{"id":167,"date":"2014-09-18T20:08:11","date_gmt":"2014-09-18T20:08:11","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/chipuklab\/?page_id=2"},"modified":"2023-04-17T23:04:44","modified_gmt":"2023-04-17T23:04:44","slug":"sample-page-2","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/chipuklab\/sample-page-2\/","title":{"rendered":"Projects"},"content":{"rendered":"

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An untransformed mouse embryonic fibroblast stained with MitoGreen\u00ae (green staining) and Hoechst 33342 (blue staining) to illuminate the mitochondrial network and nucleus, respectively.<\/p><\/div>\n

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Projects<\/strong><\/span><\/h2>\n

My laboratory\u2019s long-term goals are to: (1) provide mechanistic insights of how mitochondrial composition and shape impact on cellular metabolism and commitment to apoptosis, (2) explore how cancer-promoting pathways converge on mitochondrial function to regulate malignancy and chemotherapeutic success, and (3) reveal novel contributions of the mitochondrial network in tissue homeostasis.<\/p>\n

To achieve these goals, my laboratory developed multiple model systems, technologies, and productive collaborations to better understand the intersections between mitochondria, cell biology, and disease. My group revealed that mitochondrial shape, composition, number impact on cellular transformation and sensitivity to conventional and targeted chemotherapeutics. We actively investigate how mitochondrial stress signaling dictates cancer mechanisms (transformation, senescence, malignancy) and the immune landscape in melanomagenesis. In parallel, we translate these fundamental studies into potentially clinically relevant prognostics and therapies by developing antibodies and small molecules that detect and correct disease-related mitochondrial perturbations.<\/p>\n

Grants<\/strong><\/span><\/h2>\n

National Institutes of Health \/ National Cancer Institute<\/p>\n

Melanoma Research Alliance<\/p>\n

National Science Foundation<\/p>\n

Department of Defense \u2013 Melanoma Research Program<\/p>\n

American Cancer Society<\/p>\n

March of Dimes<\/p>\n

Irma T. Hirschl & Monique Weill-Caulier Trust<\/p>\n

JJR Foundation<\/p>\n

Fridolin Trust<\/p>\n

American Skin Association<\/p>\n","protected":false},"excerpt":{"rendered":"

    Projects My laboratory\u2019s long-term goals are to: (1) provide mechanistic insights of how mitochondrial composition and shape impact on cellular metabolism and commitment to apoptosis, (2) explore how cancer-promoting pathways converge on mitochondrial function to regulate malignancy and chemotherapeutic success, and (3) reveal novel contributions of the mitochondrial network in tissue homeostasis. To […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-167","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/chipuklab\/wp-json\/wp\/v2\/pages\/167","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/chipuklab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/chipuklab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/chipuklab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/chipuklab\/wp-json\/wp\/v2\/comments?post=167"}],"version-history":[{"count":2,"href":"https:\/\/labs.icahn.mssm.edu\/chipuklab\/wp-json\/wp\/v2\/pages\/167\/revisions"}],"predecessor-version":[{"id":252,"href":"https:\/\/labs.icahn.mssm.edu\/chipuklab\/wp-json\/wp\/v2\/pages\/167\/revisions\/252"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/chipuklab\/wp-json\/wp\/v2\/media?parent=167"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}