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Song, X.; Wu, Q.; Chen, L.; Inuzuka, H.; Zhong, Y.; Qi, Y.; Lin, Y.; Kabir, M.; Xiong, Y.*; Wei, W.*; Jin, J.* \u201cDiscovery of New OTUB1 Covalent Ligands via Structure-Activity Relationship Studies for Targeted Protein Stabilization\u201d , Journal of Medicinal Chemistry<\/strong>, 2026 May 4;. doi: https:\/\/doi.org\/10.1021\/acs.jmedchem.5c03327<\/a><\/p>\n Luo, K.; Xue, Z.; Qin, L.; Wang, Z.; Gao, P.; Xie, L.; Su, Y.; Chen, X.; Kaniskan, H. \u00dc.*; Wen, H.*; Jin, J.* \u201cDiscovery of a Highly Potent and Selective ENL Degrader\u201d Journal of Medicinal Chemistry <\/strong> , 2026 Apr 23;. doi: 10.1021\/acs.jmedchem.6c00386 doi:https\/\/doi.org\/10.1021\/acs.jmedchem.6c00386<\/a>.PMID: 42025203<\/a><\/p>\n Gao, P.; Zhong, Y.; Luo, K.; Jin, J.* “Bridged PROTAC, DNA-based PROTAC and hydrophobic tag technologies for targeted protein degradation” Advanced Drug Delivery Reviews <\/strong>, 2026, 232, 115819. PMID: 41707939<\/a>\u00a0 doi: Chen, H.; Dutta, R. P.; Li, Z.; Zhong, Y.; Ma, A.; Park, K. S.; Kottur, J.; Park, A.; Babault, N.; Wang, K.; Wang, D.; Xiong, Y.; Kaniskan, H. \u00dc.; Luo, M.; Parekh, S.; Jin, J.*, \u201cDiscovery of a Potent, Selective, and In Vivo Efficacious Covalent Inhibitor for Lysine Methyltransferase SETD8\u201d,\u00a0Journal of Medicinal Chemistry<\/strong>, 2026, 69(4), 4255-4269. doi: Yim, H.; Song, X.; Zhong, Y.; Hu, J.; Xiong, Y.; Jin, J.*, \u201cDiscovery of KRAS-G12D degraders via exploration of various E3 ligases\u201d,\u00a0European Journal of Medicinal Chemistry<\/strong>, 2026, 307, 118635. PMID:41679196 , <\/a>doi: https:\/\/doi.org\/10.1016\/j.ejmech.2026.118635<\/a><\/p>\n Xia, Z.; Yang, X.; Samovich, S. N.; Tyurina, Y. Y.; Tyurin, V. A.; Kon, N.; Zhang, J.; Jiang, X.; Stockwell, B. R.; Jin, J.; Bayir, H.; Kagan, V. E.; Gu, W.*, \u201cA GPX1\u2013OSBPL8 Axis Mediates Noncanonical In Vivo Ferroptosis and Cancer Growth Suppression\u201d,\u00a0Cell\u00a0<\/strong>, 2026, Feb 19, doi:https:\/\/doi.org\/10.1016\/j.cell.2026.01.009<\/a> PMCID: PMC12927606.<\/p>\n Gelles, J. D.; Chen, Y.; Luna-Vargas, M. P. A.; Viacava Follis, A.; Al Noman, M. A.; Kabir, M.; Bayiokos, S. G.; Mohammed, J. N.; Sebastian, T. M.; Pham, N. D.; Shi, Y.; Jin, J.; Kriwacki, R. W.; Chipuk, J. E.*, \u201cA gated hydrophobic funnel within BAX binds bioactive lipids to potentiate pro-apoptotic function\u201d,\u00a0Nature Communications\u00a0<\/strong>, 2026, Feb 25. DOI: 10.1016\/j.cell.2026.01.009 https:\/\/doi.org\/10.1016\/j.cell.2026.01.009<\/a><\/p>\n Wang, Y.; Xiong, Y.; Liu, S.; Bao, L.; Qiu, X.; Korboukh, I.; Song, X.; Toffessi Tcheuyap, V.; Wu, S.; Chen, M.; Brugarolas, J.; Jin, J.; Wang, Y.; Luo, W.*, \u201cHIF-activated priming of TRAIL-induced cell death determines epigenetic vulnerability in kidney cancer\u201d,\u00a0Cell Reports Medicine<\/strong>, 2026, Feb 18, 102630. doi: Yi, Y.; Li, Y.; Wang, R.; Yu, X.; Liu, Q.; Yum, C.; Zhang, Y.; Qiao, Y.; Szczepanski, A.; Wu, S.; Li, Q.; Fazli, L.; Shen, J.; Wang, X.; Li, X.; Mu, P.; Schaeffer, E. M.; Hundley, H. A.; Niu, H.; Chinnaiyan, A. M.; Wang, L.; Shi, J.; Jin, J.; Dong, X.; Zhao, W.; Chen, K.; Cao, Q.*, \u201cA dual role of EZH2 in regulating A-to-I RNA editing and mRNA stability through ADAR\u201d,\u00a0Nature Communications<\/strong>, 2026,\u00a0 PMID: 41882000<\/a><\/p>\n Yi, Y.; Fry, J.; Yum, C.; Wang, R.; Wu, S.; Narayan, S.; Liu, Q.; Zhang, X.; Oo, H. Z.; Xie, N.; Li, Y.; Gao, X.; Yu, X.; Hu, X.; Li, Q.; Keseroglu, K.; \u00d6zbudak, E. M.; Abdulkadir, S. A.; Chen, K.; Jin, J.; Zhao, J. C.; Dong, X.; Arango, D.; Yang, R.; Cao, Q.*, \u201cEZH2 crosstalk with RNA methylation promotes prostate cancer progression through modulation of the m6A autoregulation pathway\u201d\u00a0Journal of Clinical Investigation<\/strong>, 2026, 136(2). doi: 10.1172\/JCI195840. https:\/\/doi.org\/10.1172\/JCI195840<\/a> PMCID: PMC12807473. PMID:\u00a0<\/span>41252201<\/strong><\/span><\/p>\n <\/p>\n Posted on: May 26, 2026<\/span><\/p>\n","protected":false},"excerpt":{"rendered":" Song, X.; Wu, Q.; Chen, L.; Inuzuka, H.; Zhong, Y.; Qi, Y.; Lin, Y.; Kabir, M.; Xiong, Y.*; Wei, W.*; Jin, J.* \u201cDiscovery of New OTUB1 Covalent Ligands via Structure-Activity Relationship Studies for Targeted Protein Stabilization\u201d , Journal of Medicinal Chemistry, 2026 May 4;. doi: https:\/\/doi.org\/10.1021\/acs.jmedchem.5c03327 Luo, K.; Xue, Z.; Qin, L.; Wang, Z.; […]<\/p>\n","protected":false},"author":43,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-447","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/pages\/447","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/users\/43"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/comments?post=447"}],"version-history":[{"count":4,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/pages\/447\/revisions"}],"predecessor-version":[{"id":451,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/pages\/447\/revisions\/451"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/media?parent=447"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nhttps:\/\/doi.org\/10.1016\/j.addr.2026.115819<\/a>.<\/p>\n
\nhttps:\/\/doi.org\/10.1021\/acs.jmedchem.5c02958<\/a>PMID: 41693203<\/a><\/p>\n
\n10.1016\/j.xcrm.2026.102630. https:\/\/doi.org\/10.1016\/j.xcrm.2026.102630<\/a><\/p>\n