{"id":3010,"date":"2022-12-21T12:17:26","date_gmt":"2022-12-21T17:17:26","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/design\/?page_id=3010"},"modified":"2025-12-18T11:41:57","modified_gmt":"2025-12-18T16:41:57","slug":"research","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/dardiklab\/research\/","title":{"rendered":"Research"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”Fullwidth Header – Background Title Description – no slider – Section 1″ module_class=”header-title-desciption-no-slider-section1″ _builder_version=”4.27.4″ _module_preset=”default” background_color=”rgba(0,174,239,0.09)” background_enable_color=”off” background_image=”https:\/\/labs.icahn.mssm.edu\/dardiklab2\/wp-content\/uploads\/sites\/616\/2025\/11\/Composite.tif” parallax=”on” custom_padding=”||||false|false” bottom_divider_style=”ramp2″ bottom_divider_color=”#FFFFFF” bottom_divider_height=”11vw” bottom_divider_arrangement=”above_content” saved_tabs=”all” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” border_color_all=”RGBA(0,0,0,0)” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”10%||8vw||false|false” custom_padding_tablet=”0vw||0vw||true|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet” global_colors_info=”{}”][et_pb_text admin_label=”Text – Title” _builder_version=”4.27.4″ _module_preset=”b3e3ff14-5f5c-4608-8ecf-1885ce3da7aa” header_font=”||||||||” header_text_color=”#FFFFFF” header_font_size=”48px” header_line_height=”60px” custom_margin=”||10px||false|false” header_font_size_tablet=”40px” header_font_size_phone=”24px” header_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n

Research<\/strong><\/h1>\n

[\/et_pb_text][et_pb_text admin_label=”Text – Description” _builder_version=”4.27.4″ _module_preset=”da86b6f0-f83c-4c7c-bdd8-3019777ddffe” text_font=”||||||||” text_text_color=”#FFFFFF” text_font_size=”20px” text_line_height=”32px” text_font_size_tablet=”15px” text_font_size_phone=”14px” text_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n

Our current research focuses on the AVF outflow vein remodeling and the juxta-anastomotic neointimal hyperplasia<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Section 27 – Two Column – Title Over Text Over Button Next to Image” module_class=”section27_two_column_title_over_txt_over_btn_next_to_img” _builder_version=”4.16″ _module_preset=”default” background_image=”https:\/\/labs.icahn.mssm.edu\/dardiklab2\/wp-content\/uploads\/sites\/616\/2022\/12\/9-alt.png” parallax=”on” parallax_method=”off” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.9.0″ module_alignment=”center” custom_margin=”|||” custom_margin_tablet=”” custom_margin_phone=”” custom_margin_last_edited=”on|phone” custom_padding=”||150px|||” global_module=”3003″ collapsed=”off” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ background_color_gradient_direction=”35deg” custom_padding=”|60px||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ text_font=”||||||||” header_font=”||||||||” header_text_align=”left” header_text_color=”#2b2b2b” header_font_size=”36px” header_line_height=”1.3em” header_2_font=”|700|||||||” header_2_text_align=”left” header_2_text_color=”#2b2b2b” header_2_font_size=”36px” header_2_line_height=”1.5em” text_orientation=”center” module_alignment=”center” custom_margin=”||10px|” global_colors_info=”{}”]<\/p>\n

mouse arteriovenous fistula model with chronic kidney disease<\/strong><\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ text_font=”||||||||” text_text_color=”#141414″ text_line_height=”1.9em” header_font=”||||||||” header_2_font=”||||||||” module_alignment=”center” custom_margin=”||30px|” global_colors_info=”{}”]<\/p>\n

In this research, Bai et al showed the complex temporal and spatial changes at the juxta-anastomotic area \u00a0after AVF creation in AVF models (Bai et al, Am J Physiol Heart Circ Physiol. 2024).<\/p>\n

[\/et_pb_text][et_pb_button button_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/39173878\/” url_new_window=”on” button_text=”Read More” _builder_version=”4.27.4″ _module_preset=”default” custom_button=”on” button_text_color=”#FFFFFF” button_bg_color=”#00AEEF” button_border_radius=”0px” box_shadow_style=”preset1″ locked=”off” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_2″ module_class=”imageallignment” _builder_version=”4.16″ background_color=”RGBA(0,0,0,0)” use_background_color_gradient=”on” background_color_gradient_direction=”115deg” background_color_gradient_stops=”#00aeef 0%|#221f72 100%” background_color_gradient_start=”#00aeef” background_color_gradient_end=”#221f72″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||” custom_css_main_element_last_edited=”on|desktop” custom_css_main_element_tablet=”margin-top:60px!important” custom_css_main_element_phone=”margin-top:60px!important”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/dardiklab2\/wp-content\/uploads\/sites\/616\/2025\/11\/F1c.tiff” title_text=”F1c” align=”center” _builder_version=”4.27.4″ background_color=”#221F72″ custom_margin=”-40px|40px|40px|-40px|false|false” custom_margin_tablet=”” custom_margin_phone=”-40px|40px|40px|-40px|false|false” custom_margin_last_edited=”on|phone” custom_padding=”|||” animation_style=”zoom” animation_direction=”right” animation_intensity_zoom=”6%” animation_starting_opacity=”100%” always_center_on_mobile=”off” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.9.0″ module_alignment=”center” custom_margin=”|auto|150px|auto||” custom_padding=”0px||0px|” global_module=”3004″ collapsed=”off” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ background_color=”#00AEEF” use_background_color_gradient=”on” background_color_gradient_direction=”33deg” background_color_gradient_stops=”#00aeef 0%|#d80b8c 100%” background_color_gradient_start=”#00aeef” background_color_gradient_end=”#d80b8c” background_enable_image=”off” parallax=”on” custom_padding=”|5%||5%” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/dardiklab2\/wp-content\/uploads\/sites\/616\/2025\/11\/5.jpg” title_text=”5″ align=”center” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.27.4″ custom_margin=”-20px||-20px|” custom_padding=”|||” animation_style=”zoom” animation_direction=”left” animation_intensity_zoom=”10%” animation_starting_opacity=”100%” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”40px|40px|40px|40px” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ header_font=”|700|||||||” header_font_size=”36px” header_3_font=”Playfair Display|700|||||||” header_3_text_color=”#2b2b2b” header_3_font_size=”28px” header_3_line_height=”1.5em” custom_margin=”||10px|” global_colors_info=”{}”]<\/p>\n

Eph-B4 prevents venous adaptive remodeling in the adult arterial environment<\/h1>\n

[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ text_font=”||||||||” text_text_color=”#141414″ text_line_height=”1.9em” header_font=”||||||||” header_2_font=”||||||||” module_alignment=”center” custom_margin=”||30px|” global_colors_info=”{}”]<\/p>\n

In this research, Muto et al showed Eph-B4 is active in adult veins and regulates venous remodeling. Eph-B4\u2013Cav-1\u2013mediated vessel remodeling may be a venous-specific adaptive mechanism (Muto, et al, J Exp Med. 2011).<\/p>\n

[\/et_pb_text][et_pb_button button_url=”https:\/\/rupress.org\/jem\/article\/208\/3\/561\/41043\/Eph-B4-prevents-venous-adaptive-remodeling-in-the” url_new_window=”on” button_text=”Read More” _builder_version=”4.27.4″ _module_preset=”default” custom_button=”on” button_text_color=”#FFFFFF” button_bg_color=”#00AEEF” button_border_radius=”0px” box_shadow_style=”preset1″ locked=”off” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.9.0″ module_alignment=”center” custom_margin=”||200px|” custom_padding=”0px|0px|0px|0px” global_module=”3005″ collapsed=”off” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ background_color_gradient_direction=”35deg” custom_padding=”40px|40px|40px|40px” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ header_font=”||||||||” header_3_font=”Playfair Display|700|||||||” header_3_text_color=”#2b2b2b” header_3_font_size=”28px” header_3_line_height=”1.5em” custom_margin=”||10px|” global_colors_info=”{}”]<\/p>\n

Working model for arteriovenous fistula (AVF<\/em>) maturation.<\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ text_font=”||||||||” text_text_color=”#141414″ text_line_height=”1.9em” header_font=”||||||||” header_2_font=”||||||||” module_alignment=”center” custom_margin=”||30px|” global_colors_info=”{}”]<\/p>\n

In this paper, Dr.Dardik reviewed the 15 years’ experience on the research of AVF (Dardik, JVS Vasc Sci. 2024).<\/p>\n

[\/et_pb_text][et_pb_button button_url=”https:\/\/labs.icahn.mssm.edu\/design\/option1-research” button_text=”Read More” _builder_version=”4.16″ _module_preset=”default” custom_button=”on” button_text_color=”#FFFFFF” button_bg_color=”#00AEEF” button_border_radius=”0px” box_shadow_style=”preset1″ locked=”off” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ background_color=”#00AEEF” use_background_color_gradient=”on” background_color_gradient_direction=”33deg” background_color_gradient_stops=”#221f72 0%|#d80b8c 100%” background_color_gradient_start=”#221f72″ background_color_gradient_end=”#d80b8c” background_enable_image=”off” parallax=”on” custom_padding=”|5%||5%” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/dardiklab2\/wp-content\/uploads\/sites\/616\/2025\/11\/gr1.jpg” title_text=”gr1″ align=”center” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.27.4″ custom_margin=”-20px||-20px|” custom_padding=”|||” animation_style=”zoom” animation_direction=”right” animation_intensity_zoom=”10%” animation_starting_opacity=”100%” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|on” admin_label=”Footer – Section 13″ module_class=”footer-section” _builder_version=”4.9.0″ background_color=”#c7eafb” background_image=”https:\/\/labs.icahn.mssm.edu\/dardiklab2\/wp-content\/uploads\/sites\/616\/2022\/10\/Rectangle-3.png” max_width=”80%” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|phone” module_alignment=”center” custom_margin=”100px|||176px|false|false” custom_padding=”3px|0px|40px|0px||” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”14%” animation_starting_opacity=”100%” disabled=”on” global_module=”425″ saved_tabs=”all” locked=”off” collapsed=”on” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_color=”RGBA(0,0,0,0)” background_color_gradient_direction=”38deg” module_alignment=”center” custom_margin=”|auto||147px||” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_social_media_follow _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” text_orientation=”center” global_colors_info=”{}”][et_pb_social_media_follow_network social_network=”linkedin” url=”https:\/\/www.linkedin.com\/school\/icahnmountsinai\/%20″ use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” global_colors_info=”{}”]linkedin[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=”facebook” url=”https:\/\/www.facebook.com\/IcahnMountSinai” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” global_colors_info=”{}”]facebook[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=”twitter” url=”https:\/\/twitter.com\/icahnmountsinai” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” global_colors_info=”{}”]twitter[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=”youtube” url=”https:\/\/www.youtube.com\/user\/MountSinaiSchool” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” global_colors_info=”{}”]youtube[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=”instagram” url=”https:\/\/www.instagram.com\/icahnmountsinai\/” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” global_colors_info=”{}”]instagram[\/et_pb_social_media_follow_network][\/et_pb_social_media_follow][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_text_color=”#FFFFFF” text_font_size=”24px” global_colors_info=”{}”]<\/p>\n

Contact Us<\/strong><\/p>\n

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Contact Us
<\/a><\/span>Recent News
<\/a>Alumni
<\/a>Researchers
<\/a>Gallery
<\/a>Resources
<\/a>Submit Inquiry
<\/a>Resources
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Accessibility<\/a><\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”1.25em” header_font=”||||||||” header_4_font=”|700||on|||||” header_4_font_size=”16px” header_4_letter_spacing=”1px” header_4_line_height=”1.5em” background_layout=”dark” locked=”off” global_colors_info=”{}”]<\/p>\n

E-mail
<\/strong>labname@mssm.edu<\/p>\n

Phone
<\/strong>Tel: 555-555-5555<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”1.25em” header_font=”||||||||” header_4_font=”|700||on|||||” header_4_font_size=”16px” header_4_letter_spacing=”1px” header_4_line_height=”1.5em” background_layout=”dark” locked=”off” global_colors_info=”{}”]<\/p>\n

Lab Address <\/strong>
One Gustave L. Levy Place
Annenberg
New York, NY 10029<\/p>\n

Mailing Address <\/strong><\/p>\n

Lab Name
Icahn School of Medicine
at Mount Sinai
One Gustave L. Levy Place
<\/span>Annenberg
<\/span>New York, NY 10029<\/span><\/p>\n

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Contact Us
<\/a><\/span>Recent News
<\/a>Alumni
<\/a>Researchers
<\/a>Gallery
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<\/a>Submit Inquiry
<\/a>Resources
<\/a>Lab Trials
Accessibility<\/a><\/p>\n

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E-mail
<\/strong>alan.dardik@mountsinai.org<\/p>\n

 <\/p>\n

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Lab Address <\/strong>
Icahn School of Medicine at Mount Sinai, Annenberg Building, Room 25-98, 5 E 98th St, \u00a0New York, NY 10029, United States.<\/p>\n

Mailing Address <\/strong><\/p>\n

Icahn School of Medicine at Mount Sinai, Annenberg Building, Room 25-30B, 5 E 98th St, Box 1259, New York, NY 10029, United States.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

ResearchOur current research focuses on the AVF outflow vein remodeling and the juxta-anastomotic neointimal hyperplasiamouse arteriovenous fistula model with chronic kidney diseaseIn this research, Bai et al showed the complex temporal and spatial changes at the juxta-anastomotic area \u00a0after AVF creation in AVF models (Bai et al, Am J Physiol Heart Circ Physiol. 2024).Eph-B4 prevents […]<\/p>\n","protected":false},"author":545,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"class_list":["post-3010","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/dardiklab\/wp-json\/wp\/v2\/pages\/3010","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/dardiklab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/dardiklab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/dardiklab\/wp-json\/wp\/v2\/users\/545"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/dardiklab\/wp-json\/wp\/v2\/comments?post=3010"}],"version-history":[{"count":14,"href":"https:\/\/labs.icahn.mssm.edu\/dardiklab\/wp-json\/wp\/v2\/pages\/3010\/revisions"}],"predecessor-version":[{"id":4692,"href":"https:\/\/labs.icahn.mssm.edu\/dardiklab\/wp-json\/wp\/v2\/pages\/3010\/revisions\/4692"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/dardiklab\/wp-json\/wp\/v2\/media?parent=3010"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}