2017

Class A GPCRs: Cannabinoid and opioid receptor heteromers
Sierra S, Gomes I, Devi LA
Chapter 7. G-Protein-Coupled Receptor Dimers. 2017. doi:10.1007/978-3-319-60174-8

Two delta opioid receptor subtypes are functional in single ventral tegmental area neurons, and can interact with the mu opioid receptor.
Margolis EB, Fujita W, Devi LA, Fields HL
Neuropharmacology.  2017 Jun 20. doi: 10.1016/j.neuropharm.2017.06.019

The BigLEN-GPR171 Peptide Receptor System Within the Basolateral Amygdala Regulates Anxiety-Like Behavior and Contextual Fear Conditioning.
Bobeck EN, Gomes I, Pena DA, Cummings KA, Clem RL, Mezei M, Devi LA
Neuropsychopharmacology.  2017 Apr 20. doi: 10.1038/npp.2917.79

2016

Detection of Receptor Heteromerization Using In Situ Proximity Ligation Assay.
Gomes I, Sierra S, Devi LA
Curr Protoc Pharmacol.  2016 Dec 13;75:2.16.1-2.16.31.

Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake.
Wardman JH, Gomes I, Bobeck EN, Stockert JA, Kapoor A, Bisignano P, Gupta A, Mezei M, Kumar S, Filizola M, Devi LA
Sci Signal. 2016 May 31;9(430):ra55.

Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity.
Gupta A, Gomes I, Bobeck EN, Fakira AK, Massaro NP, Sharma I, Cavé A, Hamm HE, Parello J, Devi LA.
Proc Natl Acad Sci U S A. 2016 May 24;113(21):6041-6. Epub 2016 May 9.

Identification of GPR83 as the receptor for the neuroendocrine peptide PEN.
Gomes I, Bobeck EN, Margolis EB, Gupta A, Sierra S, Fakira AK, Fujita W, Müller TD, Müller A, Tschöp MH, Kleinau G, Fricker LD, Devi LA.
Sci Signal. 2016 Apr 26;9(425):ra43.

G Protein-Coupled Receptor Heteromers.
Gomes I, Ayoub MA, Fujita W, Jaeger WC, Pfleger KD, Devi LA.
Annu Rev Pharmacol Toxicol. 2016;56:403-25.Epub 2015 Oct 22.

2015

Morphine Regulated Synaptic Networks Revealed by Integrated Proteomics and Network Analysis.
Stockton SD Jr, Gomes I, Liu T, Moraje C, Hipólito L, Jones MR, Ma’ayan A, Morón JA, Li H, Devi LA.
Molecular & Cellular Proteomics. 2015 Jul 6.  [Epub ahead of print]

Advancements in therapeutically targeting orphan GPCRs.
Stockert JA, Devi LA.
Frontiers in Pharmacology. 2015 May 8;6:100

Endothelin-converting enzyme 2 differentially regulates opioid receptor activity.
Gupta A, Fujita W, Gomes I, Bobeck E, Devi LA.
British Journal of Pharmacology. 2015 Jan;172(2):704-19. Epub 2014 Sep 5.

Challenges for opioid receptor nomenclature.
Cox, B. M., Christie, M. J., Devi, LA. Toll, L. and Traynor, J.R.
British Journal of Pharmacology. 2015 Jan;172(2):317-23. Epub 2014 Jul 1.

Heteromers of μ-δ opioid receptors: new pharmacology and novel therapeutic possibilities.
Fujita W, Gomes I, Devi LA.
British Journal of Pharmacology. 2015 Jan;172(2):375-87. Epub 2014 Jul 1.

2014

Antibodies to probe endogenous G protein-coupled receptor heteromer expression, regulation, and function.
Gomes I, Gupta A, Bushlin I, Devi LA.
Frontiers in Pharmacology. 2014 Dec 3;5:268.

Molecular characterization of eluxadoline as a potential ligand targeting mu-delta opioid receptor heteromers.
Fujita W, Gomes I, Dove LS, Prohaska D, McIntyre G, Devi LA.
Biochemical Pharmacology. 2014 Dec 1;92(3):448-56.

Salvinorin A regulates dopamine transporter function via a kappa opioid receptor and ERK1/2-dependent mechanism.
Kivell B, Uzelac Z, Sundaramurthy S, Rajamanickam J, Ewald A, Chefer V, Jaligam V, Bolan E, Simonson B, Annamalai B, Mannangatti P, Prisinzano TE, Gomes I, Devi LA, Jayanthi LD, Sitte HH, Ramamoorthy S, Shippenberg TS. Salvinorin
Neuropharmacology. 2014 Nov;86:228-40.

Revolution in GPCR signalling: opioid receptor heteromers as novel therapeutic targets: IUPHAR review 10.
Fujita W, Gomes I, Devi LA.
British Journal of Pharmacology. 2014 Sep;171(18):4155-76.

Opioid Receptor Function is Regulated by Post-endocytic Peptide Processing.
Gupta A, Gomes I, Wardman J, Devi LA.
Journal of Biological Chemistry 2014 Jul 11;289(28):19613-26.

Hemopressin, an inverse agonist of cannabinoid receptors, inhibits neuropathic pain in rats.
Toniolo EF, Maique ET, Ferreira WA Jr, Heimann AS, Ferro ES, Ramos-Ortolaza DL, Miller L, Devi LA, Dale CS.
Peptides. 2014 Jun;56:125-31.

Optimization and characterization of an opioid kappa receptor (OPRK1) antagonist.
Guerrero M, Urbano M, Brown SJ, Cayanan C, Ferguson J, Cameron M, Devi LA, Roberts E, Rosen H.
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2013 Apr 15 [updated 2014 Sep 18].

Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy.
Yang, L, Rozenfeld, R, Wu, D, Devi, LA, Zhang, Z and Cederbaum, A.
Free. Radical Biology & Medicine. 68:260-267, 2014 Mar; Epub 2014 Jan 4.

The orally active opioid m/d dual agonist MGM-16, a derivative of indole alkaloid mitragynine, exhibits potent anti-allodynic effect on neuropathic pain in mice.
Matsumoto, K, Narita, M, Muramatsu, N, Nakayama, T, Misawa, K, Kitajima, M, Tashima, K, Devi, LA, Suzuki, T, Takayama, H and Horie, S.
Journal of Pharmacology and Experimental Therapeutics. 348:383-92, 2014 March

G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives.
Ferré S, Casadó V, Devi LA, Filizola M, Jockers R, Lohse MJ, Milligan G, Pin JP, Guitart X.
Pharmacological Reviews. 2014 Feb 10;66(2):413-34.

An integrated quantitative proteomics and systems biology approach to explore synaptic protein profile changes during morphine exposure.
Stockton SD Jr, Devi LA.
Neuropsychopharmacology 2014 Jan; 39(1).

2013

GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding.
Gomes I, Aryal DK, Wardman JH, Gupta A, Gagnidze K, Rodriguiz RM, Kumar S, Wetsel WC, Pintar JE, Fricker LD, Devi LA.
Proceedings of the National Academy of Sciences U S A. 2013 Oct 1;110(40):16211-16216.

Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity.
Gomes I, Fujita W, Gupta A, Saldanha AS, Negri A, Pinello CE, Roberts E, Filizola M, Hodder P, Devi LA.
Proceedings of the National Academy of Sciences U S A. 2013 Jul 16;110(29):12072-7.

Possible involvement of prolonging spinal µ-opioid receptor desensitization in the development of antihyperalgesic tolerance to µ-opioids under a neuropathic pain-like state.
Narita M, Imai S, Nakamura A, Ozeki A, Asato M, Rahmadi M, Sudo Y, Hojo M, Uezono Y, Devi LA, Kuzumaki N, Suzuki T.
Addict Biol. 2013 Jul;18(4):614-22.

Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy.
Hernández-Gea V, Hilscher M, Rozenfeld R, Lim MP, Nieto N, Werner S, Devi LA, Friedman SL.
J Hepatol. 2013 Jul;59(1):98-104.

Disease-specific heteromerization of G-protein-coupled receptors that target drugs of abuse.
Gomes I, Fujita W, Chandrakala MV, Devi LA.
Progress in Molecular Biology and Translational Science. 2013;117:207-65.

G-protein-coupled heteromers: regulation in disease.
Gomes I, Gupta A, Devi LA.
Methods in Enzymology. 2013;521:219-38.

Grand opening of structure-guided design for novel opioids.
Filizola M, Devi LA.
Trends in Pharmacological Sciences. 2013 Jan;34(1):6-12. Epub 2012 Nov 3. Review.

2012

Characterization of an agonist probe for opioid receptor mu 1 (OPRM1)-opioid receptor delta 1 (OPRD1) heterodimerization.
Pinello C, Guerrero M, Eberhart C, Volmar CH, Saldanha SA, Cayanan C, Urbano M, Brown SJ, Ferguson J, Gomes I, Devi LA, Roberts E, Hodder P, Rosen H.
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-2012 Dec 17 [updated 2013 Apr 5].

Dimerization with cannabinoid receptors allosterically modulates delta opioid receptor activity during neuropathic pain.
Bushlin I, Gupta A, Stockton SD Jr, Miller LK, Devi LA.
PLoS One. 2012;7(12):e49789. Epub 2012 Dec 14.

Structural biology: How opioid drugs bind to receptors.
Filizola M, Devi LA.
Nature. 2012 May 16;485(7398):314-7.

Opioid receptor heteromers in analgesia.
Costantino CM, Gomes I, Stockton SD, Lim MP, Devi LA.
Expert Reviews in Molecular Medicine. 2012 Apr 10;14:e9.

Cannabinoid receptor 2-mediated attenuation of CXCR4-tropic HIV infection in primary CD4+ T cells.
Costantino CM, Gupta A, Yewdall AW, Dale BM, Devi LA, Chen BK.
PLoS One. 2012;7(3):e33961. Epub 2012 Mar 20.

Receptor heteromerization expands the repertoire of cannabinoid signaling in rodent neurons.
Rozenfeld R, Bushlin I, Gomes I, Tzavaras N, Gupta A, Neves S, Battini L, Gusella GL, Lachmann A, Ma’ayan A, Blitzer RD, Devi LA.
PLoS One. 2012;7(1):e29239. Epub 2012 Jan 3.

Functional relevance of μ-δ opioid receptor heteromerization: a role in novel signaling and implications for the treatment of addiction disorders: from a symposium on new concepts in mu-opioid pharmacology.
Stockton SD Jr, Devi LA.
Drug and Alcohol Dependence. 2012 Mar 1;121(3):167-72. Epub 2011 Nov 23. Review.

Allosteric interactions between δ and κ opioid receptors in peripheral sensory neurons.
Berg KA, Rowan MP, Gupta A, Sanchez TA, Silva M, Gomes I, McGuire BA, Portoghese PS, Hargreaves KM, Devi LA, Clarke WP.
Molecular Pharmacology. 2012 Feb;81(2):264-72. Epub 2011 Nov 9.

2011

Mice deficient in endothelin-converting enzyme-2 exhibit abnormal responses to morphine and altered peptide levels in the spinal cord.
Miller LK, Hou X, Rodriguiz RM, Gagnidze K, Sweedler JV, Wetsel WC, Devi LA.
Journal of Neurochemistry. 2011 Dec;119(5):1074-85. Epub 2011 Nov 1.

Chronic morphine alters the presynaptic protein profile: identification of novel molecular targets using proteomics and network analysis.
Abul-Husn NS, Annangudi SP, Ma’ayan A, Ramos-Ortolaza DL, Stockton SD Jr, Gomes I, Sweedler JV, Devi LA.
PLoS One. 2011;6(10):e25535. Epub 2011 Oct 17.

Potentiation of μ-opioid receptor-mediated signaling by ketamine.
Gupta A, Devi LA, Gomes I.
Journal of Neurochemistry. 2011 Oct;119(2):294-302. Epub 2011 Sep 20.

The highs and lows of cannabinoid receptor expression in disease: mechanisms and their therapeutic implications.
Miller LK, Devi LA.
Pharmacological Reviews. 2011 Sep;63(3):461-70. Epub 2011 Jul 13. Review.

Possible involvement of β-endorphin in a loss of the coordinated balance of μ-opioid receptors trafficking processes by fentanyl.
Imai S, Sudo Y, Nakamura A, Ozeki A, Asato M, Hojo M, Devi LA, Kuzumaki N, Suzuki T, Uezono Y, Narita M.
Synapse. 2011 Sep;65(9):962-6. Epub 2011 Apr 11. No abstract available.

Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis.
Lim MP, Devi LA, Rozenfeld R.
Cell Death & Disease. 2011 Jun 9;2:e170.

G protein-coupled receptor heteromerization: a role in allosteric modulation of ligand binding.
Gomes I, Ijzerman AP, Ye K, Maillet EL, Devi LA.
Molecular Pharmacology. 2011 Jun;79(6):1044-52. doi: 10.1124/mol.110.070847. Epub 2011 Mar 17.

AT1R-CB₁R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II.
Rozenfeld R, Gupta A, Gagnidze K, Lim MP, Gomes I, Lee-Ramos D, Nieto N, Devi LA.
EMBO J. 2011 May 3;30(12):2350-63.

Exploring a role for heteromerization in GPCR signalling specificity.
Rozenfeld R, Devi LA.
Biochemical Journal. 2011 Jan 1;433(1):11-8. Review.

2010

Hemoglobin-derived peptides as novel type of bioactive signaling molecules.
Gomes I, Dale CS, Casten K, Geigner MA, Gozzo FC, Ferro ES, Heimann AS, Devi LA.
AAPS Journal. 2010 Dec;12(4):658-69. Epub 2010 Sep 2. Review.

Identification of an endothelin-converting enzyme-2-specific fluorigenic substrate and development of an in vitro and ex vivo enzymatic assay.
Ouimet T, Orng SV, Poras H, Gagnidze K, Devi LA, Fournié-Zaluski MC, Roques BP.
The Journal of Biological Chemistry. 2010 Nov 5;285(45):34390-400. Epub 2010 Aug 31.

β2-Adrenergic receptor signaling in the cardiac myocyte is modulated by interactions with CXCR4.
LaRocca TJ, Schwarzkopf M, Altman P, Zhang S, Gupta A, Gomes I, Alvin Z, Champion HC, Haddad G, Hajjar RJ, Devi LA, Schecter AD, Tarzami ST.
Journal of Cardiovascular Pharmacology. 2010 Nov;56(5):548-59.

Escorts take the lead molecular chaperones as therapeutic targets.
Williams D, Devi LA.
Progress in Molecular Biology and Translational Science. 2010;91:121-49. Review.

Role of antibodies in developing drugs that target G-protein-coupled receptor dimers.
Hipser C, Bushlin I, Gupta A, Gomes I, Devi LA.
Mount Sinai Journal of Medicine. 2010 Jul-Aug;77(4):374-80. Review.

Increased abundance of opioid receptor heteromers after chronic morphine administration.
Gupta A, Mulder J, Gomes I, Rozenfeld R, Bushlin I, Ong E, Lim M, Maillet E, Junek M, Cahill CM, Harkany T, Devi LA.
Science Signaling. 2010 Jul 20;3(131):ra54.

GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base.
Khelashvili G, Dorff K, Shan J, Camacho-Artacho M, Skrabanek L, Vroling B, Bouvier M, Devi LA, George SR, Javitch JA, Lohse MJ, Milligan G, Neubig RR, Palczewski K, Parmentier M, Pin JP, Vriend G, Campagne F, Filizola M.
Bioinformatics. 2010 Jul 15;26(14):1804-5. Epub 2010 May 25.

The propeptide precursor proSAAS is involved in fetal neuropeptide processing and body weight regulation.
Morgan DJ, Wei S, Gomes I, Czyzyk T, Mzhavia N, Pan H, Devi LA, Fricker LD, Pintar JE.
Journal of Neurochemistry. 2010 Jun;113(5):1275-84. Epub 2010 Mar 26.

Receptor heteromerization and drug discovery.
Rozenfeld R, Devi LA.
Trends in Pharmacological Sciences. 2010 Mar;31(3):124-30. Epub 2010 Jan 7.

Quantitative neuroproteomics of the synapse.
Ramos-Ortolaza DL, Bushlin I, Abul-Husn N, Annangudi SP, Sweedler J, Devi LA.
Methods in Molecular Biology. 2010;615:227-46.

Modulation of opiate-related signaling molecules in morphine-dependent conditioned behavior: conditioned place preference to morphine induces CREB phosphorylation.
Morón JA, Gullapalli S, Taylor C, Gupta A, Gomes I, Devi LA.
Neuropsychopharmacology. 2010 Mar;35(4):955-66. Epub 2009 Dec 2.

Cannabinoid-opioid interactions during neuropathic pain and analgesia.
Bushlin I, Rozenfeld R, Devi LA.
Current Opinion in Pharmacology. 2010 Feb;10(1):80-6. Epub 2009 Oct 25. Review.