{"id":374,"date":"2025-12-10T17:21:33","date_gmt":"2025-12-10T17:21:33","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/?page_id=374"},"modified":"2025-12-10T20:10:03","modified_gmt":"2025-12-10T20:10:03","slug":"2024-publications","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/2024-publications\/","title":{"rendered":"2024 Publications"},"content":{"rendered":"

2024 Publications<\/strong><\/p>\n

Kabir. M.; Hu, X.<\/u> Martin, T. C.; Pokushalov, D.; Kim, Y. J.; Chen, Y.; Zhong, Y.;\u00a0Wu, Q; Chipuk, J. Y.; Shi, Y; Xiong, Y.; Gu, W.; Parsons, R. E.;\u00a0and\u00a0Jin, J.* Advanced Science.<\/strong>, \u201cHarnessing the TAF1 Acetyltransferase for Targeted Acetylation of the Tumor Suppressor p53\u201d, 2024, doi: http:\/\/doi.org\/10.1002\/advs.202413377<\/a> <\/span><\/p>\n

Martinez, Criseyda; Xiong, Yan;<\/u> Bartkowski, Alison; Harada, Ibuki; Ren, Xiaoxiao; Byerly, Jessica; Port, Elisa; Jian\u00a0Jin*; Irie, Hanna*. Cell Chemical Biology<\/strong>, \u201cA PROTAC degrader suppresses oncogenic functions of PTK6 inducing apoptosis of breast cancer cells\u201d, 2024, doi: https:\/\/doi.org\/10.1016\/j.chembiol.2024.10.008<\/a>
\nPMID: 39541980<\/a> <\/span><\/p>\n

Inuzuka, H; Qian, Chao; Qi,Y; <\/u> Xiong, Y; Wang, C;Wang,Z; Zhang, D;Zhang, C; Jin, J*; Wei, W*; ACS Pharmacology & Translational Science <\/strong>, \u201cTargeted Degradation of Receptor-Interacting Protein Kinase 1 to Modulate the Necroptosis Pathway\u201d, https:\/\/doi.org\/10.1021\/acsptsci.4c00421<\/a> 2024, 7, 3518-3526.<\/span><\/p>\n

Corbin, J.; Yu, X.; Cai, L.; Jin, J.; Wang, G. G.* Oncogene <\/strong>, \u201cEZH2 PROTACs target EZH2- and FOXM1-associated oncogenic nodes, suppressing breast cancer cell growth\u201d, 2024, 43, 2722-2736. PMID:39112519<\/a> <\/span><\/p>\n

Xue Z;\u00a0Qin L; Xuan H; Luo K<\/u>; Huang M; Xie L; Su Y; Xu L; Harsh J; Dale B; Shi X; Chen X; Kaniskan H\u00dc; Jin J;\u00a0*.\u00a0<\/b>, Wen H.*, \u201cA potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression.\u201d.
\nScience Advances<\/strong>, 2024 Aug 30;10(35):eado1432. doi: 10.1126\/sciadv.ado1432. Epub 2024 Aug 28. PMID:39196923<\/a>.\u00a0PMCID:\u00a0PMC11352836<\/p>\n

Graboski, A.L.;Simpson,J.B.;<\/u> Pellock;S.J.; Mehta, N.; Creekmore, B.C.; Ariyarathna; Y. ;Bhatt, A.P.; Jariwala,P.B.; Sekela, J.J.; Kowalewski, M.E.; Barker, N.K.; Mordant, A.L.; Borlandelli, V.B.; Overkleeft, H.; Herring, L.E.; Jin, J.*. ; I James L, Redinbo,M.R.. RSC Chemical Biology Journal<\/strong>, \u201cAdvanced piperazine-containing inhibitors target microbial \u03b2-glucuronidases linked to gut toxicity.\u201d PMID:39211470<\/a> ; PubMed Central PMCID: PMC11353122. RSC Chemical Biology. 2024 Jul 16;5(9):853-865<\/p>\n

Hu,X; Kabir, M;<\/u> Lin, Y; Xiong Y; Parsons, R;\u00a0\u00a0<\/span>Gu, W; Jin, J*<\/b>\u201cDesign, Synthesis, and Evaluation of p53Y220C Acetylation Targeting Chimeras (AceTACs)\u201d,\u00a0Journal of Medicinal Chemistry<\/strong><\/i><\/a>, August, 2024.<\/i><\/p>\n

Wang, S, E.; Xiong, Y.<\/u>; Jang, M, A,; Park, K, S.; Donahue, M.; Velez J.; Jin J.*; Jiang, Y, H.*, \u201cNewly developed oral bioavailable EHMT2 inhibitor as a potential epigenetic therapy for Prader-Willi syndrome\u201d,\u00a0Molecular Therapy<\/strong>, 2024, PMID:38796700<\/a>. doi: 10.1016\/j.ymthe.2024.05.034.<\/p>\n

Kabir, M.<\/u>;\u00a0 Qin, L.<\/u>;\u00a0 Luo, K.;\u00a0 Xiong, Y.;\u00a0 Sidi, R. A.;\u00a0 Park, K.-S.*; Jin, J.*, Discovery and characterization of a novel Cereblon-recruiting PRC1 bridged PROTAC degrader.\u00a0Journal of Medicinal Chemistry<\/strong>. <\/em>2024,\u00a067<\/span>(8)<\/span>:6880-6892. <\/span>PMID: 38607318<\/a>.<\/span><\/p>\n

Velez, J.<\/u>;\u00a0 Han, Y.<\/u>;\u00a0 Yim, H.;\u00a0 Yang, P.;\u00a0 Deng, Z.;\u00a0 Park, K.-s.;\u00a0 Kabir, M.;\u00a0 Kaniskan, H. \u00dc.;\u00a0 Xiong, Y.*; Jin, J.*, Discovery of the first-in-class G9a\/GLP PROTAC degrader. Journal of Medicinal Chemistry.<\/em><\/strong> 2024,<\/strong>\u00a067<\/span>(8)<\/span>:6397-6409.<\/span><\/i>\u00a0PMID: 38295690.<\/a><\/p>\n

Kim, Y.<\/u>;\u00a0 Gumpper, R. H.;\u00a0 Liu, Y.<\/u>;\u00a0 Kocak, D. D.;\u00a0 Xiong, Y.;\u00a0 Cao, C.;\u00a0 Deng, Z.;\u00a0 Krumm, B. E.;\u00a0 Jain, M. K.;\u00a0 Zhang, S.;\u00a0 Jin, J.; Roth, B. L., Bitter taste receptor activation by cholesterol and an intracellular tastant. Nature <\/em>2024<\/strong>, 628<\/span>(8008)<\/span>:664-671<\/span>. PMID: 38600377.<\/a><\/p>\n

Liu, J.<\/u>;\u00a0 Hu, X.;<\/u>\u00a0 Luo, K<\/u>.;\u00a0 Xiong, Y.<\/u>;\u00a0 Chen, L.<\/u>;\u00a0 Wang, Z.;\u00a0 Inuzuka, H.;\u00a0 Qian, C.;\u00a0 Yu, X.;\u00a0 Xie, L.;\u00a0 Muneer, A.;\u00a0 Zhang, D.;\u00a0 Paulo, J. A.;\u00a0 Chen, X.;\u00a0 Jin, J.*; Wei, W.*, USP7-based deubiquitinase-targeting chimeras stabilize AMPK. Journal of the American Chemical Society. <\/em><\/strong>2024,146, 16, 11507\u201311514. PMID:38597345.<\/a><\/p>\n

Xiong, Y.<\/u>;\u00a0 Greschik, H.<\/u>;\u00a0 Johansson, C.;\u00a0 Seifert, L.;\u00a0 Gamble, V.;\u00a0 Park, K.-s.;\u00a0 Fagan, V.;\u00a0 Li, F.;\u00a0 Chau, I.;\u00a0 Vedadi, M.;\u00a0 Arrowsmith, C. H.;\u00a0 Brennan, P.;\u00a0 Fedorov, O.;\u00a0 Jung, M.;\u00a0 Farnie, G.;\u00a0 Liu, J.;\u00a0 Oppermann, U. *;\u00a0 Sch\u00fcle, R. *; Jin, J. *, Discovery of a potent, selective, and cell-active SPIN1 inhibitor. Journal of Medicinal Chemistry<\/strong>.<\/em> 2024, 67(7):5837-5853. PMID:\u00a0<\/strong><\/span>38533580.<\/a><\/span><\/p>\n

Nylund, P. <\/u>;\u00a0, Garrido-Zabala, B.;\u00a0 P\u00e1rraga, A. A.;\u00a0 Vasquez, L.;\u00a0 Pyl, P. T.;\u00a0 Harinck, G. M.;\u00a0 Ma, A.; \u00a0Jin, J.;\u00a0 \u00d6berg, F.;\u00a0 Kalushkova, A.; Wiklund, H. J.*, PVT1 interacts with polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma.\u00a0 Haematologica<\/em><\/strong> 2024, 109<\/em> (2): 567-577. PMID: 37496441.<\/a><\/p>\n

Wang, Z.<\/u>;\u00a0 Zhang, D.;\u00a0 Qiu, X.;\u00a0 Inuzuka, H.;\u00a0 Xiong, Y.;\u00a0 Liu, J.;\u00a0 Chen, L.;\u00a0 Chen, H.;\u00a0 Xie, L.;\u00a0 Kaniskan, H. \u00dc.;\u00a0 Chen, X.;\u00a0 Jin, J. *; Wei, W. *, Structurally specific Z-DNA proteolysis targeting chimera enables targeted degradation of adenosine deaminase acting on RNA 1. Journal of the American Chemical Society.<\/em> <\/strong>2024,\u00a0 146<\/em> (11): 7584-7593. PMID:\u00a0<\/span>38469801.<\/a><\/span><\/p>\n

Posted on:\u00a0Dec, 10, 2025<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

2024 Publications Kabir. M.; Hu, X. Martin, T. C.; Pokushalov, D.; Kim, Y. J.; Chen, Y.; Zhong, Y.;\u00a0Wu, Q; Chipuk, J. Y.; Shi, Y; Xiong, Y.; Gu, W.; Parsons, R. E.;\u00a0and\u00a0Jin, J.* Advanced Science., \u201cHarnessing the TAF1 Acetyltransferase for Targeted Acetylation of the Tumor Suppressor p53\u201d, 2024, doi: http:\/\/doi.org\/10.1002\/advs.202413377 Martinez, Criseyda; Xiong, Yan; Bartkowski, Alison; […]<\/p>\n","protected":false},"author":43,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-374","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/pages\/374","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/users\/43"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/comments?post=374"}],"version-history":[{"count":6,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/pages\/374\/revisions"}],"predecessor-version":[{"id":397,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/pages\/374\/revisions\/397"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/media?parent=374"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}