{"id":334,"date":"2025-05-20T17:19:02","date_gmt":"2025-05-20T17:19:02","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/?page_id=334"},"modified":"2025-12-10T20:08:36","modified_gmt":"2025-12-10T20:08:36","slug":"2023-publications","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/2023-publications\/","title":{"rendered":"2023 Publications"},"content":{"rendered":"

 <\/p>\n

2023 Publications<\/strong><\/p>\n

Selective 11 of total 24 of 2023 Publications<\/strong><\/p>\n

Dang, F.;<\/u> Bai, L.;<\/u> Dong, J.;<\/u> Hu, X.;<\/u> Wang, J.; Paulo, J. A.; Xiong, Y.; Liang, X.; Sun, Y.; Chen, Y.; Guo, M.; Wang, X.; Huang, Z.; Inuzuka, H.; Chen, L.; Chu, C.; Liu, J.; Zhang, T.; Rezaeian, A.-H.; Liu, J.; Kaniskan, H. \u00dc.; Zhong, B.; Zhang, J.; Letko, M.; Jin, J. *; Lan, K. *; Wei, W. *, USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice.\u00a0 Science Translational Medicine<\/strong>. 2023,<\/strong> 15<\/em> (725): eadh7668. PMID: 38055802<\/a>.<\/p>\n

Yu, X.; Li, D.; Kottur, J.<\/u>; Kim, H. S.; Herring, L. E.; Yu, Y.; Xie, L.; Hu, X.; Chen, X.; Cai, L.; Liu, J.; Aggarwal, A. K.; Wang, G. G. *; Jin, J.*, Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer. Journal of Medicinal Chemistry<\/strong>. <\/em><\/strong>2023, <\/strong><\/em>66(23): 16168\u201316186. PMID: 38019706.<\/a><\/span><\/p>\n

Wang Z.; Liu J.; Qiu X.; Zhang D.; Inuzuka H.; Chen L.; Chen H.; Xie L.; Kaniskan H\u00dc.; Chen X.; Jin J.* ; Wei W.* , Methylated Nucleotide-Based Proteolysis-Targeting Chimera Enables Targeted Degradation of Methyl-CpG-Binding Protein 2. Journal of the American Chemical Society <\/strong><\/em>. 2023, 145(40): 21871\u201321878. PMID: 37774414<\/a>.<\/span><\/p>\n

Kabir, M.; Sun, N.; Hu, X.;<\/span> Martin, T. C.; Yi, J.; Zhong, Y.; Xiong, Y.; Kaniskan, H. \u00dc.; Gu, W.; Parsons, R.; Jin, J.*; Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor p53. Journal of the American Chemical Society<\/em><\/strong>\u00a02023,\u00a0145(27):14932-14944. PMID: 37365684.<\/span><\/a><\/p>\n

Velez, J.; Kaniskan, H. \u00dc.*; Jin, J.*; Recent advances in developing degraders & inhibitors of lysine methyltransferases. Current Opinion in Chemical Biology,<\/strong>\u00a02023, 76:102356. PMID: 37379717.<\/span><\/a><\/p>\n

Kabir, M.; Yu, X.; Kaniskan, H. \u00dc.*; Jin, J.*; Chemically induced degradation of epigenetic targets. Chemical Society Reviews,<\/em><\/strong>\u00a0<\/strong><\/em>2023, 52(13):4313-4342. PMID:\u00a0<\/span>37314393.<\/span><\/a><\/span><\/span><\/p>\n

Zhao, N.; Ho, J. S. Y.; Meng, F.;<\/span> Zheng, S.; Kurland, A. P.; Tian, L.; Rea-Moreno, M.; Song, X.; Seo, J. S.; Kaniskan, H. \u00dc.; Te Velthuis, A. J. W.; Tortorella, D.; Chen, Y. W.; Johnson, J. R.; Jin, J.*; Marazzi, I.*; Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics. Cell Host Microbe,<\/strong><\/em>\u00a02023, 31(7):1154-1169.e10. PMID: 37339625.<\/span><\/a><\/p>\n

Yu, X.; Wang, J.;<\/span> Gong, W.; Ma, A.; Shen, Y.; Zhang, C.; Liu, X.; Cai, L.; Liu, J.; Wang, G. G.*; Jin, J.*; Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader. Oncogene<\/i><\/strong>, 2023, 42(13):994-1009. PMID:\u00a0<\/span>36747009.<\/span><\/span><\/a><\/span><\/p>\n

Park, K. S.; Qin, L.; Kabir, M.; Luo, K.; Dale, B.; Zhong, Y.; Kim, A.; Wang, G. G.; Kaniskan, H. \u00dc.; Jin, J*; Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy. Advanced science (Weinheim, Baden-W\u00fcrttemberg, Germany)<\/strong>.<\/strong><\/i>\u00a02023, 10(10):e2205573. PMID:\u00a0<\/a><\/span><\/span>36737841.<\/span><\/a><\/span><\/span><\/p>\n

Sun, N.; Kabir, M.;<\/span> Lee, Y.; Xie, L.; Hu, X.; Velez, J.; Chen, X.; Kaniskan, H. \u00dc.*; & Jin, J*; Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer. Journal of Medicinal Chemistry. <\/i><\/strong>2023, 66(1):596-610. PMID:\u00a0<\/span>36538511.<\/span><\/a><\/span><\/p>\n

Marcellino, B. K.; Yang, X.; \u00dcmit Kaniskan, H.;<\/span> Brady, C.; Chen, H.; Chen, K.; Qiu, X.; Clementelli, C.; Herschbein, L.; Li, Z.; Elghaity-Beckley, S.; Arandela, J.; Kelly, B.; Hoffman, R.; Liu, J.; Xiong, Y.; Jin, J.*; Shih, A. H.*; An MDM2 degrader for treatment of acute leukemias. Leukemia<\/i><\/strong>, 2023, 37(2):370-378. PMID:\u00a0<\/span>36309559<\/a><\/span><\/span><\/p>\n

Uma\u00f1a, J.D.; Wasserman S.R.; Song L; Goel A.A; Yu X.; Jin J; Hathaway N.A. *, Chemical Epigenetic Regulation of Adeno-Associated Virus Delivered Transgenes.\u00a0Human Gene Therapy<\/strong>.<\/em> 2023, 34(17-18): 947-957. PMID: 37624737<\/a>. <\/span><\/p>\n

Pogorelov, V. M.*; Martini, M. L.; Jin, J.; Wetsel, W. C.;* Caron, M. G., Dopamine-Depleted Dopamine Transporter Knockout (DDD) Mice: Dyskinesia with L-DOPA and Dopamine D1 Agonists. Biomolecules<\/strong><\/em>, 2023, 13(11): 1658. PMID: 38002340<\/a>.<\/span><\/p>\n

Muneer, A.;Wang, L.; Xie, L.; Zhang, F.; Wu, B.; Mei, L.; Lenarcic, E. M.; Feng, E. H.; Song, J.; Xiong, Y.; Yu, X.; Wang, C.; Jain, K.; Strahl, B.; Cook, J. G.; Wan, Y. Y.; Moorman, N. J.; Song, H.; Jin, J.; Chen, X. *, “Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation.” Cell Chemical Biology<\/span><\/strong>, 2023, 30:1525-1541.e7. PMID: 37858336<\/a>.<\/span><\/p>\n

Gray, Z. H.;Chakraborty, D.;\u00a0 Duttweiler, R. R.; Alekbaeva, G. D.;\u00a0 Murphy, S. E.;\u00a0 Chetal, K.;\u00a0 Ji, F.;\u00a0 Ferman, B. I.;\u00a0 Honer, M. A.;\u00a0 Wang, Z.;\u00a0 Myers, C.;\u00a0 Sun, R.;\u00a0 Kaniskan, H. \u00dc.;\u00a0 Toma, M. M.;\u00a0 Bondarenko, E. A.;\u00a0 Santoro, J. N.;\u00a0 Miranda, C.;\u00a0 Dillingham, M. E.;\u00a0 Tang, R.;\u00a0 Gozani, O.;\u00a0 Jin, J.;\u00a0 Skorski, T.;\u00a0 Duy, C.;\u00a0 Lee, H.;\u00a0 Sadreyev, R. I.; Whetstine, J. R.*, Epigenetic balance ensures mechanistic control of MLL<\/em> amplification and rearrangement. Cell<\/strong>, <\/em>2023, 186(21):4528-4545.e18. PMID: 37788669<\/a>.<\/span><\/p>\n

Salas-Estrada, L.; Provasi, D.; Qiu, X.; Kaniskan, H. \u00dc.; Huang, X. P.; DiBerto, J. F.; Lamim Ribeiro, J. M.; Jin, J.; Roth, B. L.; Filizola, M.; De Novo Design of \u03ba-Opioid Receptor Antagonists Using a Generative Deep-Learning Framework. Journal of Chemical Information and Modeling<\/strong>,\u00a063<\/i>(16): 5056\u20135065. PMID:\u00a0<\/span>37555591<\/span>.<\/a><\/span><\/p>\n

Rialdi, A.; Duffy, M.; Scopton, A. P.; Fonseca, F.; Zhao, J. N.; Schwarz, M.; Molina-Sanchez, P.; Mzoughi, S.; Arceci, E.; Abril-Fornaguera, J.; Meadows, A.; Ruiz de Galarreta, M.; Torre, D.; Reyes, K.; Lim, Y. T.; Rosemann, F.; Khan, Z. M.; Mohammed, K.; Wang, X.; Yu, X.; Jin, J.; Guccione, E; Dar, A. C.; WNTinib is a multi-kinase inhibitor with specificity against \u03b2-catenin mutant hepatocellular carcinoma. Nature cancer<\/strong>, 2023, 4(8):1157-1175. PMID:\u00a0<\/span>37537299.<\/span><\/a><\/span><\/span><\/p>\n

Gao, J.; Yang, L.; Lei, S.; Zhou, F.; Nie, H.; Peng, B.; Xu, T.; Chen, X.; Yang, X.; Sheng, C.; Rao, Y.; Pu, K.; Jin, J.; Xu, Z.; Yu, H.; Stimuli-activatable PROTACs for precise protein degradation and cancer therapy. Science bulletin<\/i><\/strong>, 2023, 68<\/i>(10): 1069\u20131085. PMID: 37169612.<\/span><\/a><\/span><\/p>\n

Schwalm, M. P.; Kr\u00e4mer, A.; D\u00f6lle, A.; Weckesser, J.; Yu, X.; Jin, J.; Saxena, K.; Knapp, S.; Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization. Cell Chemical Biology,<\/strong>\u00a02023, 30:753-765.e8. PMID: 37354907.<\/span><\/a><\/span><\/p>\n

Yi, J.; Li, H.; Chu, B.; Kon, N.; Hu, X.; Hu, J.; Xiong, Y.; Kaniskan, H. U.; Jin, J.; Gu, W*; Inhibition of USP7 induces p53-independent tumor growth suppression in triple-negative breast cancers by destabilizing FOXM1. Cell Death & Differentiation<\/strong>,<\/strong><\/em>\u00a02023, 30(7):1799-1810. PMID:\u00a0<\/span>37291217.<\/span><\/a><\/span><\/span><\/p>\n

Singh, I.; Li, F.; Fink, E. A.;<\/span> Chau, I.; Li, A.; Rodriguez-Hern\u00e1ndez, A.; Glenn, I.; Zapatero-Belinch\u00f3n, F. J.; Rodriguez, M. L.; Devkota, K.; Deng, Z.; White, K.; Wan, X.; Tolmachova, N. A.; Moroz, Y. S.; Kaniskan, H. \u00dc.; Ott, M.; Garc\u00eda-Sastre, A.; Jin, J.; Fujimori, D. G.; Shoichet, B. K.*; Structure-Based Discovery of Inhibitors of the SARS-CoV-2 Nsp14 N7-Methyltransferase. J. Med. Chem, <\/i><\/strong>2023, 66(12):7785-7803. PMID:\u00a0<\/span>37294077.<\/a><\/span><\/span><\/span><\/p>\n

Wang, Z.; Liu, J.<\/span>; Chen, H.; Qiu, X.; Xie, L.; Kaniskan, H. \u00dc.; Chen, X.; Jin, J.*; Wei, W.*; Telomere Targeting Chimera Enables Targeted Destruction of Telomeric Repeat-Binding Factor Proteins. Journal of the American Chemical Society<\/strong>.<\/strong><\/em> 2023, 145(19):10872-10879. PMID: 37141574.<\/span><\/a><\/p>\n

Qiang, N.; Ao, J.; Nakamura, M.*; Chiba, T.; Kusakabe, Y.; Kaneko, T.; Kurosugi, A.; Kogure, T.; Ma, Y.; Zhang, J.; Ogawa, K.; Kan, M.; Iwanaga, T.; Sakuma, T.; Kanayama, K.; Kanzaki, H.; Kojima, R.; Nakagawa, R.; Kondo, T.; Nakamoto, S.; \u2026 Jin, J.; Kato, N.; Alteration of the tumor microenvironment by pharmacological inhibition of EZH2 in hepatocellular carcinoma. Int immunopharmacol.<\/i><\/strong> 2023, 118:110068. PMID:\u00a0<\/span>37001386.<\/span><\/a><\/span><\/span><\/p>\n

Vital, T.; Wali, A.; Butler, K. V.; Xiong, Y.; Foster, J. P.; Marcel, S. S.; McFadden, A. W.; Nguyen, V. U.; Bailey, B. M.; Lamb, K. N.; James, L. I.; Frye, S. V.; Mosely, A. L.; Jin, J.; Pattenden, S. G.; Davis, I. J.*; MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing. Frontiers in Oncology<\/strong><\/em>, 2023, 13:1099550. PMID:\u00a0<\/span>36793594.<\/a><\/span><\/span><\/span><\/p>\n

For papers published before 2023, please see Dr. Jin’s full publication list <\/strong><\/p>\n

Jin Lab Full Publication List<\/strong><\/a>
\nDec 10, 2025<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

  2023 Publications Selective 11 of total 24 of 2023 Publications Dang, F.; Bai, L.; Dong, J.; Hu, X.; Wang, J.; Paulo, J. A.; Xiong, Y.; Liang, X.; Sun, Y.; Chen, Y.; Guo, M.; Wang, X.; Huang, Z.; Inuzuka, H.; Chen, L.; Chu, C.; Liu, J.; Zhang, T.; Rezaeian, A.-H.; Liu, J.; Kaniskan, H. \u00dc.; […]<\/p>\n","protected":false},"author":43,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-334","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/pages\/334","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/users\/43"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/comments?post=334"}],"version-history":[{"count":7,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/pages\/334\/revisions"}],"predecessor-version":[{"id":339,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/pages\/334\/revisions\/339"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/media?parent=334"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}