{"id":329,"date":"2025-05-20T17:14:56","date_gmt":"2025-05-20T17:14:56","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/?page_id=329"},"modified":"2025-12-10T20:10:20","modified_gmt":"2025-12-10T20:10:20","slug":"2022-publications","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/2022-publications\/","title":{"rendered":"2022 Publications"},"content":{"rendered":"

Selective 14 of total 20 of 2022 Publications<\/strong><\/p>\n

Jin, J.*<\/span>; Dar, A. C.; Doroshow, D. \u201cAdvancing Cancer Precision Medicine by Creating a Better Toolbox for Cancer Therapy\u201d in The Frontiers of Medical Research: Cancer<\/span> (Science\/AAAS, Washington, DC, 2022), pp. 10-12.<\/p>\n

Xiong, Y.; Zhong, Y.; Yim, H.<\/span>; Yang, X.; Park, K. S.; Xie, L.; Poulikakos, P. I.; Han, X.; Xiong, Y.; Chen, X.; Liu, J.; Jin, J.*; Bridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets. Journal of the American Chemical Society<\/strong><\/em>. 2022, 144(49):22622-22632. PMID:\u00a0<\/span>36448571.<\/span><\/a><\/span><\/p>\n

Yu, X.; Cheng, M.; Lu, K.; Shen, Y.; Zhong, Y.; Liu, J.*; Xiong, Y.*; Jin, J.*, \u201cExploring Degradation of Mutant and Wild-Type Epidermal Growth Factor Receptors Induced by Proteolysis-Targeting Chimeras\u201d , Journal of Medicinal Chemistry\u00a0<\/strong>, 2022, volume 65, 8416-8443.,\u00a0DOI: https:\/\/doi.org\/10.1021\/acs.jmedchem.2c01454<\/a><\/p>\n

Wang, J.; Park, K. S.;<\/span> Yu, X.; Gong, W.; Earp, H. S.; Wang, G. G.*; Jin, J.; * Cai, L.*; A cryptic transactivation domain of EZH2 binds AR and AR’s splice variant, promoting oncogene activation and tumorous transformation. Nucleic acids research<\/i>,<\/strong> 2022, 50(19):10929-10946.\u00a0PMID:\u00a0<\/span>36300627.<\/a><\/span><\/span><\/p>\n

Yu, X.; Xu, J.; Cahuzac, K. M.; Xie, L.; Shen, Y.; Chen, X.; Liu, J.*; Parsons, R. E.*; Jin, J*; Novel Allosteric Inhibitor-Derived AKT Proteolysis Targeting Chimeras (PROTACs) Enable Potent and Selective AKT Degradation in KRAS\/BRAF Mutant Cells. Journal of Medicinal Chemistry<\/strong>,\u00a0<\/i><\/strong>2022, 65(20):14237-14260. PMID:\u00a0<\/span>36197750.<\/span><\/a><\/span><\/p>\n

Zhang, S.; Chen, H.; Zhang, C.; Yang, Y.; Popov, P.; Liu, J.; Krumm, B. E.; Cao, C.; Kim, K.; Xiong, Y.; Katritch, V.; Shoichet, B. K.; Jin, J.; Fay, J. F.*; Roth, B. L.*; Inactive and active state structures template selective tools for the human 5-HT5A<\/sub> receptor. Nature Structural & Molecular Biology<\/strong><\/em>. 2022, 29(7), 677-687. PMID: 35835867.<\/span><\/a><\/p>\n

Meng, F.; <\/span>Xu, C.; <\/span>\u00a0Park, K. S.; Kaniskan, H. U.<\/span>*; <\/strong>Wang, G. G.<\/span>* <\/strong>Jin, J.*; <\/strong>Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros\/Aiolos. Journal of Medicinal Chemistry<\/strong>. <\/i>2022, 65(15), 10611-10625. PMID:\u00a0<\/span>35895319.<\/span><\/a><\/span><\/p>\n

Park, K. S.; Xiong, Y.*<\/span>; Yim, H.; Velez, J.; Babault, N.; Kumar, P.; Liu, J.; Jin, J.*; Discovery of the First-in-Class G9a\/GLP Covalent Inhibitors. Journal of Medicinal Chemistry<\/strong>.<\/em> 2022, 65(15), 10506-10522. PMID: 35763668<\/a>.<\/span><\/p>\n

Liu, J.; Yu, X.<\/span>; Chen, H.; Kaniskan H. \u00dc.; Xie, L.; Chen, X.; Jin, J*.; Wei, W*.; TF-DUBTACs Stabilize Tumor Suppressor Transcription Factors. Journal of the American Chemical Society<\/em><\/strong>. 2022, 144(28), 12934-12941. PMID: 35786952.<\/a><\/span><\/p>\n

Dale, B.; Anderson, C.<\/span>; Park, K. S.; Kaniskan H. U.; Ma, A.; Shen Y.; Zhang, C.; Xie, L.; Chen, X.; Yu, X.*; Jin, J.*; Targeting Triple-Negative Breast Cancer by a Novel Proteolysis Targeting Chimera Degrader of Enhancer of Zeste Homolog 2. ACS Pharmacol. Transl. Sci<\/strong>.<\/i><\/span>\u00a02022<\/span>, 5<\/span>, 7<\/span>, 491\u2013507. PMID: 3583371<\/a><\/span><\/span><\/p>\n

Xiong, Y.; Zhong, Y.; Yim, H.; Yang, X.; Park, K.-S.; Xie, L.; Poulikakos, P. I.; Han, X.; Chen, X.; Liu, J.; Jin, J.* ; \u201cBridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets\u201d. Journal of the American Chemical Society<\/i><\/strong>, 2022, 144<\/i>: 22622\u201322632.. PMID: 36448571 PMCID: PMC9772293 DOI: https:\/\/doi.org\/10.1021\/jacs.2c09255<\/a> <\/span><\/p>\n

For papers published before 2021, please see Dr. Jin’s full publication list <\/strong><\/p>\n

Jin Lab Full Publication List<\/strong><\/a>
\nPosted on Dec 10, 2025<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Selective 14 of total 20 of 2022 Publications Jin, J.*; Dar, A. C.; Doroshow, D. \u201cAdvancing Cancer Precision Medicine by Creating a Better Toolbox for Cancer Therapy\u201d in The Frontiers of Medical Research: Cancer (Science\/AAAS, Washington, DC, 2022), pp. 10-12. Xiong, Y.; Zhong, Y.; Yim, H.; Yang, X.; Park, K. S.; Xie, L.; Poulikakos, P. […]<\/p>\n","protected":false},"author":43,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-329","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/pages\/329","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/users\/43"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/comments?post=329"}],"version-history":[{"count":5,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/pages\/329\/revisions"}],"predecessor-version":[{"id":332,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/pages\/329\/revisions\/332"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/media?parent=329"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}