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background_image=”https:\/\/labs.icahn.mssm.edu\/drexlerlab\/wp-content\/uploads\/sites\/654\/2026\/04\/MAX_MADR-in-RN_GFP-green-TPH2-red_10x-copy-1-scaled.jpg” background_enable_image=”on” background_position=”bottom_left” text_orientation=”left” custom_padding=”|||80px|false|false” global_colors_info=”{}” sticky_transition=”on”]<\/p>\n
Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>\n
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Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>\n
[\/et_pb_slide][et_pb_slide heading=”Cancer-Induced Circuit Remodeling” _builder_version=”4.27.4″ _module_preset=”default” header_text_align=”left” body_text_align=”left” background_image=”https:\/\/labs.icahn.mssm.edu\/drexlerlab\/wp-content\/uploads\/sites\/654\/2026\/04\/C1-MAX_DR-Projections_RFP-red-DAPI-white-overview.czi-DR-Projections_RFP-red-DAPI-white-overview.czi-1-scaled.jpeg” background_enable_image=”on” background_position=”bottom_left” text_orientation=”left” custom_padding=”|||80px|false|false” global_colors_info=”{}” sticky_transition=”on”]<\/p>\n
Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>\n
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Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>\n
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Science<\/strong><\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” theme_builder_area=”post_content” hover_enabled=”0″ sticky_enabled=”0″ text_font=”–et_global_body_font||||||||” text_text_color=”#141414″ text_font_size=”22px” background_pattern_color=”rgba(0,0,0,0.2)” background_mask_color=”#ffffff” text_line_height=”1.8em” text_text_shadow_horizontal_length=”text_text_shadow_style,%91object Object%93″ text_text_shadow_horizontal_length_tablet=”0px” text_text_shadow_vertical_length=”text_text_shadow_style,%91object Object%93″ text_text_shadow_vertical_length_tablet=”0px” text_text_shadow_blur_strength=”text_text_shadow_style,%91object Object%93″ text_text_shadow_blur_strength_tablet=”1px” link_text_shadow_horizontal_length=”link_text_shadow_style,%91object Object%93″ link_text_shadow_horizontal_length_tablet=”0px” link_text_shadow_vertical_length=”link_text_shadow_style,%91object Object%93″ link_text_shadow_vertical_length_tablet=”0px” 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header_5_text_shadow_horizontal_length_tablet=”0px” header_5_text_shadow_vertical_length=”header_5_text_shadow_style,%91object Object%93″ header_5_text_shadow_vertical_length_tablet=”0px” header_5_text_shadow_blur_strength=”header_5_text_shadow_style,%91object Object%93″ header_5_text_shadow_blur_strength_tablet=”1px” header_6_text_shadow_horizontal_length=”header_6_text_shadow_style,%91object Object%93″ header_6_text_shadow_horizontal_length_tablet=”0px” header_6_text_shadow_vertical_length=”header_6_text_shadow_style,%91object Object%93″ header_6_text_shadow_vertical_length_tablet=”0px” header_6_text_shadow_blur_strength=”header_6_text_shadow_style,%91object Object%93″ header_6_text_shadow_blur_strength_tablet=”1px” box_shadow_horizontal_tablet=”0px” box_shadow_vertical_tablet=”0px” box_shadow_blur_tablet=”40px” box_shadow_spread_tablet=”0px” vertical_offset_tablet=”0″ horizontal_offset_tablet=”0″ z_index_tablet=”0″]<\/p>\n The Drexler Laboratory investigates how neuronal activity drives brain cancer progression, and how diverse brain-resident cell types shape the electrically active networks that exist between tumor cells and neurons. By dissecting these interactions, we aim to uncover novel therapeutic strategies that can be translated into the clinic to benefit patients with brain cancer.<\/p>\n In parallel, we study how brain cancer cells perturb brain-wide circuits and how this circuit-level disruption contributes to the behavioral and cognitive changes experienced by patients. Our work focuses on the signaling mechanisms by which tumors influence distant brain regions that govern essential functions, with the goal of understanding how remodeling at the circuit level gives rise to symptoms beyond the tumor itself.<\/p>\n Elucidating these mechanisms will open new avenues for therapies that not only target tumor progression but also improve quality of life for patients living with brain cancer.<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.27.4″ _module_preset=”default” theme_builder_area=”post_content”][et_pb_image _builder_version=”4.27.4″ background_pattern_color=”rgba(0,0,0,0.2)” background_mask_color=”#ffffff” align=”center” border_radii=”on|12px|12px|12px|12px” box_shadow_horizontal_tablet=”0px” box_shadow_vertical_tablet=”0px” box_shadow_blur_tablet=”40px” box_shadow_spread_tablet=”0px” vertical_offset_tablet=”0″ horizontal_offset_tablet=”0″ z_index_tablet=”0″ 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z_index_tablet=”0″]<\/p>\n Contact<\/strong><\/p>\n Drexler Lab Location<\/strong><\/p>\n Icahn (East) Building Floor 10 Room 10-26 [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ admin_label=”Fullwidth Two Column Header and Image (no slider) – Section 1 (Desktop only)” custom_padding_last_edited=”on|tablet” disabled_on=”on|on|on” module_class=”section1_header_no_slider” _builder_version=”4.16″ _module_preset=”default” background_color=”#00aeef” background_image=”https:\/\/labs.icahn.mssm.edu\/placeholder24\/wp-content\/uploads\/sites\/654\/2022\/10\/Background-2.png” parallax=”on” custom_margin=”||30px||false|false” custom_padding=”||||false|false” custom_padding_tablet=”0px||0px||false|false” bottom_divider_style=”slant” bottom_divider_color=”#FFFFFF” bottom_divider_arrangement=”above_content” custom_css_main_element=”padding: 0px !important;” disabled=”on” locked=”off” collapsed=”on” global_colors_info=”{}” prev_background_color=”#ffffff” 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header_font_size_tablet=”40px” header_font_size_phone=”24px” header_font_size_last_edited=”on|phone” custom_css_main_element=”\/*margin-right: 8vw!important;*\/” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text admin_label=”Description – Text” _builder_version=”4.16″ _module_preset=”da86b6f0-f83c-4c7c-bdd8-3019777ddffe” text_font=”||||||||” text_text_color=”#FFFFFF” text_font_size=”20px” text_line_height=”32px” header_text_align=”left” custom_margin=”||||false|false” text_font_size_tablet=”15px” text_font_size_phone=”14px” text_font_size_last_edited=”on|desktop” custom_css_main_element=”\/*margin-right: 9vw!important;*\/” global_colors_info=”{}”]<\/p>\n Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2022\/07\/210629-Nivi-graduation-scaled.jpg” align=”right” force_fullwidth=”on” _builder_version=”4.16″ _module_preset=”default” custom_margin=”80px|0px|0px|0px|false|false” custom_padding=”20px|0px|0px|0px|false|false” box_shadow_style=”preset1″ box_shadow_spread=”15px” global_colors_info=”{}”]<\/p>\n [\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ disabled_on=”on|on|on” _builder_version=”4.16″ _module_preset=”default” disabled=”on” collapsed=”on” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_blurb admin_label=”Blurb – Left Side Content” title=”Welcome to the Rendl Lab” _builder_version=”4.16″ _module_preset=”default” header_text_color=”#FFFFFF” body_text_color=”#FFFFFF” custom_margin=”80px||||false|false” global_colors_info=”{}”]<\/p>\n Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>\n [\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_blurb admin_label=”Blurb – Right-Side Image” image=”https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2022\/07\/210629-Nivi-graduation-scaled.jpg” icon_alignment=”right” _builder_version=”4.16″ _module_preset=”default” custom_margin=”80px|-40%|0px||false|false” custom_margin_tablet=”|0%|||false|false” custom_margin_phone=”|0%|||false|false” custom_margin_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n [\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ admin_label=”Header and Image (no slider) – Section 1 (Tablet and Mobile only)” disabled_on=”on|on|on” module_class=”section1_header_no_slider_mobile” _builder_version=”4.16″ background_color=”#00AEEF” background_image=”https:\/\/labs.icahn.mssm.edu\/placeholder24\/wp-content\/uploads\/sites\/654\/2022\/10\/Background-2.png” parallax=”on” width=”100%” custom_margin=”||30px||false|false” custom_padding=”80px|0px|63px|0px||” mix_blend_mode=”multiply” bottom_divider_color=”#FFFFFF” bottom_divider_height=”150px” bottom_divider_flip=”horizontal” disabled=”on” locked=”off” collapsed=”on” global_colors_info=”{}” prev_background_color=”#00aeef” next_background_color=”#ffffff”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”|||” custom_padding=”|||” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_text_color=”#FFFFFF” header_line_height=”1.7em” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_text_color=”#FFFFFF” global_colors_info=”{}”]<\/p>\n Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2022\/07\/210629-Nivi-graduation-scaled.jpg” title_text=”AdobeStock_436735485″ disabled_on=”off|off|off” _builder_version=”4.16″ animation_style=”slide” animation_direction=”left” animation_intensity_slide=”10%” box_shadow_style=”preset1″ box_shadow_blur=”30px” box_shadow_color=”#58595B” always_center_on_mobile=”off” global_colors_info=”{}”]<\/p>\n [\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ admin_label=”Two Column Image and Text over Button – Section 6 (Collections)” disabled_on=”on|on|on” module_class=”section6_two_col_img_txt_over_btn” _builder_version=”4.27.4″ custom_margin=”30px||100px||false|false” custom_margin_tablet=”100px||||false|false” custom_margin_last_edited=”on|desktop” custom_padding=”0px|0px|0px|0px|false|false” custom_css_main_element=”padding: 0px !important;” disabled=”on” locked=”off” collapsed=”on” global_colors_info=”{}” prev_background_color=”#00AEEF” next_background_color=”#00AEEF”][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.16″ module_alignment=”center” custom_margin=”|auto|0px|auto||” custom_padding=”0px||0px|||” box_shadow_style=”preset1″ box_shadow_color=”#58595B” collapsed=”off” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ use_background_color_gradient=”on” background_color_gradient_direction=”35deg” background_color_gradient_stops=”#ff6a88 0%|#ff99ac 100%” background_color_gradient_start=”#ff6a88″ background_color_gradient_end=”#ff99ac” background_image=”https:\/\/labs.icahn.mssm.edu\/placeholder24\/wp-content\/uploads\/sites\/654\/2022\/08\/Rectangle-3-copy-5.jpg” custom_padding=”|5%||5%” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/placeholder24\/wp-content\/uploads\/sites\/654\/2022\/08\/AdobeStock_182052860.png” title_text=”AdobeStock_182052860″ align=”center” align_tablet=”center” align_last_edited=”on|desktop” _builder_version=”4.16″ background_enable_image=”off” background_size=”initial” custom_margin=”-20px||-20px|” custom_padding=”|||” animation_style=”zoom” animation_direction=”left” animation_intensity_zoom=”10%” animation_starting_opacity=”100%” global_colors_info=”{}”]<\/p>\n [\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ background_image=”https:\/\/labs.icahn.mssm.edu\/placeholder24\/wp-content\/uploads\/sites\/654\/2022\/08\/ai-008-bwSm-1.png” background_position=”center_right” custom_padding=”40px|40px|40px|40px|true|true” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text disabled_on=”off|off|off” _builder_version=”4.16″ header_font=”|700|||||||” header_text_color=”#141414″ header_font_size=”36px” header_3_font=”|700|||||||” header_3_text_color=”#2b2b2b” header_3_font_size=”28px” header_3_line_height=”1.5em” custom_margin=”||10px|” custom_padding=”5%||||false|false” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16″ text_font=”||||||||” text_text_color=”#000000″ text_line_height=”22px” header_font=”||||” header_text_color=”#000000″ header_4_text_color=”#FFFFFF” header_5_text_color=”#FFFFFF” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”700px” custom_padding=”2%||5%||false|false” animation_style=”slide” animation_direction=”top” animation_intensity_slide=”4%” global_colors_info=”{}”]<\/p>\n A central question in stem cell research is how cells specialize during organ development to become adult tissue-regenerative stem cells and their instructive niche. During hair follicle development, epidermal progenitors in nascent hair placodes receive niche signals from specialized cell clusters located underneath that are called Dermal Condensates.<\/p>\n [\/et_pb_text][et_pb_text disabled_on=”on|on|on” _builder_version=”4.16″ text_font=”||||||||” text_text_color=”#141414″ text_line_height=”1.9em” header_font=”||||||||” header_2_font=”||||||||” module_alignment=”center” custom_margin=”||30px|” disabled=”on” global_colors_info=”{}”]<\/p>\n Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ornare suspendisse sed nisi lacus sed viverra tellus in.<\/p>\n [\/et_pb_text][et_pb_button button_text=”Lorem ipsum dolor sit amet” disabled_on=”on|on|on” _builder_version=”4.16″ custom_button=”on” button_text_size=”16px” button_text_color=”#FFFFFF” button_bg_color=”#00AEEF” button_border_width=”0px” button_border_radius=”0px” button_font=”||||||||” button_icon=”5||divi||400″ button_icon_color=”#FFFFFF” button_on_hover=”off” custom_margin=”20px|||” custom_padding=”12px|28px|12px|28px” box_shadow_style=”preset1″ box_shadow_vertical=”10px” box_shadow_blur=”30px” box_shadow_color=”#58595B” button_letter_spacing_hover=”2px” disabled=”on” locked=”off” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”2px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”]<\/p>\n [\/et_pb_button][et_pb_button button_url=”https:\/\/labs.icahn.mssm.edu\/design\/option1-research” button_text=”Find Out More” _builder_version=”4.16″ _module_preset=”default” custom_button=”on” button_text_color=”#FFFFFF” button_bg_color=”#00AEEF” button_border_radius=”0px” box_shadow_style=”preset1″ locked=”off” global_colors_info=”{}”]<\/p>\n [\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ admin_label=”Two Column Image and Text over Button – Section 4″ disabled_on=”on|on|on” module_class=”section4_two_col_img_txt_over_btn” _builder_version=”4.27.4″ background_color=”#00AEEF” background_image=”https:\/\/labs.icahn.mssm.edu\/placeholder24\/wp-content\/uploads\/sites\/654\/2022\/12\/Background-1ALT.png” parallax=”on” width=”100%” custom_margin=”30px||||false|false” custom_padding=”80px|0px|63px|0px||” mix_blend_mode=”multiply” bottom_divider_style=”ramp2″ bottom_divider_color=”#FFFFFF” bottom_divider_height=”150px” bottom_divider_flip=”horizontal” bottom_divider_arrangement=”above_content” disabled=”on” locked=”off” collapsed=”on” global_colors_info=”{}” prev_background_color=”#ffffff” next_background_color=”#ffffff”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”|||” custom_padding=”|||” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2022\/08\/Stalled-follicles_03MR-2560×1440-1.jpg” title_text=”AdobeStock_436735485″ disabled_on=”off|off|off” _builder_version=”4.16″ animation_style=”slide” animation_direction=”left” animation_intensity_slide=”10%” box_shadow_style=”preset1″ box_shadow_color=”#58595B” always_center_on_mobile=”off” global_colors_info=”{}”]<\/p>\n [\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”22px” header_font=”||||” header_text_color=”#FFFFFF” header_4_text_color=”#FFFFFF” header_5_text_color=”#FFFFFF” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”700px” animation_style=”slide” animation_direction=”top” animation_intensity_slide=”4%” global_colors_info=”{}”]<\/p>\n Stem cells and their immediate environment, also called stem cell niche, are critical for the growth and continuous renewal of our organs, and are also key for new growth and repair during regeneration. Unlocking the secrets of how specialized niche cells operate to activate stem cells and progenitors holds great promise for regenerative medicine.<\/p>\n Our laboratory aims to answer these fundamental questions in stem cell biology by utilizing the hair follicle mini-organ as a powerful model system. Deciphering how niche cells govern stem cell and progenitor functions in the hair follicle will also provide a rational basis for developing hair regenerative therapies. Fundamental questions towards this goal are:<\/p>\n [\/et_pb_text][et_pb_button button_url=”https:\/\/labs.icahn.mssm.edu\/design\/option1-research” button_text=”Find Out More ” _builder_version=”4.16″ _module_preset=”default” custom_button=”on” button_text_color=”#d80b8c” button_bg_color=”#FFFFFF” button_border_radius=”0px” box_shadow_style=”preset1″ global_colors_info=”{}”]<\/p>\n [\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ admin_label=”Paralax Background fullwidth Image – Section 3″ fullwidth=”on” disabled_on=”on|on|on” module_class=”section3_paralax_bg_fullwidth_img” _builder_version=”4.27.4″ _module_preset=”default” disabled=”on” locked=”off” collapsed=”on” global_colors_info=”{}” prev_background_color=”#00AEEF” next_background_color=”#000000″][et_pb_fullwidth_image title_text=”3″ _builder_version=”4.16″ _module_preset=”default” background_image=”https:\/\/labs.icahn.mssm.edu\/placeholder24\/wp-content\/uploads\/sites\/654\/2022\/10\/3.png” parallax=”on” parallax_method=”off” min_height=”217.5px” custom_margin=”-2px|||||” filter_opacity=”20%” global_colors_info=”{}”]<\/p>\n [\/et_pb_fullwidth_image][\/et_pb_section][et_pb_section bb_built=”1″ admin_label=”Two Column Title Over Text Next to Image – Section 5″ disabled_on=”on|on|on” module_class=”section5_two_col_title_over_txt_next_to_img” _builder_version=”4.27.4″ _module_preset=”default” disabled=”on” locked=”off” collapsed=”off” global_colors_info=”{}” prev_background_color=”#000000″ next_background_color=”#00AEEF”][et_pb_row admin_label=”5 (Module)” column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.9.0″ background_color=”#FFFFFF” background_size=”initial” background_position=”top_left” background_repeat=”repeat” module_alignment=”center” custom_padding=”6px||3px|||” global_module=”956″][et_pb_column type=”1_2″ global_parent=”956″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text global_parent=”956″ _builder_version=”4.9.0″ _module_preset=”default” text_text_color=”#00AEEF” header_font=”|700|||||||” header_text_color=”#00AEEF” header_font_size=”36px” module_alignment=”center” custom_padding=”10%||10%||true|false” hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n How is tissue growth, homeostasis and renewal by stem cells regulated throughout life? Understanding the core molecular controls is fundamental for realizing the therapeutic potential of the instructive niche (Rezza et al, Current Topics in Developmental Biology 2014). After initial morphogenesis of hair follicles, the Dermal Condensate gives rise to the adult follicle inductive niche, the Dermal Papilla. Dermal Papilla cells signal to progenitors in the follicle bulb to control continuous production and outgrowth of hair. They are also critical for activating stem cells to regenerate a new follicle during the hair growth cycle. Remarkably, isolated niche cells can induce new hair formation after cell transplantation into skin in mice, a yet unrealized goal in human.<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ global_parent=”956″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image global_parent=”956″ src=”https:\/\/labs.icahn.mssm.edu\/placeholder24\/wp-content\/uploads\/sites\/654\/2022\/07\/ai-008.png” title_text=”ai-008″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”#FFFFFF” hover_enabled=”0″ sticky_enabled=”0″ \/][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ admin_label=”Two Column Image with Title and Text Over Button – Section 4 (Desktop Only)” disabled_on=”on|on|on” module_class=”section4_two_col_img_next_to_title_over_txt_over_btn_desktop” _builder_version=”4.27.4″ _module_preset=”default” background_color=”#00AEEF” use_background_color_gradient=”on” background_color_gradient_direction=”33deg” background_color_gradient_stops=”#00aeef 0%|#d80b8c 100%” background_color_gradient_start=”#00aeef” background_color_gradient_end=”#d80b8c” background_image=”https:\/\/labs.icahn.mssm.edu\/placeholder24\/wp-content\/uploads\/sites\/654\/2022\/10\/Background-2.png” parallax=”on” module_alignment=”center” height=”558px” custom_margin=”||200px||false|false” disabled=”on” locked=”off” collapsed=”on” global_colors_info=”{}” prev_background_color=”#ffffff” next_background_color=”#00AEEF”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/placeholder24\/wp-content\/uploads\/sites\/654\/2022\/08\/2021-Hero-Shot-2-smallest-scaled-3.png” title_text=”2021-Hero-Shot-2-smallest-scaled-3″ _builder_version=”4.16″ _module_preset=”default” width=”91%” max_width=”91%” min_height=”550px” height=”550px” max_height=”550px” custom_padding=”40px||||false|false” global_colors_info=”{}”]<\/p>\n [\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_text_color=”#FFFFFF” header_text_align=”center” header_text_color=”#FFFFFF” text_orientation=”center” custom_padding=”||||false|false” global_colors_info=”{}”]<\/p>\n How tissues regenerate from stem cells and how different organs balance cell loss with new growth is under intensive investigation in the regenerative biology field. In the natural hair growth cycle after years of continuous hair growth, follicles enter a wave of massive progenitor death along the hair axis that \u2013 as we are just beginning to unravel \u2013 is controlled by the niche microenvironment. During this follicle regression, the Dermal Papilla niche needs to relocate from the base of growing hair bulbs to the stem cell reservoir in the upper follicle for new growth activation.<\/p>\n [\/et_pb_text][et_pb_button button_url=”https:\/\/labs.icahn.mssm.edu\/design\/option1-research” button_text=”Find Out More” _builder_version=”4.16″ _module_preset=”default” custom_button=”on” button_text_color=”#d80b8c” button_bg_color=”#FFFFFF” button_border_radius=”0px” box_shadow_style=”preset1″ locked=”off” global_colors_info=”{}”]<\/p>\n [\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ admin_label=”Two Column Image with Title and Text Over Button – Section 4 (Mobile and Tablet Only)” disabled_on=”on|on|on” module_class=”section4_one_col_img_over_title_over_txt_over_btn_mobile_tablet” _builder_version=”4.27.4″ background_color=”#00AEEF” use_background_color_gradient=”on” background_color_gradient_direction=”33deg” background_color_gradient_stops=”#00aeef 0%|#d80b8c 100%” background_color_gradient_start=”#00aeef” background_color_gradient_end=”#d80b8c” background_image=”https:\/\/labs.icahn.mssm.edu\/placeholder24\/wp-content\/uploads\/sites\/654\/2022\/10\/Background-1.png” parallax=”on” width=”100%” custom_margin=”||100px||false|false” custom_padding=”80px|0px|63px|0px||” bottom_divider_color=”#FFFFFF” bottom_divider_height=”150px” bottom_divider_flip=”horizontal” bottom_divider_arrangement=”above_content” disabled=”on” locked=”off” collapsed=”on” global_colors_info=”{}” prev_background_color=”#00AEEF” next_background_color=”#ededed”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”|||” custom_padding=”|||” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/placeholder24\/wp-content\/uploads\/sites\/654\/2022\/08\/2021-Hero-Shot-2-smallest-scaled-3.png” title_text=”2021-Hero-Shot-2-smallest-scaled-3″ disabled_on=”off|off|off” _builder_version=”4.16″ animation_style=”slide” animation_direction=”left” animation_intensity_slide=”10%” box_shadow_style=”preset1″ box_shadow_color=”#58595B” always_center_on_mobile=”off” global_colors_info=”{}”]<\/p>\n [\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”22px” header_font=”||||” header_text_color=”#FFFFFF” header_4_text_color=”#FFFFFF” header_5_text_color=”#FFFFFF” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”700px” animation_style=”slide” animation_direction=”top” animation_intensity_slide=”4%” global_colors_info=”{}”]<\/p>\n How tissues regenerate from stem cells and how different organs balance cell loss with new growth is under intensive investigation in the regenerative biology field. In the natural hair growth cycle after years of continuous hair growth, follicles enter a wave of massive progenitor death along the hair axis that \u2013 as we are just beginning to unravel \u2013 is controlled by the niche microenvironment. During this follicle regression, the Dermal Papilla niche needs to relocate from the base of growing hair bulbs to the stem cell reservoir in the upper follicle for new growth activation.<\/p>\n [\/et_pb_text][et_pb_button button_url=”https:\/\/labs.icahn.mssm.edu\/design\/option1-research” button_text=”Find Out More” _builder_version=”4.16″ _module_preset=”default” custom_button=”on” button_text_color=”#d80b8c” button_bg_color=”#FFFFFF” button_border_radius=”0px” box_shadow_style=”preset1″ locked=”off” global_colors_info=”{}”]<\/p>\n [\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ admin_label=”Fullwidth Video over Background – Section 9″ disabled_on=”on|on|on” module_class=”fullwidth-video-over-background-section-9″ _builder_version=”4.27.4″ _module_preset=”default” background_color=”#ededed” background_image=”https:\/\/labs.icahn.mssm.edu\/placeholder24\/wp-content\/uploads\/sites\/654\/2022\/10\/4.png” height_last_edited=”on|desktop” 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research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue […]<\/p>\n","protected":false},"author":545,"featured_media":4572,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-template-blank.php","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"class_list":["post-1349","page","type-page","status-publish","has-post-thumbnail","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/drexlerlab\/wp-json\/wp\/v2\/pages\/1349","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/drexlerlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/drexlerlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/drexlerlab\/wp-json\/wp\/v2\/users\/545"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/drexlerlab\/wp-json\/wp\/v2\/comments?post=1349"}],"version-history":[{"count":31,"href":"https:\/\/labs.icahn.mssm.edu\/drexlerlab\/wp-json\/wp\/v2\/pages\/1349\/revisions"}],"predecessor-version":[{"id":4567,"href":"https:\/\/labs.icahn.mssm.edu\/drexlerlab\/wp-json\/wp\/v2\/pages\/1349\/revisions\/4567"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/drexlerlab\/wp-json\/wp\/v2\/media\/4572"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/drexlerlab\/wp-json\/wp\/v2\/media?parent=1349"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Richard Drexler, MD, PhD
Assistant Professor \u00a0| \u00a0Neuroscience
Member, Friedman Brain Institute
Member, Brain-Body Research Institute<\/p>\n
1425 Madison Ave
New York, NY 10029
Email: richard.drexler@mssm.edu<\/strong><\/a><\/p>\nWelcome to the Rendl Lab<\/h1>\n
Welcome to the Rendl Lab<\/h1>\n
Welcome to the Rendl Lab<\/strong><\/h1>\n
Birth of the Hair Follicle Niche<\/strong><\/h1>\n
Formation and Function of Stem Cell Niches<\/strong><\/h4>\n
\n
Growth Control and Regeneration<\/strong><\/h1>\n
Tissue Regression and Reorganization<\/strong><\/h1>\n
Tissue Regression and Reorganization<\/strong><\/h1>\n
<\/a><\/span>Recent News
<\/a>Alumni
<\/a>Researchers
<\/a>Gallery
<\/a>Resources
<\/a>Submit Inquiry
<\/a>Resources
<\/a>Lab Trials
Accessibility<\/a><\/span><\/p>\n
<\/strong>richard.drexler@mssm.edu<\/p>\n
<\/strong>Tel: 555-555-5555<\/p>\n
1425 Madison Avenue
Icahn Medical Institute (IMI)\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Floor 10, Room 10-26\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 New York, NY 10029<\/p>\n