[et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”off|off|off” admin_label=”Header Title Description – Section – Header – Fullwidth Slider ” module_id=”header-title-description-slider-section1″ _builder_version=”4.27.4″ _module_preset=”default” background_color=”rgba(0,174,239,0.09)” background_enable_color=”off” background_image=”https:\/\/labs.icahn.mssm.edu\/dardiklab2\/wp-content\/uploads\/sites\/616\/2022\/07\/ai-002-1.jpg” parallax=”on” custom_padding=”||||false|false” bottom_divider_style=”ramp2″ bottom_divider_color=”#FFFFFF” bottom_divider_height=”11vw” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_fullwidth_slider arrows_custom_color=”#D80B8C” dot_nav_custom_color=”#D80B8C” _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”|73px||||” global_colors_info=”{}”][et_pb_slide _builder_version=”4.27.4″ _module_preset=”default” header_text_align=”left” body_text_align=”left” background_image=”https:\/\/labs.icahn.mssm.edu\/dardiklab2\/wp-content\/uploads\/sites\/616\/2022\/07\/ai-002-1.jpg” background_enable_image=”on” text_orientation=”left” custom_padding=”|||80px|false|false” global_colors_info=”{}” sticky_transition=”on”]<\/p>\n
Our current research focuses on the outflow vein remodeling using a mouse aortocaval arteriovenous fistula model.<\/p>\n
[\/et_pb_slide][et_pb_slide _builder_version=”4.27.4″ _module_preset=”default” header_text_align=”left” body_text_align=”left” background_image=”https:\/\/labs.icahn.mssm.edu\/dardiklab2\/wp-content\/uploads\/sites\/616\/2022\/07\/ai-002-1.jpg” background_enable_image=”on” text_orientation=”left” custom_padding=”|||80px|false|false” global_colors_info=”{}” sticky_transition=”on”]<\/p>\n
Our current research focuses on the juxta-anastomotic neointimal hyperplasia using a mouse arteriovenous fistula model.<\/p>\n
[\/et_pb_slide][\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”on|tablet” disabled_on=”on|on|on” admin_label=”Fullwidth Two Column Header and Image (no slider) – Section 1 (Desktop only)” module_class=”section1_header_no_slider” _builder_version=”4.16″ _module_preset=”default” background_color=”#00aeef” background_image=”https:\/\/labs.icahn.mssm.edu\/dardiklab2\/wp-content\/uploads\/sites\/616\/2022\/10\/Background-2.png” parallax=”on” custom_margin=”||30px||false|false” custom_padding=”||||false|false” custom_padding_tablet=”0px||0px||false|false” custom_padding_phone=”” bottom_divider_style=”slant” bottom_divider_color=”#FFFFFF” bottom_divider_arrangement=”above_content” custom_css_main_element=”padding: 0px !important;” disabled=”on” locked=”off” collapsed=”on” global_colors_info=”{}”][et_pb_row column_structure=”2_5,3_5″ disabled_on=”off|off|off” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” module_alignment=”right” custom_padding=”||||false|false” border_color_all=”RGBA(0,0,0,0)” collapsed=”on” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”10%||8vw||false|false” custom_padding_tablet=”0vw||0vw||true|false” custom_padding_phone=”” custom_padding_last_edited=”on|desktop” global_colors_info=”{}”][et_pb_text admin_label=”Title – Text” _builder_version=”4.27.4″ _module_preset=”da86b6f0-f83c-4c7c-bdd8-3019777ddffe” text_font=”||||||||” text_text_color=”#FFFFFF” text_font_size=”20px” text_line_height=”32px” header_text_align=”left” header_text_color=”#FFFFFF” header_font_size=”48px” header_line_height=”60px” custom_margin=”||2%||false|false” text_font_size_tablet=”15px” text_font_size_phone=”14px” text_font_size_last_edited=”on|desktop” header_font_size_tablet=”40px” header_font_size_phone=”24px” header_font_size_last_edited=”on|phone” custom_css_main_element=”\/*margin-right: 8vw!important;*\/” global_colors_info=”{}”]<\/p>\n
[\/et_pb_text][et_pb_text admin_label=”Description – Text” _builder_version=”4.27.4″ _module_preset=”da86b6f0-f83c-4c7c-bdd8-3019777ddffe” text_font=”||||||||” text_text_color=”#FFFFFF” text_font_size=”20px” text_line_height=”32px” header_text_align=”left” custom_margin=”||||false|false” text_font_size_tablet=”15px” text_font_size_phone=”14px” text_font_size_last_edited=”on|desktop” custom_css_main_element=”\/*margin-right: 9vw!important;*\/” global_colors_info=”{}”]<\/p>\n
Our current research focuses on the outflow vein and junta-anastomotic neointimal hyperplasia after AVF creation<\/p>\n
[\/et_pb_text][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ disabled_on=”on|on|on” _builder_version=”4.16″ _module_preset=”default” disabled=”on” collapsed=”on” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Two Column Image and Text over Button – Section 6 (Collections)” module_class=”section6_two_col_img_txt_over_btn” _builder_version=”4.16″ custom_margin=”30px||100px||false|false” custom_margin_tablet=”100px||||false|false” custom_margin_phone=”” custom_margin_last_edited=”on|desktop” custom_padding=”0px|0px|0px|0px|false|false” custom_css_main_element=”padding: 0px !important;” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.16″ module_alignment=”center” custom_margin=”|auto|0px|auto||” custom_padding=”0px||0px|||” box_shadow_style=”preset1″ box_shadow_color=”#58595B” collapsed=”off” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ use_background_color_gradient=”on” background_color_gradient_direction=”35deg” background_color_gradient_stops=”#ff6a88 0%|#ff99ac 100%” background_color_gradient_start=”#ff6a88″ background_color_gradient_end=”#ff99ac” background_image=”https:\/\/labs.icahn.mssm.edu\/dardiklab2\/wp-content\/uploads\/sites\/616\/2022\/08\/Rectangle-3-copy-5.jpg” custom_padding=”|5%||5%” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n
Brief history of the rodent aortocaval fistula model<\/strong><\/p>\n In 1973, Stumpe et al. introduced an ACF model in Sprague-Dawley rats. Between 1981 and 1983, Ballinger\u2019s group further refined the model. In 2001, this model was applied in cardiac hypertrophy study. \u00a0<\/p>\n In 2013, Dardik lab simplified this model using a 25G needle without suture or glue.\u00a0<\/span><\/p>\n [\/et_pb_text][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/dardiklab2\/wp-content\/uploads\/sites\/616\/2025\/11\/31.tif” title_text=”ImageJ=1.53u” align=”center” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.27.4″ background_enable_image=”off” background_size=”initial” custom_margin=”-20px||-20px|” custom_padding=”|||” animation_style=”zoom” animation_direction=”left” animation_intensity_zoom=”10%” animation_starting_opacity=”100%” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ background_image=”https:\/\/labs.icahn.mssm.edu\/dardiklab2\/wp-content\/uploads\/sites\/616\/2022\/08\/ai-008-bwSm-1.png” background_position=”center_right” custom_padding=”40px|40px|40px|40px|true|true” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text disabled_on=”off|off|off” _builder_version=”4.27.4″ header_font=”|700|||||||” header_text_color=”#141414″ header_font_size=”36px” header_3_font=”|700|||||||” header_3_text_color=”#2b2b2b” header_3_font_size=”28px” header_3_line_height=”1.5em” custom_margin=”||10px|” custom_padding=”5%||||false|false” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ text_font=”||||||||” text_text_color=”#000000″ text_line_height=”22px” header_font=”||||” header_text_color=”#000000″ header_4_text_color=”#FFFFFF” header_5_text_color=”#FFFFFF” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”700px” custom_padding=”2%||5%||false|false” animation_style=”slide” animation_direction=”top” animation_intensity_slide=”4%” global_colors_info=”{}”]<\/p>\n In mice, the outflow vein is typically examined at 50\u2013100 \u03bcm cranial to the \u201cfistula\u201d. Patent AVF display a thickened venous wall that characterized by an accumulation of \u03b1-actin\u2013positive smooth muscle cells (SMC).<\/p>\n [\/et_pb_text][et_pb_text disabled_on=”on|on|on” _builder_version=”4.16″ text_font=”||||||||” text_text_color=”#141414″ text_line_height=”1.9em” header_font=”||||||||” header_2_font=”||||||||” module_alignment=”center” custom_margin=”||30px|” disabled=”on” global_colors_info=”{}”]<\/p>\n Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ornare suspendisse sed nisi lacus sed viverra tellus in.<\/p>\n [\/et_pb_text][et_pb_button button_text=”Lorem ipsum dolor sit amet” disabled_on=”on|on|on” _builder_version=”4.16″ custom_button=”on” button_text_size=”16px” button_text_color=”#FFFFFF” button_bg_color=”#00AEEF” button_border_width=”0px” button_border_radius=”0px” button_font=”||||||||” button_icon=”5||divi||400″ button_icon_color=”#FFFFFF” button_on_hover=”off” custom_margin=”20px|||” custom_padding=”12px|28px|12px|28px” box_shadow_style=”preset1″ box_shadow_vertical=”10px” box_shadow_blur=”30px” box_shadow_color=”#58595B” button_letter_spacing_hover=”2px” disabled=”on” locked=”off” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”2px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_button][et_pb_button button_url=”https:\/\/jvsvs.org\/article\/S2666-3503(24)00018-X\/fulltext” url_new_window=”on” button_text=”Find Out More” _builder_version=”4.27.4″ _module_preset=”default” custom_button=”on” button_text_color=”#FFFFFF” button_bg_color=”#00AEEF” button_border_radius=”0px” box_shadow_style=”preset1″ locked=”off” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Two Column Image and Text over Button – Section 4″ module_class=”section4_two_col_img_txt_over_btn” _builder_version=”4.16″ background_color=”#00AEEF” background_image=”https:\/\/labs.icahn.mssm.edu\/dardiklab2\/wp-content\/uploads\/sites\/616\/2022\/12\/Background-1ALT.png” parallax=”on” width=”100%” custom_margin=”30px||||false|false” custom_padding=”80px|0px|63px|0px||” mix_blend_mode=”multiply” bottom_divider_style=”ramp2″ bottom_divider_color=”#FFFFFF” bottom_divider_height=”150px” bottom_divider_flip=”horizontal” bottom_divider_arrangement=”above_content” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”|||” custom_padding=”|||” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/dardiklab2\/wp-content\/uploads\/sites\/616\/2025\/11\/31.jpg” title_text=”31″ disabled_on=”off|off|off” _builder_version=”4.27.4″ animation_style=”slide” animation_direction=”left” animation_intensity_slide=”10%” box_shadow_style=”preset1″ box_shadow_color=”#58595B” always_center_on_mobile=”off” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”22px” header_font=”||||” header_text_color=”#FFFFFF” header_4_text_color=”#FFFFFF” header_5_text_color=”#FFFFFF” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”700px” animation_style=”slide” animation_direction=”top” animation_intensity_slide=”4%” global_colors_info=”{}”]<\/p>\n Juxta-anastomotic neointimal hyperplasia is one of the leading causes of AVF failure in human AVF; but juxta-anastomotic area (JAA) \u00a0lacks a precise definition, with 2\u20135 cm downstream of the anastomosis being commonly used. We recently investigated and defined the complex temporal and spatial changes at the JAA in a mouse AVF model.<\/p>\n [\/et_pb_text][et_pb_button button_url=”https:\/\/journals.physiology.org\/doi\/full\/10.1152\/ajpheart.00054.2024″ url_new_window=”on” button_text=”Find Out More ” _builder_version=”4.27.4″ _module_preset=”default” custom_button=”on” button_text_color=”#d80b8c” button_bg_color=”#FFFFFF” button_border_radius=”0px” box_shadow_style=”preset1″ global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|off” admin_label=”Two Column Image Next to Title Over Text Over Button – Section 4 (Desktop Only)” module_class=”section4_two_col_img_next_to_title_over_txt_over_btn_desktop” _builder_version=”4.16″ _module_preset=”default” background_color=”#00AEEF” use_background_color_gradient=”on” background_color_gradient_direction=”33deg” background_color_gradient_stops=”#00aeef 0%|#d80b8c 100%” background_color_gradient_start=”#00aeef” background_color_gradient_end=”#d80b8c” background_image=”https:\/\/labs.icahn.mssm.edu\/dardiklab2\/wp-content\/uploads\/sites\/616\/2022\/10\/Background-2.png” parallax=”on” module_alignment=”center” height=”558px” custom_margin=”||200px||false|false” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/dardiklab2\/wp-content\/uploads\/sites\/616\/2025\/11\/0000072500113076959121.jpg” title_text=”0000072500113076959121″ _builder_version=”4.27.4″ _module_preset=”default” width=”91%” max_width=”91%” min_height=”550px” height=”550px” max_height=”550px” custom_padding=”40px||||false|false” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”Text” _builder_version=”4.27.4″ _module_preset=”default” text_text_color=”#FFFFFF” header_text_align=”center” header_text_color=”#FFFFFF” text_orientation=”center” custom_padding=”||||false|false” global_colors_info=”{}”]<\/p>\n Dr. Alan Dardik is a surgeon-scientist who harnesses the power of molecular biology to achieve a modern understanding of vascular disease and then use the basic science laboratory to ultimately benefit patients with vascular diseases.<\/p>\n Dr. Dardik trained at Yale, the University of Pennsylvania, and the Johns Hopkins Hospital before his appointment to the Yale faculty in 2001. In 2025, Dr. Dardik joined the Icahn School of Medicine at Mount Sinai where he serves as the System Vice Chair for Research as well as the Co-Director of the Jacobson Aortic Center in the Department of Surgery.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Footer Fullwidth – Section 13″ module_class=”footer-section” _builder_version=”4.9.0″ background_color=”#c7eafb” background_image=”https:\/\/labs.icahn.mssm.edu\/dardiklab2\/wp-content\/uploads\/sites\/616\/2022\/10\/Rectangle-3.png” max_width=”100%” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|phone” module_alignment=”center” custom_margin=”100px|||176px|false|false” custom_padding=”3px|0px|0px|0px|false|false” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”14%” animation_starting_opacity=”100%” global_module=”3741″ saved_tabs=”all” locked=”off” collapsed=”on” global_colors_info=”{}”][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.16″ background_color=”RGBA(0,0,0,0)” background_color_gradient_direction=”38deg” module_alignment=”center” custom_margin=”|auto|-2px|auto||” custom_padding=”0px|||||” hover_enabled=”0″ locked=”off” collapsed=”on” global_colors_info=”{}” sticky_enabled=”0″][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”22px” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n Contact Usoutflow vein remodeling<\/strong><\/h1>\n
Juxta-anastomotic neointimal hyperplasia (JANIH)<\/strong><\/h4>\n
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