{"id":340,"date":"2021-10-29T13:27:06","date_gmt":"2021-10-29T13:27:06","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/dailab\/?p=340"},"modified":"2021-10-29T13:31:00","modified_gmt":"2021-10-29T13:31:00","slug":"340-2","status":"publish","type":"post","link":"https:\/\/labs.icahn.mssm.edu\/dailab\/340-2\/","title":{"rendered":"Readaptation Treatment of Mal de Debarquement Syndrome With a Virtual Reality App"},"content":{"rendered":"<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33013617\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33013617\/<\/a><\/p>\n<header id=\"heading\" class=\"heading\">\n<div id=\"full-view-heading\" class=\"full-view\">\n<h1 class=\"heading-title\">Readaptation Treatment of Mal de Debarquement Syndrome With a Virtual Reality App: A Pilot Study<\/h1>\n<div class=\"inline-authors\">\n<div class=\"authors\">\n<div class=\"authors-list\"><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Yakushin+SB&amp;cauthor_id=33013617\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Sergei B Yakushin\">Sergei B Yakushin<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33013617\/#affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Zink+R&amp;cauthor_id=33013617\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Reilly Zink\">Reilly Zink<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Ohio Musculoskeletal and Neurological Institute (OMNI), Ohio University, Athens, OH, United States.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33013617\/#affiliation-2\">2<\/a><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"School of Electrical Engineering and Computer Science, Ohio University, Athens, OH, United States.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33013617\/#affiliation-3\">3<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Clark+BC&amp;cauthor_id=33013617\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Brian C Clark\">Brian C Clark<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Ohio Musculoskeletal and Neurological Institute (OMNI), Ohio University, Athens, OH, United States.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33013617\/#affiliation-2\">2<\/a><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Department of Biomedical Sciences, Ohio University, Athens, OH, United States.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33013617\/#affiliation-4\">4<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Liu+C&amp;cauthor_id=33013617\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Chang Liu\">Chang Liu<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Ohio Musculoskeletal and Neurological Institute (OMNI), Ohio University, Athens, OH, United States.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33013617\/#affiliation-2\">2<\/a><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"School of Electrical Engineering and Computer Science, Ohio University, Athens, OH, United States.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33013617\/#affiliation-3\">3<\/a><\/sup><\/span><\/div>\n<\/div>\n<\/div>\n<div class=\"short-article-details\">Affiliations\u00a0<button id=\"toggle-authors\" class=\"more-details\" data-alt-text=\"Collapse\" data-pinger-ignore=\"\" data-fetch-url=\"\/33013617\/long-authors\/\" data-id-prefix=\"\"><span class=\"title\">expand<\/span><\/button><\/div>\n<ul id=\"full-view-identifiers\" class=\"identifiers\">\n<li><span class=\"identifier pubmed\"><span class=\"id-label\">PMID:\u00a0<\/span><strong class=\"current-id\" title=\"PubMed ID\">33013617<\/strong><\/span><\/li>\n<li><span class=\"identifier pmc\"><span class=\"id-label\">PMCID:\u00a0<\/span><a class=\"id-link\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc7461907\/\" target=\"_blank\" rel=\"noopener\" data-ga-category=\"full_text\" data-ga-action=\"PMCID\">PMC7461907<\/a><\/span><\/li>\n<li><span class=\"identifier doi\"><span class=\"id-label\">DOI:\u00a0<\/span><a class=\"id-link\" href=\"https:\/\/doi.org\/10.3389\/fneur.2020.00814\" target=\"_blank\" rel=\"noopener\" data-ga-category=\"full_text\" data-ga-action=\"DOI\">10.3389\/fneur.2020.00814<\/a><\/span><\/li>\n<\/ul>\n<p><span class=\"free-label\">Free PMC article<\/span><\/div>\n<\/header>\n<div id=\"abstract\" class=\"abstract\">\n<h2 class=\"title\">Abstract<\/h2>\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\n<p>Mal de Debarquement syndrome (MdDS) is composed of constant phantom sensations of motion, which are frequently accompanied by increased sensitivity to light, inability to walk on a patterned floor, the sensation of ear fullness, head pressure, anxiety, and depression. This disabling condition generally occurs in premenopausal women within 2 days after prolonged passive motion (e.g., travel on a cruise ship, plane, or in a car). It has been previously hypothesized that MdDS is the result of maladaptive changes in the polysynaptic vestibulo-ocular reflex (VOR) pathway called velocity storage. Past research indicates that full-field optokinetic stimulation is an optimal way to activate velocity storage. Unfortunately, such devices are typically bulky and not commonly available. We questioned whether virtual reality (VR) goggles with a restricted visual field could effectively simulate a laboratory environment for MdDS treatment. A stripes program for optokinetic stimulation was implemented using Google Daydream Viewer. Five female patients (42 \u00b1 10 years; range 26-50), whose average MdDS symptom duration was 2 months, participated in this study. Four patients had symptoms triggered by prolonged passive motion, and in one, symptoms spontaneously occurred. Symptom severity was self-scored by patients on a scale of 0-10, where 0 is no symptoms at all and 10 is the strongest symptoms that the patient could imagine. Static posturography was obtained to determine objective changes in body motion. The treatment was considered effective if the patient&#8217;s subjective score improved by at least 50%. All five patients reported immediate improvement. On 2-month follow-ups, symptoms returned only in one patient. These data provide proof of concept for the limited-visual-field goggles potentially having clinical utility as a substitute for full-field optokinetic stimulation in treating patients with MdDS in clinics or via telemedicine.<\/p>\n<\/div>\n<p><strong class=\"sub-title\">Keywords:\u00a0<\/strong>Mal de Debarquement syndrome; bobbing; readaptation; rocking; swaying; velocity storage.<\/p>\n<\/div>\n<p id=\"copyright\" class=\"copyright\">Copyright \u00a9 2020 Yakushin, Zink, Clark and Liu.<\/p>\n<div id=\"figures\" class=\"figures\">\n<h3 class=\"title\">Figures<\/h3>\n<div id=\"slides-container\" class=\"figures-list\">\n<figure class=\"figure-item \" data-slide-index=\"0\" data-label-slug=\"figure-1\"><a class=\"figure-link\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/instance\/7461907\/bin\/fneur-11-00814-g0001.jpg\" aria-describedby=\"figure-caption-0\" data-image-width=\"669\" data-image-height=\"302\" data-image-alt=\"Figure 1\" data-pmc-id=\"PMC7461907\" data-figure-id=\"F1\"><img decoding=\"async\" id=\"article-image-0\" class=\"figure-thumb\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/instance\/7461907\/bin\/fneur-11-00814-g0001.gif\" alt=\"Figure 1\" \/><\/a><\/p>\n<div class=\"figure-caption figure-caption-text\" aria-hidden=\"true\">\n<div class=\"caption-wrap\">\n<p>Figure 1<\/p>\n<div class=\"figure-caption-contents\">\n<p>Overall symptom severity self-scores before\u2026<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/figure>\n<figure class=\"figure-item \" data-slide-index=\"1\" data-label-slug=\"figure-2\"><a class=\"figure-link\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/instance\/7461907\/bin\/fneur-11-00814-g0002.jpg\" aria-describedby=\"figure-caption-1\" data-image-width=\"669\" data-image-height=\"130\" data-image-alt=\"Figure 2\" data-pmc-id=\"PMC7461907\" data-figure-id=\"F2\"><img decoding=\"async\" id=\"article-image-1\" class=\"figure-thumb\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/instance\/7461907\/bin\/fneur-11-00814-g0002.gif\" alt=\"Figure 2\" \/><\/a><\/p>\n<div class=\"figure-caption figure-caption-text\" aria-hidden=\"true\">\n<div class=\"caption-wrap\">\n<p>Figure 2<\/p>\n<div class=\"figure-caption-contents\">\n<p>The static post-urography obtained from\u2026<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/figure>\n<figure class=\"figure-item \" data-slide-index=\"2\" data-label-slug=\"figure-3\"><a class=\"figure-link\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/instance\/7461907\/bin\/fneur-11-00814-g0003.jpg\" aria-describedby=\"figure-caption-2\" data-image-width=\"669\" data-image-height=\"130\" data-image-alt=\"Figure 3\" data-pmc-id=\"PMC7461907\" data-figure-id=\"F3\"><img decoding=\"async\" id=\"article-image-2\" class=\"figure-thumb\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/instance\/7461907\/bin\/fneur-11-00814-g0003.gif\" alt=\"Figure 3\" \/><\/a><\/p>\n<div class=\"figure-caption figure-caption-text\" aria-hidden=\"true\">\n<div class=\"caption-wrap\">\n<p>Figure 3<\/p>\n<div class=\"figure-caption-contents\">\n<p>The treatment of gravitational pull-back\u2026<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/figure>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>https:\/\/pubmed.ncbi.nlm.nih.gov\/33013617\/ Readaptation Treatment of Mal de Debarquement Syndrome With a Virtual Reality App: A Pilot Study Sergei B Yakushin\u00a01,\u00a0Reilly Zink\u00a02\u00a03,\u00a0Brian C Clark\u00a02\u00a04,\u00a0Chang Liu\u00a02\u00a03 Affiliations\u00a0expand PMID:\u00a033013617 PMCID:\u00a0PMC7461907 DOI:\u00a010.3389\/fneur.2020.00814 Free PMC article Abstract Mal de Debarquement syndrome (MdDS) is composed of constant phantom sensations of motion, which are frequently accompanied by increased sensitivity to light, inability to [&hellip;]<\/p>\n","protected":false},"author":318,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-340","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/dailab\/wp-json\/wp\/v2\/posts\/340","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/dailab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/dailab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/dailab\/wp-json\/wp\/v2\/users\/318"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/dailab\/wp-json\/wp\/v2\/comments?post=340"}],"version-history":[{"count":4,"href":"https:\/\/labs.icahn.mssm.edu\/dailab\/wp-json\/wp\/v2\/posts\/340\/revisions"}],"predecessor-version":[{"id":344,"href":"https:\/\/labs.icahn.mssm.edu\/dailab\/wp-json\/wp\/v2\/posts\/340\/revisions\/344"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/dailab\/wp-json\/wp\/v2\/media?parent=340"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/dailab\/wp-json\/wp\/v2\/categories?post=340"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/dailab\/wp-json\/wp\/v2\/tags?post=340"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}