Multimodal single-cell analyses reveal mechanisms of perianal fistula in diverse patients with Crohn’s disease<\/a><\/p>\n Levantovsky RM, Tastad C, Zhang J, Gettler K, Sabic K, Werner R, Chasteau C, Korie U, Paguay D, Bao M, Han H,\u00a0 Maskey N, Talware S, Patel M, Argmann C, Suarez-Farinas M, Harpaz N, Chuang LS, Cho JH. Med 2024 Aug 9; 5(8):886-908.E11. PMID: 38663404. DOI: 10.1016\/j.medj.2024.03.021.<\/p>\n NOX1 is essential for TNF\u03b1-induced intestinal epithelial ROS secretion and inhibits M cell signatures<\/a><\/p>\n Hsu NY, Nayar S, Gettler K, Talware S, Giri M, Alter I, Argmann C, Sabic K, Thin TH, Ko HBM, Werner R, Tastad C, Stappenbeck T, Azabdaftari A, Uhlig HH, Chuang LS, Cho JH. Gut 2023 Apr; 72:654-662. PMID: 36191961. DOI: 10.1136\/gutjnl-2021-326305.<\/p>\n A myeloid-stromal niche and gp130 rescue in NOD2-driven Crohn’s disease<\/a><\/p>\n Nayar S, Morrison JK, Giri M, Gettler K, Chuang LS, Walker LA, Ko HM, Kenigsberg E, Kugathasan S, Merad M, Chu J, Cho JH. Nature 2021 May 13; 593:275\u2013281. PMID: 33789339. DOI: 10.1038\/s41586-021-03484-5.<\/p>\n Inflamed Ulcerative Colitis Regions Associated With MRGPRX2-Mediated Mast Cell Degranulation and Cell Activation Modules, Defining a New Therapeutic Target<\/a><\/p>\n Hsu NY, Nayar S, Gettler K, Talware S, Giri M, Alter I, Argmann C, Sabic K, Thin TH, Ko HBM, Werner R, Tastad C,\u00a0 Stappenbeck T, Azabdaftari A, Uhlig HH, Chuang LS, Cho JH. Gastroenterology 2021 APR; 160(5):1709 – 1724. PMID: 36191961. DOI: 10.1136\/gutjnl-2021-326305.<\/p>\n Common and Rare Variant Prediction and Penetrance of IBD in a Large, Multi-ethnic, Health System-based Biobank Cohort<\/a><\/p>\n Gettler K, Levantovsky R, Moscati A, Giri M, Wu Y, Hsu NY, Chuang LS, Sazonovs A, Venkateswaran S, Korie U,\u00a0 Chasteau C, National Institute of Diabetes, Digestive UK IBD Genetics Consortium, Kidney Diseases Inflammatory Bowel Disease Genetics Consortium,\u00a0 Duerr RH,\u00a0 Silverberg MS, Snapper SB, Daly MJ, McGovern DP, Brant SR, Rioux JD, Kugathasan S,\u00a0 Anderson CA, Itan Y, Cho JH. Gastroenterology 2021 Apr; 160(5): 1546 – 1557. PMID: 33359885. DOI: 10.1053\/j.gastro.2020.12.034<\/p>\n Single-cell analysis of Crohn\u2019s disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy.<\/a><\/p>\n Martin JC, Boschetti G, Chang C, Ungaro R, Giri M, Chuang LS, Nayar S, Greenstein A, Dubinsky M, Walker L, Leader A, Fine JS, Whitehurst CE, Mbow L, Kugathasan S, Denson LA, Hyams J, Friedman J, Desai P, Ko HM, Laface I, Akturk G, Schadt E, Gnjatic S, Rahman A, Merad M, Cho JH, Kenigsberg E.\u00a0Cell 2019 Sep 5;178(6):1493-1508. PMID: 31474370 DOI:\u00a010.1016\/j.cell.2019.08.008<\/a><\/p>\n Zebrafish modeling of intestinal injury, bacterial exposures and medications defines epithelial in vivo responses relevant to human inflammatory bowel disease. <\/a><\/p>\n Chuang LS, Morrison J, Hsu NY, Labrias PR, Nayar S, Chen E, Villaverde N, Facey JA, Boschetti G, Giri M, Castillo-Martin M, Thin TH, Sharma Y, Chu J, Cho JH. Prioritizing Crohn’s disease genes by integrating association signals with gene expression implicates monocyte subsets<\/span><\/a><\/p>\n Gettler K,\u00a0Giri M,\u00a0Kenigsberg E,\u00a0Martin J,\u00a0Chuang LS,\u00a0Hsu NY,\u00a0Denson LA,\u00a0Hyams JS,\u00a0Griffiths A,\u00a0Noe JD,\u00a0Crandall WV,\u00a0Mack DR,\u00a0Kellermayer R,\u00a0Abraham C,\u00a0Hoffman G,\u00a0Kugathasan S,\u00a0Cho JH.\u00a0Genes Immun.\u00a02019 Jan 29.\u00a0doi: 10.1038\/s41435-019-0059-y PMID:\u00a030692607<\/span><\/p>\n Functional variants in the LRRK2<\/i> gene confer shared effects on risk for Crohn’s disease and Parkinson’s disease.<\/a> Fine-mapping inflammatory bowel disease loci to single-variant resolution.<\/span><\/a> Prediction of complicated disease course for children newly diagnosed with Crohn’s disease: a multicentre inception cohort study<\/a><\/p>\n Kugathasan S, Denson LA, Walters TD, Kim MO, Marigorta UM, Schirmer M, Mondal K, Liu C, Griffiths A, Noe JD, Crandall WV, Snapper S, Rabizadeh S, Rosh JR, Shapiro JM, Guthery S, Mack DR, Kellermayer R, Kappelman MD, Steiner S, Moulton DE, Keljo D, Cohen S, Oliva-Hemker M, Heyman MB, Otley AR, Baker SS, Evans JS, Kirschner BS, Patel AS, Ziring D, Trapnell BC, Sylvester FA, Stephens MC, Baldassano RN, Markowitz JF, Cho J<\/strong>H<\/strong>, Xavier RJ, Huttenhower C, Aronow BJ, Gibson G, Hyams JS, Dubinsky MC. Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease.<\/a><\/p>\n Brant SR, Okou DT, Simpson CL, Cutler DJ, Haritunians T, Bradfield JP, Chopra P, Prince J, Begum F, Kumar A, Huang C, Venkateswaran S, Datta LW, Wei Z, Thomas K, Herrinton LJ, Klapproth JA, Quiros AJ, Seminerio J, Liu Z, Alexander JS, Baldassano RN, Dudley-Brown S, Cross RK, Dassopoulos T, Denson LA, Dhere TA, Dryden GW, Hanson JS, Hou JK, Hussain SZ, Hyams JS, Isaacs KL, Kader H, Kappelman MD, Katz J, Kellermayer R, Kirschner BS, Kuemmerle JF, Kwon JH, Lazarev M, Li E, Mack D, Mannon P, Moulton DE, Newberry RD, Osuntokun BO, Patel AS, Saeed SA, Targan SR, Valentine JF, Wang MH, Zonca M, Rioux JD, Duerr RH, Silverberg MS, Cho JH, Hakonarson H, Zwick ME, McGovern DP, Kugathasan S.Gastroenterology<\/span>. 2017 Jan;152(1):206-217.e2. doi: 10.1053\/j.gastro.2016.09.032. Epub 2016 Sep 28.PMID:27693347<\/p>\n<\/div>\n A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn’s Disease and Reduces Monocyte Signaling via GM-CSF. Bridging the Gap Between Host Immune Response and Intestinal Dysbiosis in Inflammatory Bowel Disease: Does IgA Mark the Spot?\u00a0<\/a> Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease. Pattern recognition receptor signaling in human dendritic cells is enhanced by ICOS ligand and modulated by the Crohn’s disease ICOSLG risk allele<\/a>. Extended\u00a0haplotype\u00a0association\u00a0study\u00a0in\u00a0Crohn’s disease\u00a0identifies\u00a0a\u00a0novel,\u00a0Ashkenazi\u00a0Jewish-specific\u00a0missense mutation\u00a0in the\u00a0NF-\u03baB\u00a0pathway\u00a0gene, HEATR3<\/a>. Age and CD161 expression contribute to inter-individual variation in interleukin-23 response in CD8+ memory human T cells.<\/a> Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease<\/a>. A genome-wide scan of Ashkenazi Jewish Crohn’s disease suggests novel susceptibility loci.<\/a> Genomics and the multifactorial nature of human autoimmune disease.<\/a> Improved risk prediction for Crohn’s disease with a multi-locus approach.<\/a> Practical issues in building risk-predicting models for complex diseases.<\/a> Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.<\/a> A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.<\/a> A frameshift mutation in NOD2 associated with\u00a0susceptibility to Crohn’s disease.<\/a> <\/p>\n 2024 Multimodal single-cell analyses reveal mechanisms of perianal fistula in diverse patients with Crohn’s disease Levantovsky RM, Tastad C, Zhang J, Gettler K, Sabic K, Werner R, Chasteau C, Korie U, Paguay D, Bao M, Han H,\u00a0 Maskey N, Talware S, Patel M, Argmann C, Suarez-Farinas M, Harpaz N, Chuang LS, Cho JH. Med 2024 […]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-177","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/cholab\/wp-json\/wp\/v2\/pages\/177","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/cholab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/cholab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/cholab\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/cholab\/wp-json\/wp\/v2\/comments?post=177"}],"version-history":[{"count":18,"href":"https:\/\/labs.icahn.mssm.edu\/cholab\/wp-json\/wp\/v2\/pages\/177\/revisions"}],"predecessor-version":[{"id":1455,"href":"https:\/\/labs.icahn.mssm.edu\/cholab\/wp-json\/wp\/v2\/pages\/177\/revisions\/1455"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/cholab\/wp-json\/wp\/v2\/media?parent=177"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n2023<\/h3>\n
\n2021<\/h3>\n
\n2019<\/h3>\n
\nDisease Models and Mechanisms 2019 Aug 13;12(8).\u00a0PMID:\u00a031337664\u00a0PMCID:\u00a0PMC6737949<\/a>\u00a0DOI:\u00a010.1242\/dmm.037432<\/a><\/p>\n
\n2018<\/h3>\n
\nHui KY, Fernandez-Hernandez H, Hu J, Schaffner A, Pankratz N, Hsu NY, Chuang LS, Carmi S, Villaverde N, Li X, Rivas M, Levine AP, Bao X, Labrias PR, Haritunians T, Ruane D, Gettler K, Chen E, Li D, Schiff ER, Pontikos N, Barzilai N, Brant SR, Bressman S, Cheifetz AS, Clark LN, Daly MJ, Desnick RJ, Duerr RH, Katz S, Lencz T, Myers RH, Ostrer H, Ozelius L, Payami H, Peter Y, Rioux JD, Segal AW, Scott WK, Silverberg MS, Vance JM, Ubarretxena-Belandia I, Foroud T, Atzmon G, Pe’er I, Ioannou Y, McGovern DPB, Yue Z, Schadt EE, Cho JH, Peter I.\u00a0Sci Transl Med<\/span>. 2018 Jan 10;10(423). pii: eaai7795. doi: 10.1126\/scitranslmed.aai7795 PMID:29321258<\/p>\n
\nInstitutional profile: translational pharmacogenomics at the Icahn School of Medicine at Mount Sinai.<\/a>
\nScott SA, Owusu Obeng A, Botton MR, Yang Y, Scott ER, Ellis SB, Wallsten R, Kaszemacher T, Zhou X, Chen R, Nicoletti P, Naik H, Kenny EE, Vega A, Waite E, Diaz GA, Dudley J, Halperin JL, Edelmann L, Kasarskis A, Hulot JS, Peter I, Bottinger EP, Hirschhorn K, Sklar P, Cho JH, Desnick RJ, Schadt EE. Pharmacogenomics<\/span>. 2017 Oct;18(15):1381-1386. doi: 10.2217\/pgs-2017-0137. Epub 2017 Oct 6. PMID:28982267<\/p>\n
\n2017<\/b><\/span><\/h3>\n
\nHuang H, Fang M, Jostins L, Umi\u0107evi\u0107 Mirkov M, Boucher G, Anderson CA, Andersen V, Cleynen I, Cortes A, Crins F, D’Amato M, Deffontaine V, Dmitrieva J, Docampo E, Elansary M, Farh KK, Franke A, Gori AS, Goyette P, Halfvarson J, Haritunians T, Knight J, Lawrance IC, Lees CW, Louis E, Mariman R, Meuwissen T, Mni M, Momozawa Y, Parkes M, Spain SL, Th\u00e9\u00e2tre E, Trynka G, Satsangi J, van Sommeren S, Vermeire S, Xavier RJ; International Inflammatory Bowel Disease Genetics Consortium, Weersma RK, Duerr RH, Mathew CG, Rioux JD, McGovern DPB, Cho JH, Georges M, Daly MJ, Barrett JC. Nature. 2017 Jul 13;547(7662):173-178. doi: 10.1038\/nature22969. Epub 2017 Jun 28.<\/span><\/p>\n
\nLancet. 2017 Mar 1. pii<\/p>\n
\n2016<\/h3>\n
\n<\/a>Chuang LS, Villaverde N, Hui KY, Mortha A, Rahman A, Levine AP, Haritunians T, Evelyn Ng SM, Zhang W, Hsu NY, Facey JA, Luong T, Fernandez-Hernandez H, Li D, Rivas M, Schiff ER, Gusev A, Schumm LP, Bowen BM, Sharma Y, Ning K, Remark R,<\/sup> Gnjatic S, Legnani P, George J, Sands BE, Stempak JM, Datta LW, Lipka S, Katz S, Cheifetz AS, Barzilai N, Pontikos N, Abraham C, Dubinsky MJ, Targan S, Taylor K, Rotter JI, Scherl EJ, Desnick RJ, Abreu MT, Zhao H, Atzmon G, Pe’er I, Kugathasan S, Hakonarson H, McCauley JL, Lencz T, Darvasi A, Plagnol V, Silverberg MS, Muise AM, Brant SR, Daly MJ, Segal AW, Duerr RH, Merad M, McGovern DP, Peter I, Cho JH.
\nGastroenterology. 2016 Oct;151(4):710-723.e2. doi: 10.1053\/j.gastro.2016.06.045. Epub 2016 Jul 1.<\/em><\/p>\n
\n2015<\/h3>\n
\nShapiro JM, Cho JH, \u00a0Sands BE, LeLeiko NS.
\nClinical Gastroenterology and Hepatology<\/em>, 2015, Epub Ahead of Print.<\/p>\n
\n2014<\/h3>\n
\n<\/a>Palm NW, de Zoete MR, Cullen TW, Barry NA, Stefanowski J, Hao L, Degnan PH, Hu\u00a0J, Peter I, Zhang W, Ruggiero E, Cho JH, Goodman AL, Flavell RA.
\nCell<\/em>, 2014,\u00a0158(5):1000-10.<\/p>\n
\nHedl M, Lahiri A, Ning K, Cho JH, Abraham C.
\nImmunity<\/em>, 2014,\u00a040(5):734-46.<\/p>\n
\n2013<\/h3>\n
\nZhang W, Hui KY, Gusev A, Warner N, Ng SM, Ferguson J, Choi M, Burberry A, Abraham C, Mayer L, Desnick RJ, Cardinale CJ, Hakonarson H, Waterman M, Chowers Y, Karban A, Brant SR, Silverberg MS, Gregersen PK, Katz S, Lifton RP, Zhao H, Nu\u00f1ez G, Pe’er I, Peter I, Cho JH.
\nGenes and Immunity<\/em>, 2013, 14(5):310-6.<\/p>\n
\nShen H, Zhang W, Abraham C, Cho JH.
\nPLoS<\/em>, \u00a02013,\u00a08(3):e57746.<\/p>\n
\n2012<\/h3>\n
\nJostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K, Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z, Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN, Andersen V, Andrews JM, Baidoo L, Balschun T, Bampton PA, Bitton A, Boucher G, Brand S, B\u00fcning C, Cohain A, Cichon S, D’Amato M, De Jong D, Devaney KL, Dubinsky M, Edwards C, Ellinghaus D, Ferguson LR, Franchimont D, Fransen K, Gearry R, Georges M, Gieger C, Glas J, Haritunians T, Hart A, Hawkey C, Hedl M, Hu X, Karlsen TH, Kupcinskas L, Kugathasan S, Latiano A, Laukens D, Lawrance IC, Lees CW, Louis E, Mahy G, Mansfield J, Morgan AR, Mowat C, Newman W, Palmieri O, Ponsioen CY, Potocnik U, Prescott NJ, Regueiro M, Rotter JI, Russell RK, Sanderson JD, Sans M, Satsangi J, Schreiber S, Simms LA, Sventoraityte J, Targan SR, Taylor KD, Tremelling M, Verspaget HW, De Vos M, Wijmenga C, Wilson DC, Winkelmann J, Xavier RJ, Zeissig S, Zhang B, Zhang CK, Zhao H; International IBD Genetics Consortium (IIBDGC), Silverberg MS, Annese V, Hakonarson H, Brant SR, Radford-Smith G, Mathew CG, Rioux JD, Schadt EE, Daly MJ, Franke A, Parkes M, Vermeire S, Barrett JC, Cho JH.
\nNature<\/em>, 2012,\u00a0491(7422):119-24.<\/p>\n
\nKenny EE, Pe’er I, Karban A, Ozelius L, Mitchell AA, Ng SM, Erazo M, Ostrer H, Abraham C, Abreu MT, Atzmon G, Barzilai N, Brant SR, Bressman S, Burns ER, Chowers Y, Clark LN, Darvasi A, Doheny D, Duerr RH, Eliakim R, Giladi N, Gregersen PK, Hakonarson H, Jones MR, Marder K, McGovern DP, Mulle J, Orr-Urtreger A, Proctor DD, Pulver A, Rotter JI, Silverberg MS, Ullman T, Warren ST, Waterman M, Zhang W, Bergman A, Mayer L, Katz S, Desnick RJ, Cho JH, Peter I.
\nPLoS Genetics<\/em>, 2012, 8(3):e1002559.<\/p>\n
\n2011<\/h3>\n
\nCho JH, Gregersen PK.
\nThe New England journal of Medicine<\/em>, 2011,\u00a0365(17):1612-23.<\/p>\n
\nKang J, Kugathasan S, Georges M, Zhao H, Cho JH; NIDDK IBD Genetics Consortium.
\nPLoS Genetics<\/em>, 2011,\u00a07(4):e1001353.<\/p>\n
\n2010<\/h3>\n
\nKang J, Cho J, Zhao H.
\nJournal of Biopharmaceutical Statistics<\/em>, 2010, 20(2):415-40.<\/p>\n
\n2009<\/h3>\n
\nSilverberg MS, Cho JH, Rioux JD, McGovern DP, Wu J, Annese V, Achkar JP, Goyette P, Scott R, Xu W, Barmada MM, Klei L, Daly MJ, Abraham C, Bayless TM, Bossa F, Griffiths AM, Ippoliti AF, Lahaie RG, Latiano A, Par\u00e9 P, Proctor DD, Regueiro MD, Steinhart AH, Targan SR, Schumm LP, Kistner EO, Lee AT, Gregersen PK, Rotter JI, Brant SR, Taylor KD, Roeder K, Duerr RH.
\nNature Genetics<\/em>, 2009,\u00a041(6):762<\/p>\n
\n2006<\/h3>\n
\nDuerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A, Dassopoulos T, Bitton A, Yang H, Targan S, Datta LW, Kistner EO, Schumm LP, Lee AT, Gregersen PK, Barmada MM, Rotter JI, Nicolae DL, Cho JH.
\nScience<\/em>, 2006,\u00a0314(5804):1461-3.<\/p>\n
\n2001<\/h3>\n
\nOgura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, Achkar JP, Brant SR, Bayless TM, Kirschner BS, Hanauer SB, Nu\u00f1ez G, Cho JH.
\nNature<\/em>, 2001,\u00a0411(6837):603-6.<\/p>\nA complete list of Dr. Judy Cho’s publications can be found in Pubmed<\/a>.<\/h4>\n","protected":false},"excerpt":{"rendered":"