
{"id":2494,"date":"2022-12-20T11:44:55","date_gmt":"2022-12-20T16:44:55","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/design\/?page_id=2494"},"modified":"2025-03-04T14:01:25","modified_gmt":"2025-03-04T19:01:25","slug":"publications","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/davislab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_row _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_text _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; header_text_color=&#8221;#00AEEF&#8221; header_font_size=&#8221;40px&#8221;]<\/p>\n<h1><strong>Publications<\/strong><\/h1>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Section 28 &#8211; Blog Style Publications&#8221; module_class=&#8221;section28_blog_style_publications&#8221; _builder_version=&#8221;4.9.0&#8243; background_color=&#8221;#FFFFFF&#8221; background_enable_image=&#8221;off&#8221; parallax=&#8221;on&#8221; parallax_method=&#8221;off&#8221; custom_padding=&#8221;100px||||false|false&#8221; global_module=&#8221;2511&#8243; saved_tabs=&#8221;all&#8221; locked=&#8221;off&#8221; collapsed=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;-128px|auto||auto||&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_toggle title=&#8221;2025&#8243; open_toggle_text_color=&#8221;#00AEEF&#8221; icon_color=&#8221;#00AEEF&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; title_text_color=&#8221;#00AEEF&#8221; title_level=&#8221;h4&#8243; title_font=&#8221;|800|||||||&#8221; title_font_size=&#8221;20px&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39424167\/\"><span style=\"color: #221f72\"><span style=\"color: #00aeef\">Advancing Mental Health Research Through Strategic Integration of Transdiagnostic Dimensions and Genomics.<\/span><br \/> <\/span><\/a><\/strong><span style=\"font-size: 16px\">Doyle AE, Bearden CE, Gur RE, Ledbetter DH, Martin CL, McCoy TH Jr, Pasaniuc B, Perlis RH, Smoller JW, <\/span><strong>Davis LK<\/strong>.<span style=\"font-size: 16px\">\u00a0 Biol Psychiatry. 2025 Mar 1;97(5):450-460. doi: 10.1016\/j.biopsych.2024.10.006. Epub 2024 Oct 16. PMID: 39424167.<\/span><\/p>\n<p><span style=\"font-size: 16px\"><span style=\"color: #00aeef\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39814019\/\" style=\"color: #00aeef\"><strong>Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies.<\/strong><\/a><\/span><br \/> Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Electronic address: andrew.mcintosh@ed.ac.uk; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium.\u00a0 Cell. 2025 Feb 6;188(3):640-652.e9. doi: 10.1016\/j.cell.2024.12.002. Epub 2025 Jan 14. PMID: 39814019.<\/span><\/p>\n<p><span style=\"font-size: 16px\"><span style=\"color: #00aeef\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39869013\/\" style=\"color: #00aeef\"><strong>Strength of Genetic Associations with Thyrotropin Values Differs Between Populations with Similarity to African and European Reference Populations.<\/strong><\/a><\/span><br \/> Wade AN, Guare L, Hayat M, <\/span><strong style=\"font-size: 16px\">Straub P<\/strong><span style=\"font-size: 16px\">, Gao Z, Medici M, Teumer A, <\/span><strong style=\"font-size: 16px\">Davis LK<\/strong><span style=\"font-size: 16px\">, Ramsay M, Ritchie MD, BioBank PM, Cappola AR.\u00a0 Thyroid. 2025 Jan 27. doi: 10.1089\/thy.2024.0525. Epub ahead of print. PMID: 39869013.<\/span><\/p>\n<p><span style=\"font-size: 16px\"><span style=\"color: #00aeef\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39744833\/\" style=\"color: #00aeef\"><strong>Identification of Transdiagnostic Childhood Externalizing Pathology Within an Electronic Medical Records Database and Application to the Analysis of Rare Copy Number Variation.<\/strong><\/a><\/span><br \/> <strong>Reddy IA<\/strong>, Han L, Sanchez-Roige S, <strong>Niarchou M<\/strong>, Ruderfer DM, <strong>Davis LK<\/strong>. Am J Med Genet B Neuropsychiatr Genet. 2025 Jan 2:e33020. doi: 10.1002\/ajmg.b.33020. Epub ahead of print. PMID: 39744833.<br \/> <\/span><\/p>\n<p><span style=\"font-size: 16px\"><a href=\"https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/fullarticle\/2825462\"><strong>Sexual Trauma, Polygenic Scores, and Mental Health Diagnoses and Outcomes<\/strong><\/a><br \/> <strong>Lake AM<\/strong>, Zhou Y, Wang B, <strong>Actkins KV<\/strong>, Zhang Y, Shelley JP, Rajamani A, Steigman M, Kennedy CJ, Smoller JW, Choi KW, Khankari NK, <strong>Davis LK<\/strong>. JAMA Psychiatry. 2025 Jan 1;82(1):75-84. doi: 10.1001\/jamapsychiatry.2024.3426. PMID: 39475956; PMCID: PMC11581726.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_toggle][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_toggle title=&#8221;2024&#8243; open_toggle_text_color=&#8221;#00AEEF&#8221; icon_color=&#8221;#00AEEF&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; title_text_color=&#8221;#00AEEF&#8221; title_level=&#8221;h3&#8243; title_font=&#8221;|800|||||||&#8221;]<\/p>\n<p><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39611256\/\">Sex-Specific Association Between Genetic Risk of Psychiatric Disorders and Cardiovascular Diseases<\/a><\/strong>.<br \/> Jiang JC, <strong>Singh K<\/strong>, <strong>Nitin R<\/strong>, <strong>Davis LK<\/strong>, Wray NR, Shah S.\u00a0 Circ Genom Precis Med. 2024 Dec;17(6):e004685. doi: 10.1161\/CIRCGEN.124.004685. Epub 2024 Nov 29. PMID: 39611256; PMCID: PMC11651350.<\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41467-024-53595-6\"><strong>Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction<\/strong><\/a><br \/> Braun A, Shekhar S, Levey DF, <strong>Straub P<\/strong>, Kraft J, Panagiotaropoulou GM, Heilbron K, Awasthi S, Meleka Hanna R, Hoffmann S, Stein M, Lehnerer S, Mergenthaler P, Elnahas AG, Topaloudi A, Koromina M, Palviainen T, Asbjornsdottir B, Stefansson H, Skulad\u00f3ttir AT, J\u00f3nsd\u00f3ttir I, Stefansson K, Reis K, Esko T, Palotie A, Leypoldt F, Stein MB, Fontanillas P; Estonian Biobank Research Team; 23andMe Research Team; Kaprio J, Gelernter J, <strong>Davis LK<\/strong>, Paschou P, Tannemaat MR, Verschuuren JJGM, Kuhlenb\u00e4umer G, Gregersen PK, Huijbers MG, Stascheit F, Meisel A, Ripke S. Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction. Nat Commun. 2024 Nov 13;15(1):9839. doi: 10.1038\/s41467-024-53595-6. PMID: 39537604; PMCID: PMC11560923.<\/p>\n<p><a href=\"https:\/\/psychiatryonline.org\/doi\/10.1176\/appi.ajp.20231055?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub%20%200pubmed\"><strong>Genetic Heterogeneity Across Dimensions of Alcohol Use Behaviors<\/strong><\/a><br \/> Savage JE, Barr PB, Phung T, Lee YH, Zhang Y, McCutcheon VV; COGA Investigators; Ge T, Smoller JW, <strong>Davis LK<\/strong>, Meyers J, Porjesz B, Posthuma D, Mallard TT, Sanchez-Roige S.\u00a0 Am J Psychiatry. 2024 Nov 1;181(11):1006-1017. doi: 10.1176\/appi.ajp.20231055. Epub 2024 Oct 9. PMID: 39380376.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41398-024-03011-w\"><strong>Developing a phenotype risk score for tic disorders in a large, clinical biobank<\/strong><\/a><br \/> <strong>Miller-Fleming TW<\/strong>, Allos A, Gantz E, Yu D, Isaacs DA, Mathews CA, Scharf JM, <strong>Davis LK<\/strong>. Developing a phenotype risk score for tic disorders in a large, clinical biobank. Transl Psychiatry. 2024 Jul 28;14(1):311. doi: 10.1038\/s41398-024-03011-w. PMID: 39069519; PMCID: PMC11284231.<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39050781\/\"><strong>Comorbidity Profiles of Posttraumatic Stress Disorder Across the Medical Phenome<\/strong><\/a><br \/> Hicks EM, <strong>Niarchou M<\/strong>, Goleva S, Kabir D, Johnson J, Johnston KJA, Ciarcia J, Pathak GA, Smoller JW, <strong>Davis LK<\/strong>, Nievergelt CM, Koenen KC, Huckins LM, Choi KW; PGC\/PsycheMERGE PTSD &amp; Trauma EHR Working Group. Comorbidity Profiles of Posttraumatic Stress Disorder Across the Medical Phenome. Biol Psychiatry Glob Open Sci. 2024 May 29;4(5):100337. doi: 10.1016\/j.bpsgos.2024.100337. PMID: 39050781; PMCID: PMC11268109.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41386-024-01886-3\"><strong>Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking<\/strong><\/a><br \/> Johnson EC, Austin-Zimmerman I, Thorpe HHA, Levey DF, Baranger DAA, Colbert SMC, Demontis D, Khokhar JY, <strong>Davis LK<\/strong>, Edenberg HJ, Di Forti M, Sanchez-Roige S, Gelernter J, Agrawal A. Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking. Neuropsychopharmacology. 2024 Oct;49(11):1655-1665. doi: 10.1038\/s41386-024-01886-3. Epub 2024 Jun 21. PMID: 38906991; PMCID: PMC11399264.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41386-024-01870-x\"><strong>Genome-wide association studies of coffee intake in UK\/US participants of European ancestry uncover cohort-specific genetic associations<\/strong><\/a><br \/> Thorpe HHA, Fontanillas P, Pham BK, Meredith JJ, Jennings MV, Courchesne-Krak NS, Vilar-Rib\u00f3 L, Bianchi SB, Mutz J; 23andMe Research Team; Elson SL, Khokhar JY, Abdellaoui A, <strong>Davis LK<\/strong>, Palmer AA, Sanchez-Roige S. Genome-wide association studies of coffee intake in UK\/US participants of European ancestry uncover cohort-specific genetic associations. Neuropsychopharmacology. 2024 Sep;49(10):1609-1618. doi: 10.1038\/s41386-024-01870-x. Epub 2024 Jun 11. PMID: 38858598; PMCID: PMC11319477.<\/p>\n<p><a href=\"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1832427424000197\/type\/journal_article\"><strong>Phenomewide Association Study of Health Outcomes Associated With the Genetic Correlates of 25 Hydroxyvitamin D Concentration and Vitamin D Binding Protein Concentration<\/strong><\/a><br \/> Kresge HA, Blostein F, Goleva S, Albi\u00f1ana C, Revez JA, Wray NR, Vilhj\u00e1lmsson BJ, Zhu Z, McGrath JJ, <strong>Davis LK<\/strong>. Phenomewide Association Study of Health Outcomes Associated With the Genetic Correlates of 25 Hydroxyvitamin D Concentration and Vitamin D Binding Protein Concentration. Twin Res Hum Genet. 2024 Apr;27(2):69-79. doi: 10.1017\/thg.2024.19. Epub 2024 Apr 22. PMID: 38644690; PMCID: PMC11138239.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41588-024-01707-9\"><strong>Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder<\/strong><\/a><br \/> Nievergelt CM, Maihofer AX, Atkinson EG, et al. Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder. Nat Genet. 2024;56(5):792-808. doi:10.1038\/s41588-024-01707-9<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41562-024-01851-6\"><strong>Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes<\/strong><\/a><br \/> Toikumo S, Jennings MV, Pham BK, Lee H, Mallard TT, Bianchi SB, Meredith JJ, Vilar-Rib\u00f3 L, Xu H, Hatoum AS, Johnson EC, Pazdernik VK, Jinwala Z, Pakala SR, Leger BS, Niarchou M, Ehinmowo M; Penn Medicine BioBank; Jenkins GD, Batzler A, Pendegraft R, Palmer AA, Zhou H, Biernacka JM, Coombes BJ, Gelernter J, Xu K, Hancock DB, Cox NJ, Smoller JW, <strong>Davis LK<\/strong>, Justice AC, Kranzler HR, Kember RL, Sanchez-Roige S. Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes. Nat Hum Behav. 2024 Jun;8(6):1177-1193. doi: 10.1038\/s41562-024-01851-6. Epub 2024 Apr 17. PMID: 38632388; PMCID: PMC11199106.<\/p>\n<p><a href=\"https:\/\/bmcgenomics.biomedcentral.com\/articles\/10.1186\/s12864-024-09990-w\"><strong>Body mass index stratified meta-analysis of genome-wide association studies of polycystic ovary syndrome in women of European ancestry<\/strong><\/a><br \/> Burns K, Mullin BH, Moolhuijsen LME, Laisk T, Tyrmi JS, Cui J, <strong>Actkins KV<\/strong>, Louwers YV; Estonian Biobank Research Team; <strong>Davis LK<\/strong>, Dudbridge F, Azziz R, Goodarzi MO, Laivuori H, M\u00e4gi R, Visser JA, Laven JSE, Wilson SG; FinnGen; International PCOS Consortium; Day FR, Stuckey BGA. Body mass index stratified meta-analysis of genome-wide association studies of polycystic ovary syndrome in women of European ancestry. BMC Genomics. 2024 Feb 26;25(1):208. doi: 10.1186\/s12864-024-09990-w. PMID: 38408933; PMCID: PMC10895801.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41398-023-02720-y\"><strong>Development and multi-site external validation of a generalizable risk prediction model for bipolar disorder<\/strong><\/a><br \/> Walsh CG, Ripperger MA, Hu Y, Sheu YH, Lee H, Wilimitis D, Zheutlin AB, Rocha D, Choi KW, Castro VM, Kirchner HL, Chabris CF, <strong>Davis LK<\/strong>, Smoller JW. Development and multi-site external validation of a generalizable risk prediction model for bipolar disorder. Transl Psychiatry. 2024 Jan 25;14(1):58. doi: 10.1038\/s41398-023-02720-y. PMID: 38272862; PMCID: PMC10810911.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41398-023-02713-x\"><strong>Medical and genetic correlates of long-term buprenorphine treatment in the electronic health records<\/strong><\/a><br \/> <strong>Niarchou M<\/strong>, Sanchez-Roige S, <strong>Reddy IA<\/strong>, Reese TJ, Marcovitz D, <strong>Davis LK<\/strong>. Medical and genetic correlates of long-term buprenorphine treatment in the electronic health records. Transl Psychiatry. 2024 Jan 10;14(1):20. doi: 10.1038\/s41398-023-02713-x. PMID: 38200003; PMCID: PMC10781771.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41588-023-01596-4\"><strong>Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference<\/strong><\/a><br \/> Meng X, Navoly G, Giannakopoulou O, et al. Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference. Nat Genet. 2024;56(2):222-233. doi:10.1038\/s41588-023-01596-4<\/p>\n<p>[\/et_pb_toggle][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_toggle title=&#8221;2023&#8243; open_toggle_text_color=&#8221;#00AEEF&#8221; icon_color=&#8221;#00AEEF&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; title_text_color=&#8221;#00AEEF&#8221; title_level=&#8221;h3&#8243; title_font=&#8221;|800|||||||&#8221;]<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38078748\/\"><strong>The genetic contribution to the comorbidity of depression and anxiety: a multi-site electronic health records study of almost 178 000 people<\/strong><\/a><br \/> Coombes BJ, Landi I, Choi KW, <strong>Singh K<\/strong>, Fennessy B, Jenkins GD, Batzler A, Pendegraft R, Nunez NA, Gao YN, Ryu E, Wickramaratne P, Weissman MM; Regeneron Genetics Center; Pathak J, Mann JJ, Smoller JW, <strong>Davis LK<\/strong>, Olfson M, Charney AW, Biernacka JM. The genetic contribution to the comorbidity of depression and anxiety: a multi-site electronic health records study of almost 178 000 people. Psychol Med. 2023 Nov;53(15):7368-7374. doi: 10.1017\/S0033291723000983. Epub 2023 May 5. PMID: 38078748; PMCID: PMC10719682.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41591-023-02653-5\"><strong>Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals<\/strong><\/a><br \/> Zhou H, Kember RL, Deak JD, Xu H, Toikumo S, Yuan K, Lind PA, Farajzadeh L, Wang L, Hatoum AS, Johnson J, Lee H, Mallard TT, Xu J, Johnston KJA, Johnson EC, Nielsen TT, Galimberti M, Dao C, Levey DF, Overstreet C, Byrne EM, Gillespie NA, Gordon S, Hickie IB, Whitfield JB, Xu K, Zhao H, Huckins LM, <strong>Davis LK<\/strong>, Sanchez-Roige S, Madden PAF, Heath AC, Medland SE, Martin NG, Ge T, Smoller JW, Hougaard DM, B\u00f8rglum AD, Demontis D, Krystal JH, Gaziano JM, Edenberg HJ, Agrawal A; Million Veteran Program; Justice AC, Stein MB, Kranzler HR, Gelernter J. Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals. Nat Med. 2023 Dec;29(12):3184-3192. doi: 10.1038\/s41591-023-02653-5. Epub 2023 Dec 7. PMID: 38062264; PMCID: PMC10719093.<\/p>\n<p><a href=\"https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/fullarticle\/10.1001\/jamapsychiatry.2023.4127\"><strong>Genetic Liability to Posttraumatic Stress Disorder Symptoms and Its Association With Cardiometabolic and Respiratory Outcomes<\/strong><\/a><br \/> Pathak GA, <strong>Singh K<\/strong>, Choi KW, Fang Y, Kouakou MR, Lee YH, Zhou X, Fritsche LG, Wendt FR, <strong>Davis LK<\/strong>, Polimanti R. Genetic Liability to Posttraumatic Stress Disorder Symptoms and Its Association With Cardiometabolic and Respiratory Outcomes. JAMA Psychiatry. 2024 Jan 1;81(1):34-44. doi: 10.1001\/jamapsychiatry.2023.4127. PMID: 37910111; PMCID: PMC10620678.<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37849304\/\"><strong>Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression<\/strong><\/a><br \/> Guintivano J, Byrne EM, Kiewa J, et al. Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression [published correction appears in Am J Psychiatry. 2023 Dec 1;180(12):894. doi: 10.1176\/appi.ajp.20230053correction.]. Am J Psychiatry. 2023;180(12):884-895. doi:10.1176\/appi.ajp.20230053<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37517919\/\"><strong>Exploring genetic risk for catatonia in a genome wide association study and polygenic risk score analysis<\/strong><\/a><br \/> Wilson JE, <strong>Sealock J<\/strong>, <strong>Straub P<\/strong>, Raman R, Kipp AM, Dittus RS, Heckers S, Ely W, <strong>Davis LK<\/strong>. Exploring genetic risk for catatonia in a genome wide association study and polygenic risk score analysis. Schizophr Res. 2024 Jan;263:178-190. doi: 10.1016\/j.schres.2023.07.015. Epub 2023 Jul 28. PMID: 37517919; PMCID: PMC10822029.<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37492107\/\"><strong>150 risk variants for diverticular disease of intestine prioritize cell types and enable polygenic prediction of disease susceptibility<\/strong><\/a><br \/> Wu Y, <strong>Goleva SB<\/strong>, Breidenbach LB, Kim M, MacGregor S, Gandal MJ, <strong>Davis LK<\/strong>, Wray NR. 150 risk variants for diverticular disease of intestine prioritize cell types and enable polygenic prediction of disease susceptibility. Cell Genom. 2023 Jun 5;3(7):100326. doi: 10.1016\/j.xgen.2023.100326. PMID: 37492107; PMCID: PMC10363821.<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37334860\/\"><strong>Life is pain: Fibromyalgia as a nexus of multiple liability distributions<\/strong><\/a><br \/> Moscati A, <strong>Faucon AB<\/strong>, Arnaiz-Y\u00e9pez C, L\u00f6nn SL, Sundquist J, Sundquist K, Belbin GM, Nadkarni G, Cho JH, Loos RJF, <strong>Davis LK<\/strong>, Kendler KS. Life is pain: Fibromyalgia as a nexus of multiple liability distributions. Am J Med Genet B Neuropsychiatr Genet. 2023 Oct-Dec;192(7-8):171-182. doi: 10.1002\/ajmg.b.32949. Epub 2023 Jun 19. PMID: 37334860.<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37328826\/\"><strong>The physical and psychiatric health conditions related to autism genetic scores, across genetic ancestries, sexes and age-groups in electronic health records<\/strong><\/a><br \/> <strong>Niarchou M<\/strong>, <strong>Miller-Fleming T<\/strong>, Malow BA, <strong>Davis LK<\/strong>. The physical and psychiatric health conditions related to autism genetic scores, across genetic ancestries, sexes and age-groups in electronic health records. J Neurodev Disord. 2023 Jun 16;15(1):18. doi: 10.1186\/s11689-023-09485-x. PMID: 37328826; PMCID: PMC10273739.<\/p>\n<p><a href=\"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1010764\"><strong>Sex modifies the effect of genetic risk scores for polycystic ovary syndrome on metabolic phenotypes<\/strong><\/a><br \/> <strong>Actkins KV<\/strong>, Jean-Pierre G, Aldrich MC, Velez Edwards DR, <strong>Davis LK<\/strong>. Sex modifies the effect of genetic risk scores for polycystic ovary syndrome on metabolic phenotypes. PLoS Genet. 2023 May 31;19(5):e1010764. doi: 10.1371\/journal.pgen.1010764. PMID: 37256887; PMCID: PMC10259776.<\/p>\n<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/pmid\/37250466\/\"><strong>Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders<\/strong><\/a><br \/> Hatoum AS, Colbert SMC, Johnson EC, Huggett SB, Deak JD, Pathak G, Jennings MV, Paul SE, Karcher NR, Hansen I, Baranger DAA, Edwards A, Grotzinger A; Substance Use Disorder Working Group of the Psychiatric Genomics Consortium; Tucker-Drob EM, Kranzler HR, <strong>Davis LK<\/strong>, Sanchez-Roige S, Polimanti R, Gelernter J, Edenberg HJ, Bogdan R, Agrawal A. Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders. Nat Ment Health. 2023 Mar;1(3):210-223. doi: 10.1038\/s44220-023-00034-y. Epub 2023 Mar 22. PMID: 37250466; PMCID: PMC10217792.<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37228751\/\"><strong>Toward a deeper understanding of gene-by-sex interaction models<\/strong><\/a><br \/> Khramtsova EA, Winham SJ, <strong>Davis LK<\/strong>, Stranger BE, Wilson MA. Toward a deeper understanding of gene-by-sex interaction models. Cell Genom. 2023 May 10;3(5):100324. doi: 10.1016\/j.xgen.2023.100324. PMID: 37228751; PMCID: PMC10203255.<\/p>\n<p><strong><a href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092-8674(23)00410-5\">Quality control and analytic best practices for testing genetic models of sex differences in large populations<\/a><br \/> <\/strong>Khramtsova EA, Wilson MA, Martin J, Winham SJ, He KY, <strong>Davis LK<\/strong>, Stranger BE. Quality control and analytic best practices for testing genetic models of sex differences in large populations. Cell. 2023 May 11;186(10):2044-2061. doi: 10.1016\/j.cell.2023.04.014. PMID: 37172561; PMCID: PMC10266536.<strong><br \/> <\/strong><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36851882\/\"><strong>Confronting ethical and social issues related to the genetics of musicality<\/strong><\/a><br \/> Gordon RL, Martschenko DO, Nayak S, <strong>Niarchou M<\/strong>, Morrison MD, Bell E, Jacoby N, <strong>Davis LK<\/strong>. Confronting ethical and social issues related to the genetics of musicality. Ann N Y Acad Sci. 2023 Apr;1522(1):5-14. doi: 10.1111\/nyas.14972. Epub 2023 Feb 27. PMID: 36851882; PMCID: PMC10613828.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41398-023-02341-5\"><strong>Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome<\/strong><\/a><br \/>Jain P, <strong>Miller-Fleming T<\/strong>, Topaloudi A, Yu D, Drineas P, Georgitsi M, Yang Z, Rizzo R, M\u00fcller-Vahl KR, Tumer Z, Mol Debes N, Hartmann A, Depienne C, Worbe Y, Mir P, Cath DC, Boomsma DI, Roessner V, Wolanczyk T, Janik P, Szejko N, Zekanowski C, Barta C, Nemoda Z, Tarnok Z, Buxbaum JD, Grice D, Glennon J, Stefansson H, Hengerer B, Benaroya-Milshtein N, Cardona F, Hedderly T, Heyman I, Huyser C, Morer A, Mueller N, Munchau A, Plessen KJ, Porcelli C, Walitza S, Schrag A, Martino D; Psychiatric Genomics Consortium Tourette Syndrome Working Group (PGC-TS); EMTICS collaborative group; Dietrich A; TS-EUROTRAIN Network; Mathews CA, Scharf JM, Hoekstra PJ, <strong>Davis LK<\/strong>, Paschou P. Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome. Transl Psychiatry. 2023 Feb 23;13(1):69. doi: 10.1038\/s41398-023-02341-5. PMID: 36823209; PMCID: PMC9950421.<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36743422\/\"><strong>Anti-Inflammatory Action of Antidepressants: Investigating the Longitudinal Effect of Antidepressants on White Blood Cell Count<\/strong><\/a><br \/><strong>Sealock JM<\/strong>, Chen G, <strong>Davis LK<\/strong>. Anti-Inflammatory Action of Antidepressants: Investigating the Longitudinal Effect of Antidepressants on White Blood Cell Count. Complex Psychiatry. 2023 Dec;9(1-4):1-10. doi: 10.1159\/000528605. Epub 2022 Dec 9. PMID: 36743422; PMCID: PMC9892923.<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36738982\/\"><strong>Genome-Wide Association Study Points to Novel Locus for Gilles de la Tourette Syndrome<\/strong><\/a><br \/>Tsetsos F, Topaloudi A, Jain P, et al. Genome-Wide Association Study Points to Novel Locus for Gilles de la Tourette Syndrome. Biol Psychiatry. 2024;96(2):114-124. doi:10.1016\/j.biopsych.2023.01.023<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36660008\/\"><strong>Sex Differences in Health Conditions Associated with Sexual Assault in a Large Hospital Population<\/strong><\/a><br \/><strong>Lake AM<\/strong>, <strong>Goleva SB<\/strong>, Samuels LR, Carpenter LM, <strong>Davis LK.<\/strong> Sex Differences in Health Conditions Associated with Sexual Assault in a Large Hospital Population. Complex Psychiatry. 2023 Jan;8(3-4):80-89. doi: 10.1159\/000527363. Epub 2022 Oct 7. PMID: 36660008; PMCID: PMC10288064.<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39874415\/\"><strong>Maximizing Near-Term Clinical Opportunities for Psychiatric Genetics<\/strong><\/a><br \/><strong>Davis LK<\/strong>, Appelbaum PS, Austin JC, Degenhardt F, Jacquemont S, Penninx BWJH, Smoller JW, Streit F, Lewis CM. Maximizing Near-Term Clinical Opportunities for Psychiatric Genetics. In: Gordon JA, Binder EB, editors. Exploring and Exploiting Genetic Risk for Psychiatric Disorders [Internet]. Cambridge (MA): MIT Press; 2023. Chapter 12. PMID: 39874415.<\/p>\n<p>[\/et_pb_toggle][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_toggle title=&#8221;2022&#8243; open_toggle_text_color=&#8221;#00AEEF&#8221; icon_color=&#8221;#00AEEF&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; title_text_color=&#8221;#00AEEF&#8221; title_level=&#8221;h3&#8243; title_font=&#8221;|800|||||||&#8221;]<\/p>\n<p><strong><a href=\"https:\/\/doi.org\/10.1038\/s41593-022-01160-z\">Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction<\/a><\/strong><br \/> Kember RL, Vickers-Smith R, Xu H, Toikumo S, <strong>Niarchou M<\/strong>, Zhou H, Hartwell EE, Crist RC, Rentsch CT; Million Veteran Program; <strong>Davis LK<\/strong>, Justice AC, Sanchez-Roige S, Kampman KM, Gelernter J, Kranzler HR. Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction. Nat Neurosci. 2022 Oct;25(10):1279-1287. doi: 10.1038\/s41593-022-01160-z. Epub 2022 Sep 28. PMID: 36171425; PMCID: PMC9682545.<\/p>\n<p><a href=\"https:\/\/bmcmedicine.biomedcentral.com\/articles\/10.1186\/s12916-022-02522-x\"><strong>Dense phenotyping from electronic health records enables machine learning-based prediction of preterm birth<\/strong><\/a><br \/> Abraham A, Le B, Kosti I,<strong> Straub P<\/strong>, Velez-Edwards DR, <strong>Davis LK<\/strong>, Newton JM, Muglia LJ, Rokas A, Bejan CA, Sirota M, Capra JA. Dense phenotyping from electronic health records enables machine learning-based prediction of preterm birth. BMC Med. 2022 Sep 28;20(1):333. doi: 10.1186\/s12916-022-02522-x. PMID: 36167547; PMCID: PMC9516830.<\/p>\n<p><a href=\"https:\/\/jamanetwork.com\/journals\/jamasurgery\/fullarticle\/10.1001\/jamasurg.2022.4150\"><strong>Sex-Adjusted Model for End-stage Liver Disease Scores for Liver Transplant Allocation-Reply<\/strong><\/a><br \/> <strong>Sealock JM<\/strong>, <strong>Davis LK<\/strong>. Sex-Adjusted Model for End-stage Liver Disease Scores for Liver Transplant Allocation-Reply. JAMA Surg. 2022 Dec 1;157(12):1167. doi: 10.1001\/jamasurg.2022.4150. PMID: 36069860.<\/p>\n<p><a href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2215-0366(22)00157-2\"><strong>Concerns about the use of polygenic embryo screening for psychiatric and cognitive traits<\/strong><\/a><br \/> Lencz T, Sabatello M, Docherty A, Peterson RE, Soda T, Austin J, Bierut L, Crepaz-Keay D, Curtis D, Degenhardt F, Huckins L, Lazaro-Munoz G, Mattheisen M, Meiser B, Peay H, Rietschel M, Walss-Bass C, <strong>Davis LK<\/strong>. Concerns about the use of polygenic embryo screening for psychiatric and cognitive traits. Lancet Psychiatry. 2022 Oct;9(10):838-844. doi: 10.1016\/S2215-0366(22)00157-2. Epub 2022 Aug 2. PMID: 35931093; PMCID: PMC9930635.<\/p>\n<p><strong><a href=\"https:\/\/doi.org\/10.26508\/lsa.202201382\">Improving the computation efficiency of polygenic risk score modeling: faster in Julia<\/a><\/strong><br \/> <strong>Faucon A<\/strong>, Samaroo J, Ge T, <strong>Davis LK<\/strong>, Cox NJ, Tao R, Shuey MM. Improving the computation efficiency of polygenic risk score modeling: faster in Julia. Life Sci Alliance. 2022 Jul 18;5(12):e202201382. doi: 10.26508\/lsa.202201382. PMID: 35851544; PMCID: PMC9297586.<\/p>\n<p><strong><a href=\"https:\/\/doi.org\/10.1002\/ajmg.b.32911\">A phenome-wide association study of polygenic scores for attention deficit hyperactivity disorder across two genetic ancestries in electronic health record data<\/a><\/strong><br \/> <strong>Niarchou M<\/strong>, <strong>Sealock JM<\/strong>, <strong>Straub P<\/strong>, Sanchez-Roige S, Sutcliffe JS, <strong>Davis LK<\/strong>. A phenome-wide association study of polygenic scores for attention deficit hyperactivity disorder across two genetic ancestries in electronic health record data. Am J Med Genet B Neuropsychiatr Genet. 2022 Sep;189(6):185-195. doi: 10.1002\/ajmg.b.32911. Epub 2022 Jul 15. PMID: 35841203; PMCID: PMC9378640.<\/p>\n<p><a href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0891-4222(22)00129-9\"><strong>Investigating the genetic pathways of insomnia in Autism Spectrum Disorder<\/strong><\/a><br \/> <strong>Niarchou M<\/strong>, Singer EV, <strong>Straub P<\/strong>, Malow BA, <strong>Davis LK<\/strong>. Investigating the genetic pathways of insomnia in Autism Spectrum Disorder. Res Dev Disabil. 2022 Sep;128:104299. doi: 10.1016\/j.ridd.2022.104299. Epub 2022 Jul 9. PMID: 35820265; PMCID: PMC10068748.<\/p>\n<p><a href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666-979X(22)00073-8\"><strong>Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities<\/strong><\/a><br \/> Mallard TT, Linn\u00e9r RK, Grotzinger AD, Sanchez-Roige S, Seidlitz J, Okbay A, de Vlaming R, Meddens SFW; Bipolar Disorder Working Group of the Psychiatric Genomics Consortium; Palmer AA, <strong>Davis LK<\/strong>, Tucker-Drob EM, Kendler KS, Keller MC, Koellinger PD, Harden KP. Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities. Cell Genom. 2022 Jun 8;2(6):100140. doi: 10.1016\/j.xgen.2022.100140. Epub 2022 Jun 8. PMID: 35812988; PMCID: PMC9264403.<\/p>\n<p><strong><a href=\"https:\/\/doi.org\/10.1038\/s41562-022-01359-x\">Genome-wide association study of musical beat synchronization demonstrates high polygenicity<\/a><\/strong><br \/> <strong>Niarchou M<\/strong>, Gustavson DE, Sathirapongsasuti JF, Anglada-Tort M, Eising E, Bell E, McArthur E, <strong>Straub P<\/strong>; 23andMe Research Team; McAuley JD, Capra JA, Ull\u00e9n F, Creanza N, Mosing MA, Hinds DA, <strong>Davis LK<\/strong>, Jacoby N, Gordon RL. Genome-wide association study of musical beat synchronization demonstrates high polygenicity. Nat Hum Behav. 2022 Sep;6(9):1292-1309. doi: 10.1038\/s41562-022-01359-x. Epub 2022 Jun 16. PMID: 35710621; PMCID: PMC9489530.<\/p>\n<p><strong><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.17346\">Frequency of benign neutropenia among Black versus White individuals undergoing a bone marrow assessment<\/a><\/strong><br \/> Borinstein SC, Agamasu D, Schildcrout JS, Bastarache L, Bagheri M, <strong>Davis LK<\/strong>, Roden DM, Michael Stein C, Van Driest SL, Mosley JD. Frequency of benign neutropenia among Black versus White individuals undergoing a bone marrow assessment. J Cell Mol Med. 2022 Jul;26(13):3628-3635. doi: 10.1111\/jcmm.17346. Epub 2022 Jun 1. PMID: 35642720; PMCID: PMC9258701.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1007\/s10519-022-10105-y\"><strong>LGBTQ+ Perspectives on Conducting Genomic Research on Sexual Orientation and Gender Identity<\/strong><\/a><br \/> Hammack-Aviran C, Eilmus A, Diehl C, Gottlieb KG, Gonzales G, <strong>Davis LK<\/strong>, Clayton EW. LGBTQ+ Perspectives on Conducting Genomic Research on Sexual Orientation and Gender Identity. Behav Genet. 2022 Sep;52(4-5):246-267. doi: 10.1007\/s10519-022-10105-y. Epub 2022 May 26. PMID: 35614288; PMCID: PMC9132750.<\/p>\n<p><strong><a href=\"https:\/\/jamanetwork.com\/journals\/jamasurgery\/fullarticle\/10.1001\/jamasurg.2022.1548\">Proposing a Sex-Adjusted Sodium-Adjusted MELD Score for Liver Transplant Allocation<\/a><\/strong><br \/> <strong>Sealock JM<\/strong>, Ziogas IA, Zhao Z, Ye F, Alexopoulos SP, Matsuoka L, Chen G, <strong>Davis LK<\/strong>. Proposing a Sex-Adjusted Sodium-Adjusted MELD Score for Liver Transplant Allocation. JAMA Surg. 2022 Jul 1;157(7):618-626. doi: 10.1001\/jamasurg.2022.1548. PMID: 35583884; PMCID: PMC9118088.<\/p>\n<p><strong><a href=\"https:\/\/doi.org\/10.1038\/s41380-022-01488-9\">Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits<\/a><\/strong><br \/> Pathak GA, <strong>Singh K<\/strong>, Wendt FR, <strong>Fleming TW<\/strong>, Overstreet C, Koller D, Tylee DS, De Angelis F, Cabrera Mendoza B, Levey DF, Koenen KC, Krystal JH, Pietrzak RH, O&#8217; Donell C, Gaziano JM, Falcone G, Stein MB, Gelernter J, Pasaniuc B, Mancuso N, <strong>Davis LK<\/strong>, Polimanti R. Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits. Mol Psychiatry. 2022 Mar;27(3):1394-1404. doi: 10.1038\/s41380-022-01488-9. Epub 2022 Mar 3. PMID: 35241783; PMCID: PMC9210390.<\/p>\n<p><a href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525-5050(22)00031-2\"><strong>Functional seizures are associated with cerebrovascular disease and functional stroke is more common in patients with functional seizures than epileptic seizures<\/strong><\/a><br \/> Fox J, <strong>Goleva SB<\/strong>, Haas KF, <strong>Davis LK<\/strong>. Functional seizures are associated with cerebrovascular disease and functional stroke is more common in patients with functional seizures than epileptic seizures. Epilepsy Behav. 2022 Mar;128:108582. doi: 10.1016\/j.yebeh.2022.108582. Epub 2022 Feb 3. PMID: 35123242; PMCID: PMC8898282.<\/p>\n<p><a href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021-9258(21)01344-2\"><strong>Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose<\/strong><\/a><br \/> Overway EM, Bosma KJ, Claxton DP, Oeser JK, <strong>Singh K<\/strong>, Breidenbach LB, Mchaourab HS, <strong>Davis LK<\/strong>, O&#8217;Brien RM. Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose. J Biol Chem. 2022 Feb;298(2):101534. doi: 10.1016\/j.jbc.2021.101534. Epub 2021 Dec 23. PMID: 34954144; PMCID: PMC8800118.<\/p>\n<p><a href=\"https:\/\/psychiatryonline.org\/doi\/10.1176\/appi.ajp.2020.20091390?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub%20%200pubmed\"><strong>Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts<\/strong><\/a><br \/>Mallard TT, Savage JE, Johnson EC, Huang Y, Edwards AC, Hottenga JJ, Grotzinger AD, Gustavson DE, Jennings MV, Anokhin A, Dick DM, Edenberg HJ, Kramer JR, Lai D, Meyers JL, Pandey AK, Harden KP, Nivard MG, de Geus EJC, Boomsma DI, Agrawal A, <strong>Davis LK<\/strong>, Clarke TK, Palmer AA, Sanchez-Roige S. Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts. Am J Psychiatry. 2022 Jan;179(1):58-70. doi: 10.1176\/appi.ajp.2020.20091390. Epub 2021 May 14. PMID: 33985350; PMCID: PMC9272895.<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33935230\/\"><strong>Association of Preinjury Medical Diagnoses With Pediatric Persistent Postconcussion Symptoms in Electronic Health Records<\/strong><\/a><br \/>Yengo-Kahn AM, Hibshman N, Bonfield CM, Torstenson ES, Gifford KA, Belikau D, <strong>Davis LK<\/strong>, Zuckerman SL, Dennis JK. Association of Preinjury Medical Diagnoses With Pediatric Persistent Postconcussion Symptoms in Electronic Health Records. J Head Trauma Rehabil. 2022 Mar-Apr 01;37(2):E80-E89. doi: 10.1097\/HTR.0000000000000686. PMID: 33935230.<\/p>\n<p>[\/et_pb_toggle][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;||24px|||&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_toggle title=&#8221;2021&#8243; open_toggle_text_color=&#8221;#00AEEF&#8221; icon_color=&#8221;#00AEEF&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; title_text_color=&#8221;#00AEEF&#8221; title_level=&#8221;h3&#8243; title_font=&#8221;|800|||||||&#8221;]<\/p>\n<p><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34825179\/\">Pancreatic adenocarcinoma in liver transplant recipients: a case series<\/a><\/strong><br \/> Rauf MA, Ziogas IA, <strong>Sealock JM<\/strong>, <strong>Davis LK<\/strong>, Izzy M, Alexopoulos SP, Matsuoka LK. Pancreatic adenocarcinoma in liver transplant recipients: a case series. Ann Pancreat Cancer. 2021 Oct;4:6. doi: 10.21037\/apc-21-4. Epub 2021 Oct 30. PMID: 34825179; PMCID: PMC8612297.<\/p>\n<p><strong><a href=\"https:\/\/doi.org\/10.1038\/s41380-021-01335-3\">Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry<\/a><\/strong><br \/> Sanchez-Roige S, Fontanillas P, Jennings MV, Bianchi SB, Huang Y, Hatoum AS, <strong>Sealock J<\/strong>, <strong>Davis LK<\/strong>, Elson SL; 23andMe Research Team; Palmer AA. Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry. Mol Psychiatry. 2021 Nov;26(11):6209-6217. doi: 10.1038\/s41380-021-01335-3. Epub 2021 Nov 2. PMID: 34728798; PMCID: PMC8562028.<\/p>\n<p><strong><a href=\"https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/fullarticle\/10.1001\/jamapsychiatry.2021.2959\">Use of the PsycheMERGE Network to Investigate the Association Between Depression Polygenic Scores and White Blood Cell Count<\/a><\/strong><br \/> <strong>Sealock JM<\/strong>, Lee YH, Moscati A, Venkatesh S, Voloudakis G,<strong> Straub P<\/strong>, <strong>Singh K,<\/strong> Feng YA, Ge T, Roussos P, Smoller JW, Chen G, <strong>Davis LK<\/strong>. Use of the PsycheMERGE Network to Investigate the Association Between Depression Polygenic Scores and White Blood Cell Count. JAMA Psychiatry. 2021 Dec 1;78(12):1365-1374. doi: 10.1001\/jamapsychiatry.2021.2959. PMID: 34668925; PMCID: PMC8529528.<\/p>\n<p><strong><a href=\"https:\/\/doi.org\/10.1038\/s41588-021-00921-z\">A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer&#8217;s disease<\/a><\/strong><br \/> Wightman DP, Jansen IE, Savage JE, et al. A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer&#8217;s disease [published correction appears in Nat Genet. 2021 Dec;53(12):1722. doi: 10.1038\/s41588-021-00977-x.] [published correction appears in Nat Genet. 2022 Jul;54(7):1062. doi: 10.1038\/s41588-022-01126-8.]. Nat Genet. 2021;53(9):1276-1282. doi:10.1038\/s41588-021-00921-z<\/p>\n<p><strong><a href=\"https:\/\/doi.org\/10.1111\/nyas.14671\">Medical phenome of musicians: an investigation of health records collected on 9803 musically active individuals<\/a><\/strong><br \/> <strong>Niarchou M<\/strong>, Lin GT, Lense MD, Gordon RL, <strong>Davis LK<\/strong>. Medical phenome of musicians: an investigation of health records collected on 9803 musically active individuals. Ann N Y Acad Sci. 2021 Dec;1505(1):156-168. doi: 10.1111\/nyas.14671. Epub 2021 Aug 19. PMID: 34414577; PMCID: PMC8688228.<\/p>\n<p><strong><a href=\"https:\/\/www.mdpi.com\/resolver?pii=jpm11070642\">Calcium-Sensing Receptor Polymorphisms at rs1801725 Are Associated with Increased Risk of Secondary Malignancies<\/a><\/strong><br \/> <strong>Actkins KV<\/strong>, Beasley HK, <strong>Faucon AB<\/strong>, <strong>Davis LK<\/strong>, Sakwe AM. Calcium-Sensing Receptor Polymorphisms at rs1801725 Are Associated with Increased Risk of Secondary Malignancies. J Pers Med. 2021 Jul 6;11(7):642. doi: 10.3390\/jpm11070642. PMID: 34357109; PMCID: PMC8304025.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41598-021-95154-9\"><strong>The genetic architecture of plasma kynurenine includes cardiometabolic disease mechanisms associated with the SH2B3 gene<\/strong><\/a><br \/> Bagheri M, Wang C, Shi M, Manouchehri A, Murray KT, Murphy MB, Shaffer CM, <strong>Singh K<\/strong>, <strong>Davis LK<\/strong>, Jarvik GP, Stanaway IB, Hebbring S, Reilly MP, Gerszten RE, Wang TJ, Mosley JD, Ferguson JF. The genetic architecture of plasma kynurenine includes cardiometabolic disease mechanisms associated with the SH2B3 gene. Sci Rep. 2021 Aug 2;11(1):15652. doi: 10.1038\/s41598-021-95154-9. PMID: 34341450; PMCID: PMC8329184.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41467-021-24824-z\"><strong>Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization<\/strong><\/a><br \/> Pathak GA, <strong>Singh K<\/strong>, <strong>Miller-Fleming TW<\/strong>, Wendt FR, Ehsan N, Hou K, Johnson R, Lu Z, Gopalan S, Yengo L, Mohammadi P, Pasaniuc B, Polimanti R, <strong>Davis LK<\/strong>, Mancuso N. Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization. Nat Commun. 2021 Jul 27;12(1):4569. doi: 10.1038\/s41467-021-24824-z. PMID: 34315903; PMCID: PMC8316582.<\/p>\n<p><strong><a href=\"https:\/\/doi.org\/10.1038\/s41398-021-01519-z\">A dimensional perspective on the genetics of obsessive-compulsive disorder<\/a><\/strong><br \/> Strom NI, Soda T, Mathews CA, <strong>Davis LK<\/strong>. A dimensional perspective on the genetics of obsessive-compulsive disorder. Transl Psychiatry. 2021 Jul 21;11(1):401. doi: 10.1038\/s41398-021-01519-z. PMID: 34290223; PMCID: PMC8295308.<\/p>\n<p><strong><a href=\"https:\/\/doi.org\/10.1038\/s41467-021-24387-z\">Contextualizing genetic risk score for disease screening and rare variant discovery<\/a><\/strong><br \/> Zhou D, Yu D, Scharf JM, Mathews CA, McGrath L, Cook E, Lee SH, <strong>Davis LK<\/strong>, Gamazon ER. Contextualizing genetic risk score for disease screening and rare variant discovery. Nat Commun. 2021 Jul 20;12(1):4418. doi: 10.1038\/s41467-021-24387-z. PMID: 34285202; PMCID: PMC8292385.<\/p>\n<p><strong><a href=\"https:\/\/academic.oup.com\/jcem\/article-lookup\/doi\/10.1210\/clinem\/dgab272\">Genetic Thyrotropin Regulation of Atrial Fibrillation Risk Is Mediated Through an Effect on Height<\/a><\/strong><br \/>Shi M, Manouchehri AM, Shaffer CM, Vaitinadin NS, Hellwege JN, Salem JE, <strong>Davis LK<\/strong>, Simmons JH, Roden DM, Shoemaker MB, Ferguson JF, Mosley JD. Genetic Thyrotropin Regulation of Atrial Fibrillation Risk Is Mediated Through an Effect on Height. J Clin Endocrinol Metab. 2021 Jun 16;106(7):2124-2132. doi: 10.1210\/clinem\/dgab272. PMID: 33895829; PMCID: PMC8208678.\u00a0<\/p>\n<p><strong><a href=\"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddab068\">Fate or coincidence: do COPD and major depression share genetic risk factors?<\/a><\/strong><br \/>Martucci VL, Richmond B, <strong>Davis LK<\/strong>, Blackwell TS, Cox NJ, Samuels D, Velez Edwards D, Aldrich MC. Fate or coincidence: do COPD and major depression share genetic risk factors? Hum Mol Genet. 2021 May 12;30(7):619-628. doi: 10.1093\/hmg\/ddab068. PMID: 33704461; PMCID: PMC8120137.<\/p>\n<p><a href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006-3223(21)00033-0\"><strong>Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits<\/strong><\/a><br \/>Martin J, Khramtsova EA, <strong>Goleva SB<\/strong>, Blokland GAM, Traglia M, Walters RK, H\u00fcbel C, Coleman JRI, Breen G, B\u00f8rglum AD, Demontis D, Grove J, Werge T, Bralten J, Bulik CM, Lee PH, Mathews CA, Peterson RE, Winham SJ, Wray N, Edenberg HJ, Guo W, Yao Y, Neale BM, Faraone SV, Petryshen TL, Weiss LA, Duncan LE, Goldstein JM, Smoller JW, Stranger BE, <strong>Davis LK<\/strong>; Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium. Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits. Biol Psychiatry. 2021 Jun 15;89(12):1127-1137. doi: 10.1016\/j.biopsych.2020.12.024. Epub 2021 Jan 9. PMID: 33648717; PMCID: PMC8163257.<\/p>\n<p><a href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0376-8716(21)00107-1\"><strong>Alcohol and cigarette smoking consumption as genetic proxies for alcohol misuse and nicotine dependence<\/strong><\/a><br \/>Sanchez-Roige S, Cox NJ, Johnson EO, Hancock DB, <strong>Davis LK<\/strong>. Alcohol and cigarette smoking consumption as genetic proxies for alcohol misuse and nicotine dependence. Drug Alcohol Depend. 2021 Apr 1;221:108612. doi: 10.1016\/j.drugalcdep.2021.108612. Epub 2021 Feb 15. PMID: 33631543; PMCID: PMC8026738.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41398-020-01082-z\"><strong>Synaptic processes and immune-related pathways implicated in Tourette syndrome<\/strong><\/a><br \/>Tsetsos F, Yu D, Sul JH, et al. Synaptic processes and immune-related pathways implicated in Tourette syndrome. Transl Psychiatry. 2021;11(1):56. Published 2021 Jan 18. doi:10.1038\/s41398-020-01082-z<\/p>\n<p><a href=\"https:\/\/genomemedicine.biomedcentral.com\/articles\/10.1186\/s13073-020-00820-8\"><strong>Clinical laboratory test-wide association scan of polygenic scores identifies biomarkers of complex disease<\/strong><\/a><br \/><strong>Dennis JK<\/strong>, <strong>Sealock JM<\/strong>, <strong>Straub P<\/strong>, Lee YH, <strong>Hucks D<\/strong>, <strong>Actkins K<\/strong>, <strong>Faucon A<\/strong>, Feng YA, Ge T, <strong>Goleva SB<\/strong>, <strong>Niarchou M<\/strong>, <strong>Singh K<\/strong>, Morley T, Smoller JW, Ruderfer DM, Mosley JD, Chen G, <strong>Davis LK<\/strong>. Clinical laboratory test-wide association scan of polygenic scores identifies biomarkers of complex disease. Genome Med. 2021 Jan 13;13(1):6. doi: 10.1186\/s13073-020-00820-8. PMID: 33441150; PMCID: PMC7807864.<\/p>\n<p>[\/et_pb_toggle][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_text _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;]<\/p>\n<p>For a full list of publication, please visit\u00a0<a href=\"https:\/\/scholar.google.com\/citations?user=LuYsoZwAAAAJ&amp;hl=en\"><strong>Google Scholar<\/strong><\/a> and <strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Davis+LK&amp;cauthor_id=33441150\">PudMed<\/a><\/strong>.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; disabled_on=&#8221;on|on|on&#8221; admin_label=&#8221;Footer &#8211; Section 13&#8243; module_class=&#8221;footer-section&#8221; _builder_version=&#8221;4.9.0&#8243; background_color=&#8221;#c7eafb&#8221; background_image=&#8221;https:\/\/labs.icahn.mssm.edu\/davislab\/wp-content\/uploads\/sites\/547\/2022\/10\/Rectangle-3.png&#8221; 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header_4_font_size=&#8221;16px&#8221; header_4_letter_spacing=&#8221;1px&#8221; header_4_line_height=&#8221;1.5em&#8221; background_layout=&#8221;dark&#8221; custom_padding=&#8221;||0px|||&#8221; locked=&#8221;off&#8221;]<\/p>\n<p><strong>Lab Address <\/strong><br \/>3 E. 101st Street<br \/>The Hamilton and Amabel James Center for Artificial Intelligence<br \/>New York, NY 10029<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>PublicationsAdvancing Mental Health Research Through Strategic Integration of Transdiagnostic Dimensions and Genomics. Doyle AE, Bearden CE, Gur RE, Ledbetter DH, Martin CL, McCoy TH Jr, Pasaniuc B, Perlis RH, Smoller JW, Davis LK.\u00a0 Biol Psychiatry. 2025 Mar 1;97(5):450-460. doi: 10.1016\/j.biopsych.2024.10.006. Epub 2024 Oct 16. PMID: 39424167. Trans-ancestry genome-wide study of depression identifies 697 associations implicating [&hellip;]<\/p>\n","protected":false},"author":545,"featured_media":0,"parent":0,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"class_list":["post-2494","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/davislab\/wp-json\/wp\/v2\/pages\/2494","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/davislab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/davislab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/davislab\/wp-json\/wp\/v2\/users\/545"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/davislab\/wp-json\/wp\/v2\/comments?post=2494"}],"version-history":[{"count":30,"href":"https:\/\/labs.icahn.mssm.edu\/davislab\/wp-json\/wp\/v2\/pages\/2494\/revisions"}],"predecessor-version":[{"id":4882,"href":"https:\/\/labs.icahn.mssm.edu\/davislab\/wp-json\/wp\/v2\/pages\/2494\/revisions\/4882"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/davislab\/wp-json\/wp\/v2\/media?parent=2494"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}