{"id":56,"date":"2015-01-25T16:31:52","date_gmt":"2015-01-25T16:31:52","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/devital-lab\/?page_id=56"},"modified":"2015-08-24T16:51:03","modified_gmt":"2015-08-24T16:51:03","slug":"publications","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/devita-lab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

Select publications:<\/strong><\/p>\n

Research Articles<\/strong><\/p>\n

1. \u00a0Identification and characterization of sebaceous gland atrophy-sparing DGAT1 inhibitors.<\/a> Muise, E.S.; Zhu, Y.; Verras, A.; Karanam, B.V.; Gorski, J.; Weingarth, D.; Lin, H.V.; Hwa, J.; Thompson, J.R.; Hu, G.; Liu, J.; He, S.; DeVita, R.J.; Shen, D.-M.; Pinto, S. PLoS One 2014, 9(2), e88908\/1-e88908\/12, 12 pp.<\/p>\n

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2. Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain<\/a>, Chobanian, H.R.; Guo, Y.; Liu, P.; Chioda, M.D.; Fung, S.; Lanza, T.J.; Chang, L.; Bakshi, R.K.; Dellureficio, J.P.; Hong, Q.; McLaughlin, M.; Belyk, K.M.; Krska, S.W.; Makarewicz, A.K.; Martel, E.J.; Leone, J.F.; Frey, L.; Karanam, B.; Madeira,M.; Alvaro, R.; Shuman, J.; Salituro, G.; Terebetski, J.L.; Jochnowitz, N.; Mistry, S.; McGowan, E.; Hajdu, R.; Rosenbach, M.; Abbadie, C.; Alexander, J.P.; Shiao, L.-L.; Sullivan, K.M.; Nargund, R.P.; Wyvratt, M.J.; Linus S. Lin, L.S.; and DeVita, R.J.\u00a0 ACS Med. Chem. Lett., 2014, 5(6), 717-721. DOI:10.1021\/ml5001239.<\/p>\n

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3. Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety<\/a>, He, S.; Hong, Q.; Lai, Z.; Yang, D.X.; Tong, P.C.; Kuethe, J.T.; Cernak, T.C.; Dykstra, K.D.; Sperbeck, D.M.; Wu, Z.; Yu, Y.; Yang, G.X.; Jian, T.; Liu, J.; Guiadeen, D.; Krikorian, A.D.; Sonatore, L.M.; Wiltsie, J.; Liu, J.; Gorski, J.N.; Chung, C.C.; Gibson, J.T.; Lisnock, J.; Xiao, J.; Wolff, M.; Tong, S.X.; Madeira, M.; Karanam, B.V.; Shen, D.-M.; Balkovec, J.M; Pinto, S.; Nargund, R.P.; DeVita, R.J. ACS Med. Chem. Lett., 2014, 5 (10), pp 1082\u20131087.<\/p>\n

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4. Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase<\/a>. Liu, P.; Hamill, T.G.; Chioda, M.; Chobanian, H.; Fung, S.; Guo, Y.; Chang, L.; Bakshi, R.; Hong, Q.; Dellureficio, J.; Lin, L.S.; Abbadie, C.; Alexander, J.; Jin, H.; Mandala, S.; Shiao, L.-L.; Li, W.; Sanabria, S.; Williams, D.; Zeng, Z.; Hajdu, R.; Jochnowitz, N.; Rosenbach, M.; Karanam, B.; Madeira, M.; Salituro, G.; Powell, J.; Xu, L.; Terebetski, J.L.; Leone, J.F.; Miller, P.; Cook, J.; Holahan, M.; Joshi, A.; O\u2019Malley, S.; Purcell, M.; Posavec, D.; Chen, T.-B.; Riffel, K.; Williams, M.; Hargreaves, R.; Sullivan, K.A.; Nargund, R.P.; DeVita, R.J. ACS Med. Chem. Lett. 2013, 509-513.<\/p>\n

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5. Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety<\/a>, He, S.; Hong, Q.; Lai, Z.; Wu, Z.; Yu, Y.; Kim, D.W.; Ting, P.C.; Kuethe, J.T.; Yang, G.X.; Jian, T.; Liu, J.; Guiadeen, D.; Krikorian, A.D.; Sperbeck, D.M.; Sonatore, L.M.; Wiltsie, J.; Chung, C.C.; Gibson, J.T.; Lisnock, J.; Murphy, B.A.; Gorski, J.N.; Liu, J.; Chen, D.; Chen, X.; Wolff, M.; Tong, S.X.; Madeira, M.; Karanam, B.V.; Shen, D.-M.; Balkovec, J.M; Pinto, S.; Nargund, R.P.; DeVita, R.J. ACS Med. Chem. Lett., 2013, 773-778.<\/p>\n

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6. 2-[(3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-4-(2-methylphenyl)-octahydro-2H-isoindol-2-yl]-1,3-oxazol-4(5H)-one: A Potent Human NK1 Receptor Antagonist with Multiple Clearance Pathways<\/a>, Kassick, A.J.; Jiang, J.; Bunda, J.; Wilson, D.; Bao, J.; Lu, H.; Ball, R.G.; Doss, G.A.; Tong, X.; Tsao, K.-L.C.; Wang, H.; Chicchi, G.; Karanam, B.; Tschirret-Guth, R.; Samuel, K.; Hora, D.F.; Kumar, S.; Madeira, M.; Eng, W.; Hargreaves, R.; Purcell, M.; Gantert, L.; Cook, J.; DeVita, R.J.; Mills, S.G. J. Med.Chem. 2013, 5940-5948.<\/p>\n

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 <\/p>\n

7. Synthesis of Oxaspiropiperidines as a Strategy for Lowering logD<\/a>, Cernak*, T.; Kevin Dykstra, K; Levorse, D.; Verras, A.; Balkovec, J.; Nargund, R.; DeVita, R. J..; Tetrahedron Letters, 2011, 6457-6459.<\/p>\n

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Reviews and Persectives<\/strong><\/p>\n

1. \u00a0Current Status of the Research and Development of DGAT1 Inhibitors<\/a>, DeVita, R.J.; Pinto, S.\u00a0 J. Med.Chem. 2013, 56\u00a0(24), pp 9820\u20139825. Invited perspective,\u00a0 DOI: 10.1021\/jm4007033<\/p>\n

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2. The Changing Drug Discovery Paradigm,<\/a> DeVita, R.J.; Wuelfing, W.P., McGregor, C.; Bak, A.\u00a0 American Association of Pharmaceutical Science News Magazine, 2012, July issue, 20-23.<\/p>\n","protected":false},"excerpt":{"rendered":"

Select publications: Research Articles 1. \u00a0Identification and characterization of sebaceous gland atrophy-sparing DGAT1 inhibitors. Muise, E.S.; Zhu, Y.; Verras, A.; Karanam, B.V.; Gorski, J.; Weingarth, D.; Lin, H.V.; Hwa, J.; Thompson, J.R.; Hu, G.; Liu, J.; He, S.; DeVita, R.J.; Shen, D.-M.; Pinto, S. PLoS One 2014, 9(2), e88908\/1-e88908\/12, 12 pp. 2. Discovery of MK-4409, […]<\/p>\n","protected":false},"author":30,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"open","ping_status":"open","template":"full-width.php","meta":{"footnotes":""},"class_list":["post-56","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/devita-lab\/wp-json\/wp\/v2\/pages\/56","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/devita-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/devita-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/devita-lab\/wp-json\/wp\/v2\/users\/30"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/devita-lab\/wp-json\/wp\/v2\/comments?post=56"}],"version-history":[{"count":4,"href":"https:\/\/labs.icahn.mssm.edu\/devita-lab\/wp-json\/wp\/v2\/pages\/56\/revisions"}],"predecessor-version":[{"id":269,"href":"https:\/\/labs.icahn.mssm.edu\/devita-lab\/wp-json\/wp\/v2\/pages\/56\/revisions\/269"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/devita-lab\/wp-json\/wp\/v2\/media?parent=56"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}