{"id":15,"date":"2026-03-30T13:00:03","date_gmt":"2026-03-30T13:00:03","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/?p=15"},"modified":"2026-03-30T16:49:05","modified_gmt":"2026-03-30T16:49:05","slug":"15-2","status":"publish","type":"post","link":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/15-2\/","title":{"rendered":"Home"},"content":{"rendered":"

Mount Sinai Center for Therapeutics Discovery<\/strong><\/span><\/h1>\n

Mission: To discover innovative small-molecule therapeutics for the treatment of cancers and brain disorders via collaboration with investigators and clinicians.<\/b><\/h2>\n

Director:<\/h3>\n

\"\"<\/h5>\n
Jian\u00a0Jin, PhD.
\nMount Sinai Endowed Professor in Therapeutics Discovery<\/h5>\n

Director, Mount Sinai Center for Therapeutics Discovery
\nProfessor with tenure, Departments of\u00a0Pharmacological Sciences, Oncological Sciences and Neuroscience
\nCo-Leader, Cancer Clinical Investigation Program, Tisch Cancer Institute<\/p>\n

Dr. Jian Jin is currently the Mount Sinai Endowed Professor in Therapeutics Discovery and Director of the Mount Sinai Center for Therapeutics Discovery at Icahn School of Medicine at Mount Sinai (Mount Sinai). He is also a tenured professor in Departments of Pharmacological Sciences, Oncological Sciences and Neuroscience, and a Co-Leader of the Cancer Clinical Investigation Program at The Tisch Cancer Institute at Mount Sinai.<\/p>\n

Dr. Jin is an internationally recognized medicinal chemist and chemical biologist with >25 years of experience in small-molecule drug discovery. His laboratory is a leader in discovering novel degraders targeting oncoproteins, selective inhibitors of histone methyltransferases, and biased ligands of G protein-coupled receptors. Dr. Jin was an Associate Professor in the Division of Chemical Biology and Medicinal Chemistry at the University of North Carolina at Chapel Hill (UNC) and Associate Director of Medicinal Chemistry in the Center for Integrative Chemical Biology and Drug Discovery at UNC from 2008 to 2014.<\/p>\n

Dr. Jin was recruited to Mount Sinai as a professor with tenure in 2014. Dr. Jin has published >300 peer-reviewed papers and delivered >160 invited talks. He is also an inventor of >90 issued U.S. patents and published patent applications. In particular, Dr. Jin is one of several inventors of Daprodustat, a hypoxia-inducible factor (HIF) prolyl hydroxylase small-molecule inhibitor, which has been approved in the U.S. and Japan as an oral medication for the treatment of anemia. Dr. Jin has been inducted to the National Academy of Inventors (NAI) as an NAI Fellow . As the Director of the Mount Sinai Center for Therapeutics Discovery, Dr. Jin is leading research efforts to discover innovative therapeutics for the treatment of human diseases including cancer and brain disorders. Jin Lab Webpage<\/a><\/p>\n

Associate <\/b>Directors<\/b>:<\/b><\/h3>\n

Michael Lazarus is an Associate Professor in the department of Pharmacological Sciences. His lab uses structural biology and chemical biology to study enzymes involved in proteostasis and metabolism in a range of human diseases from cancer to inborn errors of metabolism. His lab uses x-ray crystallography, cryo-EM, and chemical biology to identify and characterize chemical probes targeting enzymes in these pathways.<\/p>\n

\"\"<\/p>\n

Michael Lazarus, PhD<\/b><\/h4>\n
Associate Professor, Department of Pharmacological Sciences<\/h5>\n

Lazarus<\/a>l<\/a><\/strong>Lab<\/strong> <\/a>Webpage<\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

\"\"Daniel <\/b>Wacker<\/b>, <\/b>PhD<\/b>.<\/b>
\nAssociate Professor, Department of Pharmacological Sciences
\nAssociate Professor, Department of Neuroscience
\nWacker Lab Webpage<\/a><\/h6>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

\"\"<\/b>\u00dcmit<\/b> Kaniskan, PhD.<\/b><\/h4>\n
Associate Professor, Department of\u00a0Pharmacological Sciences<\/h5>\n

Assistant Directors<\/h4>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

\"\"<\/b>Yan Xiong, PhD.<\/h4>\n
Assistant Professor, Department of Pharmacological Sciences<\/h5>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Mount Sinai Center for Therapeutics Discovery Mission: To discover innovative small-molecule therapeutics for the treatment of cancers and brain disorders via collaboration with investigators and clinicians. Director: Jian\u00a0Jin, PhD. Mount Sinai Endowed Professor in Therapeutics Discovery Director, Mount Sinai Center for Therapeutics Discovery Professor with tenure, Departments of\u00a0Pharmacological Sciences, Oncological Sciences and Neuroscience Co-Leader, Cancer […]<\/p>\n","protected":false},"author":43,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-15","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/posts\/15","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/users\/43"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/comments?post=15"}],"version-history":[{"count":67,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/posts\/15\/revisions"}],"predecessor-version":[{"id":408,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/posts\/15\/revisions\/408"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/media?parent=15"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/categories?post=15"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/tags?post=15"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}