0,0)” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” background_color=”RGBA(255,255,255,0)” custom_padding=”10%||8vw||false|false” custom_padding_tablet=”0vw||0vw||true|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet” global_colors_info=”{}”][et_pb_text admin_label=”Text – Title” _builder_version=”4.27.4″ _module_preset=”b3e3ff14-5f5c-4608-8ecf-1885ce3da7aa” header_font=”||||||||” header_text_color=”#FFFFFF” header_font_size=”48px” header_line_height=”60px” background_color=”RGBA(255,255,255,0)” custom_margin=”||10px||false|false” header_font_size_tablet=”40px” header_font_size_phone=”24px” header_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n

Research<\/strong><\/h1>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” background_enable_color=”off” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Section 27 – Two Column – Title Over Text Over Button Next to Image” module_class=”section27_two_column_title_over_txt_over_btn_next_to_img” _builder_version=”4.16″ _module_preset=”default” background_image=”https:\/\/labs.icahn.mssm.edu\/ferlandlab\/wp-content\/uploads\/sites\/515\/2022\/12\/9-alt.png” parallax=”on” parallax_method=”off” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” background_enable_color=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” background_enable_color=”off” global_colors_info=”{}”][et_pb_cta title=”Understanding Vulnerability to Cannabis Use Disorder” _builder_version=”4.27.4″ _module_preset=”default” header_level=”h1″ header_text_color=”#141414″ body_text_align=”center” body_text_color=”#141414″ background_color=”RGBA(255,255,255,0)” background_layout=”light” custom_padding=”||50px||false|false” global_colors_info=”{}”]<\/p>\n

Cannabis use disorder impacts 10-30% of regular users and currently has no available treatments. The Ferland lab uses multidisciplinary techniques including translational animal models, next generation sequencing, computational approaches, and in vivo<\/em> recording and manipulations to investigate factors that shape CUD risk from adolescence to adulthood.<\/h4>\n

[\/et_pb_cta][et_pb_divider show_divider=”off” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.27.4″ _module_preset=”default” background_enable_color=”off” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” background_enable_color=”off” global_colors_info=”{}”][et_pb_text admin_label=”Adolescent Cannabis” _builder_version=”4.27.4″ header_font=”|700|||||||” header_text_align=”center” header_text_color=”#FFFFFF” header_2_text_color=”#141414″ header_3_font=”Playfair Display|700|||||||” header_3_text_color=”#2b2b2b” header_3_font_size=”28px” header_3_line_height=”1.5em” background_enable_image=”off” text_orientation=”center” module_alignment=”center” custom_margin=”||10px|” global_colors_info=”{}”]<\/p>\n

Developmental Origins of Cannabis Use Disorder<\/h2>\n

[\/et_pb_text][et_pb_text admin_label=”Description” _builder_version=”4.27.4″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”1.9em” header_font=”||||||||” header_2_font=”||||||||” header_5_text_color=”#141414″ text_orientation=”center” module_alignment=”center” custom_margin=”||30px|” global_colors_info=”{}”]<\/p>\n

Cannabis use during adolescence, a critical period of brain maturation, increases risk for developing cannabis use disorder (CUD). Beyond compulsive use, CUD involves disruptions in cognitive control and decision-making processes that govern cost-benefit evaluation. Using translational rodent models, we investigate how individual vulnerability and adolescent THC exposure alter the mechanisms underlying these critical cognitive outcomes.\u00a0<\/h5>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” background_color=”#221F72″ global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/ferlandlab\/wp-content\/uploads\/sites\/515\/2026\/02\/Slide1.png” title_text=”Slide1″ align=”center” _builder_version=”4.27.4″ _module_preset=”default” background_enable_color=”off” background_enable_image=”off” transform_translate=”-35px|-35px” transform_translate_linked=”off” width=”100%” max_width=”100%” animation_direction=”right” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” background_enable_color=”off” global_colors_info=”{}”][et_pb_divider show_divider=”off” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.27.4″ background_enable_color=”off” module_alignment=”center” custom_margin=”-114px|auto|200px|auto||” custom_padding=”0px|0px|0px|0px||” global_module=”3005″ saved_tabs=”all” collapsed=”off” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.27.4″ background_color=”#D80B8C” custom_padding=”40px|40px|40px|40px” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/ferlandlab\/wp-content\/uploads\/sites\/515\/2026\/02\/Slide1.jpeg” title_text=”Slide1″ align=”center” _builder_version=”4.27.4″ _module_preset=”default” background_enable_color=”off” background_enable_image=”off” transform_translate=”13px|-58px” transform_translate_linked=”off” width=”100%” max_width=”100%” animation_direction=”right” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.27.4″ background_enable_color=”off” custom_padding=”40px|40px|40px|40px” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text admin_label=”Non-neuronal Mechanisms” _builder_version=”4.27.4″ header_font=”|700|||||||” header_text_align=”center” header_text_color=”#141414″ header_2_text_color=”#141414″ header_3_font=”Playfair Display|700|||||||” header_3_text_color=”#141414″ header_3_font_size=”28px” header_3_line_height=”1.5em” header_5_text_color=”#141414″ background_enable_image=”off” text_orientation=”center” module_alignment=”center” custom_margin=”||10px|” global_colors_info=”{}”]<\/p>\n

Non-Neuronal Mechanisms<\/h2>\n

[\/et_pb_text][et_pb_text admin_label=”Description” _builder_version=”4.27.4″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”1.9em” header_font=”||||||||” header_2_font=”||||||||” header_5_text_color=”#141414″ text_orientation=”center” module_alignment=”center” custom_margin=”||30px|” global_colors_info=”{}”]<\/p>\n

Our research has revealed that non-neuronal cell-types like astrocytes play a critical role in addiction-related phenotypes. Our current work centers on how glia and other non-neuronal mechanisms contribute to cognition, affect, and drug taking.<\/h5>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” background_enable_color=”off” global_colors_info=”{}”][et_pb_text admin_label=”Epigenetic Mechanisms” _builder_version=”4.27.4″ header_font=”|700|||||||” header_text_align=”center” header_text_color=”#FFFFFF” header_2_text_color=”#141414″ header_3_font=”Playfair Display|700|||||||” header_3_text_color=”#2b2b2b” header_3_font_size=”28px” header_3_line_height=”1.5em” background_enable_image=”off” text_orientation=”center” module_alignment=”center” custom_margin=”||10px|” global_colors_info=”{}”]<\/p>\n

Epigenetic Regulation of THC Consumption<\/h2>\n

[\/et_pb_text][et_pb_text admin_label=”Description” _builder_version=”4.27.4″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”1.9em” header_font=”||||||||” header_2_font=”||||||||” header_5_text_color=”#141414″ text_orientation=”center” module_alignment=”center” custom_margin=”||30px|” global_colors_info=”{}”]<\/p>\n

Epigenetic mechanisms regulate gene expression without altering the DNA sequence. These often stable changes can create vulnerability to environmental factors such as drug exposure. Our work examines how differences in chromatin accessibility shape the development of CUD-like behaviors, from transcriptional regulation to cellular function.<\/h5>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” background_enable_color=”off” global_colors_info=”{}”][et_pb_divider show_divider=”off” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” background_enable_color=”off” global_colors_info=”{}”][et_pb_text admin_label=”Current Funding” _builder_version=”4.27.4″ header_font=”|700|||||||” header_text_align=”center” header_text_color=”#FFFFFF” header_2_text_color=”#141414″ header_3_font=”Playfair Display|700|||||||” header_3_text_color=”#2b2b2b” header_3_font_size=”28px” header_3_line_height=”1.5em” background_enable_image=”off” text_orientation=”center” module_alignment=”center” custom_margin=”||10px|” global_colors_info=”{}”]<\/p>\n

Funding<\/h2>\n

[\/et_pb_text][et_pb_text admin_label=”Description” _builder_version=”4.27.4″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”1.9em” header_font=”||||||||” header_2_font=”||||||||” header_5_text_align=”center” header_5_text_color=”#141414″ text_orientation=”center” module_alignment=”center” custom_margin=”||30px|” global_colors_info=”{}”]<\/p>\n

K01 DA059689<\/h5>\n
DP1 DA063522<\/h5>\n
Yale Proteomics Pilot Grant<\/h5>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Footer Fullwidth – Section 13″ module_class=”footer-section” _builder_version=”4.27.4″ background_color=”#c7eafb” background_image=”https:\/\/labs.icahn.mssm.edu\/ferlandlab\/wp-content\/uploads\/sites\/515\/2022\/10\/Rectangle-3.png” max_width=”100%” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|phone” module_alignment=”center” custom_margin=”100px|||176px|false|false” custom_padding=”3px|0px|0px|0px|false|false” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”14%” animation_starting_opacity=”100%” global_module=”3741″ saved_tabs=”all” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ background_color=”RGBA(0,0,0,0)” background_color_gradient_direction=”38deg” module_alignment=”center” custom_margin=”|auto||147px||” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ background_enable_color=”off” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_text_color=”#FFFFFF” text_font_size=”24px” global_colors_info=”{}”]<\/p>\n

Contact Us<\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.27.4″ background_color=”RGBA(0,0,0,0)” background_color_gradient_direction=”38deg” module_alignment=”center” custom_margin=”|auto|-2px|auto||” custom_padding=”0px|||||” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.27.4″ background_enable_color=”off” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”1.25em” header_font=”||||||||” header_text_align=”center” header_4_font=”|700||on|||||” header_4_font_size=”16px” header_4_letter_spacing=”1px” header_4_line_height=”1.5em” background_layout=”dark” hover_enabled=”0″ locked=”off” global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

E-mail
<\/strong>jacqueline-marie.ferland@mssm.edu<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.27.4″ background_enable_color=”off” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”1.25em” header_font=”||||||||” header_4_font=”|700||on|||||” header_4_font_size=”16px” header_4_letter_spacing=”1px” header_4_line_height=”1.5em” background_layout=”dark” hover_enabled=”0″ locked=”off” global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

Lab Address <\/strong>
1470 Madison Avenue
Hess
New York, NY 10029<\/p>\n

 <\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

ResearchCannabis use disorder impacts 10-30% of regular users and currently has no available treatments. The Ferland lab uses multidisciplinary techniques including translational animal models, next generation sequencing, computational approaches, and in vivo recording and manipulations to investigate factors that shape CUD risk from adolescence to adulthood.Developmental Origins of Cannabis Use DisorderCannabis use during adolescence, a […]<\/p>\n","protected":false},"author":545,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"class_list":["post-3010","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/ferlandlab\/wp-json\/wp\/v2\/pages\/3010","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/ferlandlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/ferlandlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/ferlandlab\/wp-json\/wp\/v2\/users\/545"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/ferlandlab\/wp-json\/wp\/v2\/comments?post=3010"}],"version-history":[{"count":601,"href":"https:\/\/labs.icahn.mssm.edu\/ferlandlab\/wp-json\/wp\/v2\/pages\/3010\/revisions"}],"predecessor-version":[{"id":6206,"href":"https:\/\/labs.icahn.mssm.edu\/ferlandlab\/wp-json\/wp\/v2\/pages\/3010\/revisions\/6206"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/ferlandlab\/wp-json\/wp\/v2\/media?parent=3010"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}