Research
In the Davis Lab, we are interested in understanding the genomics of a wide range of phenotypes. Here are a few projects we are currently working on.
Intersection of Sex, Gender, and Genetics
Sex and gender differences exist in the prevalence and incidence of complex disease. Multiple hypotheses exist to explain these differences, including gender- and sex-related exogenous exposures, such as environmental and socio-behavioral exposures, endogenous biological factors such as hormone exposure and reproductive events, and genetic effects, including sex chromosomes and sex differences in germline risk factors or gene expression. Our lab works to investigate these hypotheses, with the overarching goal of providing more precise disease prevention, diagnosis, and treatment.
Substance Use Disorder Genomics
The Substance Use Disorder Genomics Initiative leverages advanced statistical methods and genomic techniques alongside real-world electronic health record (EHR) data to identify individuals at high likelihood for substance use disorders, such as opioid use disorder (OUD) and alcohol use disorder (AUD). By analyzing patient biology, environment, and lifestyle, the initiative lays the groundwork for actionable clinical decision support tools, and informs precision medicine.
Mount Sinai Million Discoveries Program
Our vision for precision medicine is an equitable and inclusive future in which illness is recognized early and with accuracy, long diagnostic odysseys are avoided, chronic comorbidities are effectively prevented, treatment choices are personalized, and public health and access are supported. The mission of the Mount Sinai Million Health Discoveries Program is to create and support a sustainable, equitable, trans-disciplinary, learning healthcare ecosystem that promotes research to advance precision medicine across Sinai and the tristate area. Central to this mission are the values of equity, integrity, and collaboration. The current lack of diversity in genomic research data is hindering what we can learn about health and potential treatments in our global population. By enhancing the diversity of people participating in genomic research, we can advance our knowledge and discovery of human genetics for all populations.
Consortia and Collaborations
Besides the projects described above, the Davis lab is also actively involved in cross-institutions consortiums including PsycheMERGE (electronic MEdical Record and GEnomics) Network and the Psychiatric Genetics Consortiums (PGC). We collaborate with researchers, trainees, and staffs in different institutes across the United States and the world to improve precision medicine development on psychiatric disorder.
